Incidental Mutation 'R5954:Or5p69'
ID 471052
Institutional Source Beutler Lab
Gene Symbol Or5p69
Ensembl Gene ENSMUSG00000109631
Gene Name olfactory receptor family 5 subfamily P member 69
Synonyms GA_x6K02T2PBJ9-10697517-10698461, MOR204-10, Olfr494
MMRRC Submission 044143-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R5954 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 107966699-107967643 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 107966808 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 37 (I37N)
Ref Sequence ENSEMBL: ENSMUSP00000147830 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073059] [ENSMUST00000209743] [ENSMUST00000210291]
AlphaFold Q8VG07
Predicted Effect probably damaging
Transcript: ENSMUST00000073059
AA Change: I37N

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000072810
Gene: ENSMUSG00000109542
AA Change: I37N

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 2e-56 PFAM
Pfam:7tm_1 44 293 2e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000209743
AA Change: I37N

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000210291
AA Change: I37N

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.5%
Validation Efficiency 100% (62/62)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 T C 17: 24,616,390 (GRCm39) I944T probably benign Het
Ank2 T C 3: 126,791,510 (GRCm39) T823A probably benign Het
Ankrd42 C G 7: 92,273,175 (GRCm39) probably null Het
Anks4b T A 7: 119,781,396 (GRCm39) N142K possibly damaging Het
Armc5 A G 7: 127,841,444 (GRCm39) E484G probably benign Het
B4galnt3 A G 6: 120,202,149 (GRCm39) F118L possibly damaging Het
Bbs12 C T 3: 37,374,151 (GRCm39) L200F possibly damaging Het
Cacna1h A G 17: 25,602,175 (GRCm39) F1555S probably damaging Het
Cds2 A G 2: 132,139,191 (GRCm39) T145A probably benign Het
Cenps C A 4: 149,214,658 (GRCm39) probably benign Het
Chd6 A C 2: 160,807,747 (GRCm39) H1822Q probably benign Het
Chdh C T 14: 29,753,138 (GRCm39) R16C possibly damaging Het
Cnga1 T C 5: 72,762,221 (GRCm39) D431G probably damaging Het
Dock8 G A 19: 25,148,983 (GRCm39) R1487Q probably damaging Het
Farp1 T A 14: 121,460,079 (GRCm39) V116D probably damaging Het
Fbxo24 T A 5: 137,617,943 (GRCm39) T274S probably damaging Het
Fmnl3 G A 15: 99,223,791 (GRCm39) R302W probably damaging Het
Gatad2b T C 3: 90,258,748 (GRCm39) L257P probably damaging Het
Gm20402 C T 3: 52,176,311 (GRCm39) P30L probably damaging Het
Gm7932 C T 6: 48,839,793 (GRCm39) noncoding transcript Het
Gpatch8 A T 11: 102,371,767 (GRCm39) D590E unknown Het
Herc1 T G 9: 66,358,774 (GRCm39) probably benign Het
Hsd3b2 T A 3: 98,618,875 (GRCm39) I357F probably benign Het
Ipo5 A G 14: 121,157,396 (GRCm39) Y78C probably damaging Het
Itga8 C A 2: 12,137,297 (GRCm39) A23S probably damaging Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Kat2a A G 11: 100,599,724 (GRCm39) V451A possibly damaging Het
Knstrn A G 2: 118,661,436 (GRCm39) probably benign Het
Med23 A G 10: 24,746,381 (GRCm39) probably benign Het
Mefv A G 16: 3,533,579 (GRCm39) Y231H probably benign Het
Or4d10 A T 19: 12,051,447 (GRCm39) I183N possibly damaging Het
Or4e5 T A 14: 52,727,624 (GRCm39) I266F probably benign Het
Or8g21 A G 9: 38,906,711 (GRCm39) S7P probably damaging Het
Pak5 G T 2: 135,958,383 (GRCm39) T235K probably benign Het
Plppr3 G T 10: 79,701,960 (GRCm39) P294Q probably benign Het
Prepl A G 17: 85,372,077 (GRCm39) F725L probably benign Het
Ptchd3 A T 11: 121,727,413 (GRCm39) probably benign Het
Rprd2 T C 3: 95,672,175 (GRCm39) E1076G probably damaging Het
Sarm1 C A 11: 78,381,428 (GRCm39) E352* probably null Het
Sccpdh T A 1: 179,508,153 (GRCm39) H14Q probably benign Het
Senp7 A G 16: 55,990,234 (GRCm39) I661V probably benign Het
Septin3 T C 15: 82,174,628 (GRCm39) F140L probably damaging Het
Spag6 G T 2: 18,715,417 (GRCm39) Q65H probably damaging Het
Tnni3 C T 7: 4,522,539 (GRCm39) R137H probably damaging Het
Trank1 A G 9: 111,194,201 (GRCm39) S742G probably benign Het
Ucn3 T C 13: 3,991,413 (GRCm39) I80V probably benign Het
Ulk2 A T 11: 61,694,622 (GRCm39) probably benign Het
Uncx C T 5: 139,533,384 (GRCm39) S483L probably benign Het
Vps39 A G 2: 120,155,143 (GRCm39) V550A probably damaging Het
Zfp697 C A 3: 98,335,909 (GRCm39) T558K probably damaging Het
Zfp790 G T 7: 29,528,929 (GRCm39) G538V probably damaging Het
Other mutations in Or5p69
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01761:Or5p69 APN 7 107,967,525 (GRCm39) missense probably damaging 1.00
IGL01934:Or5p69 APN 7 107,967,368 (GRCm39) missense probably damaging 0.99
IGL02041:Or5p69 APN 7 107,966,742 (GRCm39) missense probably damaging 1.00
IGL02253:Or5p69 APN 7 107,967,261 (GRCm39) missense possibly damaging 0.80
IGL02902:Or5p69 APN 7 107,967,336 (GRCm39) missense probably damaging 1.00
R0125:Or5p69 UTSW 7 107,967,576 (GRCm39) missense probably damaging 0.98
R0523:Or5p69 UTSW 7 107,967,438 (GRCm39) missense probably damaging 1.00
R0650:Or5p69 UTSW 7 107,966,996 (GRCm39) missense probably damaging 1.00
R1268:Or5p69 UTSW 7 107,967,002 (GRCm39) missense probably benign 0.06
R2036:Or5p69 UTSW 7 107,966,947 (GRCm39) missense probably benign 0.00
R2162:Or5p69 UTSW 7 107,966,769 (GRCm39) missense probably benign 0.08
R2278:Or5p69 UTSW 7 107,967,288 (GRCm39) missense probably benign 0.01
R2368:Or5p69 UTSW 7 107,967,576 (GRCm39) missense probably damaging 0.98
R3410:Or5p69 UTSW 7 107,967,551 (GRCm39) missense possibly damaging 0.52
R3411:Or5p69 UTSW 7 107,967,551 (GRCm39) missense possibly damaging 0.52
R3834:Or5p69 UTSW 7 107,967,279 (GRCm39) missense probably damaging 0.98
R4322:Or5p69 UTSW 7 107,967,555 (GRCm39) missense probably damaging 1.00
R4625:Or5p69 UTSW 7 107,966,895 (GRCm39) missense probably damaging 0.98
R4724:Or5p69 UTSW 7 107,967,205 (GRCm39) missense probably benign
R4843:Or5p69 UTSW 7 107,967,350 (GRCm39) missense probably benign 0.01
R5525:Or5p69 UTSW 7 107,967,206 (GRCm39) missense probably benign
R7027:Or5p69 UTSW 7 107,967,557 (GRCm39) missense probably damaging 0.98
R8041:Or5p69 UTSW 7 107,966,741 (GRCm39) missense probably damaging 1.00
R8237:Or5p69 UTSW 7 107,967,234 (GRCm39) missense probably damaging 1.00
R9566:Or5p69 UTSW 7 107,966,783 (GRCm39) missense probably benign 0.01
Z1177:Or5p69 UTSW 7 107,967,468 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTAATGCGCTCAGTGTCTG -3'
(R):5'- GCCAAACTGAATAGAACATGCAATG -3'

Sequencing Primer
(F):5'- TTTCCTGCAGGATGGGAA -3'
(R):5'- ATGCAATGTAGGAGATGGTATTTTGC -3'
Posted On 2017-03-31