Incidental Mutation 'R0501:Apc2'
| ID |
47136 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Apc2
|
| Ensembl Gene |
ENSMUSG00000020135 |
| Gene Name |
APC regulator of WNT signaling pathway 2 |
| Synonyms |
APCL |
| MMRRC Submission |
038696-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.172)
|
| Stock # |
R0501 (G1)
|
| Quality Score |
202 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
80131811-80154097 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 80150958 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 1975
(L1975P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000020349
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020341]
[ENSMUST00000020349]
[ENSMUST00000105359]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000020341
|
| SMART Domains |
Protein: ENSMUSP00000020341
Gene: ENSMUSG00000020133
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:UPF0449
|
6 |
103 |
7.5e-40 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000020349
AA Change: L1975P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000020349
Gene: ENSMUSG00000020135
AA Change: L1975P
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:1DEB|B
|
4 |
57 |
9e-17 |
PDB |
|
Pfam:Suppressor_APC
|
123 |
205 |
1.3e-28 |
PFAM |
|
coiled coil region
|
214 |
236 |
N/A |
INTRINSIC |
|
low complexity region
|
242 |
261 |
N/A |
INTRINSIC |
|
ARM
|
300 |
355 |
2.95e0 |
SMART |
|
ARM
|
417 |
468 |
2.22e-2 |
SMART |
|
ARM
|
470 |
511 |
3.22e0 |
SMART |
|
ARM
|
513 |
555 |
3.56e-1 |
SMART |
|
ARM
|
557 |
602 |
2.1e1 |
SMART |
|
ARM
|
607 |
647 |
1.82e-7 |
SMART |
|
Blast:ARM
|
649 |
689 |
6e-18 |
BLAST |
|
low complexity region
|
772 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
817 |
844 |
N/A |
INTRINSIC |
|
low complexity region
|
859 |
870 |
N/A |
INTRINSIC |
|
low complexity region
|
971 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1103 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1134 |
1159 |
4.4e-9 |
PFAM |
|
low complexity region
|
1197 |
1208 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1244 |
1269 |
4.1e-8 |
PFAM |
|
Pfam:SAMP
|
1323 |
1343 |
2.1e-10 |
PFAM |
|
Pfam:APC_crr
|
1369 |
1394 |
5.8e-8 |
PFAM |
|
low complexity region
|
1500 |
1516 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1540 |
1565 |
5.7e-8 |
PFAM |
|
Pfam:SAMP
|
1594 |
1613 |
8.8e-11 |
PFAM |
|
low complexity region
|
1673 |
1699 |
N/A |
INTRINSIC |
|
Pfam:APC_basic
|
1757 |
2093 |
1.1e-142 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000105359
AA Change: L2004P
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000100996
Gene: ENSMUSG00000020135
AA Change: L2004P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:APC_N_CC
|
30 |
81 |
2.7e-34 |
PFAM |
|
Pfam:Suppressor_APC
|
148 |
228 |
1.4e-27 |
PFAM |
|
coiled coil region
|
238 |
260 |
N/A |
INTRINSIC |
|
low complexity region
|
266 |
285 |
N/A |
INTRINSIC |
|
ARM
|
324 |
379 |
2.95e0 |
SMART |
|
ARM
|
446 |
497 |
2.22e-2 |
SMART |
|
ARM
|
499 |
540 |
3.22e0 |
SMART |
|
ARM
|
542 |
584 |
3.56e-1 |
SMART |
|
ARM
|
586 |
631 |
2.1e1 |
SMART |
|
ARM
|
636 |
676 |
1.82e-7 |
SMART |
|
Blast:ARM
|
678 |
718 |
6e-18 |
BLAST |
|
Pfam:Arm_APC_u3
|
719 |
977 |
1.1e-26 |
PFAM |
|
low complexity region
|
1000 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1086 |
1098 |
N/A |
INTRINSIC |
|
low complexity region
|
1116 |
1132 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1164 |
1187 |
9.3e-8 |
PFAM |
|
low complexity region
|
1226 |
1237 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1274 |
1297 |
7.9e-10 |
PFAM |
|
Pfam:APC_crr
|
1399 |
1423 |
1.3e-9 |
PFAM |
|
low complexity region
|
1529 |
1545 |
N/A |
INTRINSIC |
|
low complexity region
|
1585 |
1603 |
N/A |
INTRINSIC |
|
Pfam:SAMP
|
1624 |
1642 |
1.3e-11 |
PFAM |
|
low complexity region
|
1702 |
1728 |
N/A |
INTRINSIC |
|
Pfam:APC_basic
|
1786 |
2122 |
1.3e-122 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.7%
- 3x: 98.9%
- 10x: 97.0%
- 20x: 94.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele display gradual postnatal growth retardation, abnormal lamination of the cerebral cortex, hippocampus, olfactory bulb and cerebellum, impaired neuronal migration and impaired coordination. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700030K09Rik |
T |
C |
8: 73,209,216 (GRCm39) |
S415P |
probably benign |
Het |
| Adam19 |
C |
T |
11: 46,013,957 (GRCm39) |
P316S |
probably damaging |
Het |
| Adamts2 |
A |
G |
11: 50,558,972 (GRCm39) |
D229G |
probably benign |
Het |
| Adcy10 |
C |
T |
1: 165,337,959 (GRCm39) |
P191L |
probably damaging |
Het |
| Adgrv1 |
T |
C |
13: 81,707,269 (GRCm39) |
Y1379C |
probably damaging |
Het |
| Akap9 |
T |
C |
5: 4,020,685 (GRCm39) |
L1132P |
probably damaging |
Het |
| Aoah |
A |
G |
13: 21,189,243 (GRCm39) |
T489A |
probably benign |
Het |
| Bpifa5 |
A |
T |
2: 154,005,616 (GRCm39) |
D66V |
probably benign |
Het |
| C230029F24Rik |
T |
C |
1: 49,374,629 (GRCm39) |
|
noncoding transcript |
Het |
| Cacna1h |
A |
T |
17: 25,607,641 (GRCm39) |
V892E |
probably damaging |
Het |
| Car4 |
G |
A |
11: 84,854,268 (GRCm39) |
V72I |
probably benign |
Het |
| Cfap91 |
C |
G |
16: 38,155,997 (GRCm39) |
M75I |
probably damaging |
Het |
| Chst3 |
A |
G |
10: 60,022,049 (GRCm39) |
L266P |
probably damaging |
Het |
| Ckap2l |
G |
A |
2: 129,127,411 (GRCm39) |
R256W |
possibly damaging |
Het |
| Cntn4 |
A |
T |
6: 106,595,296 (GRCm39) |
D471V |
probably damaging |
Het |
| Cntrob |
G |
A |
11: 69,213,694 (GRCm39) |
S32F |
probably damaging |
Het |
| Cpne7 |
T |
A |
8: 123,852,994 (GRCm39) |
N200K |
possibly damaging |
Het |
| Creb3l3 |
C |
A |
10: 80,922,416 (GRCm39) |
M271I |
probably benign |
Het |
| Csmd1 |
T |
A |
8: 17,077,339 (GRCm39) |
Q106L |
probably damaging |
Het |
| D7Ertd443e |
G |
A |
7: 133,896,701 (GRCm39) |
T563I |
probably damaging |
Het |
| Dmac1 |
T |
G |
4: 75,196,413 (GRCm39) |
N26H |
unknown |
Het |
| Dop1b |
T |
C |
16: 93,549,750 (GRCm39) |
F230L |
probably benign |
Het |
| Dpp6 |
T |
A |
5: 27,930,604 (GRCm39) |
I812N |
probably damaging |
Het |
| Fabp12 |
T |
C |
3: 10,315,203 (GRCm39) |
D48G |
probably benign |
Het |
| Fbn1 |
G |
A |
2: 125,143,669 (GRCm39) |
T2820M |
probably benign |
Het |
| Fcho1 |
C |
T |
8: 72,165,204 (GRCm39) |
A418T |
probably benign |
Het |
| Fcho2 |
A |
T |
13: 98,901,023 (GRCm39) |
S277R |
possibly damaging |
Het |
| Fmo2 |
A |
G |
1: 162,704,497 (GRCm39) |
S470P |
probably benign |
Het |
| Gm17541 |
T |
G |
12: 4,739,730 (GRCm39) |
|
probably benign |
Het |
| Gm4353 |
A |
T |
7: 115,682,706 (GRCm39) |
Y292N |
probably benign |
Het |
| Igkv4-71 |
A |
T |
6: 69,220,290 (GRCm39) |
I69N |
probably damaging |
Het |
| Insrr |
G |
T |
3: 87,717,991 (GRCm39) |
A871S |
probably benign |
Het |
| Irs2 |
C |
T |
8: 11,056,396 (GRCm39) |
V679M |
probably damaging |
Het |
| Itpr3 |
T |
A |
17: 27,326,263 (GRCm39) |
H1344Q |
probably benign |
Het |
| Kcnma1 |
T |
C |
14: 23,361,784 (GRCm39) |
M1074V |
possibly damaging |
Het |
| Kif1a |
G |
A |
1: 92,983,967 (GRCm39) |
R602W |
probably damaging |
Het |
| Kif21b |
A |
T |
1: 136,090,837 (GRCm39) |
D1215V |
probably benign |
Het |
| Mapk13 |
G |
A |
17: 28,995,327 (GRCm39) |
V183M |
probably damaging |
Het |
| Mbp |
C |
T |
18: 82,593,322 (GRCm39) |
S100F |
probably damaging |
Het |
| Mcm6 |
A |
G |
1: 128,283,373 (GRCm39) |
I44T |
probably benign |
Het |
| Ncor1 |
T |
A |
11: 62,264,148 (GRCm39) |
D418V |
possibly damaging |
Het |
| Nid2 |
T |
A |
14: 19,839,736 (GRCm39) |
|
probably null |
Het |
| Nolc1 |
T |
C |
19: 46,067,359 (GRCm39) |
V80A |
probably damaging |
Het |
| Or10a5 |
A |
T |
7: 106,635,439 (GRCm39) |
T26S |
probably benign |
Het |
| Or10ak14 |
C |
A |
4: 118,611,027 (GRCm39) |
C238F |
probably benign |
Het |
| Or12e9 |
A |
T |
2: 87,201,896 (GRCm39) |
R7W |
probably damaging |
Het |
| Or13e8 |
A |
C |
4: 43,697,079 (GRCm39) |
C31W |
probably damaging |
Het |
| Or1j1 |
A |
T |
2: 36,702,492 (GRCm39) |
L204* |
probably null |
Het |
| Or2ag1 |
A |
T |
7: 106,313,810 (GRCm39) |
M26K |
probably benign |
Het |
| Or2ag18 |
G |
A |
7: 106,405,018 (GRCm39) |
S217F |
probably damaging |
Het |
| Or4a68 |
T |
C |
2: 89,270,060 (GRCm39) |
T188A |
probably benign |
Het |
| Or4e1 |
T |
A |
14: 52,701,383 (GRCm39) |
M1L |
possibly damaging |
Het |
| Or5d14 |
A |
T |
2: 87,880,815 (GRCm39) |
I51N |
probably damaging |
Het |
| Or5m12 |
A |
G |
2: 85,735,348 (GRCm39) |
F17L |
probably damaging |
Het |
| Or7g35 |
T |
A |
9: 19,495,914 (GRCm39) |
I27N |
probably damaging |
Het |
| Pcgf3 |
T |
A |
5: 108,622,978 (GRCm39) |
C38S |
probably damaging |
Het |
| Pdia4 |
A |
T |
6: 47,777,936 (GRCm39) |
V352E |
probably damaging |
Het |
| Pik3c2a |
C |
A |
7: 115,953,290 (GRCm39) |
V1202L |
probably damaging |
Het |
| Rbm15 |
G |
T |
3: 107,239,846 (GRCm39) |
A184E |
possibly damaging |
Het |
| Rsph3a |
T |
A |
17: 8,197,952 (GRCm39) |
L442* |
probably null |
Het |
| Scg2 |
G |
C |
1: 79,413,320 (GRCm39) |
L468V |
probably damaging |
Het |
| Sdk1 |
A |
T |
5: 141,923,473 (GRCm39) |
I365L |
probably benign |
Het |
| Setdb1 |
A |
G |
3: 95,246,140 (GRCm39) |
V595A |
probably benign |
Het |
| Skic3 |
A |
C |
13: 76,295,925 (GRCm39) |
M1063L |
probably benign |
Het |
| Slc22a22 |
T |
A |
15: 57,113,046 (GRCm39) |
T398S |
probably benign |
Het |
| Stk11 |
C |
A |
10: 79,962,119 (GRCm39) |
P217Q |
probably damaging |
Het |
| Tes |
G |
A |
6: 17,097,557 (GRCm39) |
D222N |
probably benign |
Het |
| Tmem132e |
T |
A |
11: 82,325,894 (GRCm39) |
I206N |
possibly damaging |
Het |
| Tmem214 |
G |
T |
5: 31,029,876 (GRCm39) |
R251L |
probably damaging |
Het |
| Tmem253 |
T |
A |
14: 52,256,036 (GRCm39) |
I105N |
probably damaging |
Het |
| Toe1 |
A |
G |
4: 116,664,682 (GRCm39) |
V12A |
probably benign |
Het |
| Top1 |
C |
A |
2: 160,556,079 (GRCm39) |
H513N |
probably damaging |
Het |
| Tph1 |
G |
T |
7: 46,299,412 (GRCm39) |
Y376* |
probably null |
Het |
| Trim45 |
T |
A |
3: 100,830,535 (GRCm39) |
L103Q |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,774,518 (GRCm39) |
|
probably null |
Het |
| Twnk |
T |
C |
19: 44,996,185 (GRCm39) |
V206A |
probably damaging |
Het |
| Ube2z |
A |
G |
11: 95,941,114 (GRCm39) |
S343P |
probably damaging |
Het |
| Vmn2r8 |
T |
C |
5: 108,951,049 (GRCm39) |
D132G |
probably benign |
Het |
| Wdr20rt |
A |
T |
12: 65,272,581 (GRCm39) |
T15S |
probably benign |
Het |
| Wdr59 |
C |
T |
8: 112,185,579 (GRCm39) |
R841Q |
possibly damaging |
Het |
| Wdtc1 |
A |
G |
4: 133,036,151 (GRCm39) |
F130L |
possibly damaging |
Het |
| Wnk1 |
C |
T |
6: 119,939,764 (GRCm39) |
R43Q |
probably damaging |
Het |
| Ythdf3 |
T |
C |
3: 16,259,236 (GRCm39) |
L461P |
probably damaging |
Het |
| Zcchc2 |
T |
G |
1: 105,943,821 (GRCm39) |
F462C |
possibly damaging |
Het |
|
| Other mutations in Apc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01069:Apc2
|
APN |
10 |
80,147,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01154:Apc2
|
APN |
10 |
80,148,903 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01411:Apc2
|
APN |
10 |
80,150,912 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01598:Apc2
|
APN |
10 |
80,148,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01621:Apc2
|
APN |
10 |
80,142,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01720:Apc2
|
APN |
10 |
80,150,333 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01837:Apc2
|
APN |
10 |
80,150,492 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01933:Apc2
|
APN |
10 |
80,147,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02243:Apc2
|
APN |
10 |
80,138,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02292:Apc2
|
APN |
10 |
80,138,258 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02956:Apc2
|
APN |
10 |
80,142,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03081:Apc2
|
APN |
10 |
80,148,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03172:Apc2
|
APN |
10 |
80,149,220 (GRCm39) |
missense |
probably damaging |
0.98 |
|
LCD18:Apc2
|
UTSW |
10 |
80,135,808 (GRCm39) |
intron |
probably benign |
|
|
R0278:Apc2
|
UTSW |
10 |
80,148,647 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0594:Apc2
|
UTSW |
10 |
80,142,090 (GRCm39) |
nonsense |
probably null |
|
|
R0607:Apc2
|
UTSW |
10 |
80,149,935 (GRCm39) |
missense |
probably benign |
|
|
R0624:Apc2
|
UTSW |
10 |
80,150,417 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0633:Apc2
|
UTSW |
10 |
80,143,289 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0638:Apc2
|
UTSW |
10 |
80,140,801 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0647:Apc2
|
UTSW |
10 |
80,140,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0830:Apc2
|
UTSW |
10 |
80,151,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1071:Apc2
|
UTSW |
10 |
80,147,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1221:Apc2
|
UTSW |
10 |
80,142,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1432:Apc2
|
UTSW |
10 |
80,148,183 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1579:Apc2
|
UTSW |
10 |
80,147,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1654:Apc2
|
UTSW |
10 |
80,137,676 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1700:Apc2
|
UTSW |
10 |
80,148,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Apc2
|
UTSW |
10 |
80,144,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Apc2
|
UTSW |
10 |
80,149,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Apc2
|
UTSW |
10 |
80,150,678 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1915:Apc2
|
UTSW |
10 |
80,151,701 (GRCm39) |
missense |
probably benign |
|
|
R1999:Apc2
|
UTSW |
10 |
80,144,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2050:Apc2
|
UTSW |
10 |
80,143,443 (GRCm39) |
splice site |
probably null |
|
|
R2219:Apc2
|
UTSW |
10 |
80,144,943 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2393:Apc2
|
UTSW |
10 |
80,148,903 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3862:Apc2
|
UTSW |
10 |
80,143,393 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3900:Apc2
|
UTSW |
10 |
80,131,806 (GRCm39) |
splice site |
probably null |
|
|
R3901:Apc2
|
UTSW |
10 |
80,150,922 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3952:Apc2
|
UTSW |
10 |
80,150,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4009:Apc2
|
UTSW |
10 |
80,149,426 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4090:Apc2
|
UTSW |
10 |
80,141,378 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4695:Apc2
|
UTSW |
10 |
80,146,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4754:Apc2
|
UTSW |
10 |
80,150,192 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4807:Apc2
|
UTSW |
10 |
80,150,196 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4886:Apc2
|
UTSW |
10 |
80,150,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4964:Apc2
|
UTSW |
10 |
80,149,841 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5056:Apc2
|
UTSW |
10 |
80,137,148 (GRCm39) |
missense |
probably benign |
|
|
R5057:Apc2
|
UTSW |
10 |
80,144,903 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5165:Apc2
|
UTSW |
10 |
80,151,684 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5241:Apc2
|
UTSW |
10 |
80,148,068 (GRCm39) |
missense |
probably benign |
|
|
R5649:Apc2
|
UTSW |
10 |
80,149,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5924:Apc2
|
UTSW |
10 |
80,147,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6124:Apc2
|
UTSW |
10 |
80,142,185 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6218:Apc2
|
UTSW |
10 |
80,142,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6376:Apc2
|
UTSW |
10 |
80,148,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6490:Apc2
|
UTSW |
10 |
80,149,757 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6572:Apc2
|
UTSW |
10 |
80,147,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6620:Apc2
|
UTSW |
10 |
80,149,401 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7171:Apc2
|
UTSW |
10 |
80,151,170 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7180:Apc2
|
UTSW |
10 |
80,146,990 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7326:Apc2
|
UTSW |
10 |
80,147,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7340:Apc2
|
UTSW |
10 |
80,149,316 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7378:Apc2
|
UTSW |
10 |
80,147,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7384:Apc2
|
UTSW |
10 |
80,148,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Apc2
|
UTSW |
10 |
80,138,017 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7543:Apc2
|
UTSW |
10 |
80,150,720 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7743:Apc2
|
UTSW |
10 |
80,140,749 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7759:Apc2
|
UTSW |
10 |
80,147,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8244:Apc2
|
UTSW |
10 |
80,151,166 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8327:Apc2
|
UTSW |
10 |
80,137,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8489:Apc2
|
UTSW |
10 |
80,143,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8494:Apc2
|
UTSW |
10 |
80,150,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8669:Apc2
|
UTSW |
10 |
80,149,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8773:Apc2
|
UTSW |
10 |
80,142,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8920:Apc2
|
UTSW |
10 |
80,149,934 (GRCm39) |
missense |
probably benign |
|
|
R9178:Apc2
|
UTSW |
10 |
80,150,235 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9224:Apc2
|
UTSW |
10 |
80,150,111 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9357:Apc2
|
UTSW |
10 |
80,146,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9394:Apc2
|
UTSW |
10 |
80,145,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9666:Apc2
|
UTSW |
10 |
80,147,183 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R9689:Apc2
|
UTSW |
10 |
80,150,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0018:Apc2
|
UTSW |
10 |
80,148,098 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1177:Apc2
|
UTSW |
10 |
80,147,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATTCATGCAAAGGCCAGCCAG -3'
(R):5'- TAATATGTGGCAGGGATGCGTACCG -3'
Sequencing Primer
(F):5'- GAGTGCCACCTCCACTG -3'
(R):5'- ATGCGTACCGCTTGACTG -3'
|
| Posted On |
2013-06-12 |
Incidental Mutation