Mutagenetix > Incidental Mutation

Incidental Mutation 'R5959:Fpr-rs7'

471378

Institutional Source

Beutler Lab

Gene Symbol

Fpr-rs7

Ensembl Gene

ENSMUSG00000071276

Gene Name

formyl peptide receptor, related sequence 7

Synonyms

MMRRC Submission

044146-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.110) question?

Stock #

R5959 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

20113210-20114226 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 20113749 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Tyrosine at position 160 (H160Y)

Ref Sequence

ENSEMBL: ENSMUSP00000093297 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095637]

AlphaFold

Q71MR7

Predicted Effect

probably benign
Transcript: ENSMUST00000095637
AA Change: H160Y

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000093297
Gene: ENSMUSG00000071276
AA Change: H160Y

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	1.2e-38	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176711

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.3%
20x: 94.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acaca	A	T	11: 84,215,966	N164Y	probably damaging	Het
Acp6	A	G	3: 97,166,572	E164G	probably damaging	Het
Adcy5	A	T	16: 35,298,410	I1044F	probably damaging	Het
Ahcyl2	A	G	6: 29,886,174	D363G	probably damaging	Het
Ankrd28	T	C	14: 31,729,922	T273A	probably benign	Het
Cc2d1a	A	T	8: 84,133,503	Y862*	probably null	Het
Cfap221	T	A	1: 119,932,781	H705L	probably damaging	Het
Cfap61	C	T	2: 145,947,133	T19M	probably benign	Het
Chga	T	C	12: 102,561,855	S202P	probably benign	Het
Cnmd	T	C	14: 79,656,669	I93V	probably damaging	Het
Cpne1	G	A	2: 156,078,223	S188L	probably benign	Het
Dchs2	G	A	3: 83,325,418	V2237I	probably benign	Het
Dguok	C	T	6: 83,490,592	R91H	probably benign	Het
Eed	A	G	7: 89,969,627	I193T	probably damaging	Het
Fasn	C	T	11: 120,808,564	E2353K	probably damaging	Het
Gm12394	T	A	4: 42,793,492	K213N	probably damaging	Het
Gramd4	T	A	15: 86,127,557	M272K	probably damaging	Het
Hfm1	A	G	5: 106,874,917	S940P	probably damaging	Het
Ifnlr1	T	A	4: 135,705,341	S363T	possibly damaging	Het
Jak3	A	G	8: 71,682,071	N481D	probably damaging	Het
Kcnj3	A	G	2: 55,437,318	K40E	probably benign	Het
Kif20a	G	A	18: 34,632,415	A822T	probably benign	Het
Lpcat4	T	A	2: 112,240,035	L31H	possibly damaging	Het
Myo1c	A	G	11: 75,657,519	T38A	probably benign	Het
Myt1l	T	C	12: 29,920,040		probably null	Het
Nbas	T	C	12: 13,288,801	V214A	probably damaging	Het
Neb	C	A	2: 52,156,377	R6537L	probably benign	Het
Nwd2	T	A	5: 63,808,070	F1666I	probably benign	Het
Olfr67	T	A	7: 103,787,516	I254F	probably damaging	Het
Olfr906	A	G	9: 38,488,911	N294S	probably damaging	Het
Prmt8	C	A	6: 127,729,418	V137L	probably damaging	Het
Ptpn21	A	T	12: 98,708,889		probably null	Het
Rab15	A	G	12: 76,822,269	S17P	probably damaging	Het
Rbm5	T	G	9: 107,752,140	I338L	probably benign	Het
Rragc	G	A	4: 123,923,974	S218N	probably damaging	Het
Sacs	T	C	14: 61,212,400	M3965T	probably damaging	Het
Sgo2b	T	A	8: 63,927,288	I837F	probably benign	Het
Sorcs3	T	G	19: 48,749,396	C751G	probably damaging	Het
Sowahc	A	G	10: 59,223,098	D352G	probably benign	Het
Sox15	C	T	11: 69,655,730	R120C	probably damaging	Het
Srr	A	G	11: 74,911,065	V126A	possibly damaging	Het
Tenm3	T	A	8: 48,646,447	R108*	probably null	Het
Traf3ip2	A	T	10: 39,641,341	M403L	probably benign	Het
Trappc11	T	C	8: 47,501,558	D949G	probably damaging	Het
Ttn	A	G	2: 76,714,616	I32714T	probably damaging	Het
Ttn	T	A	2: 76,863,505	T218S	possibly damaging	Het
Uaca	A	T	9: 60,870,770	H811L	probably damaging	Het
Ugt2b1	T	C	5: 86,925,954	E182G	probably benign	Het
Vmn1r49	T	C	6: 90,072,804	D72G	probably damaging	Het
Vmn2r80	A	T	10: 79,169,479	M317L	probably benign	Het
Vwa2	T	C	19: 56,881,172	L13P	possibly damaging	Het
Zc3hav1	G	A	6: 38,307,444	T912I	probably benign	Het
Zfp703	C	T	8: 26,979,205	P299L	probably damaging	Het
Zfp948	A	G	17: 21,587,514	K323E	probably benign	Het
Zfyve27	T	G	19: 42,179,448	V143G	unknown	Het

Other mutations in Fpr-rs7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00332:Fpr-rs7	APN	17	20113218	nonsense	probably null
IGL01386:Fpr-rs7	APN	17	20114192	missense	probably damaging	0.98
IGL02293:Fpr-rs7	APN	17	20113970	missense	probably benign	0.01
IGL03303:Fpr-rs7	APN	17	20113739	missense	possibly damaging	0.55
R0731:Fpr-rs7	UTSW	17	20113854	missense	probably benign	0.00
R0826:Fpr-rs7	UTSW	17	20113626	missense	probably benign	0.01
R1439:Fpr-rs7	UTSW	17	20113607	missense	probably benign	0.10
R1590:Fpr-rs7	UTSW	17	20113416	missense	probably benign	0.05
R1778:Fpr-rs7	UTSW	17	20114015	missense	probably damaging	1.00
R4715:Fpr-rs7	UTSW	17	20113428	missense	probably benign	0.00
R4744:Fpr-rs7	UTSW	17	20114003	missense	probably benign	0.17
R4921:Fpr-rs7	UTSW	17	20113820	missense	possibly damaging	0.70
R5540:Fpr-rs7	UTSW	17	20114094	missense	probably damaging	1.00
R5677:Fpr-rs7	UTSW	17	20114103	missense	probably benign
R6042:Fpr-rs7	UTSW	17	20113215	missense	probably benign	0.00
R7921:Fpr-rs7	UTSW	17	20113405	missense	probably benign	0.03
R7984:Fpr-rs7	UTSW	17	20113409	missense	probably benign	0.01
R8137:Fpr-rs7	UTSW	17	20113793	missense	possibly damaging	0.49
R8172:Fpr-rs7	UTSW	17	20114181	missense	probably benign	0.04
R8762:Fpr-rs7	UTSW	17	20113527	missense	probably benign	0.07
R9134:Fpr-rs7	UTSW	17	20114063	missense	probably damaging	1.00
Z1176:Fpr-rs7	UTSW	17	20113393	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- ATCTTGGCAGCCATGAGTCC -3'
(R):5'- CAATTGTCATGAATGGAGAATGGC -3'

Sequencing Primer
(F):5'- TTGGCAGCCATGAGTCCATAGC -3'
(R):5'- GGTTCCTTTGCAAATTTGTTCACATG -3'

Posted On

2017-03-31