Incidental Mutation 'R5972:Adgra1'
ID 471471
Institutional Source Beutler Lab
Gene Symbol Adgra1
Ensembl Gene ENSMUSG00000025475
Gene Name adhesion G protein-coupled receptor A1
Synonyms D7Ertd680e, Gpr123, 2900059M17Rik
MMRRC Submission 044155-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.125) question?
Stock # R5972 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 139414090-139458004 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 139425583 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 32 (L32P)
Ref Sequence ENSEMBL: ENSMUSP00000026548 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026548]
AlphaFold Q8C4G9
Predicted Effect probably damaging
Transcript: ENSMUST00000026548
AA Change: L32P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000026548
Gene: ENSMUSG00000025475
AA Change: L32P

DomainStartEndE-ValueType
Pfam:7tm_2 19 307 1.4e-16 PFAM
low complexity region 407 419 N/A INTRINSIC
low complexity region 423 434 N/A INTRINSIC
low complexity region 469 481 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129454
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137584
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 93.9%
Validation Efficiency 100% (51/51)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the adhesion family of G-protein-coupled receptors. Members of this family function in several sensory systems and regulate blood pressure, immune responses, food intake and development. A similar protein in rodents is thought to play a role in in the regulation of neuronal signaling pathways. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Mar 2014]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg2 T A 6: 58,649,070 (GRCm39) M305K probably benign Het
Accs G T 2: 93,669,572 (GRCm39) H283N probably damaging Het
Actl6b A T 5: 137,564,818 (GRCm39) H283L possibly damaging Het
Afg3l2 G T 18: 67,554,329 (GRCm39) L458M probably damaging Het
Arfgef2 T C 2: 166,733,756 (GRCm39) I1672T probably damaging Het
Bambi T A 18: 3,512,354 (GRCm39) V246E probably damaging Het
BC048679 A G 7: 81,145,479 (GRCm39) L29P probably damaging Het
Bmal2 A G 6: 146,711,187 (GRCm39) M64V probably damaging Het
Camk4 T C 18: 33,240,979 (GRCm39) L92P probably damaging Het
Ddx11 C A 17: 66,455,085 (GRCm39) Q655K probably benign Het
Ddx52 A G 11: 83,844,051 (GRCm39) probably null Het
Entrep3 T A 3: 89,093,115 (GRCm39) V213D probably damaging Het
Eps8l3 T C 3: 107,791,763 (GRCm39) probably null Het
Erap1 T A 13: 74,810,423 (GRCm39) probably null Het
Flg T A 3: 93,186,849 (GRCm39) N100K probably benign Het
Grip2 A T 6: 91,784,262 (GRCm39) V13E probably benign Het
Iars1 T C 13: 49,863,108 (GRCm39) V520A possibly damaging Het
Impa1 A G 3: 10,394,064 (GRCm39) M1T probably null Het
Ip6k3 T C 17: 27,368,934 (GRCm39) T179A possibly damaging Het
Krt87 T A 15: 101,385,467 (GRCm39) M302L probably benign Het
Lrp8 T C 4: 107,726,267 (GRCm39) Y899H probably damaging Het
Lrpprc A T 17: 85,020,250 (GRCm39) I1145N possibly damaging Het
Mapk11 A T 15: 89,028,387 (GRCm39) D324E probably benign Het
Melk C T 4: 44,351,007 (GRCm39) T516I probably benign Het
Mia2 C T 12: 59,193,723 (GRCm39) H130Y probably damaging Het
Mroh5 C T 15: 73,662,568 (GRCm39) probably null Het
Ncam1 T C 9: 49,418,829 (GRCm39) T824A possibly damaging Het
Neurog1 T C 13: 56,399,211 (GRCm39) S179G probably damaging Het
Ntrk2 T A 13: 58,985,633 (GRCm39) L79Q probably damaging Het
Patj T A 4: 98,457,290 (GRCm39) M46K probably damaging Het
Pdcd6ip T C 9: 113,491,366 (GRCm39) K626E probably benign Het
Pdss2 T A 10: 43,174,922 (GRCm39) Y143N probably damaging Het
Pkhd1l1 G A 15: 44,408,812 (GRCm39) S2433N probably damaging Het
Plekha5 A G 6: 140,518,639 (GRCm39) T309A possibly damaging Het
Prdm4 C T 10: 85,743,365 (GRCm39) V297M probably damaging Het
Rab15 T C 12: 76,847,377 (GRCm39) Y148C probably damaging Het
Ryr3 A T 2: 112,664,409 (GRCm39) N1627K probably damaging Het
Scn1a G T 2: 66,181,454 (GRCm39) A23E possibly damaging Het
Smtn A T 11: 3,483,486 (GRCm39) I30N probably damaging Het
Sympk A G 7: 18,780,749 (GRCm39) K751E probably benign Het
Usp24 C T 4: 106,225,264 (GRCm39) P632L probably damaging Het
Vmn2r106 A G 17: 20,498,738 (GRCm39) I391T probably benign Het
Vmn2r54 G A 7: 12,349,279 (GRCm39) P768S probably damaging Het
Vmn2r54 C T 7: 12,369,874 (GRCm39) C63Y probably damaging Het
Zfhx3 T G 8: 109,677,483 (GRCm39) C2844W possibly damaging Het
Other mutations in Adgra1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00484:Adgra1 APN 7 139,455,860 (GRCm39) missense probably benign 0.01
IGL01014:Adgra1 APN 7 139,455,577 (GRCm39) missense probably damaging 1.00
IGL01014:Adgra1 APN 7 139,455,576 (GRCm39) missense probably benign 0.05
IGL01068:Adgra1 APN 7 139,425,541 (GRCm39) missense probably damaging 0.96
IGL01095:Adgra1 APN 7 139,425,570 (GRCm39) missense possibly damaging 0.79
IGL02717:Adgra1 APN 7 139,456,094 (GRCm39) missense probably damaging 0.98
adaga UTSW 7 139,455,196 (GRCm39) missense probably damaging 1.00
I2288:Adgra1 UTSW 7 139,432,495 (GRCm39) missense probably damaging 0.98
R0630:Adgra1 UTSW 7 139,432,500 (GRCm39) nonsense probably null
R0653:Adgra1 UTSW 7 139,456,063 (GRCm39) missense probably damaging 0.98
R1388:Adgra1 UTSW 7 139,453,919 (GRCm39) missense probably damaging 0.97
R1462:Adgra1 UTSW 7 139,455,745 (GRCm39) missense probably damaging 1.00
R1462:Adgra1 UTSW 7 139,455,745 (GRCm39) missense probably damaging 1.00
R1667:Adgra1 UTSW 7 139,425,564 (GRCm39) missense possibly damaging 0.95
R1770:Adgra1 UTSW 7 139,453,947 (GRCm39) nonsense probably null
R2083:Adgra1 UTSW 7 139,455,547 (GRCm39) missense probably damaging 0.99
R2967:Adgra1 UTSW 7 139,455,601 (GRCm39) missense possibly damaging 0.68
R3410:Adgra1 UTSW 7 139,427,619 (GRCm39) missense possibly damaging 0.94
R3411:Adgra1 UTSW 7 139,427,619 (GRCm39) missense possibly damaging 0.94
R3687:Adgra1 UTSW 7 139,432,506 (GRCm39) missense probably damaging 1.00
R3804:Adgra1 UTSW 7 139,425,510 (GRCm39) missense probably benign 0.01
R3912:Adgra1 UTSW 7 139,425,630 (GRCm39) critical splice donor site probably null
R4452:Adgra1 UTSW 7 139,432,437 (GRCm39) missense probably benign 0.02
R4466:Adgra1 UTSW 7 139,420,752 (GRCm39) intron probably benign
R4469:Adgra1 UTSW 7 139,455,977 (GRCm39) missense probably damaging 0.96
R4675:Adgra1 UTSW 7 139,456,102 (GRCm39) missense probably damaging 1.00
R4724:Adgra1 UTSW 7 139,455,505 (GRCm39) missense probably benign
R5220:Adgra1 UTSW 7 139,455,512 (GRCm39) missense probably benign 0.06
R5846:Adgra1 UTSW 7 139,455,196 (GRCm39) missense probably damaging 1.00
R6453:Adgra1 UTSW 7 139,455,343 (GRCm39) missense probably benign 0.09
R7242:Adgra1 UTSW 7 139,427,573 (GRCm39) critical splice acceptor site probably null
R7343:Adgra1 UTSW 7 139,456,058 (GRCm39) missense probably damaging 1.00
R7774:Adgra1 UTSW 7 139,427,628 (GRCm39) missense possibly damaging 0.79
R8190:Adgra1 UTSW 7 139,456,034 (GRCm39) missense probably benign
R8355:Adgra1 UTSW 7 139,455,567 (GRCm39) nonsense probably null
R8455:Adgra1 UTSW 7 139,455,567 (GRCm39) nonsense probably null
R8905:Adgra1 UTSW 7 139,455,763 (GRCm39) missense probably damaging 1.00
R9045:Adgra1 UTSW 7 139,432,566 (GRCm39) missense possibly damaging 0.64
R9056:Adgra1 UTSW 7 139,432,492 (GRCm39) missense probably damaging 1.00
R9183:Adgra1 UTSW 7 139,455,716 (GRCm39) missense probably benign 0.24
R9438:Adgra1 UTSW 7 139,432,525 (GRCm39) missense probably benign 0.00
V1662:Adgra1 UTSW 7 139,432,495 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AGTAGTCACTAAAGAGAGTCCCTCTC -3'
(R):5'- GGCTGATGTTAAGAAGTCCCAG -3'

Sequencing Primer
(F):5'- GAGTCCCTCTCTGCTACCAG -3'
(R):5'- TTAGTTCTAGGGAATCAGGCACCC -3'
Posted On 2017-03-31