Incidental Mutation 'R5973:Or10ak11'
ID 471526
Institutional Source Beutler Lab
Gene Symbol Or10ak11
Ensembl Gene ENSMUSG00000110947
Gene Name olfactory receptor family 10 subfamily AK member 11
Synonyms Olfr1333, MOR259-6, MOR259-11, GA_x6K02T2QD9B-18703033-18703986
MMRRC Submission 044156-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R5973 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 118686682-118687635 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 118687413 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 75 (V75I)
Ref Sequence ENSEMBL: ENSMUSP00000075398 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076019] [ENSMUST00000106361] [ENSMUST00000214477]
AlphaFold Q7TQV7
Predicted Effect probably benign
Transcript: ENSMUST00000076019
AA Change: V75I

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000075398
Gene: ENSMUSG00000110947
AA Change: V75I

DomainStartEndE-ValueType
Pfam:7tm_1 42 291 4.1e-31 PFAM
Pfam:7tm_4 140 284 2.9e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106361
AA Change: V76I

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000101968
Gene: ENSMUSG00000073768
AA Change: V76I

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.1e-56 PFAM
Pfam:7tm_1 43 292 3.9e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214477
AA Change: V74I

PolyPhen 2 Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000214477
AA Change: V74I

PolyPhen 2 Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.5%
  • 20x: 92.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb T A 5: 114,364,928 (GRCm39) I1536N probably damaging Het
Actr1b A G 1: 36,741,162 (GRCm39) S140P probably damaging Het
Afg3l2 G T 18: 67,554,329 (GRCm39) L458M probably damaging Het
Anapc7 A T 5: 122,566,366 (GRCm39) T92S probably benign Het
Ash2l G A 8: 26,307,642 (GRCm39) T585M possibly damaging Het
Asxl1 T C 2: 153,243,931 (GRCm39) F1495L probably damaging Het
Atp5pf T C 16: 84,625,328 (GRCm39) probably null Het
Bcl2a1c A G 9: 114,159,465 (GRCm39) N81S probably benign Het
Bfsp2 A C 9: 103,309,856 (GRCm39) probably null Het
Casq1 A G 1: 172,047,068 (GRCm39) Y64H probably damaging Het
Ceacam16 A G 7: 19,590,262 (GRCm39) V227A probably damaging Het
Cers6 T A 2: 68,898,969 (GRCm39) probably null Het
Chrnb1 A G 11: 69,686,671 (GRCm39) probably benign Het
Clpb G A 7: 101,313,204 (GRCm39) V63I probably benign Het
Dnah11 G T 12: 118,074,687 (GRCm39) D1388E probably benign Het
Dst T C 1: 34,195,938 (GRCm39) L405P probably damaging Het
Dstyk A G 1: 132,362,149 (GRCm39) E193G probably damaging Het
Dusp2 A T 2: 127,179,208 (GRCm39) S188C probably damaging Het
Ep400 T C 5: 110,877,697 (GRCm39) I810V unknown Het
Faim2 C T 15: 99,419,132 (GRCm39) G79D probably benign Het
Fpgt A T 3: 154,793,040 (GRCm39) I329K probably damaging Het
Fut8 A G 12: 77,411,771 (GRCm39) T78A probably benign Het
Gm15130 A G 2: 110,965,714 (GRCm39) probably benign Het
Gm17087 A C 17: 8,785,529 (GRCm39) I58R probably benign Het
Grk2 T C 19: 4,337,925 (GRCm39) D485G possibly damaging Het
Hax1 GTCATCATCATCATCATC GTCATCATCATCATCATCATC 3: 89,905,247 (GRCm39) probably benign Het
Hmcn1 A G 1: 150,439,568 (GRCm39) S5539P probably damaging Het
Hmcn2 G A 2: 31,310,335 (GRCm39) V3310M probably damaging Het
Impdh1 A T 6: 29,207,161 (GRCm39) L61Q probably damaging Het
Inhbb A T 1: 119,345,806 (GRCm39) V161D possibly damaging Het
Kansl2 C T 15: 98,427,306 (GRCm39) V192M probably damaging Het
Krt1c T C 15: 101,724,747 (GRCm39) K288E probably damaging Het
Lyar A G 5: 38,385,290 (GRCm39) K110R probably damaging Het
Lyrm9 C A 11: 78,726,961 (GRCm39) H35N probably damaging Het
Mab21l1 A G 3: 55,690,533 (GRCm39) D40G probably benign Het
Maml2 A C 9: 13,532,915 (GRCm39) probably benign Het
Mbd5 A G 2: 49,162,401 (GRCm39) H69R probably benign Het
Morc2b G T 17: 33,356,446 (GRCm39) A442E probably damaging Het
Moxd2 A T 6: 40,855,744 (GRCm39) L615Q probably damaging Het
Msh2 G A 17: 88,016,011 (GRCm39) G548S probably damaging Het
Napg G A 18: 63,128,054 (GRCm39) S279N possibly damaging Het
Ncor1 A T 11: 62,240,136 (GRCm39) probably null Het
Nkiras2 G T 11: 100,516,866 (GRCm39) R128L probably damaging Het
Npy4r T C 14: 33,868,664 (GRCm39) D208G probably benign Het
Or52e2 A G 7: 102,804,081 (GRCm39) V291A possibly damaging Het
Or8b42 G T 9: 38,341,627 (GRCm39) L16F probably damaging Het
Pcdhgb2 A G 18: 37,823,560 (GRCm39) T184A probably benign Het
Plxna4 T C 6: 32,228,000 (GRCm39) probably null Het
Pnldc1 C T 17: 13,113,260 (GRCm39) E328K probably benign Het
Pon1 T A 6: 5,185,334 (GRCm39) L55F probably damaging Het
Pramel51 T C 12: 88,142,683 (GRCm39) I312V probably benign Het
Prkci G T 3: 31,092,605 (GRCm39) D296Y probably damaging Het
Prkd1 T C 12: 50,435,038 (GRCm39) H563R probably damaging Het
Ptpru T C 4: 131,546,236 (GRCm39) N266S probably benign Het
Rapgef6 A T 11: 54,530,609 (GRCm39) I589F probably damaging Het
Rcan3 A T 4: 135,145,853 (GRCm39) S127T probably benign Het
Sh3tc2 A G 18: 62,110,975 (GRCm39) D277G probably benign Het
Sipa1l3 G A 7: 29,098,949 (GRCm39) A440V probably benign Het
Slc13a2 A C 11: 78,291,358 (GRCm39) I372S probably damaging Het
Slco1a7 T A 6: 141,700,182 (GRCm39) T117S probably benign Het
Spns1 A T 7: 125,969,495 (GRCm39) I528N probably damaging Het
Sult6b2 T C 6: 142,736,021 (GRCm39) K191R probably benign Het
Swt1 A G 1: 151,278,700 (GRCm39) probably null Het
Tcn2 A T 11: 3,877,546 (GRCm39) L34* probably null Het
Tmem131l C T 3: 83,829,553 (GRCm39) A1035T possibly damaging Het
Trpc4 A G 3: 54,223,263 (GRCm39) E733G probably damaging Het
Uap1l1 A T 2: 25,254,642 (GRCm39) H184Q possibly damaging Het
Vil1 T G 1: 74,455,192 (GRCm39) V48G possibly damaging Het
Vps39 A T 2: 120,159,186 (GRCm39) H367Q probably damaging Het
Wars2 A G 3: 99,094,962 (GRCm39) T86A probably benign Het
Wdr90 A G 17: 26,064,107 (GRCm39) S1872P probably damaging Het
Wdr90 A G 17: 26,065,381 (GRCm39) L1625P probably damaging Het
Xaf1 A T 11: 72,194,256 (GRCm39) M46L probably damaging Het
Zfp1005 A G 2: 150,109,855 (GRCm39) T182A unknown Het
Other mutations in Or10ak11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01088:Or10ak11 APN 4 118,686,989 (GRCm39) missense probably benign 0.30
IGL03023:Or10ak11 APN 4 118,687,449 (GRCm39) missense probably damaging 0.99
IGL03387:Or10ak11 APN 4 118,687,238 (GRCm39) missense probably damaging 1.00
R0326:Or10ak11 UTSW 4 118,687,022 (GRCm39) missense possibly damaging 0.90
R0532:Or10ak11 UTSW 4 118,686,897 (GRCm39) missense probably damaging 1.00
R1775:Or10ak11 UTSW 4 118,687,065 (GRCm39) missense probably benign 0.00
R1906:Or10ak11 UTSW 4 118,687,467 (GRCm39) missense probably damaging 1.00
R1946:Or10ak11 UTSW 4 118,687,223 (GRCm39) missense probably benign 0.00
R2260:Or10ak11 UTSW 4 118,687,359 (GRCm39) missense probably damaging 1.00
R5084:Or10ak11 UTSW 4 118,686,767 (GRCm39) missense probably damaging 1.00
R5337:Or10ak11 UTSW 4 118,686,863 (GRCm39) missense probably benign 0.44
R5444:Or10ak11 UTSW 4 118,687,308 (GRCm39) missense probably benign
R5817:Or10ak11 UTSW 4 118,687,296 (GRCm39) missense probably damaging 0.96
R5987:Or10ak11 UTSW 4 118,687,478 (GRCm39) missense probably damaging 0.96
R6031:Or10ak11 UTSW 4 118,687,588 (GRCm39) splice site probably null
R6031:Or10ak11 UTSW 4 118,687,588 (GRCm39) splice site probably null
R7255:Or10ak11 UTSW 4 118,687,149 (GRCm39) missense probably benign 0.17
R7483:Or10ak11 UTSW 4 118,687,517 (GRCm39) missense probably damaging 0.98
R8214:Or10ak11 UTSW 4 118,687,288 (GRCm39) missense probably benign
R8479:Or10ak11 UTSW 4 118,687,212 (GRCm39) missense probably damaging 1.00
R8847:Or10ak11 UTSW 4 118,686,821 (GRCm39) missense probably damaging 0.97
R9661:Or10ak11 UTSW 4 118,687,526 (GRCm39) missense probably benign 0.45
Z1176:Or10ak11 UTSW 4 118,687,247 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGTGGATAGCAAATGGCCAC -3'
(R):5'- GTTTTCGATGATTCCAGGGCAG -3'

Sequencing Primer
(F):5'- TGGCCACATACCGGTCATAAG -3'
(R):5'- CCAAAGTTGGGTCTCTGAGTTCATC -3'
Posted On 2017-03-31