Incidental Mutation 'R5975:Zfp341'
ID 471665
Institutional Source Beutler Lab
Gene Symbol Zfp341
Ensembl Gene ENSMUSG00000059842
Gene Name zinc finger protein 341
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5975 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 154613297-154646821 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 154630441 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 315 (C315S)
Ref Sequence ENSEMBL: ENSMUSP00000105324 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081926] [ENSMUST00000109702] [ENSMUST00000126421]
AlphaFold Q6PGC9
Predicted Effect probably damaging
Transcript: ENSMUST00000081926
AA Change: C322S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000080596
Gene: ENSMUSG00000059842
AA Change: C322S

DomainStartEndE-ValueType
ZnF_C2H2 53 73 4.16e1 SMART
low complexity region 96 110 N/A INTRINSIC
low complexity region 154 161 N/A INTRINSIC
low complexity region 177 200 N/A INTRINSIC
ZnF_C2H2 320 342 3.69e-4 SMART
ZnF_C2H2 348 370 1.04e-3 SMART
ZnF_C2H2 442 464 1.45e-2 SMART
ZnF_C2H2 470 494 2.17e-1 SMART
ZnF_C2H2 500 522 2.91e-2 SMART
ZnF_C2H2 537 561 1.23e0 SMART
ZnF_C2H2 563 585 3.58e-2 SMART
ZnF_C2H2 591 613 1.62e0 SMART
ZnF_C2H2 619 641 2.27e-4 SMART
ZnF_C2H2 647 674 7.29e0 SMART
ZnF_C2H2 680 702 5.14e-3 SMART
low complexity region 740 759 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000109702
AA Change: C315S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105324
Gene: ENSMUSG00000059842
AA Change: C315S

DomainStartEndE-ValueType
ZnF_C2H2 53 73 4.16e1 SMART
low complexity region 96 110 N/A INTRINSIC
low complexity region 154 161 N/A INTRINSIC
low complexity region 177 200 N/A INTRINSIC
ZnF_C2H2 313 335 3.69e-4 SMART
ZnF_C2H2 341 363 1.04e-3 SMART
ZnF_C2H2 435 457 1.45e-2 SMART
ZnF_C2H2 463 487 2.17e-1 SMART
ZnF_C2H2 493 515 2.91e-2 SMART
ZnF_C2H2 530 554 1.23e0 SMART
ZnF_C2H2 556 578 3.58e-2 SMART
ZnF_C2H2 584 606 1.62e0 SMART
ZnF_C2H2 612 634 2.27e-4 SMART
ZnF_C2H2 640 667 7.29e0 SMART
ZnF_C2H2 673 695 5.14e-3 SMART
low complexity region 733 752 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000126421
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153208
Meta Mutation Damage Score 0.9440 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.8%
  • 20x: 93.3%
Validation Efficiency 98% (80/82)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik C T 3: 36,969,221 (GRCm38) T2233I possibly damaging Het
9430038I01Rik T C 7: 137,387,292 (GRCm38) probably benign Het
Abhd14a A T 9: 106,443,951 (GRCm38) probably null Het
Actn2 T C 13: 12,340,497 (GRCm38) N2D probably benign Het
Adcy9 T C 16: 4,311,567 (GRCm38) E722G probably damaging Het
Alox12 C A 11: 70,242,783 (GRCm38) V572L possibly damaging Het
Ankrd11 T C 8: 122,889,749 (GRCm38) I2434V possibly damaging Het
Anks1 T A 17: 27,991,447 (GRCm38) probably null Het
Bpifa3 T A 2: 154,136,321 (GRCm38) S148T probably damaging Het
Bptf C T 11: 107,035,864 (GRCm38) probably benign Het
Cabin1 A T 10: 75,657,839 (GRCm38) L1655H probably damaging Het
Ccdc13 G T 9: 121,827,235 (GRCm38) Q171K probably benign Het
Ccdc33 T A 9: 58,117,478 (GRCm38) Q155L possibly damaging Het
Cckbr G A 7: 105,470,619 (GRCm38) G280E probably benign Het
Cdk11b G A 4: 155,648,240 (GRCm38) probably benign Het
Celsr1 G T 15: 85,919,038 (GRCm38) probably null Het
Cenpj A T 14: 56,564,066 (GRCm38) I150N possibly damaging Het
Cep135 C A 5: 76,640,890 (GRCm38) A1110E possibly damaging Het
Chit1 C A 1: 134,146,626 (GRCm38) H224N probably damaging Het
Cul5 T C 9: 53,622,793 (GRCm38) R680G probably damaging Het
Dhx58 C A 11: 100,702,209 (GRCm38) R224L probably damaging Het
Dlx1 C A 2: 71,531,009 (GRCm38) N122K probably damaging Het
Dnah5 A C 15: 28,234,282 (GRCm38) D279A probably damaging Het
Enpp3 A G 10: 24,774,842 (GRCm38) W799R probably benign Het
Ercc5 A G 1: 44,173,406 (GRCm38) T675A probably benign Het
Farsa T A 8: 84,864,432 (GRCm38) probably null Het
Fbxw15 A T 9: 109,555,252 (GRCm38) V397D probably damaging Het
Fcrl5 G A 3: 87,442,103 (GRCm38) V62I probably benign Het
Gart A G 16: 91,624,336 (GRCm38) S815P probably damaging Het
Glrx5 A G 12: 105,040,323 (GRCm38) N111S possibly damaging Het
Gm10845 A G 14: 79,863,174 (GRCm38) noncoding transcript Het
Gm11639 A G 11: 104,687,549 (GRCm38) probably benign Het
Gm8882 A G 6: 132,362,073 (GRCm38) S61P unknown Het
Gm9925 T A 18: 74,065,516 (GRCm38) probably benign Het
Gsdme T C 6: 50,227,359 (GRCm38) N206S probably benign Het
Helz2 T C 2: 181,231,050 (GRCm38) S2459G probably benign Het
Hnrnpul1 A G 7: 25,754,359 (GRCm38) S93P possibly damaging Het
Ints2 A T 11: 86,226,748 (GRCm38) I716N possibly damaging Het
Lmnb2 G A 10: 80,905,128 (GRCm38) Q248* probably null Het
Map3k7cl A G 16: 87,570,321 (GRCm38) I32V probably benign Het
Mfsd4b4 A T 10: 39,892,470 (GRCm38) I255N probably benign Het
Myh6 A G 14: 54,950,508 (GRCm38) I1163T probably benign Het
Nphs1 A T 7: 30,466,115 (GRCm38) T636S possibly damaging Het
Ntsr1 T A 2: 180,500,788 (GRCm38) L124Q probably damaging Het
Obscn C T 11: 59,122,619 (GRCm38) probably null Het
P4ha2 G A 11: 54,126,412 (GRCm38) probably null Het
Pcdha9 T A 18: 36,999,111 (GRCm38) V411D probably benign Het
Pkhd1l1 A T 15: 44,525,988 (GRCm38) I1380F probably damaging Het
Plekha1 T C 7: 130,892,253 (GRCm38) V106A probably benign Het
Plekhm1 A T 11: 103,376,691 (GRCm38) V818E possibly damaging Het
Pprc1 T G 19: 46,065,370 (GRCm38) probably benign Het
Prmt9 T C 8: 77,561,018 (GRCm38) probably benign Het
Rab26 T C 17: 24,530,399 (GRCm38) N193D possibly damaging Het
Rnf111 A G 9: 70,429,580 (GRCm38) S942P probably damaging Het
Scgb2b18 T C 7: 33,173,225 (GRCm38) T52A probably damaging Het
Syt3 C T 7: 44,392,763 (GRCm38) Q349* probably null Het
Tas2r107 T C 6: 131,659,780 (GRCm38) N102S probably benign Het
Tas2r126 T A 6: 42,435,000 (GRCm38) Y156N possibly damaging Het
Tcaf2 A T 6: 42,642,778 (GRCm38) I105N probably benign Het
Tet1 A C 10: 62,879,773 (GRCm38) M81R probably benign Het
Togaram2 T C 17: 71,729,205 (GRCm38) Y897H probably damaging Het
Trerf1 A T 17: 47,314,271 (GRCm38) noncoding transcript Het
Ttn G A 2: 76,761,235 (GRCm38) T12703I probably damaging Het
Unc79 A G 12: 103,125,626 (GRCm38) K1735E possibly damaging Het
Usp54 G A 14: 20,583,351 (GRCm38) T372I possibly damaging Het
Wdr24 T C 17: 25,827,128 (GRCm38) S476P probably benign Het
Wdr78 G A 4: 103,049,589 (GRCm38) P676S probably benign Het
Zbtb1 T C 12: 76,386,275 (GRCm38) I345T possibly damaging Het
Zcrb1 T A 15: 93,395,615 (GRCm38) I29L probably benign Het
Zfp623 C A 15: 75,948,163 (GRCm38) R323S probably benign Het
Zfp831 T A 2: 174,644,092 (GRCm38) Y187N possibly damaging Het
Other mutations in Zfp341
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00499:Zfp341 APN 2 154,634,231 (GRCm38) missense probably damaging 1.00
IGL01352:Zfp341 APN 2 154,628,896 (GRCm38) missense probably benign 0.00
IGL01748:Zfp341 APN 2 154,628,927 (GRCm38) missense probably damaging 0.99
IGL02260:Zfp341 APN 2 154,642,049 (GRCm38) missense possibly damaging 0.89
IGL02329:Zfp341 APN 2 154,632,304 (GRCm38) missense possibly damaging 0.90
casanova_grimbacher UTSW 2 154,624,881 (GRCm38) missense probably damaging 1.00
Specious UTSW 2 154,646,134 (GRCm38) missense possibly damaging 0.63
R0079:Zfp341 UTSW 2 154,624,994 (GRCm38) nonsense probably null
R0570:Zfp341 UTSW 2 154,646,068 (GRCm38) missense probably benign 0.02
R0620:Zfp341 UTSW 2 154,634,273 (GRCm38) missense possibly damaging 0.94
R1018:Zfp341 UTSW 2 154,646,052 (GRCm38) missense probably damaging 1.00
R1611:Zfp341 UTSW 2 154,645,703 (GRCm38) missense probably damaging 1.00
R1733:Zfp341 UTSW 2 154,641,378 (GRCm38) missense probably benign 0.19
R1822:Zfp341 UTSW 2 154,646,134 (GRCm38) missense possibly damaging 0.63
R1956:Zfp341 UTSW 2 154,638,212 (GRCm38) missense probably benign 0.09
R2437:Zfp341 UTSW 2 154,628,801 (GRCm38) missense probably damaging 0.97
R3623:Zfp341 UTSW 2 154,624,881 (GRCm38) missense probably damaging 1.00
R4417:Zfp341 UTSW 2 154,628,987 (GRCm38) missense possibly damaging 0.94
R4806:Zfp341 UTSW 2 154,645,866 (GRCm38) utr 3 prime probably benign
R4807:Zfp341 UTSW 2 154,645,866 (GRCm38) utr 3 prime probably benign
R4863:Zfp341 UTSW 2 154,645,866 (GRCm38) utr 3 prime probably benign
R4955:Zfp341 UTSW 2 154,638,030 (GRCm38) missense probably damaging 0.98
R4962:Zfp341 UTSW 2 154,626,814 (GRCm38) missense possibly damaging 0.80
R5484:Zfp341 UTSW 2 154,625,001 (GRCm38) missense probably benign 0.00
R5864:Zfp341 UTSW 2 154,643,554 (GRCm38) missense possibly damaging 0.95
R5877:Zfp341 UTSW 2 154,632,289 (GRCm38) missense probably damaging 1.00
R5990:Zfp341 UTSW 2 154,645,659 (GRCm38) missense probably damaging 0.98
R6057:Zfp341 UTSW 2 154,625,034 (GRCm38) missense probably benign 0.01
R6882:Zfp341 UTSW 2 154,638,023 (GRCm38) missense probably damaging 1.00
R7686:Zfp341 UTSW 2 154,624,861 (GRCm38) missense probably damaging 0.96
R7701:Zfp341 UTSW 2 154,634,080 (GRCm38) splice site probably null
R7847:Zfp341 UTSW 2 154,634,194 (GRCm38) missense probably damaging 1.00
R8109:Zfp341 UTSW 2 154,627,900 (GRCm38) missense probably benign 0.04
R9313:Zfp341 UTSW 2 154,627,987 (GRCm38) missense probably damaging 1.00
R9484:Zfp341 UTSW 2 154,643,843 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAGCAAGCCTTGGACTTTCC -3'
(R):5'- ATCTTCCTGTCTCAGCGAGTATG -3'

Sequencing Primer
(F):5'- AAGCCTTGGACTTTCCCTCTTACAG -3'
(R):5'- CTGTCTCAGCGAGTATGCTCAG -3'
Posted On 2017-03-31