Mutagenetix > Incidental Mutation

Incidental Mutation 'R5975:Tas2r126'

471676

Institutional Source

Beutler Lab

Gene Symbol

Tas2r126

Ensembl Gene

ENSMUSG00000048284

Gene Name

taste receptor, type 2, member 126

Synonyms

T2R12, mt2r35, T2R26, mGR26, Tas2r26

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R5975 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

42434535-42435464 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 42435000 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 156 (Y156N)

Ref Sequence

ENSEMBL: ENSMUSP00000056581 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059534]

AlphaFold

P59532

Predicted Effect

possibly damaging
Transcript: ENSMUST00000059534
AA Change: Y156N

PolyPhen 2 Score 0.695 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000056581
Gene: ENSMUSG00000048284
AA Change: Y156N

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	303	2.5e-97	PFAM

Meta Mutation Damage Score

0.2120

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.8%
20x: 93.3%

Validation Efficiency

98% (80/82)

Allele List at MGI

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	C	T	3: 36,969,221 (GRCm38)	T2233I	possibly damaging	Het
9430038I01Rik	T	C	7: 137,387,292 (GRCm38)		probably benign	Het
Abhd14a	A	T	9: 106,443,951 (GRCm38)		probably null	Het
Actn2	T	C	13: 12,340,497 (GRCm38)	N2D	probably benign	Het
Adcy9	T	C	16: 4,311,567 (GRCm38)	E722G	probably damaging	Het
Alox12	C	A	11: 70,242,783 (GRCm38)	V572L	possibly damaging	Het
Ankrd11	T	C	8: 122,889,749 (GRCm38)	I2434V	possibly damaging	Het
Anks1	T	A	17: 27,991,447 (GRCm38)		probably null	Het
Bpifa3	T	A	2: 154,136,321 (GRCm38)	S148T	probably damaging	Het
Bptf	C	T	11: 107,035,864 (GRCm38)		probably benign	Het
Cabin1	A	T	10: 75,657,839 (GRCm38)	L1655H	probably damaging	Het
Ccdc13	G	T	9: 121,827,235 (GRCm38)	Q171K	probably benign	Het
Ccdc33	T	A	9: 58,117,478 (GRCm38)	Q155L	possibly damaging	Het
Cckbr	G	A	7: 105,470,619 (GRCm38)	G280E	probably benign	Het
Cdk11b	G	A	4: 155,648,240 (GRCm38)		probably benign	Het
Celsr1	G	T	15: 85,919,038 (GRCm38)		probably null	Het
Cenpj	A	T	14: 56,564,066 (GRCm38)	I150N	possibly damaging	Het
Cep135	C	A	5: 76,640,890 (GRCm38)	A1110E	possibly damaging	Het
Chit1	C	A	1: 134,146,626 (GRCm38)	H224N	probably damaging	Het
Cul5	T	C	9: 53,622,793 (GRCm38)	R680G	probably damaging	Het
Dhx58	C	A	11: 100,702,209 (GRCm38)	R224L	probably damaging	Het
Dlx1	C	A	2: 71,531,009 (GRCm38)	N122K	probably damaging	Het
Dnah5	A	C	15: 28,234,282 (GRCm38)	D279A	probably damaging	Het
Enpp3	A	G	10: 24,774,842 (GRCm38)	W799R	probably benign	Het
Ercc5	A	G	1: 44,173,406 (GRCm38)	T675A	probably benign	Het
Farsa	T	A	8: 84,864,432 (GRCm38)		probably null	Het
Fbxw15	A	T	9: 109,555,252 (GRCm38)	V397D	probably damaging	Het
Fcrl5	G	A	3: 87,442,103 (GRCm38)	V62I	probably benign	Het
Gart	A	G	16: 91,624,336 (GRCm38)	S815P	probably damaging	Het
Glrx5	A	G	12: 105,040,323 (GRCm38)	N111S	possibly damaging	Het
Gm10845	A	G	14: 79,863,174 (GRCm38)		noncoding transcript	Het
Gm11639	A	G	11: 104,687,549 (GRCm38)		probably benign	Het
Gm8882	A	G	6: 132,362,073 (GRCm38)	S61P	unknown	Het
Gm9925	T	A	18: 74,065,516 (GRCm38)		probably benign	Het
Gsdme	T	C	6: 50,227,359 (GRCm38)	N206S	probably benign	Het
Helz2	T	C	2: 181,231,050 (GRCm38)	S2459G	probably benign	Het
Hnrnpul1	A	G	7: 25,754,359 (GRCm38)	S93P	possibly damaging	Het
Ints2	A	T	11: 86,226,748 (GRCm38)	I716N	possibly damaging	Het
Lmnb2	G	A	10: 80,905,128 (GRCm38)	Q248*	probably null	Het
Map3k7cl	A	G	16: 87,570,321 (GRCm38)	I32V	probably benign	Het
Mfsd4b4	A	T	10: 39,892,470 (GRCm38)	I255N	probably benign	Het
Myh6	A	G	14: 54,950,508 (GRCm38)	I1163T	probably benign	Het
Nphs1	A	T	7: 30,466,115 (GRCm38)	T636S	possibly damaging	Het
Ntsr1	T	A	2: 180,500,788 (GRCm38)	L124Q	probably damaging	Het
Obscn	C	T	11: 59,122,619 (GRCm38)		probably null	Het
P4ha2	G	A	11: 54,126,412 (GRCm38)		probably null	Het
Pcdha9	T	A	18: 36,999,111 (GRCm38)	V411D	probably benign	Het
Pkhd1l1	A	T	15: 44,525,988 (GRCm38)	I1380F	probably damaging	Het
Plekha1	T	C	7: 130,892,253 (GRCm38)	V106A	probably benign	Het
Plekhm1	A	T	11: 103,376,691 (GRCm38)	V818E	possibly damaging	Het
Pprc1	T	G	19: 46,065,370 (GRCm38)		probably benign	Het
Prmt9	T	C	8: 77,561,018 (GRCm38)		probably benign	Het
Rab26	T	C	17: 24,530,399 (GRCm38)	N193D	possibly damaging	Het
Rnf111	A	G	9: 70,429,580 (GRCm38)	S942P	probably damaging	Het
Scgb2b18	T	C	7: 33,173,225 (GRCm38)	T52A	probably damaging	Het
Syt3	C	T	7: 44,392,763 (GRCm38)	Q349*	probably null	Het
Tas2r107	T	C	6: 131,659,780 (GRCm38)	N102S	probably benign	Het
Tcaf2	A	T	6: 42,642,778 (GRCm38)	I105N	probably benign	Het
Tet1	A	C	10: 62,879,773 (GRCm38)	M81R	probably benign	Het
Togaram2	T	C	17: 71,729,205 (GRCm38)	Y897H	probably damaging	Het
Trerf1	A	T	17: 47,314,271 (GRCm38)		noncoding transcript	Het
Ttn	G	A	2: 76,761,235 (GRCm38)	T12703I	probably damaging	Het
Unc79	A	G	12: 103,125,626 (GRCm38)	K1735E	possibly damaging	Het
Usp54	G	A	14: 20,583,351 (GRCm38)	T372I	possibly damaging	Het
Wdr24	T	C	17: 25,827,128 (GRCm38)	S476P	probably benign	Het
Wdr78	G	A	4: 103,049,589 (GRCm38)	P676S	probably benign	Het
Zbtb1	T	C	12: 76,386,275 (GRCm38)	I345T	possibly damaging	Het
Zcrb1	T	A	15: 93,395,615 (GRCm38)	I29L	probably benign	Het
Zfp341	T	A	2: 154,630,441 (GRCm38)	C315S	probably damaging	Het
Zfp623	C	A	15: 75,948,163 (GRCm38)	R323S	probably benign	Het
Zfp831	T	A	2: 174,644,092 (GRCm38)	Y187N	possibly damaging	Het

Other mutations in Tas2r126

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00915:Tas2r126	APN	6	42,435,349 (GRCm38)	missense	possibly damaging	0.67
IGL01327:Tas2r126	APN	6	42,434,750 (GRCm38)	missense	probably benign	0.09
IGL01690:Tas2r126	APN	6	42,435,307 (GRCm38)	missense	probably benign	0.02
IGL02153:Tas2r126	APN	6	42,434,664 (GRCm38)	missense	probably benign	0.32
IGL02291:Tas2r126	APN	6	42,435,287 (GRCm38)	missense	probably benign	0.00
IGL03365:Tas2r126	APN	6	42,435,457 (GRCm38)	missense	probably benign	0.36
R0091:Tas2r126	UTSW	6	42,435,102 (GRCm38)	missense	probably benign
R0486:Tas2r126	UTSW	6	42,435,291 (GRCm38)	missense	probably benign	0.01
R0611:Tas2r126	UTSW	6	42,435,091 (GRCm38)	missense	probably damaging	0.99
R1527:Tas2r126	UTSW	6	42,435,136 (GRCm38)	missense	probably benign	0.03
R1529:Tas2r126	UTSW	6	42,434,568 (GRCm38)	missense	probably benign	0.00
R1883:Tas2r126	UTSW	6	42,435,027 (GRCm38)	missense	probably benign
R1884:Tas2r126	UTSW	6	42,435,027 (GRCm38)	missense	probably benign
R2039:Tas2r126	UTSW	6	42,434,623 (GRCm38)	missense	probably benign	0.22
R4863:Tas2r126	UTSW	6	42,435,390 (GRCm38)	missense	probably benign	0.02
R7127:Tas2r126	UTSW	6	42,434,805 (GRCm38)	missense	probably damaging	1.00
R7351:Tas2r126	UTSW	6	42,435,306 (GRCm38)	missense	probably benign	0.02
R7714:Tas2r126	UTSW	6	42,435,097 (GRCm38)	missense	probably benign	0.12
R9154:Tas2r126	UTSW	6	42,435,240 (GRCm38)	missense	probably benign	0.25
R9336:Tas2r126	UTSW	6	42,434,943 (GRCm38)	missense	probably benign	0.45
R9516:Tas2r126	UTSW	6	42,435,373 (GRCm38)	missense	probably null	0.98
R9722:Tas2r126	UTSW	6	42,435,148 (GRCm38)	missense	possibly damaging	0.78

Predicted Primers

PCR Primer
(F):5'- CCGGCAGCTCATTAGTCTTC -3'
(R):5'- ATTCTTAGCGAATGCCTTCTGAG -3'

Sequencing Primer
(F):5'- ACTGGGACTTCTTGAACTCAG -3'
(R):5'- CGAATGCCTTCTGAGAGAACTGATC -3'

Posted On

2017-03-31