Incidental Mutation 'R5975:Gm8882'
ID 471680
Institutional Source Beutler Lab
Gene Symbol Gm8882
Ensembl Gene ENSMUSG00000030143
Gene Name predicted gene 8882
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.102) question?
Stock # R5975 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 132361041-132364134 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 132362073 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 61 (S61P)
Ref Sequence ENSEMBL: ENSMUSP00000079660 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080849]
AlphaFold E9Q7E4
Predicted Effect unknown
Transcript: ENSMUST00000080849
AA Change: S61P
SMART Domains Protein: ENSMUSP00000079660
Gene: ENSMUSG00000030143
AA Change: S61P

DomainStartEndE-ValueType
Pfam:Pro-rich 1 118 2.2e-32 PFAM
Pfam:Pro-rich 155 228 6.3e-14 PFAM
Pfam:Pro-rich 211 277 5.8e-10 PFAM
Meta Mutation Damage Score 0.0869 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.8%
  • 20x: 93.3%
Validation Efficiency 98% (80/82)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik C T 3: 36,969,221 T2233I possibly damaging Het
9430038I01Rik T C 7: 137,387,292 probably benign Het
Abhd14a A T 9: 106,443,951 probably null Het
Actn2 T C 13: 12,340,497 N2D probably benign Het
Adcy9 T C 16: 4,311,567 E722G probably damaging Het
Alox12 C A 11: 70,242,783 V572L possibly damaging Het
Ankrd11 T C 8: 122,889,749 I2434V possibly damaging Het
Anks1 T A 17: 27,991,447 probably null Het
Bpifa3 T A 2: 154,136,321 S148T probably damaging Het
Bptf C T 11: 107,035,864 probably benign Het
Cabin1 A T 10: 75,657,839 L1655H probably damaging Het
Ccdc13 G T 9: 121,827,235 Q171K probably benign Het
Ccdc33 T A 9: 58,117,478 Q155L possibly damaging Het
Cckbr G A 7: 105,470,619 G280E probably benign Het
Cdk11b G A 4: 155,648,240 probably benign Het
Celsr1 G T 15: 85,919,038 probably null Het
Cenpj A T 14: 56,564,066 I150N possibly damaging Het
Cep135 C A 5: 76,640,890 A1110E possibly damaging Het
Chit1 C A 1: 134,146,626 H224N probably damaging Het
Cul5 T C 9: 53,622,793 R680G probably damaging Het
Dhx58 C A 11: 100,702,209 R224L probably damaging Het
Dlx1 C A 2: 71,531,009 N122K probably damaging Het
Dnah5 A C 15: 28,234,282 D279A probably damaging Het
Enpp3 A G 10: 24,774,842 W799R probably benign Het
Ercc5 A G 1: 44,173,406 T675A probably benign Het
Farsa T A 8: 84,864,432 probably null Het
Fbxw15 A T 9: 109,555,252 V397D probably damaging Het
Fcrl5 G A 3: 87,442,103 V62I probably benign Het
Gart A G 16: 91,624,336 S815P probably damaging Het
Glrx5 A G 12: 105,040,323 N111S possibly damaging Het
Gm10845 A G 14: 79,863,174 noncoding transcript Het
Gm11639 A G 11: 104,687,549 probably benign Het
Gm9925 T A 18: 74,065,516 probably benign Het
Gsdme T C 6: 50,227,359 N206S probably benign Het
Helz2 T C 2: 181,231,050 S2459G probably benign Het
Hnrnpul1 A G 7: 25,754,359 S93P possibly damaging Het
Ints2 A T 11: 86,226,748 I716N possibly damaging Het
Lmnb2 G A 10: 80,905,128 Q248* probably null Het
Map3k7cl A G 16: 87,570,321 I32V probably benign Het
Mfsd4b4 A T 10: 39,892,470 I255N probably benign Het
Myh6 A G 14: 54,950,508 I1163T probably benign Het
Nphs1 A T 7: 30,466,115 T636S possibly damaging Het
Ntsr1 T A 2: 180,500,788 L124Q probably damaging Het
Obscn C T 11: 59,122,619 probably null Het
P4ha2 G A 11: 54,126,412 probably null Het
Pcdha9 T A 18: 36,999,111 V411D probably benign Het
Pkhd1l1 A T 15: 44,525,988 I1380F probably damaging Het
Plekha1 T C 7: 130,892,253 V106A probably benign Het
Plekhm1 A T 11: 103,376,691 V818E possibly damaging Het
Pprc1 T G 19: 46,065,370 probably benign Het
Prmt9 T C 8: 77,561,018 probably benign Het
Rab26 T C 17: 24,530,399 N193D possibly damaging Het
Rnf111 A G 9: 70,429,580 S942P probably damaging Het
Scgb2b18 T C 7: 33,173,225 T52A probably damaging Het
Syt3 C T 7: 44,392,763 Q349* probably null Het
Tas2r107 T C 6: 131,659,780 N102S probably benign Het
Tas2r126 T A 6: 42,435,000 Y156N possibly damaging Het
Tcaf2 A T 6: 42,642,778 I105N probably benign Het
Tet1 A C 10: 62,879,773 M81R probably benign Het
Togaram2 T C 17: 71,729,205 Y897H probably damaging Het
Trerf1 A T 17: 47,314,271 noncoding transcript Het
Ttn G A 2: 76,761,235 T12703I probably damaging Het
Unc79 A G 12: 103,125,626 K1735E possibly damaging Het
Usp54 G A 14: 20,583,351 T372I possibly damaging Het
Wdr24 T C 17: 25,827,128 S476P probably benign Het
Wdr78 G A 4: 103,049,589 P676S probably benign Het
Zbtb1 T C 12: 76,386,275 I345T possibly damaging Het
Zcrb1 T A 15: 93,395,615 I29L probably benign Het
Zfp341 T A 2: 154,630,441 C315S probably damaging Het
Zfp623 C A 15: 75,948,163 R323S probably benign Het
Zfp831 T A 2: 174,644,092 Y187N possibly damaging Het
Other mutations in Gm8882
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02797:Gm8882 APN 6 132363045 critical splice acceptor site probably null
IGL02961:Gm8882 APN 6 132361408 missense unknown
R0334:Gm8882 UTSW 6 132364058 missense unknown
R1167:Gm8882 UTSW 6 132361590 missense unknown
R1635:Gm8882 UTSW 6 132363006 critical splice donor site probably null
R3956:Gm8882 UTSW 6 132361851 missense unknown
R4734:Gm8882 UTSW 6 132361928 missense unknown
R5275:Gm8882 UTSW 6 132361877 missense unknown
R5295:Gm8882 UTSW 6 132361877 missense unknown
R5506:Gm8882 UTSW 6 132361856 missense unknown
R5580:Gm8882 UTSW 6 132361469 missense unknown
R6503:Gm8882 UTSW 6 132361692 nonsense probably null
R8110:Gm8882 UTSW 6 132361568 missense unknown
R8714:Gm8882 UTSW 6 132364088 missense unknown
R8931:Gm8882 UTSW 6 132361934 missense
R9054:Gm8882 UTSW 6 132361893 missense unknown
R9526:Gm8882 UTSW 6 132361928 missense unknown
Predicted Primers PCR Primer
(F):5'- GATCTCTGCTGTGAGCTTCC -3'
(R):5'- CGGTCTGAGAAGTGTAAGTTACATAAG -3'

Sequencing Primer
(F):5'- CTGCTGTGAGCTTCCCTGTG -3'
(R):5'- TCACAGCATTTAAGGACGAATACTC -3'
Posted On 2017-03-31