|Institutional Source||Beutler Lab|
|Gene Name||mitochondrial ribosomal protein S24|
|Is this an essential gene?||Probably essential (E-score: 0.959)|
|Stock #||R5963 (G1)|
|Chromosomal Location||5703983-5715680 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to T at 5707481 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000119535 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000154330]|
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||99% (68/69)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 11. Read-through transcription exists between this gene and the upstream upregulator of cell proliferation (URGCP) gene. [provided by RefSeq, Mar 2011]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Mrps24||
(F):5'- ACGTTCAAGAGTGACCCGTG -3'
(R):5'- CCGTTAGTTCCTGCTCTGAG -3'
(F):5'- TCACCTGTGTGCAGCGACAG -3'
(R):5'- CAAGATGGCGTGGTCCG -3'