Incidental Mutation 'R5965:Gps2'
| ID |
472041 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gps2
|
| Ensembl Gene |
ENSMUSG00000023170 |
| Gene Name |
G protein pathway suppressor 2 |
| Synonyms |
|
| MMRRC Submission |
044150-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.891)
|
| Stock # |
R5965 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
69804714-69807417 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 69805620 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 46
(E46G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112062
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000043419]
[ENSMUST00000057884]
[ENSMUST00000061837]
[ENSMUST00000070996]
[ENSMUST00000071026]
[ENSMUST00000072581]
[ENSMUST00000108607]
[ENSMUST00000116358]
[ENSMUST00000134581]
[ENSMUST00000108613]
[ENSMUST00000133203]
[ENSMUST00000108608]
[ENSMUST00000108611]
[ENSMUST00000108612]
[ENSMUST00000152589]
[ENSMUST00000108617]
[ENSMUST00000108609]
[ENSMUST00000108610]
[ENSMUST00000153652]
[ENSMUST00000164359]
[ENSMUST00000177138]
[ENSMUST00000177476]
|
| AlphaFold |
Q921N8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000043419
|
| SMART Domains |
Protein: ENSMUSP00000047008
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
eIF-5a
|
83 |
150 |
2.43e-29 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000057884
AA Change: E46G
PolyPhen 2
Score 0.601 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000054072
Gene: ENSMUSG00000023170
AA Change: E46G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:G_path_suppress
|
5 |
294 |
6.1e-93 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000061837
|
| SMART Domains |
Protein: ENSMUSP00000053235
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
1.02e-28 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
317 |
442 |
7.22e-52 |
SMART |
|
low complexity region
|
492 |
503 |
N/A |
INTRINSIC |
|
NEUZ
|
520 |
644 |
6.15e-46 |
SMART |
|
low complexity region
|
686 |
700 |
N/A |
INTRINSIC |
|
NEUZ
|
716 |
840 |
7.81e-39 |
SMART |
|
NEUZ
|
913 |
1043 |
2.27e-17 |
SMART |
|
low complexity region
|
1108 |
1117 |
N/A |
INTRINSIC |
|
NEUZ
|
1130 |
1250 |
4.93e-6 |
SMART |
|
low complexity region
|
1453 |
1464 |
N/A |
INTRINSIC |
|
low complexity region
|
1474 |
1483 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000070996
|
| SMART Domains |
Protein: ENSMUSP00000067077
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000071026
|
| SMART Domains |
Protein: ENSMUSP00000068651
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000072581
AA Change: E46G
PolyPhen 2
Score 0.601 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000072389
Gene: ENSMUSG00000023170
AA Change: E46G
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1jjva_
|
22 |
83 |
9e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108607
|
| SMART Domains |
Protein: ENSMUSP00000104247
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000116358
AA Change: E46G
PolyPhen 2
Score 0.601 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000112062
Gene: ENSMUSG00000023170
AA Change: E46G
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1jjva_
|
22 |
83 |
9e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143861
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000124596
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000134581
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108613
|
| SMART Domains |
Protein: ENSMUSP00000104253
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000133203
|
| SMART Domains |
Protein: ENSMUSP00000117917
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
NEUZ
|
60 |
185 |
7.22e-52 |
SMART |
|
low complexity region
|
235 |
246 |
N/A |
INTRINSIC |
|
NEUZ
|
263 |
387 |
6.15e-46 |
SMART |
|
low complexity region
|
429 |
443 |
N/A |
INTRINSIC |
|
NEUZ
|
459 |
583 |
7.81e-39 |
SMART |
|
NEUZ
|
656 |
786 |
2.27e-17 |
SMART |
|
low complexity region
|
851 |
860 |
N/A |
INTRINSIC |
|
Pfam:Neuralized
|
875 |
942 |
6.5e-10 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108608
|
| SMART Domains |
Protein: ENSMUSP00000104248
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108611
|
| SMART Domains |
Protein: ENSMUSP00000104251
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108612
|
| SMART Domains |
Protein: ENSMUSP00000104252
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132183
|
| SMART Domains |
Protein: ENSMUSP00000118868
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
161 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
182 |
191 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000152589
|
| SMART Domains |
Protein: ENSMUSP00000123402
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
2e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
149 |
6.9e-26 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108617
|
| SMART Domains |
Protein: ENSMUSP00000104257
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
3.5e-31 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
295 |
420 |
2.5e-54 |
SMART |
|
low complexity region
|
470 |
481 |
N/A |
INTRINSIC |
|
NEUZ
|
498 |
622 |
2e-48 |
SMART |
|
low complexity region
|
664 |
678 |
N/A |
INTRINSIC |
|
NEUZ
|
694 |
818 |
2.6e-41 |
SMART |
|
NEUZ
|
891 |
1021 |
7.6e-20 |
SMART |
|
low complexity region
|
1086 |
1095 |
N/A |
INTRINSIC |
|
NEUZ
|
1108 |
1228 |
1.7e-8 |
SMART |
|
low complexity region
|
1431 |
1442 |
N/A |
INTRINSIC |
|
low complexity region
|
1452 |
1461 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108609
|
| SMART Domains |
Protein: ENSMUSP00000104249
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108610
|
| SMART Domains |
Protein: ENSMUSP00000104250
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000175761
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153652
|
| SMART Domains |
Protein: ENSMUSP00000137459
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:eIF-5a
|
5 |
72 |
1.7e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164359
|
| SMART Domains |
Protein: ENSMUSP00000132717
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177138
|
| SMART Domains |
Protein: ENSMUSP00000135277
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
1.02e-28 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
295 |
420 |
7.22e-52 |
SMART |
|
low complexity region
|
470 |
481 |
N/A |
INTRINSIC |
|
NEUZ
|
498 |
622 |
6.15e-46 |
SMART |
|
low complexity region
|
664 |
678 |
N/A |
INTRINSIC |
|
NEUZ
|
694 |
818 |
7.81e-39 |
SMART |
|
NEUZ
|
889 |
1019 |
2.27e-17 |
SMART |
|
low complexity region
|
1084 |
1093 |
N/A |
INTRINSIC |
|
NEUZ
|
1106 |
1226 |
4.93e-6 |
SMART |
|
low complexity region
|
1429 |
1440 |
N/A |
INTRINSIC |
|
low complexity region
|
1450 |
1459 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177476
|
| SMART Domains |
Protein: ENSMUSP00000135185
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
1.02e-28 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
317 |
442 |
7.22e-52 |
SMART |
|
low complexity region
|
492 |
503 |
N/A |
INTRINSIC |
|
NEUZ
|
520 |
644 |
6.15e-46 |
SMART |
|
low complexity region
|
686 |
700 |
N/A |
INTRINSIC |
|
NEUZ
|
716 |
840 |
7.81e-39 |
SMART |
|
NEUZ
|
911 |
1041 |
2.27e-17 |
SMART |
|
low complexity region
|
1106 |
1115 |
N/A |
INTRINSIC |
|
NEUZ
|
1128 |
1248 |
4.93e-6 |
SMART |
|
low complexity region
|
1451 |
1462 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1481 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.1011 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.1%
- 20x: 94.1%
|
| Validation Efficiency |
98% (80/82) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality during organogenesis. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(1) : Gene trapped(1)
|
| Other mutations in this stock |
Total: 69 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrf3 |
T |
A |
5: 30,410,637 (GRCm39) |
T23S |
probably benign |
Het |
| Armc2 |
A |
G |
10: 41,798,568 (GRCm39) |
I747T |
possibly damaging |
Het |
| Cacna1c |
T |
A |
6: 118,579,261 (GRCm39) |
H1729L |
probably damaging |
Het |
| Crebbp |
A |
G |
16: 3,905,525 (GRCm39) |
|
probably benign |
Het |
| Cyp4f17 |
T |
A |
17: 32,743,611 (GRCm39) |
M326K |
probably damaging |
Het |
| Dchs1 |
T |
G |
7: 105,405,132 (GRCm39) |
D2470A |
probably damaging |
Het |
| Ddhd2 |
T |
C |
8: 26,225,804 (GRCm39) |
T518A |
probably damaging |
Het |
| Derl2 |
T |
C |
11: 70,905,378 (GRCm39) |
T109A |
probably benign |
Het |
| Dnah7b |
T |
C |
1: 46,402,147 (GRCm39) |
L3994P |
probably damaging |
Het |
| Dock10 |
T |
C |
1: 80,546,461 (GRCm39) |
|
probably null |
Het |
| Dync1h1 |
T |
A |
12: 110,599,212 (GRCm39) |
S1856T |
probably benign |
Het |
| Ehd2 |
T |
C |
7: 15,685,999 (GRCm39) |
K358E |
possibly damaging |
Het |
| Enpp2 |
A |
G |
15: 54,746,367 (GRCm39) |
|
probably null |
Het |
| Esco1 |
T |
C |
18: 10,593,867 (GRCm39) |
E473G |
possibly damaging |
Het |
| Exoc5 |
A |
G |
14: 49,272,388 (GRCm39) |
F342S |
probably damaging |
Het |
| Fam186a |
T |
A |
15: 99,842,978 (GRCm39) |
T1089S |
probably benign |
Het |
| Fanca |
T |
C |
8: 124,043,149 (GRCm39) |
D79G |
possibly damaging |
Het |
| Gabrb2 |
A |
G |
11: 42,517,696 (GRCm39) |
Y506C |
probably damaging |
Het |
| Galntl6 |
T |
C |
8: 58,310,565 (GRCm39) |
T379A |
probably benign |
Het |
| Garin2 |
T |
A |
12: 78,757,080 (GRCm39) |
N12K |
unknown |
Het |
| Gm34768 |
A |
G |
2: 11,913,316 (GRCm39) |
|
noncoding transcript |
Het |
| Gsdmc |
T |
C |
15: 63,676,447 (GRCm39) |
|
probably null |
Het |
| Gys1 |
C |
T |
7: 45,104,763 (GRCm39) |
T666I |
probably benign |
Het |
| Hsd17b11 |
T |
A |
5: 104,169,651 (GRCm39) |
|
probably benign |
Het |
| Iffo1 |
T |
A |
6: 125,129,471 (GRCm39) |
|
probably benign |
Het |
| Ighv1-51 |
T |
C |
12: 115,095,177 (GRCm39) |
|
noncoding transcript |
Het |
| Kansl3 |
T |
A |
1: 36,384,601 (GRCm39) |
|
probably null |
Het |
| Kdm3a |
A |
G |
6: 71,598,364 (GRCm39) |
I174T |
probably benign |
Het |
| Klhl26 |
A |
T |
8: 70,905,381 (GRCm39) |
D95E |
probably damaging |
Het |
| Lair1 |
T |
C |
7: 4,032,023 (GRCm39) |
D28G |
possibly damaging |
Het |
| Lama3 |
A |
G |
18: 12,562,944 (GRCm39) |
D489G |
possibly damaging |
Het |
| Lamb3 |
A |
T |
1: 193,025,768 (GRCm39) |
I1153F |
probably damaging |
Het |
| Lsp1 |
T |
A |
7: 142,044,161 (GRCm39) |
|
probably null |
Het |
| Man1a |
A |
G |
10: 53,809,586 (GRCm39) |
|
probably benign |
Het |
| Mcam |
A |
C |
9: 44,047,925 (GRCm39) |
S57R |
probably damaging |
Het |
| Mrgprf |
C |
A |
7: 144,861,168 (GRCm39) |
|
probably benign |
Het |
| Nfia |
T |
C |
4: 97,999,529 (GRCm39) |
*499Q |
probably null |
Het |
| Nmbr |
C |
A |
10: 14,642,554 (GRCm39) |
R38S |
probably benign |
Het |
| Or12e7 |
T |
G |
2: 87,288,381 (GRCm39) |
F291V |
probably benign |
Het |
| Or51a25 |
C |
A |
7: 102,373,467 (GRCm39) |
V77L |
probably benign |
Het |
| Or5h23 |
T |
C |
16: 58,906,666 (GRCm39) |
Y60C |
probably damaging |
Het |
| P3h1 |
C |
T |
4: 119,105,424 (GRCm39) |
H741Y |
probably benign |
Het |
| Parp4 |
A |
T |
14: 56,861,489 (GRCm39) |
M941L |
probably benign |
Het |
| Phaf1 |
T |
C |
8: 105,961,171 (GRCm39) |
F69L |
probably damaging |
Het |
| Pik3c3 |
C |
T |
18: 30,431,633 (GRCm39) |
T331M |
probably damaging |
Het |
| Prkg1 |
T |
C |
19: 30,701,556 (GRCm39) |
|
probably null |
Het |
| Qsox2 |
A |
T |
2: 26,112,233 (GRCm39) |
V103D |
probably benign |
Het |
| Ranbp1 |
T |
C |
16: 18,063,092 (GRCm39) |
T95A |
probably damaging |
Het |
| Ric1 |
G |
A |
19: 29,548,171 (GRCm39) |
D280N |
probably damaging |
Het |
| Scd1 |
A |
G |
19: 44,388,579 (GRCm39) |
|
probably null |
Het |
| Serpinb3c |
A |
G |
1: 107,204,653 (GRCm39) |
I31T |
probably benign |
Het |
| Slc7a11 |
T |
A |
3: 50,333,593 (GRCm39) |
Y386F |
probably benign |
Het |
| Smtnl2 |
A |
T |
11: 72,291,279 (GRCm39) |
|
probably null |
Het |
| Snx2 |
G |
T |
18: 53,327,534 (GRCm39) |
E87* |
probably null |
Het |
| Tars2 |
A |
C |
3: 95,655,464 (GRCm39) |
|
probably null |
Het |
| Tax1bp1 |
C |
A |
6: 52,706,317 (GRCm39) |
T106N |
probably damaging |
Het |
| Tcof1 |
A |
G |
18: 60,966,490 (GRCm39) |
|
probably null |
Het |
| Tenm3 |
C |
A |
8: 48,681,543 (GRCm39) |
E2680* |
probably null |
Het |
| Thap7 |
C |
T |
16: 17,348,611 (GRCm39) |
|
probably benign |
Het |
| Thoc6 |
T |
A |
17: 23,889,842 (GRCm39) |
I23F |
possibly damaging |
Het |
| Tmem185b |
T |
G |
1: 119,454,294 (GRCm39) |
Y18* |
probably null |
Het |
| Trav6-1 |
A |
C |
14: 52,876,254 (GRCm39) |
Y58S |
probably damaging |
Het |
| Trbv16 |
A |
T |
6: 41,128,989 (GRCm39) |
I58F |
probably benign |
Het |
| Ubtfl1 |
T |
A |
9: 18,320,838 (GRCm39) |
M122K |
probably benign |
Het |
| Vps13a |
T |
C |
19: 16,596,392 (GRCm39) |
|
probably null |
Het |
| Zdhhc24 |
T |
G |
19: 4,933,778 (GRCm39) |
D278E |
probably benign |
Het |
| Zfp316 |
T |
C |
5: 143,250,427 (GRCm39) |
|
probably null |
Het |
| Zfyve9 |
T |
C |
4: 108,548,878 (GRCm39) |
T769A |
possibly damaging |
Het |
| Znhit6 |
T |
A |
3: 145,284,103 (GRCm39) |
N96K |
possibly damaging |
Het |
|
| Other mutations in Gps2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0067:Gps2
|
UTSW |
11 |
69,805,607 (GRCm39) |
nonsense |
probably null |
|
|
R0067:Gps2
|
UTSW |
11 |
69,805,607 (GRCm39) |
nonsense |
probably null |
|
|
R1086:Gps2
|
UTSW |
11 |
69,806,050 (GRCm39) |
unclassified |
probably benign |
|
|
R1109:Gps2
|
UTSW |
11 |
69,806,507 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1938:Gps2
|
UTSW |
11 |
69,806,195 (GRCm39) |
missense |
probably benign |
|
|
R1964:Gps2
|
UTSW |
11 |
69,807,246 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2355:Gps2
|
UTSW |
11 |
69,806,207 (GRCm39) |
frame shift |
probably null |
|
|
R3773:Gps2
|
UTSW |
11 |
69,806,927 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4765:Gps2
|
UTSW |
11 |
69,807,187 (GRCm39) |
unclassified |
probably benign |
|
|
R4811:Gps2
|
UTSW |
11 |
69,806,754 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5119:Gps2
|
UTSW |
11 |
69,805,617 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5183:Gps2
|
UTSW |
11 |
69,806,023 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5218:Gps2
|
UTSW |
11 |
69,807,121 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7172:Gps2
|
UTSW |
11 |
69,807,262 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7562:Gps2
|
UTSW |
11 |
69,807,308 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7854:Gps2
|
UTSW |
11 |
69,806,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8524:Gps2
|
UTSW |
11 |
69,805,832 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8713:Gps2
|
UTSW |
11 |
69,806,180 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1186:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1187:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1188:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1189:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1190:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1191:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1192:Gps2
|
UTSW |
11 |
69,807,130 (GRCm39) |
missense |
probably benign |
0.26 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTTCCAGACCAGAACCCTG -3'
(R):5'- GCTGCAAGAAAAGCTGGTGC -3'
Sequencing Primer
(F):5'- CTGGGCTGGGAAGGACCTTG -3'
(R):5'- GTGCTTCTCCTCCTGTAGAGCAG -3'
|
| Posted On |
2017-03-31 |
Incidental Mutation