Incidental Mutation 'R5249:Ccdc177'
ID 472489
Institutional Source Beutler Lab
Gene Symbol Ccdc177
Ensembl Gene ENSMUSG00000062961
Gene Name coiled-coil domain containing 177
Synonyms Gm1568, LOC380768
MMRRC Submission 042820-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.110) question?
Stock # R5249 (G1)
Quality Score 54
Status Validated
Chromosome 12
Chromosomal Location 80802221-80807489 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 80805282 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 331 (R331C)
Ref Sequence ENSEMBL: ENSMUSP00000072982 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073251]
AlphaFold Q3UHB8
Predicted Effect unknown
Transcript: ENSMUST00000073251
AA Change: R331C
SMART Domains Protein: ENSMUSP00000072982
Gene: ENSMUSG00000062961
AA Change: R331C

DomainStartEndE-ValueType
low complexity region 7 20 N/A INTRINSIC
low complexity region 28 49 N/A INTRINSIC
internal_repeat_1 116 139 2.91e-5 PROSPERO
low complexity region 146 159 N/A INTRINSIC
low complexity region 165 227 N/A INTRINSIC
low complexity region 229 263 N/A INTRINSIC
Pfam:DUF4659 332 705 1.9e-115 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181092
Meta Mutation Damage Score 0.0877 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 98% (93/95)
Allele List at MGI
Other mutations in this stock
Total: 89 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A4gnt A G 9: 99,502,284 (GRCm39) H148R probably damaging Het
Acrbp A G 6: 125,037,885 (GRCm39) D394G probably damaging Het
Adam18 T C 8: 25,115,868 (GRCm39) T609A probably benign Het
Adam25 T A 8: 41,208,991 (GRCm39) N752K probably benign Het
Ano6 A C 15: 95,811,469 (GRCm39) S176R probably benign Het
Ano7 T C 1: 93,302,918 (GRCm39) S19P probably benign Het
Ap1b1 A G 11: 4,976,364 (GRCm39) E437G probably damaging Het
Arfgap2 T A 2: 91,095,982 (GRCm39) C46* probably null Het
Arhgef26 T A 3: 62,247,981 (GRCm39) L355Q probably damaging Het
B4galnt4 C T 7: 140,644,983 (GRCm39) T219I probably damaging Het
Bap1 C T 14: 30,979,243 (GRCm39) probably benign Het
Catip T G 1: 74,401,954 (GRCm39) L43R probably damaging Het
Cep85l T C 10: 53,195,690 (GRCm39) probably null Het
Cfap206 T A 4: 34,714,502 (GRCm39) Q398L probably benign Het
Clec18a A G 8: 111,800,368 (GRCm39) C352R probably damaging Het
Clic6 A T 16: 92,336,339 (GRCm39) Y549F probably damaging Het
Cpne9 C T 6: 113,270,034 (GRCm39) probably benign Het
Cyb5r3 A C 15: 83,042,836 (GRCm39) probably benign Het
Dnah6 C T 6: 73,090,471 (GRCm39) R2293K probably damaging Het
Dnmbp C A 19: 43,890,879 (GRCm39) R296L probably damaging Het
Dtwd1 C A 2: 125,996,694 (GRCm39) Q60K probably benign Het
Esyt1 C A 10: 128,352,443 (GRCm39) V723L probably benign Het
Fbxo42 T C 4: 140,926,335 (GRCm39) L339P probably damaging Het
Furin A T 7: 80,043,169 (GRCm39) N347K probably damaging Het
Fzd7 T C 1: 59,522,522 (GRCm39) M135T probably damaging Het
Garin1b A G 6: 29,323,896 (GRCm39) D207G probably damaging Het
Hlf A G 11: 90,278,632 (GRCm39) M144T probably benign Het
Hyal5 C T 6: 24,876,648 (GRCm39) Q174* probably null Het
Kcnb1 T A 2: 166,947,103 (GRCm39) M582L possibly damaging Het
Kdm5d T C Y: 916,692 (GRCm39) Y391H probably damaging Het
Khdc4 T A 3: 88,604,032 (GRCm39) I283N probably damaging Het
Kif21b C T 1: 136,096,966 (GRCm39) T1297M probably damaging Het
Krt8 T G 15: 101,906,875 (GRCm39) N317T possibly damaging Het
Lctl G T 9: 64,045,196 (GRCm39) V372L probably benign Het
Lig1 C T 7: 13,042,432 (GRCm39) H822Y possibly damaging Het
Lrrc4b A G 7: 44,111,988 (GRCm39) D620G possibly damaging Het
Mboat4 C T 8: 34,582,275 (GRCm39) H10Y probably benign Het
Med1 A T 11: 98,048,066 (GRCm39) M910K probably benign Het
Mia2 A T 12: 59,154,911 (GRCm39) D209V probably damaging Het
Mpp4 C T 1: 59,184,017 (GRCm39) probably benign Het
Mrgprb1 A T 7: 48,097,225 (GRCm39) V229E possibly damaging Het
Mtor T A 4: 148,548,189 (GRCm39) C485S probably damaging Het
Mx1 T C 16: 97,258,628 (GRCm39) D23G probably damaging Het
Myrfl T C 10: 116,619,138 (GRCm39) D740G probably benign Het
Myt1l G A 12: 29,882,331 (GRCm39) G509R unknown Het
Nav2 G A 7: 49,185,661 (GRCm39) V874I probably damaging Het
Ntrk3 A T 7: 78,110,914 (GRCm39) N262K possibly damaging Het
Opa1 A T 16: 29,437,077 (GRCm39) D699V probably damaging Het
Or10u4 C T 10: 129,802,078 (GRCm39) A164T probably benign Het
Or8b51 A G 9: 38,569,374 (GRCm39) C105R possibly damaging Het
Otud7a A G 7: 63,407,181 (GRCm39) N495D possibly damaging Het
Pcsk9 T C 4: 106,320,950 (GRCm39) D53G probably benign Het
Pdcd5 A G 7: 35,346,421 (GRCm39) probably benign Het
Phf21a C T 2: 92,058,822 (GRCm39) P28L probably damaging Het
Pitpnm1 T A 19: 4,158,130 (GRCm39) D573E probably damaging Het
Ppp1r35 C T 5: 137,777,406 (GRCm39) probably benign Het
Ptprq T C 10: 107,535,496 (GRCm39) Q423R probably damaging Het
Pum1 A T 4: 130,490,125 (GRCm39) Y699F probably benign Het
Rabgef1 A G 5: 130,241,841 (GRCm39) D415G probably benign Het
Rapgef6 A G 11: 54,413,943 (GRCm39) E23G probably benign Het
Rpia G T 6: 70,760,563 (GRCm39) C121* probably null Het
Sanbr A G 11: 23,525,483 (GRCm39) *719Q probably null Het
Serpinb13 T A 1: 106,926,427 (GRCm39) W201R probably damaging Het
Sh3bp4 T C 1: 89,065,456 (GRCm39) C17R probably damaging Het
Sh3d21 A G 4: 126,055,858 (GRCm39) probably benign Het
Slamf6 A C 1: 171,764,249 (GRCm39) N214T probably damaging Het
Slc7a2 T C 8: 41,361,130 (GRCm39) Y365H possibly damaging Het
Sox18 T C 2: 181,312,971 (GRCm39) probably null Het
Spink7 A T 18: 62,725,507 (GRCm39) F79I possibly damaging Het
Srpk3 C T X: 72,818,555 (GRCm39) R82* probably null Het
Sspo A T 6: 48,470,244 (GRCm39) H4561L probably damaging Het
Tcaf1 T C 6: 42,653,793 (GRCm39) K700R probably benign Het
Tcf25 G T 8: 124,115,372 (GRCm39) R203L probably damaging Het
Tcp11 T C 17: 28,290,757 (GRCm39) I201V possibly damaging Het
Tex2 T C 11: 106,437,615 (GRCm39) D685G unknown Het
Themis G T 10: 28,637,195 (GRCm39) E100* probably null Het
Tmem52b G A 6: 129,491,221 (GRCm39) probably null Het
Tnr C T 1: 159,512,226 (GRCm39) probably benign Het
Tox3 T C 8: 90,975,444 (GRCm39) I396V probably benign Het
Tpm2 T A 4: 43,514,828 (GRCm39) E269V probably benign Het
Tulp1 C T 17: 28,581,651 (GRCm39) probably benign Het
Tymp GC GCC 15: 89,258,567 (GRCm39) probably null Het
Ube2j2 A C 4: 156,033,515 (GRCm39) K30Q possibly damaging Het
Usp19 T A 9: 108,369,807 (GRCm39) M1K probably null Het
Vmn2r52 C A 7: 9,910,197 (GRCm39) R6L probably benign Het
Zbed4 G A 15: 88,665,290 (GRCm39) V453M probably benign Het
Zfp319 T C 8: 96,055,099 (GRCm39) E368G probably benign Het
Zfp366 A C 13: 99,366,117 (GRCm39) E426A probably damaging Het
Zfp687 A T 3: 94,916,777 (GRCm39) I783N probably damaging Het
Other mutations in Ccdc177
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01598:Ccdc177 APN 12 80,805,519 (GRCm39) missense unknown
IGL02433:Ccdc177 APN 12 80,804,372 (GRCm39) missense unknown
R0829:Ccdc177 UTSW 12 80,806,253 (GRCm39) missense probably damaging 0.96
R1739:Ccdc177 UTSW 12 80,806,013 (GRCm39) missense probably damaging 1.00
R1970:Ccdc177 UTSW 12 80,805,486 (GRCm39) missense unknown
R2337:Ccdc177 UTSW 12 80,805,465 (GRCm39) missense unknown
R5001:Ccdc177 UTSW 12 80,804,160 (GRCm39) missense unknown
R5164:Ccdc177 UTSW 12 80,805,336 (GRCm39) missense unknown
R5461:Ccdc177 UTSW 12 80,804,816 (GRCm39) missense unknown
R6802:Ccdc177 UTSW 12 80,806,057 (GRCm39) missense probably damaging 1.00
R7051:Ccdc177 UTSW 12 80,805,927 (GRCm39) missense probably damaging 0.98
R7412:Ccdc177 UTSW 12 80,805,792 (GRCm39) missense possibly damaging 0.85
R7510:Ccdc177 UTSW 12 80,804,457 (GRCm39) missense unknown
R7511:Ccdc177 UTSW 12 80,804,457 (GRCm39) missense unknown
R7712:Ccdc177 UTSW 12 80,804,712 (GRCm39) nonsense probably null
R8036:Ccdc177 UTSW 12 80,804,897 (GRCm39) missense unknown
R8693:Ccdc177 UTSW 12 80,804,582 (GRCm39) missense unknown
R8708:Ccdc177 UTSW 12 80,805,891 (GRCm39) missense probably benign 0.08
R8862:Ccdc177 UTSW 12 80,804,208 (GRCm39) missense unknown
R8894:Ccdc177 UTSW 12 80,806,077 (GRCm39) missense probably damaging 1.00
R9423:Ccdc177 UTSW 12 80,804,162 (GRCm39) missense unknown
R9727:Ccdc177 UTSW 12 80,806,044 (GRCm39) missense probably benign 0.04
Z1177:Ccdc177 UTSW 12 80,804,510 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- AGGTTCTGCTCCTGCTGCA -3'
(R):5'- CAGGTAGAAAGAGCCACTCGC -3'

Sequencing Primer
(F):5'- AGCAGTCCCTGACGCTC -3'
(R):5'- AGAGCCTTCGGGAGCTTC -3'
Posted On 2017-04-14