Incidental Mutation 'R4825:Sdk1'
| ID |
472640 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sdk1
|
| Ensembl Gene |
ENSMUSG00000039683 |
| Gene Name |
sidekick cell adhesion molecule 1 |
| Synonyms |
6720466O15Rik |
| MMRRC Submission |
042441-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.088)
|
| Stock # |
R4825 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
141227245-142201341 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 141568049 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 82
(D82E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000082928
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000085774]
|
| AlphaFold |
Q3UH53 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000085774
AA Change: D82E
PolyPhen 2
Score 0.108 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000082928
Gene: ENSMUSG00000039683
AA Change: D82E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
29 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
80 |
N/A |
INTRINSIC |
|
IGc2
|
99 |
158 |
2.77e-6 |
SMART |
|
IG
|
179 |
264 |
3.74e-3 |
SMART |
|
IGc2
|
288 |
351 |
4.67e-4 |
SMART |
|
IGc2
|
381 |
447 |
1.45e-9 |
SMART |
|
IGc2
|
474 |
542 |
1.58e-10 |
SMART |
|
IG
|
562 |
647 |
1.8e-5 |
SMART |
|
FN3
|
650 |
734 |
7.39e-14 |
SMART |
|
FN3
|
750 |
836 |
8.96e-13 |
SMART |
|
FN3
|
851 |
939 |
1.95e-4 |
SMART |
|
FN3
|
954 |
1036 |
2e-10 |
SMART |
|
FN3
|
1052 |
1139 |
4.22e-9 |
SMART |
|
FN3
|
1156 |
1243 |
1.41e-10 |
SMART |
|
FN3
|
1259 |
1344 |
2.7e-7 |
SMART |
|
FN3
|
1360 |
1443 |
1.3e-9 |
SMART |
|
FN3
|
1459 |
1544 |
2.19e-7 |
SMART |
|
FN3
|
1560 |
1668 |
5.73e-11 |
SMART |
|
FN3
|
1684 |
1769 |
1.79e-12 |
SMART |
|
FN3
|
1784 |
1871 |
1.16e-11 |
SMART |
|
FN3
|
1885 |
1969 |
1.32e-10 |
SMART |
|
transmembrane domain
|
1990 |
2012 |
N/A |
INTRINSIC |
|
low complexity region
|
2066 |
2075 |
N/A |
INTRINSIC |
|
low complexity region
|
2106 |
2118 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129831
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000145908
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.8%
- 20x: 93.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 130 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700012B07Rik |
C |
A |
11: 109,682,498 (GRCm39) |
L229F |
probably benign |
Het |
| A930002H24Rik |
A |
C |
17: 64,170,603 (GRCm39) |
S62A |
unknown |
Het |
| Abca12 |
T |
A |
1: 71,341,844 (GRCm39) |
Q1039L |
possibly damaging |
Het |
| Adgrg5 |
T |
A |
8: 95,668,362 (GRCm39) |
F476I |
possibly damaging |
Het |
| Alms1 |
A |
G |
6: 85,655,227 (GRCm39) |
K2789E |
probably damaging |
Het |
| Arrdc2 |
G |
A |
8: 71,291,921 (GRCm39) |
|
probably null |
Het |
| Atp2b1 |
T |
A |
10: 98,845,426 (GRCm39) |
I743K |
probably damaging |
Het |
| Atp6v1c2 |
C |
T |
12: 17,339,061 (GRCm39) |
G230D |
probably benign |
Het |
| AU040320 |
G |
A |
4: 126,685,586 (GRCm39) |
C54Y |
probably damaging |
Het |
| BC024139 |
C |
T |
15: 76,004,517 (GRCm39) |
V680I |
possibly damaging |
Het |
| Bckdhb |
A |
G |
9: 83,870,958 (GRCm39) |
D156G |
probably damaging |
Het |
| Bltp3a |
G |
A |
17: 28,096,368 (GRCm39) |
A107T |
probably damaging |
Het |
| Canx |
T |
A |
11: 50,199,636 (GRCm39) |
D143V |
probably benign |
Het |
| Ccdc180 |
T |
A |
4: 45,912,794 (GRCm39) |
V591E |
possibly damaging |
Het |
| Ccno |
T |
C |
13: 113,124,633 (GRCm39) |
S68P |
probably benign |
Het |
| Cdc45 |
C |
T |
16: 18,603,613 (GRCm39) |
E527K |
probably damaging |
Het |
| Cep290 |
T |
A |
10: 100,324,210 (GRCm39) |
D14E |
probably damaging |
Het |
| Cgnl1 |
A |
G |
9: 71,537,806 (GRCm39) |
V1238A |
probably benign |
Het |
| Ciz1 |
C |
T |
2: 32,261,753 (GRCm39) |
A455V |
probably damaging |
Het |
| Coro2b |
T |
A |
9: 62,361,905 (GRCm39) |
Y86F |
probably benign |
Het |
| Csf2ra |
C |
T |
19: 61,214,990 (GRCm39) |
R158Q |
probably benign |
Het |
| Cubn |
A |
T |
2: 13,330,036 (GRCm39) |
I2615N |
probably damaging |
Het |
| Dhx8 |
C |
T |
11: 101,628,996 (GRCm39) |
R129* |
probably null |
Het |
| Disc1 |
T |
A |
8: 125,862,041 (GRCm39) |
M471K |
possibly damaging |
Het |
| Dmxl2 |
G |
T |
9: 54,311,325 (GRCm39) |
L1799I |
probably benign |
Het |
| Dnah2 |
A |
G |
11: 69,314,031 (GRCm39) |
S4108P |
probably damaging |
Het |
| Ecpas |
G |
A |
4: 58,850,911 (GRCm39) |
L421F |
probably damaging |
Het |
| Ehmt2 |
C |
G |
17: 35,125,940 (GRCm39) |
P211R |
probably benign |
Het |
| Eif4g3 |
A |
G |
4: 137,921,392 (GRCm39) |
D1557G |
probably benign |
Het |
| Epha5 |
T |
C |
5: 84,381,699 (GRCm39) |
D384G |
probably damaging |
Het |
| Etl4 |
A |
G |
2: 20,811,738 (GRCm39) |
I1274V |
probably damaging |
Het |
| Fhip1a |
G |
A |
3: 85,580,739 (GRCm39) |
P489S |
possibly damaging |
Het |
| Fip1l1 |
G |
A |
5: 74,748,866 (GRCm39) |
|
probably null |
Het |
| Fubp1 |
T |
C |
3: 151,923,527 (GRCm39) |
|
probably null |
Het |
| Glul |
T |
C |
1: 153,778,790 (GRCm39) |
V33A |
probably benign |
Het |
| Gm4846 |
A |
G |
1: 166,319,237 (GRCm39) |
F167S |
probably damaging |
Het |
| Heatr6 |
T |
A |
11: 83,649,148 (GRCm39) |
L168M |
probably damaging |
Het |
| Hif1a |
T |
A |
12: 73,979,175 (GRCm39) |
I233N |
probably damaging |
Het |
| Hivep2 |
T |
A |
10: 14,007,063 (GRCm39) |
H1220Q |
possibly damaging |
Het |
| Igkv8-21 |
T |
C |
6: 70,292,410 (GRCm39) |
I9M |
probably benign |
Het |
| Izumo1 |
T |
A |
7: 45,274,411 (GRCm39) |
C62* |
probably null |
Het |
| Jakmip3 |
G |
A |
7: 138,628,495 (GRCm39) |
E424K |
probably damaging |
Het |
| Klhl2 |
A |
G |
8: 65,205,847 (GRCm39) |
V358A |
probably damaging |
Het |
| Klk10 |
C |
G |
7: 43,433,022 (GRCm39) |
D139E |
probably damaging |
Het |
| Klk14 |
T |
C |
7: 43,341,500 (GRCm39) |
C51R |
probably damaging |
Het |
| Klk1b5 |
T |
G |
7: 43,494,814 (GRCm39) |
I99S |
probably damaging |
Het |
| L3hypdh |
T |
C |
12: 72,124,167 (GRCm39) |
T258A |
probably benign |
Het |
| Lrp5 |
A |
G |
19: 3,664,292 (GRCm39) |
Y812H |
probably damaging |
Het |
| Lrrc40 |
T |
A |
3: 157,766,967 (GRCm39) |
L474* |
probably null |
Het |
| Mkks |
A |
T |
2: 136,722,575 (GRCm39) |
M194K |
probably benign |
Het |
| Mmp20 |
A |
G |
9: 7,654,121 (GRCm39) |
D347G |
probably damaging |
Het |
| Mmp27 |
A |
G |
9: 7,581,195 (GRCm39) |
E460G |
probably damaging |
Het |
| Mms22l |
T |
C |
4: 24,536,226 (GRCm39) |
F605S |
probably damaging |
Het |
| Mpzl3 |
A |
G |
9: 44,979,627 (GRCm39) |
S193G |
probably benign |
Het |
| Muc4 |
A |
T |
16: 32,570,565 (GRCm39) |
T542S |
probably benign |
Het |
| Muc5b |
T |
C |
7: 141,422,202 (GRCm39) |
L4446P |
possibly damaging |
Het |
| Mxi1 |
C |
A |
19: 53,358,769 (GRCm39) |
S131* |
probably null |
Het |
| Nanog |
G |
T |
6: 122,690,299 (GRCm39) |
A210S |
probably benign |
Het |
| Nrcam |
C |
T |
12: 44,622,769 (GRCm39) |
Q988* |
probably null |
Het |
| Nsg1 |
C |
A |
5: 38,316,391 (GRCm39) |
|
probably benign |
Het |
| Ogfod3 |
G |
A |
11: 121,086,027 (GRCm39) |
A189V |
probably benign |
Het |
| Or10g9b |
A |
T |
9: 39,918,038 (GRCm39) |
M69K |
possibly damaging |
Het |
| Or12e9 |
T |
A |
2: 87,202,432 (GRCm39) |
C185* |
probably null |
Het |
| Or4a68 |
A |
G |
2: 89,270,209 (GRCm39) |
V138A |
probably benign |
Het |
| Or4c122 |
T |
C |
2: 89,079,034 (GRCm39) |
|
probably null |
Het |
| Or4c35 |
G |
A |
2: 89,808,497 (GRCm39) |
C125Y |
probably damaging |
Het |
| Or51ai2 |
T |
C |
7: 103,586,710 (GRCm39) |
V41A |
probably benign |
Het |
| Or52b4i |
T |
A |
7: 102,191,587 (GRCm39) |
V148E |
possibly damaging |
Het |
| Or5b111 |
A |
T |
19: 13,291,684 (GRCm39) |
|
probably null |
Het |
| Or7e165 |
T |
G |
9: 19,694,872 (GRCm39) |
S148A |
possibly damaging |
Het |
| Or8b53 |
A |
T |
9: 38,667,703 (GRCm39) |
T240S |
probably damaging |
Het |
| Orc3 |
A |
T |
4: 34,571,774 (GRCm39) |
M665K |
possibly damaging |
Het |
| Pabpc1 |
A |
G |
15: 36,597,255 (GRCm39) |
S591P |
probably damaging |
Het |
| Pacc1 |
A |
T |
1: 191,073,040 (GRCm39) |
I154F |
probably damaging |
Het |
| Parp6 |
T |
A |
9: 59,531,645 (GRCm39) |
|
probably null |
Het |
| Pcdh1 |
T |
C |
18: 38,322,912 (GRCm39) |
M974V |
possibly damaging |
Het |
| Pcdhb22 |
T |
A |
18: 37,653,713 (GRCm39) |
V727E |
possibly damaging |
Het |
| Pex5l |
T |
C |
3: 33,047,134 (GRCm39) |
E272G |
probably damaging |
Het |
| Pglyrp2 |
G |
T |
17: 32,637,235 (GRCm39) |
N264K |
probably benign |
Het |
| Phxr4 |
T |
A |
9: 13,342,882 (GRCm39) |
|
probably benign |
Het |
| Piezo2 |
A |
G |
18: 63,278,025 (GRCm39) |
F293S |
probably damaging |
Het |
| Pkhd1 |
T |
C |
1: 20,607,625 (GRCm39) |
D1077G |
probably damaging |
Het |
| Plekhs1 |
A |
G |
19: 56,461,700 (GRCm39) |
|
probably null |
Het |
| Prex1 |
G |
T |
2: 166,427,777 (GRCm39) |
C788* |
probably null |
Het |
| Prrt3 |
A |
T |
6: 113,475,099 (GRCm39) |
M41K |
probably benign |
Het |
| Ptgir |
T |
C |
7: 16,642,768 (GRCm39) |
V326A |
probably damaging |
Het |
| Ptprg |
T |
A |
14: 12,220,654 (GRCm38) |
D455E |
probably damaging |
Het |
| Ptpru |
T |
A |
4: 131,526,914 (GRCm39) |
Q686L |
probably benign |
Het |
| Pxdc1 |
G |
T |
13: 34,814,343 (GRCm39) |
T190K |
probably benign |
Het |
| Rap1b |
A |
T |
10: 117,654,487 (GRCm39) |
C118S |
probably benign |
Het |
| Rapgef2 |
T |
C |
3: 78,990,534 (GRCm39) |
M915V |
probably benign |
Het |
| Rnd2 |
C |
T |
11: 101,359,825 (GRCm39) |
L57F |
probably damaging |
Het |
| Rpe65 |
C |
T |
3: 159,330,318 (GRCm39) |
A495V |
probably benign |
Het |
| Samd15 |
A |
G |
12: 87,247,608 (GRCm39) |
T98A |
possibly damaging |
Het |
| Slc26a7 |
T |
C |
4: 14,546,309 (GRCm39) |
D340G |
probably benign |
Het |
| Slc6a15 |
T |
A |
10: 103,253,921 (GRCm39) |
M619K |
probably benign |
Het |
| Slc7a4 |
C |
A |
16: 17,392,385 (GRCm39) |
D350Y |
probably damaging |
Het |
| Slk |
T |
G |
19: 47,608,395 (GRCm39) |
N449K |
probably benign |
Het |
| Spta1 |
A |
T |
1: 174,071,608 (GRCm39) |
|
probably null |
Het |
| Sptbn5 |
A |
T |
2: 119,886,374 (GRCm39) |
|
probably benign |
Het |
| Srd5a2 |
A |
T |
17: 74,354,800 (GRCm39) |
V8D |
probably benign |
Het |
| Srgap3 |
G |
A |
6: 112,704,271 (GRCm39) |
A906V |
probably benign |
Het |
| Stab2 |
A |
T |
10: 86,783,011 (GRCm39) |
M679K |
probably benign |
Het |
| Stk3 |
T |
C |
15: 35,000,054 (GRCm39) |
I291V |
probably benign |
Het |
| Supt6 |
T |
A |
11: 78,098,960 (GRCm39) |
Q1637L |
possibly damaging |
Het |
| Svil |
T |
C |
18: 5,114,564 (GRCm39) |
F2047S |
probably damaging |
Het |
| Swsap1 |
A |
G |
9: 21,867,284 (GRCm39) |
E76G |
probably benign |
Het |
| Syndig1 |
G |
T |
2: 149,741,473 (GRCm39) |
G20C |
probably damaging |
Het |
| Synj2bp |
A |
T |
12: 81,548,926 (GRCm39) |
N104K |
probably damaging |
Het |
| Synpo2 |
T |
A |
3: 122,908,068 (GRCm39) |
D416V |
probably damaging |
Het |
| Tacc3 |
G |
T |
5: 33,829,357 (GRCm39) |
C620F |
probably damaging |
Het |
| Tanc1 |
A |
G |
2: 59,529,766 (GRCm39) |
E19G |
probably damaging |
Het |
| Tars3 |
C |
T |
7: 65,297,302 (GRCm39) |
A139V |
probably benign |
Het |
| Tbc1d22a |
T |
A |
15: 86,235,935 (GRCm39) |
C365S |
probably damaging |
Het |
| Tdpoz2 |
T |
C |
3: 93,559,381 (GRCm39) |
H197R |
possibly damaging |
Het |
| Tha1 |
A |
T |
11: 117,760,205 (GRCm39) |
N300K |
probably damaging |
Het |
| Tm6sf1 |
T |
A |
7: 81,515,008 (GRCm39) |
F70L |
probably damaging |
Het |
| Tmem132b |
T |
A |
5: 125,860,497 (GRCm39) |
S581T |
probably benign |
Het |
| Tnfsf13 |
G |
T |
11: 69,576,075 (GRCm39) |
S4* |
probably null |
Het |
| Tonsl |
G |
A |
15: 76,517,448 (GRCm39) |
S757L |
probably benign |
Het |
| Trem2 |
G |
T |
17: 48,658,719 (GRCm39) |
R161S |
possibly damaging |
Het |
| Trpm2 |
A |
T |
10: 77,777,007 (GRCm39) |
V430E |
probably damaging |
Het |
| Ttc14 |
T |
A |
3: 33,855,518 (GRCm39) |
D154E |
possibly damaging |
Het |
| Ugt2b37 |
T |
C |
5: 87,398,498 (GRCm39) |
M313V |
possibly damaging |
Het |
| Vmn2r24 |
A |
G |
6: 123,792,739 (GRCm39) |
I689V |
probably benign |
Het |
| Wdr76 |
A |
G |
2: 121,372,975 (GRCm39) |
T601A |
probably benign |
Het |
| Xirp1 |
T |
C |
9: 119,846,069 (GRCm39) |
D938G |
possibly damaging |
Het |
| Zfp608 |
A |
T |
18: 55,031,041 (GRCm39) |
D966E |
probably benign |
Het |
| Zfp957 |
A |
G |
14: 79,451,796 (GRCm39) |
M1T |
probably null |
Het |
| Zkscan16 |
A |
T |
4: 58,957,809 (GRCm39) |
H697L |
possibly damaging |
Het |
|
| Other mutations in Sdk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00498:Sdk1
|
APN |
5 |
142,071,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00945:Sdk1
|
APN |
5 |
142,070,368 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL00946:Sdk1
|
APN |
5 |
142,070,368 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01394:Sdk1
|
APN |
5 |
141,598,970 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01398:Sdk1
|
APN |
5 |
141,923,332 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01410:Sdk1
|
APN |
5 |
142,197,875 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01525:Sdk1
|
APN |
5 |
141,985,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01548:Sdk1
|
APN |
5 |
142,071,520 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01672:Sdk1
|
APN |
5 |
142,170,930 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL01676:Sdk1
|
APN |
5 |
142,113,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01679:Sdk1
|
APN |
5 |
142,031,919 (GRCm39) |
missense |
probably benign |
|
|
IGL01929:Sdk1
|
APN |
5 |
141,938,785 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01970:Sdk1
|
APN |
5 |
142,071,437 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02016:Sdk1
|
APN |
5 |
142,020,184 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02060:Sdk1
|
APN |
5 |
141,938,767 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02457:Sdk1
|
APN |
5 |
141,938,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02634:Sdk1
|
APN |
5 |
141,595,787 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02637:Sdk1
|
APN |
5 |
142,080,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02731:Sdk1
|
APN |
5 |
142,158,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03180:Sdk1
|
APN |
5 |
142,071,497 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03259:Sdk1
|
APN |
5 |
141,938,788 (GRCm39) |
nonsense |
probably null |
|
|
PIT4453001:Sdk1
|
UTSW |
5 |
142,197,793 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4544001:Sdk1
|
UTSW |
5 |
141,941,987 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0149:Sdk1
|
UTSW |
5 |
141,842,809 (GRCm39) |
intron |
probably benign |
|
|
R0173:Sdk1
|
UTSW |
5 |
142,159,564 (GRCm39) |
splice site |
probably benign |
|
|
R0240:Sdk1
|
UTSW |
5 |
141,984,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0240:Sdk1
|
UTSW |
5 |
141,984,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0242:Sdk1
|
UTSW |
5 |
142,129,677 (GRCm39) |
splice site |
probably benign |
|
|
R0245:Sdk1
|
UTSW |
5 |
141,940,713 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0270:Sdk1
|
UTSW |
5 |
142,070,321 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0398:Sdk1
|
UTSW |
5 |
141,948,476 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0401:Sdk1
|
UTSW |
5 |
142,031,916 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R0501:Sdk1
|
UTSW |
5 |
141,923,473 (GRCm39) |
missense |
probably benign |
|
|
R0558:Sdk1
|
UTSW |
5 |
142,117,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0652:Sdk1
|
UTSW |
5 |
141,940,713 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0834:Sdk1
|
UTSW |
5 |
141,227,779 (GRCm39) |
missense |
probably benign |
|
|
R0962:Sdk1
|
UTSW |
5 |
142,147,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1424:Sdk1
|
UTSW |
5 |
142,147,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1438:Sdk1
|
UTSW |
5 |
142,024,078 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1517:Sdk1
|
UTSW |
5 |
142,113,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1519:Sdk1
|
UTSW |
5 |
141,985,705 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1539:Sdk1
|
UTSW |
5 |
142,080,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1574:Sdk1
|
UTSW |
5 |
141,984,634 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1574:Sdk1
|
UTSW |
5 |
141,984,634 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1673:Sdk1
|
UTSW |
5 |
141,934,261 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1686:Sdk1
|
UTSW |
5 |
142,020,292 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1806:Sdk1
|
UTSW |
5 |
142,147,681 (GRCm39) |
missense |
probably benign |
|
|
R1806:Sdk1
|
UTSW |
5 |
141,598,950 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1925:Sdk1
|
UTSW |
5 |
142,171,040 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1956:Sdk1
|
UTSW |
5 |
142,080,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1976:Sdk1
|
UTSW |
5 |
142,129,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2124:Sdk1
|
UTSW |
5 |
142,170,943 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R2152:Sdk1
|
UTSW |
5 |
141,778,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2186:Sdk1
|
UTSW |
5 |
142,032,047 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2187:Sdk1
|
UTSW |
5 |
142,100,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2306:Sdk1
|
UTSW |
5 |
141,948,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2520:Sdk1
|
UTSW |
5 |
142,071,526 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2698:Sdk1
|
UTSW |
5 |
142,197,805 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2763:Sdk1
|
UTSW |
5 |
142,070,306 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3023:Sdk1
|
UTSW |
5 |
142,031,991 (GRCm39) |
missense |
probably benign |
|
|
R3500:Sdk1
|
UTSW |
5 |
141,992,371 (GRCm39) |
splice site |
probably benign |
|
|
R3613:Sdk1
|
UTSW |
5 |
142,105,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3824:Sdk1
|
UTSW |
5 |
141,921,804 (GRCm39) |
missense |
probably benign |
|
|
R3916:Sdk1
|
UTSW |
5 |
142,036,999 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3917:Sdk1
|
UTSW |
5 |
142,036,999 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4158:Sdk1
|
UTSW |
5 |
142,100,154 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4160:Sdk1
|
UTSW |
5 |
142,100,154 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4161:Sdk1
|
UTSW |
5 |
142,100,154 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4386:Sdk1
|
UTSW |
5 |
142,080,381 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4649:Sdk1
|
UTSW |
5 |
141,992,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4701:Sdk1
|
UTSW |
5 |
142,170,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4780:Sdk1
|
UTSW |
5 |
141,944,993 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4787:Sdk1
|
UTSW |
5 |
141,568,168 (GRCm39) |
missense |
probably benign |
|
|
R4853:Sdk1
|
UTSW |
5 |
142,132,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4857:Sdk1
|
UTSW |
5 |
142,147,531 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4928:Sdk1
|
UTSW |
5 |
141,842,758 (GRCm39) |
intron |
probably benign |
|
|
R5111:Sdk1
|
UTSW |
5 |
142,113,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5188:Sdk1
|
UTSW |
5 |
141,942,015 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5246:Sdk1
|
UTSW |
5 |
142,100,317 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5273:Sdk1
|
UTSW |
5 |
141,984,583 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5484:Sdk1
|
UTSW |
5 |
142,085,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5525:Sdk1
|
UTSW |
5 |
142,171,020 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5578:Sdk1
|
UTSW |
5 |
141,598,880 (GRCm39) |
nonsense |
probably null |
|
|
R5593:Sdk1
|
UTSW |
5 |
141,941,879 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5654:Sdk1
|
UTSW |
5 |
141,921,853 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5672:Sdk1
|
UTSW |
5 |
142,173,900 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5768:Sdk1
|
UTSW |
5 |
142,129,626 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5781:Sdk1
|
UTSW |
5 |
141,921,803 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5846:Sdk1
|
UTSW |
5 |
142,100,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5851:Sdk1
|
UTSW |
5 |
141,948,424 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6164:Sdk1
|
UTSW |
5 |
142,117,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6235:Sdk1
|
UTSW |
5 |
142,020,181 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6364:Sdk1
|
UTSW |
5 |
141,948,464 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6453:Sdk1
|
UTSW |
5 |
142,082,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6892:Sdk1
|
UTSW |
5 |
142,032,053 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6996:Sdk1
|
UTSW |
5 |
142,197,769 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7003:Sdk1
|
UTSW |
5 |
142,082,489 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7022:Sdk1
|
UTSW |
5 |
142,080,412 (GRCm39) |
splice site |
probably null |
|
|
R7027:Sdk1
|
UTSW |
5 |
142,082,481 (GRCm39) |
splice site |
probably null |
|
|
R7098:Sdk1
|
UTSW |
5 |
142,082,625 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7107:Sdk1
|
UTSW |
5 |
142,067,471 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7203:Sdk1
|
UTSW |
5 |
142,031,931 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7313:Sdk1
|
UTSW |
5 |
141,923,377 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7363:Sdk1
|
UTSW |
5 |
142,173,897 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7375:Sdk1
|
UTSW |
5 |
141,984,598 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7446:Sdk1
|
UTSW |
5 |
142,130,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7527:Sdk1
|
UTSW |
5 |
141,778,731 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R7598:Sdk1
|
UTSW |
5 |
141,595,753 (GRCm39) |
nonsense |
probably null |
|
|
R7747:Sdk1
|
UTSW |
5 |
142,070,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7810:Sdk1
|
UTSW |
5 |
141,923,434 (GRCm39) |
missense |
probably benign |
|
|
R7985:Sdk1
|
UTSW |
5 |
142,113,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8129:Sdk1
|
UTSW |
5 |
142,177,648 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8217:Sdk1
|
UTSW |
5 |
142,197,713 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8249:Sdk1
|
UTSW |
5 |
142,173,770 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8376:Sdk1
|
UTSW |
5 |
142,144,376 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8779:Sdk1
|
UTSW |
5 |
141,948,457 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8807:Sdk1
|
UTSW |
5 |
142,071,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8907:Sdk1
|
UTSW |
5 |
142,070,278 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8942:Sdk1
|
UTSW |
5 |
142,082,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8945:Sdk1
|
UTSW |
5 |
141,598,935 (GRCm39) |
missense |
probably benign |
|
|
R9006:Sdk1
|
UTSW |
5 |
141,923,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9249:Sdk1
|
UTSW |
5 |
142,129,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9275:Sdk1
|
UTSW |
5 |
141,941,953 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9345:Sdk1
|
UTSW |
5 |
142,147,708 (GRCm39) |
missense |
probably benign |
|
|
R9463:Sdk1
|
UTSW |
5 |
141,948,548 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9549:Sdk1
|
UTSW |
5 |
141,940,657 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9572:Sdk1
|
UTSW |
5 |
141,595,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9602:Sdk1
|
UTSW |
5 |
142,071,353 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9703:Sdk1
|
UTSW |
5 |
142,100,283 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9720:Sdk1
|
UTSW |
5 |
142,197,796 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9771:Sdk1
|
UTSW |
5 |
142,082,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0017:Sdk1
|
UTSW |
5 |
141,984,535 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Sdk1
|
UTSW |
5 |
141,945,065 (GRCm39) |
missense |
probably null |
0.58 |
|
Z1177:Sdk1
|
UTSW |
5 |
141,948,463 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAATTATTTGCTACTTCACTGGGC -3'
(R):5'- TGTCACCAGGTCCTACAAGG -3'
Sequencing Primer
(F):5'- GCTACTTCACTGGGCTACATAG -3'
(R):5'- AGGGGTTCAGCTATAACCTCG -3'
|
| Posted On |
2017-04-14 |
Incidental Mutation