Incidental Mutation 'R3551:Prr14l'
ID 473003
Institutional Source Beutler Lab
Gene Symbol Prr14l
Ensembl Gene ENSMUSG00000054280
Gene Name proline rich 14-like
Synonyms
MMRRC Submission 040668-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.269) question?
Stock # R3551 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 32789820-32854256 bp(-) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 32828619 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000124923 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000120129] [ENSMUST00000144673] [ENSMUST00000155392]
AlphaFold E9Q7C4
Predicted Effect silent
Transcript: ENSMUST00000120129
SMART Domains Protein: ENSMUSP00000113259
Gene: ENSMUSG00000054280

DomainStartEndE-ValueType
low complexity region 720 731 N/A INTRINSIC
low complexity region 1433 1446 N/A INTRINSIC
low complexity region 1471 1480 N/A INTRINSIC
Pfam:Tantalus 1838 1895 2.9e-28 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000144673
SMART Domains Protein: ENSMUSP00000124923
Gene: ENSMUSG00000093574

DomainStartEndE-ValueType
Pfam:Tantalus 158 193 1.2e-15 PFAM
Pfam:PS_Dcarbxylase 332 575 2.1e-71 PFAM
Predicted Effect silent
Transcript: ENSMUST00000155392
SMART Domains Protein: ENSMUSP00000119569
Gene: ENSMUSG00000054280

DomainStartEndE-ValueType
low complexity region 276 289 N/A INTRINSIC
low complexity region 314 323 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T A 11: 84,261,624 (GRCm38) Y866N probably damaging Het
Adam24 G C 8: 40,679,593 (GRCm38) W33C probably benign Het
Adgrl2 A T 3: 148,858,963 (GRCm38) V327E probably damaging Het
Aqp7 T A 4: 41,045,329 (GRCm38) N17I probably benign Het
Bicra T A 7: 15,979,733 (GRCm38) Q848L probably benign Het
C4b T C 17: 34,741,872 (GRCm38) E240G possibly damaging Het
Ccni T C 5: 93,187,761 (GRCm38) S173G probably benign Het
Clca3a2 T A 3: 144,803,081 (GRCm38) N50I probably damaging Het
Dcaf7 A G 11: 106,054,796 (GRCm38) T324A probably benign Het
Dnah12 G A 14: 26,770,972 (GRCm38) R1230H probably benign Het
Dsg4 G A 18: 20,451,756 (GRCm38) V176M probably damaging Het
Ect2l A G 10: 18,163,393 (GRCm38) I339T probably damaging Het
Edc4 A T 8: 105,885,494 (GRCm38) I138F probably damaging Het
Ercc6l2 T A 13: 63,844,595 (GRCm38) V401E probably damaging Het
Gm3269 T A 14: 4,845,893 (GRCm38) V260D possibly damaging Het
Gm4076 C T 13: 85,127,150 (GRCm38) noncoding transcript Het
Gm4922 A T 10: 18,784,496 (GRCm38) N159K probably benign Het
Gm5134 G T 10: 76,000,447 (GRCm38) A421S probably benign Het
Gm5724 T C 6: 141,708,596 (GRCm38) K647E probably benign Het
Hrc G C 7: 45,336,333 (GRCm38) E303Q possibly damaging Het
Ipo4 A G 14: 55,633,103 (GRCm38) V288A probably benign Het
Kng2 A G 16: 23,011,995 (GRCm38) probably null Het
Lrfn1 T C 7: 28,460,054 (GRCm38) L466P possibly damaging Het
Magi1 T A 6: 93,699,629 (GRCm38) K916N probably damaging Het
Mms19 T C 19: 41,949,798 (GRCm38) T720A probably benign Het
Muc5b A G 7: 141,861,335 (GRCm38) T2673A possibly damaging Het
Myo15 C T 11: 60,509,663 (GRCm38) A1767V possibly damaging Het
Npas2 A T 1: 39,287,562 (GRCm38) M43L probably benign Het
Nup43 A G 10: 7,675,014 (GRCm38) D216G possibly damaging Het
Olfr378 T C 11: 73,425,852 (GRCm38) I44V probably benign Het
Orc4 G A 2: 48,937,489 (GRCm38) P31S probably benign Het
Pcdhga6 G T 18: 37,708,217 (GRCm38) R330L probably benign Het
Pear1 A G 3: 87,758,132 (GRCm38) F145L probably benign Het
Pgap1 A G 1: 54,530,143 (GRCm38) S355P possibly damaging Het
Ptpn12 T C 5: 20,989,049 (GRCm38) K742E possibly damaging Het
Ryr1 T A 7: 29,056,997 (GRCm38) Q3464L probably damaging Het
Sema4c G C 1: 36,553,723 (GRCm38) T138S probably benign Het
Slc4a2 C T 5: 24,430,101 (GRCm38) T168M probably benign Het
Spice1 G T 16: 44,357,869 (GRCm38) S85I probably damaging Het
Thrb T A 14: 17,963,214 (GRCm38) I59N probably damaging Het
Trav7-1 A G 14: 52,655,299 (GRCm38) D103G probably damaging Het
Ubap2l G T 3: 90,015,451 (GRCm38) T766N unknown Het
Zfp692 C T 11: 58,309,428 (GRCm38) T170I possibly damaging Het
Zfp704 A G 3: 9,474,525 (GRCm38) V255A probably damaging Het
Zfp759 T C 13: 67,138,967 (GRCm38) V194A probably benign Het
Other mutations in Prr14l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00229:Prr14l APN 5 32,830,676 (GRCm38) missense probably benign 0.04
IGL00331:Prr14l APN 5 32,831,066 (GRCm38) missense probably benign 0.02
IGL01571:Prr14l APN 5 32,828,806 (GRCm38) missense probably benign 0.01
IGL01795:Prr14l APN 5 32,831,845 (GRCm38) unclassified probably benign
IGL01929:Prr14l APN 5 32,828,243 (GRCm38) missense probably benign 0.09
IGL01959:Prr14l APN 5 32,830,205 (GRCm38) missense possibly damaging 0.84
IGL02139:Prr14l APN 5 32,827,532 (GRCm38) missense probably damaging 1.00
IGL02321:Prr14l APN 5 32,827,807 (GRCm38) missense probably benign 0.10
IGL02508:Prr14l APN 5 32,830,942 (GRCm38) missense probably benign 0.01
IGL02551:Prr14l APN 5 32,831,484 (GRCm38) missense probably damaging 1.00
IGL02585:Prr14l APN 5 32,829,484 (GRCm38) missense possibly damaging 0.59
IGL02614:Prr14l APN 5 32,830,543 (GRCm38) missense possibly damaging 0.76
IGL02808:Prr14l APN 5 32,828,182 (GRCm38) missense possibly damaging 0.94
IGL02836:Prr14l APN 5 32,831,096 (GRCm38) missense probably benign 0.42
IGL02952:Prr14l APN 5 32,835,670 (GRCm38) missense unknown
IGL03034:Prr14l APN 5 32,827,438 (GRCm38) missense possibly damaging 0.48
Polymer UTSW 5 32,827,145 (GRCm38) missense probably benign 0.34
Postwar UTSW 5 32,830,684 (GRCm38) missense probably benign 0.17
H8562:Prr14l UTSW 5 32,793,728 (GRCm38) missense probably damaging 1.00
R0086:Prr14l UTSW 5 32,831,559 (GRCm38) unclassified probably benign
R0149:Prr14l UTSW 5 32,793,641 (GRCm38) missense probably damaging 1.00
R0333:Prr14l UTSW 5 32,827,993 (GRCm38) missense probably damaging 1.00
R0361:Prr14l UTSW 5 32,793,641 (GRCm38) missense probably damaging 1.00
R0416:Prr14l UTSW 5 32,828,717 (GRCm38) missense probably benign 0.25
R0480:Prr14l UTSW 5 32,829,880 (GRCm38) missense probably benign 0.02
R0511:Prr14l UTSW 5 32,844,216 (GRCm38) intron probably benign
R0639:Prr14l UTSW 5 32,828,915 (GRCm38) missense probably benign 0.02
R0673:Prr14l UTSW 5 32,828,915 (GRCm38) missense probably benign 0.02
R0743:Prr14l UTSW 5 32,831,194 (GRCm38) missense possibly damaging 0.55
R0792:Prr14l UTSW 5 32,828,423 (GRCm38) missense probably damaging 1.00
R1006:Prr14l UTSW 5 32,829,482 (GRCm38) missense probably benign 0.00
R1342:Prr14l UTSW 5 32,830,260 (GRCm38) missense probably damaging 1.00
R1433:Prr14l UTSW 5 32,828,833 (GRCm38) missense probably damaging 1.00
R1527:Prr14l UTSW 5 32,827,949 (GRCm38) missense possibly damaging 0.75
R1704:Prr14l UTSW 5 32,830,282 (GRCm38) missense probably benign 0.01
R1967:Prr14l UTSW 5 32,844,469 (GRCm38) intron probably benign
R2129:Prr14l UTSW 5 32,831,828 (GRCm38) unclassified probably benign
R2150:Prr14l UTSW 5 32,830,702 (GRCm38) missense probably benign 0.14
R2318:Prr14l UTSW 5 32,830,078 (GRCm38) missense probably benign 0.04
R2915:Prr14l UTSW 5 32,829,768 (GRCm38) missense probably benign 0.04
R3820:Prr14l UTSW 5 32,828,984 (GRCm38) missense probably damaging 0.99
R3852:Prr14l UTSW 5 32,830,345 (GRCm38) missense probably damaging 1.00
R4126:Prr14l UTSW 5 32,828,003 (GRCm38) missense probably damaging 0.97
R4345:Prr14l UTSW 5 32,828,576 (GRCm38) missense probably damaging 1.00
R4388:Prr14l UTSW 5 32,829,254 (GRCm38) missense probably damaging 1.00
R4575:Prr14l UTSW 5 32,793,644 (GRCm38) missense probably damaging 1.00
R4596:Prr14l UTSW 5 32,829,308 (GRCm38) missense probably benign 0.01
R4690:Prr14l UTSW 5 32,844,156 (GRCm38) intron probably benign
R4824:Prr14l UTSW 5 32,844,399 (GRCm38) intron probably benign
R4868:Prr14l UTSW 5 32,829,937 (GRCm38) missense probably benign 0.04
R4869:Prr14l UTSW 5 32,828,833 (GRCm38) missense probably damaging 1.00
R5201:Prr14l UTSW 5 32,830,247 (GRCm38) missense possibly damaging 0.52
R5328:Prr14l UTSW 5 32,830,021 (GRCm38) missense probably benign 0.00
R5410:Prr14l UTSW 5 32,827,777 (GRCm38) missense probably damaging 0.98
R5476:Prr14l UTSW 5 32,844,138 (GRCm38) intron probably benign
R5623:Prr14l UTSW 5 32,844,508 (GRCm38) intron probably benign
R5730:Prr14l UTSW 5 32,793,603 (GRCm38) missense probably damaging 1.00
R5988:Prr14l UTSW 5 32,830,851 (GRCm38) missense probably damaging 0.98
R6261:Prr14l UTSW 5 32,829,404 (GRCm38) missense possibly damaging 0.46
R6283:Prr14l UTSW 5 32,830,264 (GRCm38) missense probably benign 0.14
R6307:Prr14l UTSW 5 32,827,525 (GRCm38) missense probably damaging 0.97
R6825:Prr14l UTSW 5 32,828,548 (GRCm38) missense possibly damaging 0.86
R6862:Prr14l UTSW 5 32,827,759 (GRCm38) missense probably damaging 1.00
R6880:Prr14l UTSW 5 32,830,867 (GRCm38) missense probably benign 0.01
R6931:Prr14l UTSW 5 32,830,691 (GRCm38) missense probably damaging 0.98
R7101:Prr14l UTSW 5 32,829,427 (GRCm38) missense probably damaging 1.00
R7164:Prr14l UTSW 5 32,829,166 (GRCm38) missense probably damaging 1.00
R7203:Prr14l UTSW 5 32,827,145 (GRCm38) missense probably benign 0.34
R7211:Prr14l UTSW 5 32,830,087 (GRCm38) missense probably damaging 0.98
R7305:Prr14l UTSW 5 32,831,101 (GRCm38) missense probably benign 0.14
R7346:Prr14l UTSW 5 32,830,684 (GRCm38) missense probably benign 0.17
R7395:Prr14l UTSW 5 32,828,638 (GRCm38) missense probably benign 0.00
R7624:Prr14l UTSW 5 32,829,623 (GRCm38) missense possibly damaging 0.54
R7649:Prr14l UTSW 5 32,828,245 (GRCm38) missense probably benign 0.18
R7753:Prr14l UTSW 5 32,827,253 (GRCm38) missense probably damaging 1.00
R7828:Prr14l UTSW 5 32,844,391 (GRCm38) intron probably benign
R7898:Prr14l UTSW 5 32,829,966 (GRCm38) missense probably benign 0.04
R8071:Prr14l UTSW 5 32,831,164 (GRCm38) missense probably benign 0.02
R9052:Prr14l UTSW 5 32,830,134 (GRCm38) nonsense probably null
R9136:Prr14l UTSW 5 32,828,736 (GRCm38) missense
R9682:Prr14l UTSW 5 32,830,679 (GRCm38) missense probably benign 0.02
Predicted Primers
Posted On 2017-04-14