Mutagenetix > Incidental Mutation

Incidental Mutation 'R3615:Foxi2'

473054

Institutional Source

Beutler Lab

Gene Symbol

Foxi2

Ensembl Gene

ENSMUSG00000048377

Gene Name

forkhead box I2

Synonyms

B130055A05Rik

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R3615 (G1)

Quality Score

175

Status

Not validated

Chromosome

Chromosomal Location

135410308-135413622 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 135410451 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 23 (C23S)

Ref Sequence

ENSEMBL: ENSMUSP00000053641 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060356]

AlphaFold

Q3I5G5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000060356
AA Change: C23S

PolyPhen 2 Score 0.876 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000053641
Gene: ENSMUSG00000048377
AA Change: C23S

Domain	Start	End	E-Value	Type
low complexity region	64	82	N/A	INTRINSIC
low complexity region	87	108	N/A	INTRINSIC
FH	115	205	1.29e-58	SMART
low complexity region	207	213	N/A	INTRINSIC
low complexity region	237	249	N/A	INTRINSIC
low complexity region	262	278	N/A	INTRINSIC

Meta Mutation Damage Score

0.1010

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.3%

Validation Efficiency

98% (40/41)

MGI Phenotype

PHENOTYPE: Mice homozygous for a null allele are viable and fertile with no gross abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700022I11Rik	A	G	4: 42,971,864	N399S	probably benign	Het
A2ml1	T	C	6: 128,558,294	T818A	probably benign	Het
Aasdh	A	G	5: 76,888,782	V304A	probably benign	Het
Angptl3	G	A	4: 99,034,465	A248T	probably benign	Het
Ap2b1	T	A	11: 83,324,565	C112S	possibly damaging	Het
Aqr	A	T	2: 114,136,887	I549N	probably damaging	Het
Barhl1	C	T	2: 28,911,550	D161N	possibly damaging	Het
Col28a1	A	G	6: 8,014,942	V821A	probably damaging	Het
Dclk2	G	A	3: 86,920,035	P46S	probably damaging	Het
Dnah1	A	G	14: 31,315,148	L247P	possibly damaging	Het
Dpysl2	T	A	14: 66,834,370	H107L	probably damaging	Het
Dzip3	A	G	16: 48,937,063	L869S	probably damaging	Het
Efs	T	C	14: 54,920,095	Y160C	probably damaging	Het
Enam	A	T	5: 88,504,447	N1197Y	possibly damaging	Het
Espl1	A	G	15: 102,312,989	I944V	probably damaging	Het
Fam184b	A	G	5: 45,582,815	V343A	possibly damaging	Het
Fbxw26	A	T	9: 109,743,760	Y105*	probably null	Het
Fiz1	A	G	7: 5,008,172	L449P	probably benign	Het
Gdf2	G	A	14: 33,944,957	R212Q	probably damaging	Het
Gm5105	C	A	3: 138,049,688	A46S	unknown	Het
Gm597	T	C	1: 28,776,575	D792G	probably benign	Het
Grik5	C	T	7: 25,022,571	A581T	probably benign	Het
Gse1	C	G	8: 120,572,742		probably benign	Het
Hsp90aa1	T	A	12: 110,695,680	M1L	possibly damaging	Het
Hsp90aa1	C	A	12: 110,695,681		probably null	Het
Krt25	A	C	11: 99,317,298	V368G	possibly damaging	Het
Lacc1	A	G	14: 77,033,287	V269A	probably benign	Het
Lamc1	T	C	1: 153,251,150	K417E	probably damaging	Het
Miip	A	G	4: 147,865,914	M75T	probably benign	Het
Nlrp10	A	G	7: 108,924,476	F599S	probably benign	Het
Nlrp12	T	A	7: 3,240,575	M436L	probably benign	Het
Olfr142	T	C	2: 90,252,409	E193G	possibly damaging	Het
Pafah1b1	G	A	11: 74,690,232	S57F	probably damaging	Het
Pla2g2e	G	A	4: 138,880,374	V22I	probably benign	Het
Plekhd1	A	G	12: 80,717,270	E202G	probably damaging	Het
Prss21	A	G	17: 23,872,831	T258A	probably benign	Het
Prss34	A	G	17: 25,298,846	E65G	probably benign	Het
Psap	A	G	10: 60,294,603	N149S	probably benign	Het
Ptprf	C	T	4: 118,237,883	A275T	probably benign	Het
Sem1	A	G	6: 6,578,520	L12P	probably damaging	Het
Sf3b3	A	G	8: 110,844,523	Y4H	probably damaging	Het
Sh3bp4	G	T	1: 89,137,705	R7L	probably damaging	Het
Slc16a1	T	A	3: 104,653,570	L397Q	probably damaging	Het
Smg5	A	G	3: 88,336,451	S10G	possibly damaging	Het
Tas2r102	C	T	6: 132,762,818	Q230*	probably null	Het
Tdo2	A	G	3: 81,975,428	Y13H	possibly damaging	Het
Tmem231	C	T	8: 111,918,313	R187H	possibly damaging	Het
Tmem30b	A	G	12: 73,545,579	M254T	probably damaging	Het
Trpm1	G	A	7: 64,243,570	G1057R	probably damaging	Het
Tusc3	A	T	8: 39,164,838	K347N	probably damaging	Het
Usp36	C	T	11: 118,276,759		probably null	Het
Vash2	T	C	1: 190,970,419	Y117C	probably damaging	Het
Vrk2	A	G	11: 26,489,866	I235T	possibly damaging	Het
Wdr20	A	G	12: 110,793,939	T420A	probably benign	Het

Other mutations in Foxi2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01101:Foxi2	APN	7	135412007	missense	probably benign	0.07
IGL02984:Foxi2	UTSW	7	135410398	missense	possibly damaging	0.96
R0030:Foxi2	UTSW	7	135411616	missense	probably damaging	0.99
R0030:Foxi2	UTSW	7	135411616	missense	probably damaging	0.99
R0121:Foxi2	UTSW	7	135411911	missense	probably benign
R0830:Foxi2	UTSW	7	135411730	missense	probably benign
R2059:Foxi2	UTSW	7	135410677	missense	probably damaging	1.00
R3616:Foxi2	UTSW	7	135410451	missense	possibly damaging	0.88
R4021:Foxi2	UTSW	7	135410530	missense	probably damaging	1.00
R4764:Foxi2	UTSW	7	135410667	missense	probably damaging	1.00
R5048:Foxi2	UTSW	7	135411635	missense	probably damaging	1.00
R5257:Foxi2	UTSW	7	135410527	missense	probably benign	0.19
R5258:Foxi2	UTSW	7	135410527	missense	probably benign	0.19
R5561:Foxi2	UTSW	7	135411647	missense	probably damaging	1.00
R5611:Foxi2	UTSW	7	135411704	missense	probably benign	0.00
R5667:Foxi2	UTSW	7	135410939	splice site	probably null
R7492:Foxi2	UTSW	7	135410572	missense	probably damaging	0.99
R8726:Foxi2	UTSW	7	135410404	missense	probably damaging	0.98
R9205:Foxi2	UTSW	7	135411796	missense	probably benign
R9644:Foxi2	UTSW	7	135411998	missense	possibly damaging	0.95
Z1177:Foxi2	UTSW	7	135410415	missense	probably benign	0.40
Z1177:Foxi2	UTSW	7	135411958	missense	probably benign	0.32

Predicted Primers

Posted On

2017-04-14