Incidental Mutation 'R3741:Sbp'
ID473334
Institutional Source Beutler Lab
Gene Symbol Sbp
Ensembl Gene ENSMUSG00000024128
Gene Namespermine binding protein
Synonymsp25
MMRRC Submission 040727-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #R3741 (G1)
Quality Score225
Status Not validated
Chromosome17
Chromosomal Location23941672-23945607 bp(+) (GRCm38)
Type of Mutationutr 3 prime
DNA Base Change (assembly) T to A at 23945582 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000138219 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024940] [ENSMUST00000181985] [ENSMUST00000182519] [ENSMUST00000182868] [ENSMUST00000183017] [ENSMUST00000183155] [ENSMUST00000183252]
Predicted Effect probably benign
Transcript: ENSMUST00000024940
SMART Domains Protein: ENSMUSP00000024940
Gene: ENSMUSG00000024128

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Jacalin 26 151 2.32e-15 SMART
low complexity region 161 198 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000181985
SMART Domains Protein: ENSMUSP00000138422
Gene: ENSMUSG00000024128

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Jacalin 26 151 2.32e-15 SMART
low complexity region 161 198 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000182519
AA Change: V95D
SMART Domains Protein: ENSMUSP00000138338
Gene: ENSMUSG00000024128
AA Change: V95D

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Blast:Jacalin 26 87 3e-38 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000182868
SMART Domains Protein: ENSMUSP00000138491
Gene: ENSMUSG00000024128

DomainStartEndE-ValueType
signal peptide 1 44 N/A INTRINSIC
Jacalin 53 178 2.32e-15 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000183017
Predicted Effect probably benign
Transcript: ENSMUST00000183155
SMART Domains Protein: ENSMUSP00000138341
Gene: ENSMUSG00000024128

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Jacalin 26 151 2.32e-15 SMART
low complexity region 161 198 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000183252
SMART Domains Protein: ENSMUSP00000138219
Gene: ENSMUSG00000024128

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Jacalin 26 151 2.32e-15 SMART
low complexity region 161 198 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency 97% (37/38)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aspm T C 1: 139,478,619 V1748A possibly damaging Het
Atp10b A T 11: 43,235,662 S1082C probably damaging Het
Atp8b2 C G 3: 89,946,031 A726P probably benign Het
B4galt3 C A 1: 171,274,043 H196N probably damaging Het
Bbip1 T C 19: 53,932,175 M1V probably null Het
Bbox1 A G 2: 110,305,577 I19T possibly damaging Het
Bclaf3 T A X: 159,551,832 H41Q probably benign Het
Ctsm T A 13: 61,539,627 Q107L probably benign Het
Ctso G A 3: 81,952,249 V288I probably benign Het
Cyp2a4 A C 7: 26,308,544 K125N probably damaging Het
Dapk1 T C 13: 60,748,200 S701P probably benign Het
Dnah1 A G 14: 31,265,467 probably benign Het
Dnah11 A G 12: 118,131,341 M718T probably benign Het
Dnah2 C A 11: 69,448,469 A3071S probably damaging Het
Epb41l4a A T 18: 33,828,102 probably null Het
Fam135a A T 1: 24,014,811 M1215K probably damaging Het
Gm6489 T A 1: 31,287,683 noncoding transcript Het
Hhipl1 A G 12: 108,318,717 Y443C probably damaging Het
Hoxc13 G A 15: 102,921,438 G84D possibly damaging Het
Ifi207 T C 1: 173,727,562 I851M probably damaging Het
Lipk T G 19: 34,021,707 L134R probably damaging Het
Mov10l1 A G 15: 89,012,142 N678D possibly damaging Het
Msrb3 A T 10: 120,784,214 F67I probably damaging Het
Myo1a A G 10: 127,714,898 D593G probably benign Het
Nsf C T 11: 103,930,752 E26K possibly damaging Het
Nup210l A T 3: 90,207,394 M1759L probably benign Het
Optn C A 2: 5,034,198 M371I possibly damaging Het
Rims1 A T 1: 22,373,443 V380D probably damaging Het
Rnf148 A G 6: 23,654,065 C311R possibly damaging Het
Rrp12 T C 19: 41,885,728 D377G probably damaging Het
Sipa1 T C 19: 5,654,857 E570G probably damaging Het
Spem2 T C 11: 69,816,730 R470G possibly damaging Het
Syngr4 T C 7: 45,895,770 E5G possibly damaging Het
Tmem88b A G 4: 155,785,427 L59P probably damaging Het
Ttn T A 2: 76,790,359 K13995* probably null Het
Vmn1r69 A G 7: 10,580,142 Y221H possibly damaging Het
Zfp386 T A 12: 116,059,550 L296* probably null Het
Other mutations in Sbp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01431:Sbp APN 17 23945348 utr 3 prime probably benign
IGL02035:Sbp APN 17 23942612 missense possibly damaging 0.73
FR4449:Sbp UTSW 17 23945364 small insertion probably benign
FR4737:Sbp UTSW 17 23945382 small insertion probably benign
FR4737:Sbp UTSW 17 23945389 small insertion probably benign
R0457:Sbp UTSW 17 23945312 missense probably benign 0.04
R1083:Sbp UTSW 17 23942730 splice site probably benign
R1544:Sbp UTSW 17 23945069 missense probably benign 0.01
R2075:Sbp UTSW 17 23945158 splice site probably null
R4513:Sbp UTSW 17 23945312 missense probably benign 0.04
R4774:Sbp UTSW 17 23945244 missense probably damaging 1.00
R5338:Sbp UTSW 17 23942422 start gained probably benign
R5576:Sbp UTSW 17 23945578 missense probably benign 0.05
R7315:Sbp UTSW 17 23945306 missense probably benign 0.10
R7894:Sbp UTSW 17 23942189 intron probably benign
RF003:Sbp UTSW 17 23945369 small insertion probably benign
RF010:Sbp UTSW 17 23945351 small insertion probably benign
RF011:Sbp UTSW 17 23945354 small insertion probably benign
RF024:Sbp UTSW 17 23945387 small insertion probably benign
RF037:Sbp UTSW 17 23945384 small insertion probably benign
RF037:Sbp UTSW 17 23945387 small insertion probably benign
RF038:Sbp UTSW 17 23945384 small insertion probably benign
RF042:Sbp UTSW 17 23945384 small insertion probably benign
RF044:Sbp UTSW 17 23945366 small insertion probably benign
RF048:Sbp UTSW 17 23945389 small insertion probably benign
RF054:Sbp UTSW 17 23945371 small insertion probably benign
RF056:Sbp UTSW 17 23945366 small insertion probably benign
RF059:Sbp UTSW 17 23945377 small insertion probably benign
RF061:Sbp UTSW 17 23945377 small insertion probably benign
Predicted Primers
Posted On2017-04-14