Mutagenetix > Incidental Mutations

Incidental Mutation 'R3758:Cd200r3'

473498

Institutional Source

Beutler Lab

Gene Symbol

Cd200r3

Ensembl Gene

ENSMUSG00000036172

Gene Name

CD200 receptor 3

Synonyms

4833409J19Rik, mCD200RLb, 4733401I18Rik

MMRRC Submission

040739-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R3758 (G1)

Quality Score

223

Status

Not validated

Chromosome

Chromosomal Location

44943678-44981380 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to G at 44964628 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000110260 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048479] [ENSMUST00000077178] [ENSMUST00000114611] [ENSMUST00000114612] [ENSMUST00000114613] [ENSMUST00000114622] [ENSMUST00000164007] [ENSMUST00000166731] [ENSMUST00000171779]

Predicted Effect

probably benign
Transcript: ENSMUST00000048479

SMART Domains

Protein: ENSMUSP00000036624
Gene: ENSMUSG00000036172

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
low complexity region	33	49	N/A	INTRINSIC
PDB:4BFI\|A	58	238	1e-42	PDB
Blast:IG	65	163	1e-21	BLAST
Blast:IG_like	165	270	8e-32	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000077178

SMART Domains

Protein: ENSMUSP00000076421
Gene: ENSMUSG00000036172

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
low complexity region	33	49	N/A	INTRINSIC
PDB:4BFI\|A	58	163	1e-12	PDB
Blast:IG	65	163	2e-22	BLAST
transmembrane domain	171	193	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000114611

SMART Domains

Protein: ENSMUSP00000110258
Gene: ENSMUSG00000036172

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
low complexity region	33	49	N/A	INTRINSIC
PDB:4BFI\|A	58	238	9e-43	PDB
Blast:IG	65	163	1e-21	BLAST
Blast:IG_like	165	273	2e-32	BLAST

Predicted Effect

probably null
Transcript: ENSMUST00000114612

SMART Domains

Protein: ENSMUSP00000110259
Gene: ENSMUSG00000036172

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
low complexity region	33	49	N/A	INTRINSIC
PDB:4BFI\|A	58	163	8e-13	PDB
Blast:IG	65	163	2e-22	BLAST
transmembrane domain	171	193	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000114613

SMART Domains

Protein: ENSMUSP00000110260
Gene: ENSMUSG00000036172

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
low complexity region	33	49	N/A	INTRINSIC
PDB:4BFI\|A	58	238	9e-43	PDB
Blast:IG	65	163	1e-21	BLAST
Blast:IG_like	165	274	2e-32	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000114622

SMART Domains

Protein: ENSMUSP00000110269
Gene: ENSMUSG00000036172

Domain	Start	End	E-Value	Type
Pfam:V-set	22	164	6.9e-6	PFAM
transmembrane domain	171	193	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000163358

Predicted Effect

probably benign
Transcript: ENSMUST00000164007

SMART Domains

Protein: ENSMUSP00000130480
Gene: ENSMUSG00000036172

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
low complexity region	33	49	N/A	INTRINSIC
PDB:4BFI\|A	58	238	1e-42	PDB
Blast:IG	65	163	1e-21	BLAST
Blast:IG_like	165	273	2e-32	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000166731

SMART Domains

Protein: ENSMUSP00000128974
Gene: ENSMUSG00000036172

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
low complexity region	33	49	N/A	INTRINSIC
PDB:4BFI\|A	58	238	8e-43	PDB
Blast:IG	65	163	9e-22	BLAST
Blast:IG_like	165	273	2e-32	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000171779

SMART Domains

Protein: ENSMUSP00000132938
Gene: ENSMUSG00000036172

Domain	Start	End	E-Value	Type
Pfam:V-set	22	164	6.7e-6	PFAM
transmembrane domain	171	193	N/A	INTRINSIC

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.0%
20x: 94.1%

Validation Efficiency

93% (28/30)

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acat3	A	G	17: 12,927,467		probably benign	Het
Bcat1	T	A	6: 145,032,872	I208F	probably damaging	Het
Cage1	A	C	13: 38,025,729	F91V	possibly damaging	Het
Coq8b	C	T	7: 27,242,227	Q246*	probably null	Het
Dmxl1	G	A	18: 49,935,317	G2719D	probably damaging	Het
Fbln2	T	C	6: 91,256,381	S616P	probably damaging	Het
Fkbp10	G	A	11: 100,422,625		probably null	Het
Gabra1	G	T	11: 42,175,936	D50E	probably benign	Het
Hist1h1e	T	A	13: 23,622,257	K81*	probably null	Het
Hmgcs2	A	G	3: 98,291,090	N103S	probably damaging	Het
Htt	A	G	5: 34,895,970	H2549R	probably damaging	Het
Lrba	A	G	3: 86,776,049	E2726G	probably damaging	Het
Lrrc7	T	C	3: 158,163,965	N706D	probably damaging	Het
Mill1	G	A	7: 18,262,703		probably null	Het
Nipa2	T	C	7: 55,935,941	Y102C	probably damaging	Het
Nmd3	T	A	3: 69,724,308	C32*	probably null	Het
Olfr1251	A	G	2: 89,667,572	F105L	probably benign	Het
Olfr582	A	G	7: 103,041,970	S159G	probably benign	Het
Olfr745	A	G	14: 50,643,036	K252E	possibly damaging	Het
Olfr777	T	C	10: 129,269,065	D86G	probably damaging	Het
Pcdhb7	A	G	18: 37,343,026	D405G	possibly damaging	Het
Ptprt	A	T	2: 161,812,030	L560Q	probably damaging	Het
Serpinb9b	A	G	13: 33,035,588	Y166C	probably damaging	Het
Soga1	T	C	2: 157,020,638	N1457S	possibly damaging	Het
Sprr1a	T	G	3: 92,484,397	K99T	probably damaging	Het
Spsb4	A	G	9: 96,995,871	V133A	probably damaging	Het
Suz12	A	G	11: 80,024,942	T391A	probably benign	Het
Tor1aip2	A	G	1: 156,065,289	E447G	probably damaging	Het
Ube4a	G	A	9: 44,949,900		probably benign	Het
Wdfy4	A	C	14: 33,023,374	H2296Q	probably benign	Het

Other mutations in Cd200r3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02996:Cd200r3	APN	16	44954317	missense	probably damaging	1.00
IGL03003:Cd200r3	APN	16	44943775	start codon destroyed	probably null	0.90
IGL03003:Cd200r3	APN	16	44943776	missense	probably benign	0.01
IGL03005:Cd200r3	APN	16	44953610	missense	probably damaging	1.00
IGL03354:Cd200r3	APN	16	44953597	missense	possibly damaging	0.64
R0620:Cd200r3	UTSW	16	44957717	splice site	probably null
R1451:Cd200r3	UTSW	16	44951547	missense	possibly damaging	0.76
R1623:Cd200r3	UTSW	16	44951448	missense	possibly damaging	0.71
R2980:Cd200r3	UTSW	16	44954189	missense	probably benign	0.25
R2982:Cd200r3	UTSW	16	44954189	missense	probably benign	0.25
R4167:Cd200r3	UTSW	16	44954189	missense	probably benign	0.25
R4168:Cd200r3	UTSW	16	44954189	missense	probably benign	0.25
R4175:Cd200r3	UTSW	16	44954189	missense	probably benign	0.25
R4534:Cd200r3	UTSW	16	44954189	missense	probably benign	0.25
R4535:Cd200r3	UTSW	16	44954189	missense	probably benign	0.25
R4801:Cd200r3	UTSW	16	44957825	missense	possibly damaging	0.82
R4802:Cd200r3	UTSW	16	44957825	missense	possibly damaging	0.82
R4937:Cd200r3	UTSW	16	44954259	missense	probably benign	0.01
R5460:Cd200r3	UTSW	16	44957730	missense	possibly damaging	0.66
R6109:Cd200r3	UTSW	16	44953682	missense	probably benign	0.02
R8071:Cd200r3	UTSW	16	44954140	missense	probably damaging	1.00
R8110:Cd200r3	UTSW	16	44951472	missense	probably benign	0.41

Predicted Primers

Posted On

2017-04-14