Incidental Mutation 'R3789:Olfr663'
ID 473594
Institutional Source Beutler Lab
Gene Symbol Olfr663
Ensembl Gene ENSMUSG00000073919
Gene Name olfactory receptor 663
Synonyms GA_x6K02T2PBJ9-7331927-7332961, MOR40-12
MMRRC Submission 041604-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.398) question?
Stock # R3789 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 104703569-104704527 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 104703949 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 127 (D127E)
Ref Sequence ENSEMBL: ENSMUSP00000147953 (fasta)
AlphaFold no structure available at present
Predicted Effect noncoding transcript
Transcript: ENSMUST00000098167
Predicted Effect probably damaging
Transcript: ENSMUST00000209914
AA Change: D127E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210704
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9230104L09Rik C A 2: 148,847,958 E92* probably null Het
Abca13 T A 11: 9,510,668 I4226N probably damaging Het
Abhd16a A G 17: 35,101,587 N411S probably damaging Het
Acvrl1 C T 15: 101,137,469 T292M probably damaging Het
Adamts8 T C 9: 30,959,292 S688P probably damaging Het
Adprhl2 A T 4: 126,316,751 I312N probably damaging Het
Bclaf3 A G X: 159,566,496 H619R probably benign Het
Clca4a C A 3: 144,974,956 G20V probably damaging Het
Col12a1 C A 9: 79,639,723 V2276L possibly damaging Het
Drosha T A 15: 12,912,537 Y1080* probably null Het
Dysf G A 6: 84,186,509 probably null Het
Ebf2 T A 14: 67,239,493 probably null Het
Emc8 T C 8: 120,658,130 T195A probably benign Het
Fam60a A G 6: 148,926,119 S134P possibly damaging Het
Frs3 G A 17: 47,699,696 probably null Het
Fsip2 T C 2: 82,982,714 S640P probably damaging Het
Hdhd2 G A 18: 76,955,187 probably null Het
Hivep3 T C 4: 120,098,416 S1310P probably damaging Het
Hltf C T 3: 20,069,047 P200S probably damaging Het
Lnpk A T 2: 74,522,263 S358R probably benign Het
Lrp1 T C 10: 127,571,969 D1817G possibly damaging Het
Lrpprc T C 17: 84,771,528 I253V probably benign Het
Map2 A G 1: 66,416,863 T1512A probably damaging Het
Mcm9 G A 10: 53,616,017 R403W probably damaging Het
Mms22l A G 4: 24,517,115 D222G possibly damaging Het
Mug1 G A 6: 121,884,628 V1350I probably benign Het
Pclo A G 5: 14,680,450 probably benign Het
Plekha7 A C 7: 116,175,734 I175R probably damaging Het
Plxnb1 T A 9: 109,109,287 V1303D possibly damaging Het
Pou2f1 G C 1: 165,894,969 P349R probably damaging Het
Prmt8 A T 6: 127,711,147 I236N probably damaging Het
Rexo2 A G 9: 48,473,062 I139T probably damaging Het
Rsbn1l A C 5: 20,896,108 S811R probably benign Het
Sec24b T C 3: 130,020,627 D345G probably benign Het
Serpina1b A G 12: 103,729,272 S337P probably damaging Het
Snx33 T C 9: 56,918,560 E539G probably benign Het
Sorcs3 A G 19: 48,398,711 T212A possibly damaging Het
Spa17 T G 9: 37,611,845 K49Q possibly damaging Het
St3gal6 C T 16: 58,484,773 E109K probably benign Het
Stat4 A G 1: 52,011,796 N5D probably benign Het
Tmem232 C T 17: 65,382,525 D532N probably benign Het
Tmem232 C A 17: 65,382,633 D496Y possibly damaging Het
Tmem81 A G 1: 132,508,071 N205S probably benign Het
Tomm20l C T 12: 71,111,742 A58V possibly damaging Het
Ttn A G 2: 76,974,208 V240A probably benign Het
Vmn2r23 A T 6: 123,741,389 N567I probably damaging Het
Other mutations in Olfr663
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4884:Olfr663 UTSW 7 104703861 missense probably damaging 1.00
R5227:Olfr663 UTSW 7 104704322 missense possibly damaging 0.49
R5372:Olfr663 UTSW 7 104703795 missense probably benign 0.24
R5416:Olfr663 UTSW 7 104703716 missense probably benign 0.18
R5699:Olfr663 UTSW 7 104703993 missense probably damaging 1.00
R6207:Olfr663 UTSW 7 104703611 missense probably damaging 0.96
R6715:Olfr663 UTSW 7 104703956 missense possibly damaging 0.64
R7426:Olfr663 UTSW 7 104703589 missense probably benign 0.00
R7994:Olfr663 UTSW 7 104704428 missense probably damaging 1.00
R8405:Olfr663 UTSW 7 104704001 missense probably benign 0.02
R8746:Olfr663 UTSW 7 104703860 missense probably damaging 1.00
Z1088:Olfr663 UTSW 7 104704493 missense probably benign 0.01
Predicted Primers
Posted On 2017-04-14