Incidental Mutation 'R3817:Wdr37'
ID473912
Institutional Source Beutler Lab
Gene Symbol Wdr37
Ensembl Gene ENSMUSG00000021147
Gene NameWD repeat domain 37
Synonyms3110035P10Rik, 4933417A01Rik
MMRRC Submission 040771-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R3817 (G1)
Quality Score225
Status Not validated
Chromosome13
Chromosomal Location8802968-8871909 bp(-) (GRCm38)
Type of Mutationintron
DNA Base Change (assembly) A to G at 8853596 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000135097 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021572] [ENSMUST00000054251] [ENSMUST00000164183] [ENSMUST00000175958] [ENSMUST00000176098] [ENSMUST00000176329] [ENSMUST00000176587] [ENSMUST00000176715] [ENSMUST00000176813] [ENSMUST00000176922]
Predicted Effect probably benign
Transcript: ENSMUST00000021572
SMART Domains Protein: ENSMUSP00000021572
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
coiled coil region 63 101 N/A INTRINSIC
WD40 145 185 9.75e-3 SMART
WD40 188 227 4.27e-8 SMART
WD40 272 311 1.06e-3 SMART
WD40 314 353 4.91e-8 SMART
WD40 358 396 2.38e-6 SMART
Blast:WD40 400 438 8e-17 BLAST
WD40 445 486 6.19e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000054251
SMART Domains Protein: ENSMUSP00000062174
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
coiled coil region 63 101 N/A INTRINSIC
WD40 145 185 9.75e-3 SMART
WD40 188 227 4.27e-8 SMART
WD40 272 311 1.06e-3 SMART
WD40 314 353 4.91e-8 SMART
WD40 358 396 2.38e-6 SMART
Blast:WD40 400 438 8e-17 BLAST
WD40 445 486 6.19e-1 SMART
Predicted Effect unknown
Transcript: ENSMUST00000164183
AA Change: I157T
SMART Domains Protein: ENSMUSP00000131469
Gene: ENSMUSG00000021147
AA Change: I157T

DomainStartEndE-ValueType
coiled coil region 63 101 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175687
Predicted Effect probably benign
Transcript: ENSMUST00000175958
Predicted Effect probably benign
Transcript: ENSMUST00000176098
SMART Domains Protein: ENSMUSP00000135094
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
WD40 19 58 4.27e-8 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000176329
SMART Domains Protein: ENSMUSP00000135101
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
WD40 100 140 9.75e-3 SMART
WD40 143 182 4.27e-8 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000176429
SMART Domains Protein: ENSMUSP00000134916
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
WD40 26 66 9.75e-3 SMART
WD40 69 113 3.81e-5 SMART
WD40 118 156 2.38e-6 SMART
Blast:WD40 160 193 2e-14 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000176587
SMART Domains Protein: ENSMUSP00000135271
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
coiled coil region 62 100 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176715
Predicted Effect probably benign
Transcript: ENSMUST00000176813
SMART Domains Protein: ENSMUSP00000135097
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
coiled coil region 63 101 N/A INTRINSIC
SCOP:d1ijqa1 128 180 3e-4 SMART
Blast:WD40 145 180 5e-19 BLAST
Predicted Effect unknown
Transcript: ENSMUST00000176922
AA Change: I157T
SMART Domains Protein: ENSMUSP00000135742
Gene: ENSMUSG00000021147
AA Change: I157T

DomainStartEndE-ValueType
coiled coil region 63 101 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177112
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 100% (34/34)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Appbp2 G T 11: 85,198,108 P369T probably damaging Het
Atp1b1 C T 1: 164,443,305 R35H probably benign Het
B3galt2 G T 1: 143,647,073 G316C probably damaging Het
Chd9 T C 8: 90,984,265 probably benign Het
Clec4a4 A C 6: 122,990,407 N14T probably damaging Het
Crb1 T A 1: 139,248,097 Q716L probably benign Het
Cts7 T C 13: 61,356,536 N71S probably damaging Het
Cyb561a3 T C 19: 10,582,364 S18P possibly damaging Het
Cyp2c67 A T 19: 39,638,683 F234L probably benign Het
Cyp4a12b A T 4: 115,432,470 D178V probably damaging Het
Exph5 C T 9: 53,375,494 Q1292* probably null Het
Gjb2 A G 14: 57,100,073 V226A probably benign Het
Hivep2 T C 10: 14,143,941 V2152A possibly damaging Het
Lig3 G A 11: 82,796,115 V695M possibly damaging Het
Lrp1b T C 2: 40,876,658 E2735G probably damaging Het
Lrrtm4 A G 6: 80,022,061 E152G probably benign Het
Ly9 G T 1: 171,589,085 T537N possibly damaging Het
Nav2 A G 7: 49,464,562 T765A probably benign Het
Olfr483 A G 7: 108,103,498 Y63C possibly damaging Het
Olfr876 C T 9: 37,804,169 S86L probably benign Het
Olfr889 A T 9: 38,116,626 T277S possibly damaging Het
Olfr922 A G 9: 38,816,426 K308E possibly damaging Het
Olfr965 A G 9: 39,720,108 N294D possibly damaging Het
Pomgnt1 T A 4: 116,153,942 probably null Het
Ppp2r5c T C 12: 110,544,187 probably null Het
Rufy4 T C 1: 74,147,663 C537R probably damaging Het
Secisbp2l C T 2: 125,740,737 G933D possibly damaging Het
Skint5 A G 4: 113,629,122 probably benign Het
Slc27a1 T C 8: 71,584,478 V422A probably damaging Het
Sorl1 A G 9: 42,064,049 L487P possibly damaging Het
Tnfrsf11a C T 1: 105,809,360 T64I probably damaging Het
Tns3 G C 11: 8,434,619 R1400G probably damaging Het
Vmn2r19 A T 6: 123,309,642 Y78F probably damaging Het
Zfp672 G T 11: 58,316,636 H286Q possibly damaging Het
Other mutations in Wdr37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00231:Wdr37 APN 13 8820505 missense probably damaging 1.00
IGL00753:Wdr37 APN 13 8861174 missense probably damaging 1.00
IGL02479:Wdr37 APN 13 8842784 missense probably damaging 1.00
profound UTSW 13 8842728 critical splice donor site probably null
radical UTSW 13 8847674 unclassified probably null
R0885:Wdr37 UTSW 13 8835252 intron probably null
R1073:Wdr37 UTSW 13 8805840 missense probably damaging 0.99
R1085:Wdr37 UTSW 13 8805928 missense probably damaging 1.00
R1537:Wdr37 UTSW 13 8837003 missense probably benign 0.01
R1538:Wdr37 UTSW 13 8836792 missense probably benign
R1541:Wdr37 UTSW 13 8820538 missense probably benign 0.26
R1868:Wdr37 UTSW 13 8836851 missense probably damaging 1.00
R2240:Wdr37 UTSW 13 8861232 start gained probably benign
R3815:Wdr37 UTSW 13 8853596 intron probably benign
R3818:Wdr37 UTSW 13 8853596 intron probably benign
R3819:Wdr37 UTSW 13 8853596 intron probably benign
R4721:Wdr37 UTSW 13 8854029 missense possibly damaging 0.89
R5080:Wdr37 UTSW 13 8847674 unclassified probably null
R6297:Wdr37 UTSW 13 8842728 critical splice donor site probably null
R6761:Wdr37 UTSW 13 8849648 missense probably benign 0.07
R7505:Wdr37 UTSW 13 8819935 missense probably damaging 1.00
R7840:Wdr37 UTSW 13 8836875 missense probably damaging 0.96
R7873:Wdr37 UTSW 13 8805933 missense probably damaging 0.99
R7923:Wdr37 UTSW 13 8836875 missense probably damaging 0.96
R7956:Wdr37 UTSW 13 8805933 missense probably damaging 0.99
Predicted Primers
Posted On2017-04-14