Incidental Mutation 'R3818:Wdr37'
ID 473916
Institutional Source Beutler Lab
Gene Symbol Wdr37
Ensembl Gene ENSMUSG00000021147
Gene Name WD repeat domain 37
Synonyms 4933417A01Rik, 3110035P10Rik
MMRRC Submission 040772-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3818 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 8853004-8921945 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) A to G at 8903632 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000135097 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021572] [ENSMUST00000054251] [ENSMUST00000164183] [ENSMUST00000175958] [ENSMUST00000176098] [ENSMUST00000176922] [ENSMUST00000176813] [ENSMUST00000176329] [ENSMUST00000176587] [ENSMUST00000176715]
AlphaFold Q8CBE3
Predicted Effect probably benign
Transcript: ENSMUST00000021572
SMART Domains Protein: ENSMUSP00000021572
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
coiled coil region 63 101 N/A INTRINSIC
WD40 145 185 9.75e-3 SMART
WD40 188 227 4.27e-8 SMART
WD40 272 311 1.06e-3 SMART
WD40 314 353 4.91e-8 SMART
WD40 358 396 2.38e-6 SMART
Blast:WD40 400 438 8e-17 BLAST
WD40 445 486 6.19e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000054251
SMART Domains Protein: ENSMUSP00000062174
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
coiled coil region 63 101 N/A INTRINSIC
WD40 145 185 9.75e-3 SMART
WD40 188 227 4.27e-8 SMART
WD40 272 311 1.06e-3 SMART
WD40 314 353 4.91e-8 SMART
WD40 358 396 2.38e-6 SMART
Blast:WD40 400 438 8e-17 BLAST
WD40 445 486 6.19e-1 SMART
Predicted Effect unknown
Transcript: ENSMUST00000164183
AA Change: I157T
SMART Domains Protein: ENSMUSP00000131469
Gene: ENSMUSG00000021147
AA Change: I157T

DomainStartEndE-ValueType
coiled coil region 63 101 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175687
Predicted Effect probably benign
Transcript: ENSMUST00000175958
Predicted Effect probably benign
Transcript: ENSMUST00000176098
SMART Domains Protein: ENSMUSP00000135094
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
WD40 19 58 4.27e-8 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177112
Predicted Effect unknown
Transcript: ENSMUST00000176922
AA Change: I157T
SMART Domains Protein: ENSMUSP00000135742
Gene: ENSMUSG00000021147
AA Change: I157T

DomainStartEndE-ValueType
coiled coil region 63 101 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176813
SMART Domains Protein: ENSMUSP00000135097
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
coiled coil region 63 101 N/A INTRINSIC
SCOP:d1ijqa1 128 180 3e-4 SMART
Blast:WD40 145 180 5e-19 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000176329
SMART Domains Protein: ENSMUSP00000135101
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
WD40 100 140 9.75e-3 SMART
WD40 143 182 4.27e-8 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000176587
SMART Domains Protein: ENSMUSP00000135271
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
coiled coil region 62 100 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176429
SMART Domains Protein: ENSMUSP00000134916
Gene: ENSMUSG00000021147

DomainStartEndE-ValueType
WD40 26 66 9.75e-3 SMART
WD40 69 113 3.81e-5 SMART
WD40 118 156 2.38e-6 SMART
Blast:WD40 160 193 2e-14 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000176715
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.7%
  • 20x: 96.4%
Validation Efficiency 100% (34/34)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310011J03Rik T C 10: 80,155,351 (GRCm39) D54G probably damaging Het
Adra2b G T 2: 127,205,755 (GRCm39) E86* probably null Het
Cachd1 A T 4: 100,848,062 (GRCm39) D1059V probably damaging Het
Cd177 A G 7: 24,453,817 (GRCm39) V358A probably benign Het
Col25a1 A G 3: 130,343,720 (GRCm39) K396R possibly damaging Het
Csmd1 C T 8: 16,052,522 (GRCm39) A2201T probably damaging Het
Cyp4a12b A T 4: 115,289,667 (GRCm39) D178V probably damaging Het
Cyp4a30b G T 4: 115,316,206 (GRCm39) A311S probably damaging Het
Dse T C 10: 34,029,429 (GRCm39) I554V probably benign Het
Gabrg3 G A 7: 57,031,412 (GRCm39) Q43* probably null Het
Gjb2 A G 14: 57,337,530 (GRCm39) V226A probably benign Het
Gpr21 C A 2: 37,408,324 (GRCm39) T290N probably damaging Het
Gsdme A C 6: 50,196,391 (GRCm39) S340A probably benign Het
Hivep2 T C 10: 14,019,685 (GRCm39) V2152A possibly damaging Het
Mamdc4 C T 2: 25,455,785 (GRCm39) S840N probably benign Het
Or5p59 A G 7: 107,702,705 (GRCm39) Y63C possibly damaging Het
Or8i2 G A 2: 86,852,054 (GRCm39) T278I probably benign Het
Pah A G 10: 87,357,866 (GRCm39) probably benign Het
Pikfyve T A 1: 65,284,917 (GRCm39) S794T probably damaging Het
Plekhn1 T C 4: 156,309,990 (GRCm39) H108R probably damaging Het
Pomgnt1 T A 4: 116,011,139 (GRCm39) probably null Het
Prkd1 A T 12: 50,466,667 (GRCm39) probably benign Het
Pwp1 C T 10: 85,723,993 (GRCm39) P498L possibly damaging Het
Rasa4 A G 5: 136,131,147 (GRCm39) T414A possibly damaging Het
Rbm26 A T 14: 105,378,706 (GRCm39) L594I probably damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Skint5 A G 4: 113,486,319 (GRCm39) probably benign Het
Sorcs3 A G 19: 48,592,343 (GRCm39) N336S probably benign Het
Sspo A T 6: 48,458,037 (GRCm39) E3269V possibly damaging Het
Tlr4 A G 4: 66,759,553 (GRCm39) E782G probably benign Het
Tnfrsf11a C T 1: 105,737,085 (GRCm39) T64I probably damaging Het
Top2b T G 14: 16,409,189 (GRCm38) I777M probably damaging Het
Ttl T C 2: 128,934,914 (GRCm39) V358A probably damaging Het
Wdhd1 A G 14: 47,481,258 (GRCm39) probably null Het
Zfp939 T C 7: 39,122,792 (GRCm39) noncoding transcript Het
Other mutations in Wdr37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00231:Wdr37 APN 13 8,870,541 (GRCm39) missense probably damaging 1.00
IGL00753:Wdr37 APN 13 8,911,210 (GRCm39) missense probably damaging 1.00
IGL02479:Wdr37 APN 13 8,892,820 (GRCm39) missense probably damaging 1.00
profound UTSW 13 8,892,764 (GRCm39) critical splice donor site probably null
radical UTSW 13 8,897,710 (GRCm39) splice site probably null
R0885:Wdr37 UTSW 13 8,885,288 (GRCm39) splice site probably null
R1073:Wdr37 UTSW 13 8,855,876 (GRCm39) missense probably damaging 0.99
R1085:Wdr37 UTSW 13 8,855,964 (GRCm39) missense probably damaging 1.00
R1537:Wdr37 UTSW 13 8,887,039 (GRCm39) missense probably benign 0.01
R1538:Wdr37 UTSW 13 8,886,828 (GRCm39) missense probably benign
R1541:Wdr37 UTSW 13 8,870,574 (GRCm39) missense probably benign 0.26
R1868:Wdr37 UTSW 13 8,886,887 (GRCm39) missense probably damaging 1.00
R2240:Wdr37 UTSW 13 8,911,268 (GRCm39) start gained probably benign
R3815:Wdr37 UTSW 13 8,903,632 (GRCm39) intron probably benign
R3817:Wdr37 UTSW 13 8,903,632 (GRCm39) intron probably benign
R3819:Wdr37 UTSW 13 8,903,632 (GRCm39) intron probably benign
R4721:Wdr37 UTSW 13 8,904,065 (GRCm39) missense possibly damaging 0.89
R5080:Wdr37 UTSW 13 8,897,710 (GRCm39) splice site probably null
R6297:Wdr37 UTSW 13 8,892,764 (GRCm39) critical splice donor site probably null
R6761:Wdr37 UTSW 13 8,899,684 (GRCm39) missense probably benign 0.07
R7505:Wdr37 UTSW 13 8,869,971 (GRCm39) missense probably damaging 1.00
R7840:Wdr37 UTSW 13 8,886,911 (GRCm39) missense probably damaging 0.96
R7873:Wdr37 UTSW 13 8,855,969 (GRCm39) missense probably damaging 0.99
R8081:Wdr37 UTSW 13 8,885,406 (GRCm39) missense probably damaging 1.00
R8311:Wdr37 UTSW 13 8,903,609 (GRCm39) missense unknown
R9030:Wdr37 UTSW 13 8,885,424 (GRCm39) missense probably damaging 1.00
R9452:Wdr37 UTSW 13 8,897,663 (GRCm39) missense
R9736:Wdr37 UTSW 13 8,911,136 (GRCm39) missense probably benign 0.00
Predicted Primers
Posted On 2017-04-14