Incidental Mutation 'R0760:Igkv3-1'
ID 474013
Institutional Source Beutler Lab
Gene Symbol Igkv3-1
Ensembl Gene ENSMUSG00000095682
Gene Name immunoglobulin kappa variable 3-1
Synonyms V(kappa)21G
MMRRC Submission 038940-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.126) question?
Stock # R0760 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 70680562-70681161 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 70681119 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 106 (D106V)
Ref Sequence ENSEMBL: ENSMUSP00000100205 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103404]
AlphaFold A0A075B5P1
Predicted Effect probably damaging
Transcript: ENSMUST00000103404
AA Change: D106V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000100205
Gene: ENSMUSG00000095682
AA Change: D106V

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
IGv 38 114 3.96e-16 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 96.8%
  • 20x: 92.8%
Validation Efficiency 95% (39/41)
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013D24Rik A G 6: 124,324,661 (GRCm39) V120A possibly damaging Het
Adamts2 T C 11: 50,666,153 (GRCm39) V383A probably damaging Het
Alcam C T 16: 52,116,035 (GRCm39) V180M probably benign Het
Catip A G 1: 74,402,118 (GRCm39) probably benign Het
Ccm2l A C 2: 152,914,104 (GRCm39) N298T probably damaging Het
Ccni A G 5: 93,331,188 (GRCm39) V261A possibly damaging Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Cyb5d1 A G 11: 69,285,999 (GRCm39) F41L probably benign Het
Fbxw8 A G 5: 118,203,966 (GRCm39) probably null Het
Garin2 A G 12: 78,761,927 (GRCm39) D197G probably damaging Het
Gpaa1 T C 15: 76,216,119 (GRCm39) I33T probably benign Het
Grip1 T A 10: 119,853,983 (GRCm39) S512T probably damaging Het
Gtpbp1 G A 15: 79,603,356 (GRCm39) G140E probably damaging Het
Hspa4l T A 3: 40,739,155 (GRCm39) L681* probably null Het
Hspg2 A G 4: 137,239,660 (GRCm39) T456A probably damaging Het
Inhbc C T 10: 127,193,237 (GRCm39) G260S probably damaging Het
Itga2 C T 13: 114,996,168 (GRCm39) V708I possibly damaging Het
Kif5c T C 2: 49,578,765 (GRCm39) I131T probably damaging Het
Kmt2c A G 5: 25,558,315 (GRCm39) Y1133H possibly damaging Het
Lama2 A G 10: 26,920,429 (GRCm39) probably null Het
N4bp1 A G 8: 87,573,540 (GRCm39) Y744H probably damaging Het
Or14j7 C T 17: 38,235,005 (GRCm39) Q183* probably null Het
Or1n2 A G 2: 36,797,233 (GRCm39) S92G probably benign Het
Ovol2 A G 2: 144,173,679 (GRCm39) probably null Het
Pappa2 C A 1: 158,544,531 (GRCm39) probably null Het
Pcdh10 G A 3: 45,335,005 (GRCm39) E440K probably benign Het
Pcsk4 A G 10: 80,161,775 (GRCm39) probably benign Het
Plcl2 A G 17: 50,915,802 (GRCm39) N937S possibly damaging Het
Ppp6r1 A G 7: 4,642,722 (GRCm39) F541L probably benign Het
Rad54l2 A G 9: 106,596,805 (GRCm39) probably null Het
Ranbp2 C T 10: 58,312,613 (GRCm39) P1111L possibly damaging Het
Rasal3 A G 17: 32,611,146 (GRCm39) F929S probably benign Het
Rnf111 A G 9: 70,336,960 (GRCm39) V909A probably damaging Het
Rnf168 A G 16: 32,117,204 (GRCm39) probably null Het
Slc2a5 T C 4: 150,224,124 (GRCm39) L244P probably benign Het
Snta1 T A 2: 154,222,860 (GRCm39) I288F probably damaging Het
Sv2a G A 3: 96,095,498 (GRCm39) C297Y probably damaging Het
Trim44 C T 2: 102,230,905 (GRCm39) probably benign Het
Uggt1 A T 1: 36,200,805 (GRCm39) I1164N possibly damaging Het
Other mutations in Igkv3-1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01443:Igkv3-1 APN 6 70,681,088 (GRCm39) missense possibly damaging 0.46
IGL02536:Igkv3-1 APN 6 70,681,035 (GRCm39) missense probably benign 0.01
R4858:Igkv3-1 UTSW 6 70,681,028 (GRCm39) missense probably damaging 1.00
R7855:Igkv3-1 UTSW 6 70,681,053 (GRCm39) missense probably benign 0.23
R9394:Igkv3-1 UTSW 6 70,680,953 (GRCm39) missense probably benign
Predicted Primers
Posted On 2017-04-14