Incidental Mutation 'R3861:Scly'
Institutional Source Beutler Lab
Gene Symbol Scly
Ensembl Gene ENSMUSG00000026307
Gene Nameselenocysteine lyase
SynonymsSCL, Scly2, A930015N15Rik, Selenocysteine reductase, Scly1
MMRRC Submission 040788-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.090) question?
Stock #R3861 (G1)
Quality Score225
Status Not validated
Chromosomal Location91298338-91321075 bp(+) (GRCm38)
Type of Mutationutr 3 prime
DNA Base Change (assembly) C to T at 91302851 bp
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000137796 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027532] [ENSMUST00000137074] [ENSMUST00000142488] [ENSMUST00000145843] [ENSMUST00000147523] [ENSMUST00000154045]
Predicted Effect silent
Transcript: ENSMUST00000027532
SMART Domains Protein: ENSMUSP00000027532
Gene: ENSMUSG00000026307

Pfam:Aminotran_5 20 417 1.7e-58 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123651
Predicted Effect silent
Transcript: ENSMUST00000124832
SMART Domains Protein: ENSMUSP00000116382
Gene: ENSMUSG00000026307

Pfam:Aminotran_5 18 215 2e-25 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000137074
AA Change: H19Y
SMART Domains Protein: ENSMUSP00000122449
Gene: ENSMUSG00000026307
AA Change: H19Y

Pfam:Aminotran_5 48 216 7.4e-30 PFAM
Predicted Effect silent
Transcript: ENSMUST00000142488
SMART Domains Protein: ENSMUSP00000119979
Gene: ENSMUSG00000026307

Pfam:Aminotran_5 42 238 2.2e-32 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142802
Predicted Effect silent
Transcript: ENSMUST00000145843
SMART Domains Protein: ENSMUSP00000116824
Gene: ENSMUSG00000026307

Pfam:Aminotran_5 1 68 1.5e-15 PFAM
Predicted Effect silent
Transcript: ENSMUST00000147523
SMART Domains Protein: ENSMUSP00000114759
Gene: ENSMUSG00000026307

Pfam:Aminotran_5 22 249 2.5e-42 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153621
Predicted Effect probably benign
Transcript: ENSMUST00000154045
SMART Domains Protein: ENSMUSP00000137796
Gene: ENSMUSG00000026307

PDB:3A9Z|B 1 57 5e-30 PDB
SCOP:d1eg5a_ 20 57 3e-10 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000171768
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181737
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Selenocysteine lyase (SCLY; EC catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice fed a selenium-deficient diet exhibit mild learning impairment. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730507C01Rik G A 12: 18,533,410 S157N probably benign Het
A830018L16Rik T C 1: 11,588,554 probably benign Het
Akip1 C T 7: 109,707,406 probably benign Het
Anxa5 T C 3: 36,450,658 T252A probably benign Het
Arhgef10l A G 4: 140,515,487 F1072L possibly damaging Het
Armc1 C T 3: 19,135,032 R186Q probably damaging Het
Atxn2l A T 7: 126,501,951 probably null Het
Cadps2 A G 6: 23,355,861 I849T probably damaging Het
Ccdc28a T A 10: 18,224,995 Q28L probably damaging Het
Cdh4 T A 2: 179,874,097 V356D probably damaging Het
Chd8 T A 14: 52,237,121 Q151L probably benign Het
Chgb T A 2: 132,793,144 H335Q probably damaging Het
Col19a1 G A 1: 24,326,017 P506S probably damaging Het
Col5a2 T C 1: 45,380,237 T1228A probably damaging Het
Cpxm2 A G 7: 132,054,919 V538A probably benign Het
Cramp1l A T 17: 24,997,614 probably benign Het
Cttnbp2 T C 6: 18,423,833 R831G probably benign Het
Cyp4f17 A G 17: 32,528,104 D436G probably damaging Het
Dcaf6 A T 1: 165,429,269 N48K probably damaging Het
Ddx50 C A 10: 62,642,946 V154L possibly damaging Het
Dnah9 T C 11: 66,052,994 probably benign Het
Dnm3 T A 1: 162,311,405 I395L possibly damaging Het
Elp2 C T 18: 24,606,920 R68C probably benign Het
Frg1 A T 8: 41,407,783 probably null Het
Fsip2 G T 2: 82,984,776 D3618Y probably damaging Het
Gabra2 T C 5: 70,973,543 D314G probably damaging Het
Gm906 T C 13: 50,246,851 K480E probably benign Het
Gramd1a A C 7: 31,135,940 D407E possibly damaging Het
Grm5 T A 7: 88,129,994 S881T possibly damaging Het
Ikbkb T A 8: 22,678,836 I216F possibly damaging Het
Kif3a T C 11: 53,597,978 V634A probably benign Het
Ltbp1 A T 17: 75,359,338 Y1342F possibly damaging Het
Mia2 G T 12: 59,109,021 V508L probably benign Het
Mtus2 C T 5: 148,313,413 T155M probably damaging Het
Napepld A T 5: 21,683,289 V54E probably benign Het
Nlrc4 T C 17: 74,445,621 E589G probably benign Het
Nphp3 G T 9: 104,039,326 probably benign Het
Nr2f1 T A 13: 78,195,675 R10* probably null Het
Nsfl1c C A 2: 151,510,904 probably null Het
Olfr304 A G 7: 86,386,123 V179A possibly damaging Het
Pcdhgc3 A G 18: 37,808,528 T661A probably damaging Het
Pdzrn3 A G 6: 101,172,371 V332A possibly damaging Het
Pkhd1 C T 1: 20,200,927 C3134Y probably damaging Het
Ptprz1 T C 6: 23,036,895 V1131A probably damaging Het
Rccd1 T C 7: 80,320,368 E167G probably benign Het
Ror1 T C 4: 100,407,923 I198T possibly damaging Het
Rpl31-ps17 C T 12: 54,701,612 noncoding transcript Het
Scn4a T C 11: 106,326,124 probably benign Het
Sh3rf2 T C 18: 42,153,319 S594P probably damaging Het
Slc19a1 G A 10: 77,041,975 V115M possibly damaging Het
Slc26a6 A T 9: 108,854,196 probably benign Het
Smg7 C T 1: 152,852,598 R439K probably null Het
Syne2 A G 12: 75,966,479 R2815G probably damaging Het
Tmem55a A G 4: 14,902,506 N169S probably damaging Het
Trim75 G A 8: 64,982,827 R324C probably damaging Het
Ucp3 T C 7: 100,480,251 S98P probably benign Het
Zscan29 G C 2: 121,160,731 R859G probably benign Het
Other mutations in Scly
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02314:Scly APN 1 91319041 missense probably benign 0.00
IGL02690:Scly APN 1 91305325 missense probably benign
R0597:Scly UTSW 1 91309833 missense probably damaging 1.00
R1782:Scly UTSW 1 91308380 missense probably damaging 1.00
R1950:Scly UTSW 1 91305394 missense probably benign 0.08
R1978:Scly UTSW 1 91320169 missense probably damaging 0.98
R2290:Scly UTSW 1 91298450 critical splice donor site probably null
R4508:Scly UTSW 1 91308325 missense possibly damaging 0.95
R4876:Scly UTSW 1 91320128 missense probably damaging 0.98
R7035:Scly UTSW 1 91308403 missense probably damaging 0.98
R7701:Scly UTSW 1 91308308 missense
R7887:Scly UTSW 1 91300641 critical splice donor site probably null
R8079:Scly UTSW 1 91308367 missense probably damaging 0.99
R8501:Scly UTSW 1 91319076 missense probably damaging 1.00
X0021:Scly UTSW 1 91320106 missense probably damaging 0.98
Z1176:Scly UTSW 1 91305313 missense probably benign 0.00
Predicted Primers
Posted On2017-04-14