Incidental Mutation 'R3902:Pira1'
ID 474504
Institutional Source Beutler Lab
Gene Symbol Pira1
Ensembl Gene
Gene Name paired-Ig-like receptor A1
Synonyms Gm15922, PIR-A1, Ly89, 6M21, Gm15922, Pir
MMRRC Submission 040811-MU
Accession Numbers
Essential gene? Not available question?
Stock # R3902 (G1)
Quality Score 168
Status Not validated
Chromosome 7
Chromosomal Location 3734629-3742888 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 3740276 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 315 (T315I)
Ref Sequence ENSEMBL: ENSMUSP00000145713 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000118068]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000118068
AA Change: T315I

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atmin A G 8: 117,683,036 (GRCm39) N232S probably benign Het
Brat1 A C 5: 140,703,751 (GRCm39) D668A possibly damaging Het
Eif2b3 C T 4: 116,879,404 (GRCm39) R15W probably damaging Het
Eprs1 G A 1: 185,111,939 (GRCm39) probably null Het
F5 A G 1: 164,003,798 (GRCm39) T198A probably benign Het
Fbxl20 T A 11: 97,987,861 (GRCm39) T61S probably benign Het
Fry A G 5: 150,269,392 (GRCm39) E211G probably damaging Het
Gatd1 A G 7: 140,989,014 (GRCm39) L215P probably damaging Het
Gys2 A G 6: 142,418,526 (GRCm39) M1T probably null Het
Hacd4 A C 4: 88,355,738 (GRCm39) I49R probably damaging Het
Jph3 G T 8: 122,480,158 (GRCm39) D279Y possibly damaging Het
Klhl26 T C 8: 70,905,016 (GRCm39) D217G probably damaging Het
Kmt2e A G 5: 23,706,640 (GRCm39) N1401S probably benign Het
Mettl21a C T 1: 64,647,240 (GRCm39) V106I probably benign Het
Mpdz A G 4: 81,225,353 (GRCm39) V1427A probably damaging Het
Mug2 A T 6: 122,052,526 (GRCm39) D1024V probably damaging Het
Myl7 T A 11: 5,848,430 (GRCm39) K38M probably damaging Het
Myl7 T G 11: 5,848,431 (GRCm39) K38Q probably damaging Het
Myom2 T C 8: 15,154,165 (GRCm39) V701A probably benign Het
Nipbl A G 15: 8,379,730 (GRCm39) S1021P possibly damaging Het
Optc A G 1: 133,825,701 (GRCm39) M275T probably benign Het
Pclo A T 5: 14,762,536 (GRCm39) T385S probably benign Het
Pdgfra T A 5: 75,353,169 (GRCm39) N986K probably benign Het
Plekhn1 T A 4: 156,310,126 (GRCm39) I63F possibly damaging Het
Pogk C T 1: 166,231,193 (GRCm39) V45I probably damaging Het
Rassf1 A G 9: 107,432,039 (GRCm39) Y21C probably damaging Het
Slc12a1 A T 2: 125,030,113 (GRCm39) I562F probably damaging Het
Slc16a6 A G 11: 109,349,387 (GRCm39) S141P probably damaging Het
Sntn T C 14: 13,679,084 (GRCm38) L86P probably damaging Het
Styx-ps A G X: 67,865,253 (GRCm39) M101V probably benign Het
Taar4 T A 10: 23,836,913 (GRCm39) N174K probably damaging Het
Trav12-3 G T 14: 53,859,486 (GRCm39) C44F probably damaging Het
Triml2 A G 8: 43,643,397 (GRCm39) R240G probably benign Het
Vmn1r3 A G 4: 3,185,241 (GRCm39) M22T probably benign Het
Vmn2r7 C A 3: 64,626,937 (GRCm39) Q26H possibly damaging Het
Vmn2r72 T C 7: 85,398,943 (GRCm39) D470G possibly damaging Het
Xpo6 A G 7: 125,719,581 (GRCm39) Y602H probably damaging Het
Zfp287 T C 11: 62,603,028 (GRCm39) T241A probably benign Het
Zfp386 A G 12: 116,023,775 (GRCm39) K498E probably damaging Het
Zzef1 T C 11: 72,799,326 (GRCm39) L2392P probably damaging Het
Other mutations in Pira1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1514:Pira1 UTSW 7 3,742,639 (GRCm39) missense possibly damaging 0.82
R4246:Pira1 UTSW 7 3,740,348 (GRCm39) missense probably damaging 1.00
R5125:Pira1 UTSW 7 3,742,396 (GRCm39) nonsense probably null
R5178:Pira1 UTSW 7 3,742,396 (GRCm39) nonsense probably null
R5388:Pira1 UTSW 7 3,741,856 (GRCm39) missense possibly damaging 0.49
R5471:Pira1 UTSW 7 3,738,514 (GRCm39) missense probably benign 0.02
R5985:Pira1 UTSW 7 3,740,316 (GRCm39) missense probably damaging 1.00
R6248:Pira1 UTSW 7 3,739,337 (GRCm39) missense probably benign
R6360:Pira1 UTSW 7 3,739,503 (GRCm39) missense probably damaging 1.00
R6451:Pira1 UTSW 7 3,740,319 (GRCm39) missense probably damaging 1.00
R6453:Pira1 UTSW 7 3,740,319 (GRCm39) missense probably damaging 1.00
R6454:Pira1 UTSW 7 3,740,319 (GRCm39) missense probably damaging 1.00
R6455:Pira1 UTSW 7 3,741,930 (GRCm39) missense probably benign 0.00
R6594:Pira1 UTSW 7 3,739,498 (GRCm39) nonsense probably null
R6654:Pira1 UTSW 7 3,738,928 (GRCm39) missense probably benign 0.19
R6813:Pira1 UTSW 7 3,739,002 (GRCm39) missense probably benign 0.03
R6972:Pira1 UTSW 7 3,740,319 (GRCm39) missense probably damaging 1.00
R6975:Pira1 UTSW 7 3,740,319 (GRCm39) missense probably damaging 1.00
R7069:Pira1 UTSW 7 3,740,319 (GRCm39) missense probably damaging 1.00
R7072:Pira1 UTSW 7 3,740,319 (GRCm39) missense probably damaging 1.00
R7188:Pira1 UTSW 7 3,741,828 (GRCm39) missense probably damaging 0.99
R7304:Pira1 UTSW 7 3,740,493 (GRCm39) missense probably damaging 1.00
R7329:Pira1 UTSW 7 3,742,875 (GRCm39) start gained probably benign
R7404:Pira1 UTSW 7 3,742,344 (GRCm39) missense probably damaging 1.00
R7454:Pira1 UTSW 7 3,738,509 (GRCm39) missense probably benign 0.03
R7493:Pira1 UTSW 7 3,742,023 (GRCm39) missense not run
R7655:Pira1 UTSW 7 3,742,281 (GRCm39) missense probably damaging 0.98
R7656:Pira1 UTSW 7 3,742,281 (GRCm39) missense probably damaging 0.98
R7953:Pira1 UTSW 7 3,740,319 (GRCm39) missense probably damaging 1.00
R7956:Pira1 UTSW 7 3,740,319 (GRCm39) missense probably damaging 1.00
R7957:Pira1 UTSW 7 3,740,319 (GRCm39) missense probably damaging 1.00
R8037:Pira1 UTSW 7 3,740,319 (GRCm39) missense probably damaging 1.00
R8038:Pira1 UTSW 7 3,740,319 (GRCm39) missense probably damaging 1.00
R8043:Pira1 UTSW 7 3,740,319 (GRCm39) missense probably damaging 1.00
R8096:Pira1 UTSW 7 3,740,319 (GRCm39) missense probably damaging 1.00
R8117:Pira1 UTSW 7 3,740,075 (GRCm39) missense probably damaging 1.00
R8128:Pira1 UTSW 7 3,740,319 (GRCm39) missense probably damaging 1.00
R8134:Pira1 UTSW 7 3,738,838 (GRCm39) missense probably damaging 0.99
R8142:Pira1 UTSW 7 3,739,842 (GRCm39) missense possibly damaging 0.88
R8311:Pira1 UTSW 7 3,739,482 (GRCm39) missense probably benign 0.42
R8511:Pira1 UTSW 7 3,742,347 (GRCm39) missense probably damaging 1.00
R8519:Pira1 UTSW 7 3,740,432 (GRCm39) missense probably benign 0.27
R8927:Pira1 UTSW 7 3,742,358 (GRCm39) missense probably benign
R8928:Pira1 UTSW 7 3,742,358 (GRCm39) missense probably benign
R9306:Pira1 UTSW 7 3,740,360 (GRCm39) missense probably benign 0.00
R9330:Pira1 UTSW 7 3,742,234 (GRCm39) missense probably damaging 1.00
R9564:Pira1 UTSW 7 3,742,646 (GRCm39) missense possibly damaging 0.73
Predicted Primers PCR Primer
(F):5'- TGGAGTGTCATGTTCCCTCC -3'
(R):5'- TCTGTGATCACCTCCAAAAGAGC -3'

Sequencing Primer
(F):5'- TGTCACCACAGGGCTGG -3'
(R):5'- CATCTGGTGTCAGGGGAAC -3'
Posted On 2017-04-14