Mutagenetix > Incidental Mutation

Incidental Mutation 'R3925:Trgv7'

474855

Institutional Source

Beutler Lab

Gene Symbol

Trgv7

Ensembl Gene

ENSMUSG00000076744

Gene Name

T cell receptor gamma, variable 7

Synonyms

Tcrg-V7

MMRRC Submission

040916-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

R3925 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

19362212-19362662 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19362644 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 111 (Y111C)

Ref Sequence

ENSEMBL: ENSMUSP00000100334 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103553]

AlphaFold

A0A0A6YYE8

Predicted Effect

probably damaging
Transcript: ENSMUST00000103553
AA Change: Y111C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000100334
Gene: ENSMUSG00000076744
AA Change: Y111C

Domain	Start	End	E-Value	Type
low complexity region	2	14	N/A	INTRINSIC
IG	26	117	2.19e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000197661

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.5%
20x: 95.8%

Validation Efficiency

97% (30/31)

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	G	A	13: 81,726,891 (GRCm39)	T487I	possibly damaging	Het
Amn	T	C	12: 111,242,114 (GRCm39)	V367A	possibly damaging	Het
Becn2	T	C	1: 175,748,852 (GRCm39)	V306A	probably benign	Het
C230029F24Rik	AGAAAG	A	1: 49,350,088 (GRCm39)		noncoding transcript	Het
Cdkl1	G	T	12: 69,803,373 (GRCm39)	R168S	probably damaging	Het
Cfap43	T	C	19: 47,785,555 (GRCm39)	K445R	probably benign	Het
Crct1	C	A	3: 92,922,014 (GRCm39)		probably benign	Het
Eif4e	G	A	3: 138,261,198 (GRCm39)	G164D	probably damaging	Het
Eno1	T	C	4: 150,324,025 (GRCm39)		probably null	Het
Hmcn2	G	A	2: 31,343,169 (GRCm39)	R4565Q	probably benign	Het
Itgal	A	T	7: 126,923,709 (GRCm39)		probably benign	Het
Klhl1	A	T	14: 96,584,316 (GRCm39)	C305S	possibly damaging	Het
Ms4a2	A	G	19: 11,596,312 (GRCm39)	M139T	probably benign	Het
Nr2e3	C	T	9: 59,855,716 (GRCm39)	R213H	probably damaging	Het
Onecut2	A	G	18: 64,474,591 (GRCm39)	K381E	probably damaging	Het
Or2t43	T	A	11: 58,457,652 (GRCm39)	H173L	probably benign	Het
Or52n1	T	A	7: 104,383,396 (GRCm39)	E58D	probably benign	Het
Or5t17	A	G	2: 86,832,718 (GRCm39)	Y135C	possibly damaging	Het
Pabpc1l	T	A	2: 163,869,596 (GRCm39)		probably benign	Het
Prim2	A	G	1: 33,572,380 (GRCm39)	L253P	probably damaging	Het
Pycr1	T	C	11: 120,532,961 (GRCm39)	T100A	probably benign	Het
Qrfpr	T	C	3: 36,276,072 (GRCm39)	N106S	possibly damaging	Het
Rsf1	GCG	GCGACGGCGACG	7: 97,229,114 (GRCm39)		probably benign	Het
Selenoi	T	A	5: 30,461,086 (GRCm39)	D107E	probably damaging	Het
Synrg	C	T	11: 83,931,725 (GRCm39)	P1321S	probably benign	Het
Trp53rkb	A	G	2: 166,637,392 (GRCm39)	Y116C	probably damaging	Het
Usp34	T	A	11: 23,293,640 (GRCm39)	F245I	probably benign	Het
Utrn	C	T	10: 12,573,786 (GRCm39)	V1095I	probably benign	Het
Xpnpep1	T	C	19: 52,980,128 (GRCm39)	H632R	probably damaging	Het
Zfp735	T	C	11: 73,601,950 (GRCm39)	I298T	probably benign	Het
Zfp953	T	A	13: 67,496,002 (GRCm39)	Y13F	probably damaging	Het

Other mutations in Trgv7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01640:Trgv7	APN	13	19,362,260 (GRCm39)	splice site	probably benign
IGL02320:Trgv7	APN	13	19,362,249 (GRCm39)	missense	unknown
IGL03178:Trgv7	APN	13	19,362,211 (GRCm39)	utr 5 prime	probably benign
IGL03310:Trgv7	APN	13	19,362,664 (GRCm39)	unclassified	probably benign
R0069:Trgv7	UTSW	13	19,362,592 (GRCm39)	missense	probably benign	0.19
R5030:Trgv7	UTSW	13	19,362,558 (GRCm39)	missense	probably damaging	0.97
R5085:Trgv7	UTSW	13	19,362,598 (GRCm39)	nonsense	probably null
R9456:Trgv7	UTSW	13	19,362,385 (GRCm39)	nonsense	probably null

Predicted Primers

Posted On

2017-04-14