Mutagenetix > Incidental Mutation

Incidental Mutation 'R3978:Or5p61'

474990

Institutional Source

Beutler Lab

Gene Symbol

Or5p61

Ensembl Gene

ENSMUSG00000108995

Gene Name

olfactory receptor family 5 subfamily P member 61

Synonyms

MOR204-30P, GA_x6K02T2PBJ9-10489044-10488091, Olfr485, MOR204-40_p

MMRRC Submission

040941-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

R3978 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

107758125-107759078 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 107758819 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 87 (M87T)

Ref Sequence

ENSEMBL: ENSMUSP00000147194 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094105] [ENSMUST00000208296]

AlphaFold

A0A140LJF5

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000094105
AA Change: M83T

Predicted Effect

possibly damaging
Transcript: ENSMUST00000208296
AA Change: M87T

PolyPhen 2 Score 0.525 (Sensitivity: 0.88; Specificity: 0.90)

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.1%
20x: 94.5%

Validation Efficiency

100% (65/65)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930579F01Rik	T	C	3: 137,889,435 (GRCm39)	T61A	probably benign	Het
Adam28	A	G	14: 68,848,443 (GRCm39)	V671A	probably benign	Het
Ankhd1	A	T	18: 36,780,666 (GRCm39)	H1906L	probably damaging	Het
Ano5	G	A	7: 51,237,554 (GRCm39)	V743I	probably benign	Het
Arfgef1	A	G	1: 10,279,859 (GRCm39)	V236A	probably benign	Het
Arid2	A	G	15: 96,261,503 (GRCm39)	D453G	probably damaging	Het
Atp2b1	C	A	10: 98,832,795 (GRCm39)		probably null	Het
Azin1	A	T	15: 38,498,957 (GRCm39)	N135K	probably damaging	Het
B020004C17Rik	G	T	14: 57,254,645 (GRCm39)	M156I	possibly damaging	Het
Cfap54	T	C	10: 92,798,274 (GRCm39)	T1662A	probably benign	Het
Cog8	T	A	8: 107,779,669 (GRCm39)	I203F	probably damaging	Het
Col6a6	T	C	9: 105,576,078 (GRCm39)	H2094R	probably damaging	Het
Cybb	T	C	X: 9,310,827 (GRCm39)	Y425C	probably damaging	Het
Dab2	A	G	15: 6,464,644 (GRCm39)		probably null	Het
Dpyd	AAAT	AAATGTATATAAAT	3: 118,690,737 (GRCm39)		probably benign	Het
Dpyd	AAT	AATGTATATATAT	3: 118,690,738 (GRCm39)		probably benign	Het
Eif3i	T	C	4: 129,486,129 (GRCm39)	E276G	probably damaging	Het
Fam171a1	A	C	2: 3,226,072 (GRCm39)	M402L	probably benign	Het
Fga	A	T	3: 82,937,490 (GRCm39)		probably null	Het
Foxp2	A	G	6: 15,197,207 (GRCm39)		probably benign	Het
Gbp2	C	T	3: 142,335,747 (GRCm39)	T149I	possibly damaging	Het
Gm9631	A	G	11: 121,834,394 (GRCm39)	Y281H	possibly damaging	Het
Gpr21	C	T	2: 37,407,862 (GRCm39)	T136I	probably benign	Het
Gprc5b	C	T	7: 118,583,354 (GRCm39)	V172M	probably damaging	Het
Gprc6a	C	A	10: 51,497,197 (GRCm39)	V449L	probably benign	Het
Hdlbp	T	C	1: 93,349,073 (GRCm39)	I535V	probably damaging	Het
Helb	A	G	10: 119,925,530 (GRCm39)	V949A	probably benign	Het
Hoxc13	T	C	15: 102,829,675 (GRCm39)	V18A	possibly damaging	Het
Hr	A	G	14: 70,801,024 (GRCm39)	T699A	probably benign	Het
Il27ra	G	A	8: 84,767,313 (GRCm39)	T170I	probably benign	Het
Insm2	T	C	12: 55,647,623 (GRCm39)	Y456H	probably benign	Het
Katna1	T	C	10: 7,628,518 (GRCm39)	M249T	probably damaging	Het
Lin9	T	A	1: 180,496,357 (GRCm39)	I298N	possibly damaging	Het
Lyst	G	A	13: 13,808,753 (GRCm39)	R141Q	possibly damaging	Het
Nos3	T	A	5: 24,582,929 (GRCm39)	D685E	probably damaging	Het
Oasl1	C	T	5: 115,070,957 (GRCm39)	T274I	probably damaging	Het
Pdgfrb	A	T	18: 61,206,757 (GRCm39)	H661L	probably damaging	Het
Ppfia2	A	G	10: 106,666,490 (GRCm39)	T399A	possibly damaging	Het
Ppp1ca	T	C	19: 4,242,253 (GRCm39)	I13T	probably benign	Het
Psmd1	T	C	1: 86,055,909 (GRCm39)	M757T	probably benign	Het
Rdh19	A	T	10: 127,685,944 (GRCm39)	R19W	possibly damaging	Het
Rfx7	A	G	9: 72,522,393 (GRCm39)	T296A	possibly damaging	Het
Rgl2	G	A	17: 34,154,136 (GRCm39)	R472H	probably benign	Het
Rhcg	T	C	7: 79,267,147 (GRCm39)	E43G	probably benign	Het
Rif1	T	A	2: 52,006,759 (GRCm39)		probably null	Het
Rorb	A	G	19: 18,915,254 (GRCm39)	V468A	probably benign	Het
Rxrb	C	T	17: 34,255,300 (GRCm39)	P209L	possibly damaging	Het
Sbf2	G	T	7: 109,929,092 (GRCm39)	T1438K	probably benign	Het
Setd3	A	T	12: 108,124,201 (GRCm39)	C163S	possibly damaging	Het
Slc15a1	C	T	14: 121,727,239 (GRCm39)	D110N	probably benign	Het
Slc26a3	T	A	12: 31,515,859 (GRCm39)		probably null	Het
Slc5a5	A	G	8: 71,342,039 (GRCm39)	V305A	probably benign	Het
Slc6a6	A	T	6: 91,732,033 (GRCm39)	M621L	probably benign	Het
Smgc	A	T	15: 91,744,546 (GRCm39)	D301V	probably damaging	Het
Spata31d1c	A	G	13: 65,182,974 (GRCm39)	D172G	possibly damaging	Het
Syt15	T	A	14: 33,945,061 (GRCm39)	C203S	probably benign	Het
Tdrd1	A	G	19: 56,855,066 (GRCm39)	R1171G	probably benign	Het
Trp63	A	G	16: 25,639,490 (GRCm39)		probably benign	Het
Tspan9	A	G	6: 127,944,210 (GRCm39)	V30A	probably damaging	Het
Ubp1	A	T	9: 113,785,773 (GRCm39)		probably null	Het
Vmn2r68	T	A	7: 84,881,670 (GRCm39)	Y470F	probably benign	Het
Wbp1l	T	A	19: 46,642,396 (GRCm39)		probably null	Het
Wee1	G	T	7: 109,723,762 (GRCm39)	D226Y	probably damaging	Het
Yap1	C	T	9: 8,004,285 (GRCm39)	G36D	probably damaging	Het
Zmym6	T	C	4: 127,017,348 (GRCm39)	I951T	possibly damaging	Het

Other mutations in Or5p61

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R3115:Or5p61	UTSW	7	107,759,029 (GRCm39)	missense	probably benign	0.00
R3116:Or5p61	UTSW	7	107,759,029 (GRCm39)	missense	probably benign	0.00
R4722:Or5p61	UTSW	7	107,758,445 (GRCm39)	missense	probably benign	0.04
R5337:Or5p61	UTSW	7	107,758,480 (GRCm39)	missense	probably benign	0.01
R5553:Or5p61	UTSW	7	107,758,478 (GRCm39)	missense	probably benign	0.02
R6258:Or5p61	UTSW	7	107,758,181 (GRCm39)	missense	probably damaging	1.00
R6386:Or5p61	UTSW	7	107,758,409 (GRCm39)	missense	probably damaging	1.00
R6498:Or5p61	UTSW	7	107,758,639 (GRCm39)	missense	probably benign	0.20
R7096:Or5p61	UTSW	7	107,758,848 (GRCm39)	missense	probably benign
R7134:Or5p61	UTSW	7	107,758,883 (GRCm39)	missense	probably damaging	1.00
R7187:Or5p61	UTSW	7	107,758,585 (GRCm39)	missense	probably benign	0.00
R7226:Or5p61	UTSW	7	107,758,164 (GRCm39)	missense	probably benign	0.00
R7799:Or5p61	UTSW	7	107,758,637 (GRCm39)	missense	probably benign	0.00
R8371:Or5p61	UTSW	7	107,758,435 (GRCm39)	missense	probably benign
R8704:Or5p61	UTSW	7	107,758,711 (GRCm39)	missense	possibly damaging	0.66
R8814:Or5p61	UTSW	7	107,758,272 (GRCm39)	missense	probably benign	0.03
R9451:Or5p61	UTSW	7	107,758,468 (GRCm39)	missense	probably benign	0.06
R9536:Or5p61	UTSW	7	107,759,075 (GRCm39)	missense	probably benign	0.03

Predicted Primers

Posted On

2017-04-14