Incidental Mutation 'R3975:Vmn2r70'
| ID |
475183 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r70
|
| Ensembl Gene |
ENSMUSG00000090806 |
| Gene Name |
vomeronasal 2, receptor 70 |
| Synonyms |
EG620835 |
| MMRRC Submission |
040939-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.112)
|
| Stock # |
R3975 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
85558703-85569088 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 85559332 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 646
(V646I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129703
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168230]
|
| AlphaFold |
K7N702 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168230
AA Change: V646I
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000129703
Gene: ENSMUSG00000090806
AA Change: V646I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
468 |
2.5e-28 |
PFAM |
|
Pfam:NCD3G
|
510 |
562 |
1.5e-19 |
PFAM |
|
Pfam:7tm_3
|
592 |
830 |
1.2e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 93.6%
|
| Validation Efficiency |
95% (59/62) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 59 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam23 |
T |
A |
1: 63,547,729 (GRCm38) |
Y416* |
probably null |
Het |
| Akr1b10 |
G |
T |
6: 34,392,496 (GRCm38) |
|
probably null |
Het |
| Arap2 |
G |
T |
5: 62,748,894 (GRCm38) |
P261T |
possibly damaging |
Het |
| Bckdha |
C |
A |
7: 25,631,433 (GRCm38) |
D53Y |
probably damaging |
Het |
| Bfsp2 |
A |
G |
9: 103,480,072 (GRCm38) |
V52A |
probably benign |
Het |
| Bola3 |
T |
C |
6: 83,351,267 (GRCm38) |
L45P |
probably benign |
Het |
| Cacna2d4 |
A |
G |
6: 119,278,173 (GRCm38) |
|
probably null |
Het |
| Ceacam16 |
C |
A |
7: 19,853,612 (GRCm38) |
Q410H |
probably damaging |
Het |
| Cenpe |
A |
G |
3: 135,235,225 (GRCm38) |
|
probably null |
Het |
| Cenpe |
T |
C |
3: 135,238,472 (GRCm38) |
|
probably null |
Het |
| Clca1 |
A |
T |
3: 145,032,639 (GRCm38) |
V36D |
probably damaging |
Het |
| Copa |
T |
A |
1: 172,121,245 (GRCm38) |
S1155T |
probably benign |
Het |
| Crb2 |
C |
A |
2: 37,793,668 (GRCm38) |
P1061T |
possibly damaging |
Het |
| Crot |
T |
C |
5: 8,977,541 (GRCm38) |
T264A |
probably benign |
Het |
| Cyp51 |
C |
T |
5: 4,091,877 (GRCm38) |
G346S |
probably damaging |
Het |
| Dnah6 |
A |
G |
6: 73,121,992 (GRCm38) |
S2027P |
possibly damaging |
Het |
| Fam129a |
T |
C |
1: 151,649,335 (GRCm38) |
Y164H |
probably damaging |
Het |
| Fbxo18 |
T |
C |
2: 11,767,210 (GRCm38) |
H220R |
possibly damaging |
Het |
| Gdf2 |
T |
A |
14: 33,944,834 (GRCm38) |
V171D |
probably damaging |
Het |
| Gm9825 |
A |
T |
6: 7,983,149 (GRCm38) |
|
noncoding transcript |
Het |
| Golgb1 |
T |
G |
16: 36,918,571 (GRCm38) |
V2424G |
probably damaging |
Het |
| Gpbp1l1 |
T |
C |
4: 116,570,985 (GRCm38) |
|
probably null |
Het |
| Gpx6 |
C |
A |
13: 21,317,658 (GRCm38) |
S150Y |
probably damaging |
Het |
| Greb1l |
A |
G |
18: 10,522,247 (GRCm38) |
N672S |
possibly damaging |
Het |
| Kcnma1 |
C |
T |
14: 24,003,747 (GRCm38) |
|
probably null |
Het |
| Lrba |
T |
C |
3: 86,351,255 (GRCm38) |
F1350L |
probably damaging |
Het |
| Nat8f4 |
A |
G |
6: 85,901,070 (GRCm38) |
V157A |
possibly damaging |
Het |
| Nt5dc2 |
T |
C |
14: 31,138,875 (GRCm38) |
S439P |
probably damaging |
Het |
| Olfr1090 |
T |
A |
2: 86,754,543 (GRCm38) |
H65L |
probably damaging |
Het |
| Olfr134 |
A |
G |
17: 38,175,495 (GRCm38) |
N137S |
probably benign |
Het |
| Olfr141 |
G |
A |
2: 86,806,460 (GRCm38) |
P180S |
possibly damaging |
Het |
| Olfr693 |
T |
C |
7: 106,677,785 (GRCm38) |
R234G |
probably damaging |
Het |
| Orm3 |
A |
T |
4: 63,356,158 (GRCm38) |
|
probably null |
Het |
| Otof |
A |
G |
5: 30,370,712 (GRCm38) |
L1929P |
probably damaging |
Het |
| Pex5l |
C |
A |
3: 33,015,015 (GRCm38) |
C111F |
probably damaging |
Het |
| Plcl1 |
T |
A |
1: 55,698,215 (GRCm38) |
M905K |
probably benign |
Het |
| Prdm6 |
T |
C |
18: 53,540,206 (GRCm38) |
I186T |
possibly damaging |
Het |
| Rara |
T |
G |
11: 98,970,569 (GRCm38) |
I236S |
probably damaging |
Het |
| Reln |
A |
T |
5: 21,995,366 (GRCm38) |
S1379T |
possibly damaging |
Het |
| Rp1l1 |
T |
A |
14: 64,030,309 (GRCm38) |
Y1115N |
probably damaging |
Het |
| Rpe65 |
A |
T |
3: 159,604,585 (GRCm38) |
N135I |
probably damaging |
Het |
| Rps6 |
A |
G |
4: 86,856,813 (GRCm38) |
V18A |
probably benign |
Het |
| Scrn3 |
T |
C |
2: 73,335,777 (GRCm38) |
S385P |
possibly damaging |
Het |
| Sis |
T |
C |
3: 72,943,635 (GRCm38) |
T577A |
probably damaging |
Het |
| Slx1b |
G |
A |
7: 126,691,807 (GRCm38) |
L239F |
probably damaging |
Het |
| Smad4 |
G |
T |
18: 73,677,736 (GRCm38) |
T59K |
possibly damaging |
Het |
| Smad6 |
A |
G |
9: 64,020,930 (GRCm38) |
V32A |
probably benign |
Het |
| Smc6 |
T |
A |
12: 11,274,074 (GRCm38) |
F73L |
probably damaging |
Het |
| Sorbs2 |
T |
C |
8: 45,772,710 (GRCm38) |
|
probably null |
Het |
| Svbp |
T |
A |
4: 119,195,893 (GRCm38) |
F32I |
probably benign |
Het |
| Tap1 |
C |
A |
17: 34,189,567 (GRCm38) |
|
probably benign |
Het |
| Tesk1 |
C |
T |
4: 43,445,786 (GRCm38) |
P280S |
possibly damaging |
Het |
| Thrb |
A |
G |
14: 18,033,456 (GRCm38) |
I406M |
probably damaging |
Het |
| Tsc22d1 |
T |
C |
14: 76,418,609 (GRCm38) |
S761P |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,876,653 (GRCm38) |
|
probably benign |
Het |
| Umodl1 |
C |
A |
17: 30,984,789 (GRCm38) |
Y525* |
probably null |
Het |
| Wipf1 |
C |
T |
2: 73,437,169 (GRCm38) |
G295D |
probably benign |
Het |
| Wisp3 |
C |
G |
10: 39,155,098 (GRCm38) |
C143S |
probably damaging |
Het |
| Zim1 |
A |
T |
7: 6,677,130 (GRCm38) |
H511Q |
probably damaging |
Het |
|
| Other mutations in Vmn2r70 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00978:Vmn2r70
|
APN |
7 |
85,563,799 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01140:Vmn2r70
|
APN |
7 |
85,565,171 (GRCm38) |
nonsense |
probably null |
|
|
IGL01287:Vmn2r70
|
APN |
7 |
85,569,019 (GRCm38) |
nonsense |
probably null |
|
|
IGL01581:Vmn2r70
|
APN |
7 |
85,563,914 (GRCm38) |
splice site |
probably null |
|
|
IGL01632:Vmn2r70
|
APN |
7 |
85,566,072 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01725:Vmn2r70
|
APN |
7 |
85,559,386 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02244:Vmn2r70
|
APN |
7 |
85,565,003 (GRCm38) |
missense |
probably benign |
|
|
IGL02288:Vmn2r70
|
APN |
7 |
85,565,134 (GRCm38) |
missense |
probably benign |
0.31 |
|
IGL02313:Vmn2r70
|
APN |
7 |
85,565,168 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02591:Vmn2r70
|
APN |
7 |
85,564,945 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL02725:Vmn2r70
|
APN |
7 |
85,565,345 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
IGL02797:Vmn2r70
|
APN |
7 |
85,559,087 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0045:Vmn2r70
|
UTSW |
7 |
85,566,044 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0729:Vmn2r70
|
UTSW |
7 |
85,565,904 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0967:Vmn2r70
|
UTSW |
7 |
85,559,619 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1217:Vmn2r70
|
UTSW |
7 |
85,559,061 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1351:Vmn2r70
|
UTSW |
7 |
85,565,054 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1387:Vmn2r70
|
UTSW |
7 |
85,558,761 (GRCm38) |
missense |
probably benign |
0.12 |
|
R1483:Vmn2r70
|
UTSW |
7 |
85,559,167 (GRCm38) |
missense |
probably benign |
0.04 |
|
R1796:Vmn2r70
|
UTSW |
7 |
85,563,803 (GRCm38) |
nonsense |
probably null |
|
|
R1809:Vmn2r70
|
UTSW |
7 |
85,565,922 (GRCm38) |
missense |
probably benign |
0.23 |
|
R2154:Vmn2r70
|
UTSW |
7 |
85,563,715 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R2173:Vmn2r70
|
UTSW |
7 |
85,565,082 (GRCm38) |
missense |
probably benign |
|
|
R2334:Vmn2r70
|
UTSW |
7 |
85,559,592 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2871:Vmn2r70
|
UTSW |
7 |
85,559,019 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2871:Vmn2r70
|
UTSW |
7 |
85,559,019 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4525:Vmn2r70
|
UTSW |
7 |
85,559,579 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4527:Vmn2r70
|
UTSW |
7 |
85,559,579 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4535:Vmn2r70
|
UTSW |
7 |
85,565,333 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5181:Vmn2r70
|
UTSW |
7 |
85,559,179 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5600:Vmn2r70
|
UTSW |
7 |
85,563,727 (GRCm38) |
missense |
probably benign |
0.07 |
|
R5641:Vmn2r70
|
UTSW |
7 |
85,559,364 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5726:Vmn2r70
|
UTSW |
7 |
85,559,107 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5943:Vmn2r70
|
UTSW |
7 |
85,565,991 (GRCm38) |
missense |
probably benign |
0.09 |
|
R6166:Vmn2r70
|
UTSW |
7 |
85,565,981 (GRCm38) |
missense |
probably benign |
0.25 |
|
R6272:Vmn2r70
|
UTSW |
7 |
85,558,986 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6324:Vmn2r70
|
UTSW |
7 |
85,558,879 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6429:Vmn2r70
|
UTSW |
7 |
85,559,068 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6449:Vmn2r70
|
UTSW |
7 |
85,564,949 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6512:Vmn2r70
|
UTSW |
7 |
85,566,097 (GRCm38) |
missense |
probably benign |
|
|
R7000:Vmn2r70
|
UTSW |
7 |
85,559,611 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7141:Vmn2r70
|
UTSW |
7 |
85,558,836 (GRCm38) |
missense |
probably benign |
|
|
R7153:Vmn2r70
|
UTSW |
7 |
85,565,054 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7424:Vmn2r70
|
UTSW |
7 |
85,563,868 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7565:Vmn2r70
|
UTSW |
7 |
85,565,291 (GRCm38) |
missense |
probably benign |
0.35 |
|
R7567:Vmn2r70
|
UTSW |
7 |
85,565,035 (GRCm38) |
missense |
probably benign |
0.41 |
|
R7593:Vmn2r70
|
UTSW |
7 |
85,566,104 (GRCm38) |
nonsense |
probably null |
|
|
R7660:Vmn2r70
|
UTSW |
7 |
85,568,922 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7806:Vmn2r70
|
UTSW |
7 |
85,559,193 (GRCm38) |
missense |
probably benign |
|
|
R7892:Vmn2r70
|
UTSW |
7 |
85,559,380 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R7965:Vmn2r70
|
UTSW |
7 |
85,561,863 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8052:Vmn2r70
|
UTSW |
7 |
85,563,715 (GRCm38) |
missense |
probably benign |
|
|
R8251:Vmn2r70
|
UTSW |
7 |
85,565,978 (GRCm38) |
nonsense |
probably null |
|
|
R8814:Vmn2r70
|
UTSW |
7 |
85,565,961 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8934:Vmn2r70
|
UTSW |
7 |
85,561,980 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R9225:Vmn2r70
|
UTSW |
7 |
85,559,034 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9322:Vmn2r70
|
UTSW |
7 |
85,559,290 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R9430:Vmn2r70
|
UTSW |
7 |
85,566,032 (GRCm38) |
missense |
probably benign |
0.10 |
|
R9477:Vmn2r70
|
UTSW |
7 |
85,569,036 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
Z1088:Vmn2r70
|
UTSW |
7 |
85,564,760 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
Z1176:Vmn2r70
|
UTSW |
7 |
85,569,045 (GRCm38) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
|
| Posted On |
2017-04-14 |
Incidental Mutation