Mutagenetix > Incidental Mutation

Incidental Mutation 'R3882:Miip'

475218

Institutional Source

Beutler Lab

Gene Symbol

Miip

Ensembl Gene

ENSMUSG00000029022

Gene Name

migration and invasion inhibitory protein

Synonyms

D4Wsu114e

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

R3882 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

147860778-147868816 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 147861052 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Alanine at position 376 (S376A)

Ref Sequence

ENSEMBL: ENSMUSP00000134085 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030886] [ENSMUST00000119975] [ENSMUST00000172710]

AlphaFold

A2A7Y5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000030886
AA Change: S376A

PolyPhen 2 Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000030886
Gene: ENSMUSG00000029022
AA Change: S376A

Domain	Start	End	E-Value	Type
low complexity region	13	24	N/A	INTRINSIC
low complexity region	60	69	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000119975

SMART Domains

Protein: ENSMUSP00000113897
Gene: ENSMUSG00000029022

Domain	Start	End	E-Value	Type
low complexity region	13	24	N/A	INTRINSIC
Pfam:MIIP	41	382	1.4e-142	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141166

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141534

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000156374

Predicted Effect

possibly damaging
Transcript: ENSMUST00000172710
AA Change: S376A

PolyPhen 2 Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000134085
Gene: ENSMUSG00000029022
AA Change: S376A

Domain	Start	End	E-Value	Type
low complexity region	13	24	N/A	INTRINSIC
low complexity region	60	69	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173034

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.2%

Validation Efficiency

97% (33/34)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610507B11Rik	T	A	11: 78,262,700	W24R	probably damaging	Het
Acy1	G	T	9: 106,435,509	T181K	possibly damaging	Het
Adcy4	A	G	14: 55,774,546	F581L	probably benign	Het
Amhr2	G	A	15: 102,445,898	G48D	probably damaging	Het
Angptl4	G	A	17: 33,777,034	P323S	possibly damaging	Het
Arhgef17	A	G	7: 100,876,454	F1979S	possibly damaging	Het
C2	T	C	17: 34,873,489	T191A	probably benign	Het
Cmya5	T	A	13: 93,091,219	T2454S	probably benign	Het
Dstn	A	G	2: 143,942,187	E150G	probably benign	Het
Dync1h1	G	T	12: 110,629,058	V1444F	probably benign	Het
Eif3f	T	C	7: 108,940,955	V319A	possibly damaging	Het
Gpha2	T	C	19: 6,226,889		probably null	Het
Hps5	A	G	7: 46,771,996	V648A	possibly damaging	Het
Jup	A	G	11: 100,378,381	V402A	probably benign	Het
Kif18a	A	G	2: 109,306,974	N517S	probably benign	Het
Kif20b	T	A	19: 34,950,080	I874N	probably damaging	Het
Lepr	T	A	4: 101,815,265	V1162E	probably damaging	Het
Man2a2	A	T	7: 80,362,315	V698D	possibly damaging	Het
Nsun7	G	A	5: 66,278,640	R285Q	probably damaging	Het
Nup210l	T	C	3: 90,124,210	V281A	probably benign	Het
Paxip1	C	T	5: 27,748,839	R953Q	probably damaging	Het
Pcdha8	C	A	18: 36,993,046	L194I	probably damaging	Het
Pcdha8	A	G	18: 36,993,571	I369V	probably benign	Het
Pcdhga10	C	A	18: 37,747,441	A85E	possibly damaging	Het
Ppfibp1	A	G	6: 146,998,221	R137G	possibly damaging	Het
Rcor1	C	T	12: 111,103,753	A230V	probably damaging	Het
Scn3a	T	C	2: 65,482,279	M1191V	probably benign	Het
Skor2	A	G	18: 76,862,689	D904G	probably damaging	Het
Suco	A	T	1: 161,834,744	V706E	probably benign	Het
Tex11	C	A	X: 100,933,415	A487S	possibly damaging	Het
Vmn1r83	A	T	7: 12,321,402	C243S	probably damaging	Het
Wdr17	A	T	8: 54,639,501	C1083S	possibly damaging	Het
Zfp952	G	T	17: 33,001,975	E18*	probably null	Het
Zfr	G	A	15: 12,162,233	R823H	probably benign	Het
Zscan25	G	T	5: 145,291,052	G509C	probably damaging	Het

Other mutations in Miip

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00531:Miip	APN	4	147865865	missense	probably damaging	1.00
IGL02134:Miip	APN	4	147865278	splice site	probably benign
IGL02829:Miip	APN	4	147863061	missense	probably benign	0.01
IGL03350:Miip	APN	4	147862522	missense	probably benign	0.01
R0200:Miip	UTSW	4	147862263	missense	probably damaging	0.99
R1647:Miip	UTSW	4	147865234	missense	probably benign	0.02
R1783:Miip	UTSW	4	147865774	missense	probably damaging	1.00
R1848:Miip	UTSW	4	147863092	missense	probably damaging	0.99
R1944:Miip	UTSW	4	147865965	missense	probably benign	0.15
R3615:Miip	UTSW	4	147865914	missense	probably benign	0.00
R3616:Miip	UTSW	4	147865914	missense	probably benign	0.00
R4579:Miip	UTSW	4	147861061	missense	probably damaging	1.00
R5183:Miip	UTSW	4	147863069	missense	probably damaging	1.00
R6054:Miip	UTSW	4	147865678	missense	probably benign	0.00
R6056:Miip	UTSW	4	147862335	missense	probably damaging	1.00
R6304:Miip	UTSW	4	147863083	missense	probably benign	0.12
R6568:Miip	UTSW	4	147865915	missense	probably benign
R6603:Miip	UTSW	4	147865923	missense	possibly damaging	0.92
R7639:Miip	UTSW	4	147862564	missense	probably benign	0.22
R7701:Miip	UTSW	4	147862914	missense	probably null	0.86
R7795:Miip	UTSW	4	147862918	missense	probably benign	0.17
R7796:Miip	UTSW	4	147862918	missense	probably benign	0.17
R7797:Miip	UTSW	4	147862918	missense	probably benign	0.17
R7872:Miip	UTSW	4	147862918	missense	probably benign	0.17
R7920:Miip	UTSW	4	147862918	missense	probably benign	0.17
R8468:Miip	UTSW	4	147861471	missense	probably damaging	1.00
R8492:Miip	UTSW	4	147861424	missense	probably damaging	1.00
R8677:Miip	UTSW	4	147863046	missense	probably damaging	1.00
R8852:Miip	UTSW	4	147866382	start gained	probably benign
R8860:Miip	UTSW	4	147866382	start gained	probably benign
R9755:Miip	UTSW	4	147865862	nonsense	probably null

Predicted Primers

Posted On

2017-04-14