Incidental Mutation 'R3882:Miip'
ID 475218
Institutional Source Beutler Lab
Gene Symbol Miip
Ensembl Gene ENSMUSG00000029022
Gene Name migration and invasion inhibitory protein
Synonyms D4Wsu114e
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R3882 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 147945235-147953176 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 147945509 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 376 (S376A)
Ref Sequence ENSEMBL: ENSMUSP00000134085 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030886] [ENSMUST00000119975] [ENSMUST00000172710]
AlphaFold A2A7Y5
Predicted Effect possibly damaging
Transcript: ENSMUST00000030886
AA Change: S376A

PolyPhen 2 Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000030886
Gene: ENSMUSG00000029022
AA Change: S376A

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
low complexity region 60 69 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000119975
SMART Domains Protein: ENSMUSP00000113897
Gene: ENSMUSG00000029022

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
Pfam:MIIP 41 382 1.4e-142 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141166
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141534
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156374
Predicted Effect possibly damaging
Transcript: ENSMUST00000172710
AA Change: S376A

PolyPhen 2 Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000134085
Gene: ENSMUSG00000029022
AA Change: S376A

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
low complexity region 60 69 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173034
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 97% (33/34)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acy1 G T 9: 106,312,708 (GRCm39) T181K possibly damaging Het
Adcy4 A G 14: 56,012,003 (GRCm39) F581L probably benign Het
Amhr2 G A 15: 102,354,333 (GRCm39) G48D probably damaging Het
Angptl4 G A 17: 33,996,008 (GRCm39) P323S possibly damaging Het
Arhgef17 A G 7: 100,525,661 (GRCm39) F1979S possibly damaging Het
Bltp2 T A 11: 78,153,526 (GRCm39) W24R probably damaging Het
C2 T C 17: 35,092,465 (GRCm39) T191A probably benign Het
Cmya5 T A 13: 93,227,727 (GRCm39) T2454S probably benign Het
Dstn A G 2: 143,784,107 (GRCm39) E150G probably benign Het
Dync1h1 G T 12: 110,595,492 (GRCm39) V1444F probably benign Het
Eif3f T C 7: 108,540,162 (GRCm39) V319A possibly damaging Het
Gpha2 T C 19: 6,276,919 (GRCm39) probably null Het
Hps5 A G 7: 46,421,420 (GRCm39) V648A possibly damaging Het
Jup A G 11: 100,269,207 (GRCm39) V402A probably benign Het
Kif18a A G 2: 109,137,319 (GRCm39) N517S probably benign Het
Kif20b T A 19: 34,927,480 (GRCm39) I874N probably damaging Het
Lepr T A 4: 101,672,462 (GRCm39) V1162E probably damaging Het
Man2a2 A T 7: 80,012,063 (GRCm39) V698D possibly damaging Het
Nsun7 G A 5: 66,435,983 (GRCm39) R285Q probably damaging Het
Nup210l T C 3: 90,031,517 (GRCm39) V281A probably benign Het
Paxip1 C T 5: 27,953,837 (GRCm39) R953Q probably damaging Het
Pcdha8 C A 18: 37,126,099 (GRCm39) L194I probably damaging Het
Pcdha8 A G 18: 37,126,624 (GRCm39) I369V probably benign Het
Pcdhga10 C A 18: 37,880,494 (GRCm39) A85E possibly damaging Het
Ppfibp1 A G 6: 146,899,719 (GRCm39) R137G possibly damaging Het
Rcor1 C T 12: 111,070,187 (GRCm39) A230V probably damaging Het
Scn3a T C 2: 65,312,623 (GRCm39) M1191V probably benign Het
Skor2 A G 18: 76,950,384 (GRCm39) D904G probably damaging Het
Suco A T 1: 161,662,313 (GRCm39) V706E probably benign Het
Tex11 C A X: 99,977,021 (GRCm39) A487S possibly damaging Het
Vmn1r83 A T 7: 12,055,329 (GRCm39) C243S probably damaging Het
Wdr17 A T 8: 55,092,536 (GRCm39) C1083S possibly damaging Het
Zfp952 G T 17: 33,220,949 (GRCm39) E18* probably null Het
Zfr G A 15: 12,162,319 (GRCm39) R823H probably benign Het
Zscan25 G T 5: 145,227,862 (GRCm39) G509C probably damaging Het
Other mutations in Miip
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00531:Miip APN 4 147,950,322 (GRCm39) missense probably damaging 1.00
IGL02134:Miip APN 4 147,949,735 (GRCm39) splice site probably benign
IGL02829:Miip APN 4 147,947,518 (GRCm39) missense probably benign 0.01
IGL03350:Miip APN 4 147,946,979 (GRCm39) missense probably benign 0.01
R0200:Miip UTSW 4 147,946,720 (GRCm39) missense probably damaging 0.99
R1647:Miip UTSW 4 147,949,691 (GRCm39) missense probably benign 0.02
R1783:Miip UTSW 4 147,950,231 (GRCm39) missense probably damaging 1.00
R1848:Miip UTSW 4 147,947,549 (GRCm39) missense probably damaging 0.99
R1944:Miip UTSW 4 147,950,422 (GRCm39) missense probably benign 0.15
R3615:Miip UTSW 4 147,950,371 (GRCm39) missense probably benign 0.00
R3616:Miip UTSW 4 147,950,371 (GRCm39) missense probably benign 0.00
R4579:Miip UTSW 4 147,945,518 (GRCm39) missense probably damaging 1.00
R5183:Miip UTSW 4 147,947,526 (GRCm39) missense probably damaging 1.00
R6054:Miip UTSW 4 147,950,135 (GRCm39) missense probably benign 0.00
R6056:Miip UTSW 4 147,946,792 (GRCm39) missense probably damaging 1.00
R6304:Miip UTSW 4 147,947,540 (GRCm39) missense probably benign 0.12
R6568:Miip UTSW 4 147,950,372 (GRCm39) missense probably benign
R6603:Miip UTSW 4 147,950,380 (GRCm39) missense possibly damaging 0.92
R7639:Miip UTSW 4 147,947,021 (GRCm39) missense probably benign 0.22
R7701:Miip UTSW 4 147,947,371 (GRCm39) missense probably null 0.86
R7795:Miip UTSW 4 147,947,375 (GRCm39) missense probably benign 0.17
R7796:Miip UTSW 4 147,947,375 (GRCm39) missense probably benign 0.17
R7797:Miip UTSW 4 147,947,375 (GRCm39) missense probably benign 0.17
R7872:Miip UTSW 4 147,947,375 (GRCm39) missense probably benign 0.17
R7920:Miip UTSW 4 147,947,375 (GRCm39) missense probably benign 0.17
R8468:Miip UTSW 4 147,945,928 (GRCm39) missense probably damaging 1.00
R8492:Miip UTSW 4 147,945,881 (GRCm39) missense probably damaging 1.00
R8677:Miip UTSW 4 147,947,503 (GRCm39) missense probably damaging 1.00
R8852:Miip UTSW 4 147,950,839 (GRCm39) start gained probably benign
R8860:Miip UTSW 4 147,950,839 (GRCm39) start gained probably benign
R9755:Miip UTSW 4 147,950,319 (GRCm39) nonsense probably null
Predicted Primers
Posted On 2017-04-14