Incidental Mutation 'R3942:Trav6-5'
ID 475235
Institutional Source Beutler Lab
Gene Symbol Trav6-5
Ensembl Gene ENSMUSG00000096149
Gene Name T cell receptor alpha variable 6-5
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.181) question?
Stock # R3942 (G1)
Quality Score 159
Status Not validated
Chromosome 14
Chromosomal Location 53728609-53729079 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 53728838 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 32 (S32P)
Ref Sequence ENSEMBL: ENSMUSP00000139176 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103581] [ENSMUST00000181210] [ENSMUST00000183488]
AlphaFold A0A075B6D4
Predicted Effect probably benign
Transcript: ENSMUST00000103581
SMART Domains Protein: ENSMUSP00000100358
Gene: ENSMUSG00000096900

DomainStartEndE-ValueType
IGv 36 111 1.61e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000181210
AA Change: S33P

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000137814
Gene: ENSMUSG00000096149
AA Change: S33P

DomainStartEndE-ValueType
IG 27 112 4.04e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000183488
AA Change: S32P

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000139176
Gene: ENSMUSG00000096149
AA Change: S32P

DomainStartEndE-ValueType
IG 26 111 4.04e0 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 T C 13: 81,330,908 (GRCm39) N6049S probably damaging Het
Aph1a C T 3: 95,801,573 (GRCm39) R31W probably damaging Het
Atp10b T C 11: 43,063,581 (GRCm39) V172A probably damaging Het
Atp13a2 T C 4: 140,733,733 (GRCm39) S1041P probably damaging Het
Best3 T A 10: 116,824,579 (GRCm39) F15Y possibly damaging Het
Brinp3 C A 1: 146,627,599 (GRCm39) D277E probably damaging Het
Crb1 A C 1: 139,265,211 (GRCm39) L69R possibly damaging Het
Crcp T C 5: 130,063,791 (GRCm39) probably null Het
Dysf G A 6: 84,163,491 (GRCm39) probably null Het
Hps3 T C 3: 20,051,103 (GRCm39) Y859C probably damaging Het
Irx5 C A 8: 93,086,314 (GRCm39) N132K probably damaging Het
Itgb2 A G 10: 77,393,867 (GRCm39) T436A probably benign Het
Kit A G 5: 75,769,978 (GRCm39) D130G probably benign Het
Krt12 A G 11: 99,312,922 (GRCm39) S41P unknown Het
Lypd6b G T 2: 49,833,552 (GRCm39) S64I probably damaging Het
Mpc1 T A 17: 8,507,420 (GRCm39) probably null Het
Or4c109 T A 2: 88,818,455 (GRCm39) L30F probably benign Het
Or5b95 A T 19: 12,657,768 (GRCm39) M99L probably benign Het
Pard3b T A 1: 62,198,611 (GRCm39) I233N probably damaging Het
Pcdh1 A G 18: 38,332,511 (GRCm39) V164A probably benign Het
Pclo A G 5: 14,729,932 (GRCm39) probably benign Het
Pkhd1l1 T C 15: 44,455,422 (GRCm39) probably null Het
Slco1a7 A G 6: 141,673,440 (GRCm39) I366T probably damaging Het
Spata31d1d T C 13: 59,875,276 (GRCm39) Q753R probably benign Het
Stxbp6 A G 12: 44,949,641 (GRCm39) probably null Het
Zp3r A C 1: 130,504,791 (GRCm39) D470E possibly damaging Het
Other mutations in Trav6-5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4704:Trav6-5 UTSW 14 53,728,883 (GRCm39) nonsense probably null
R4745:Trav6-5 UTSW 14 53,728,960 (GRCm39) missense probably benign 0.00
R5168:Trav6-5 UTSW 14 53,728,973 (GRCm39) missense probably benign 0.02
R5229:Trav6-5 UTSW 14 53,729,045 (GRCm39) missense probably damaging 0.98
R6234:Trav6-5 UTSW 14 53,728,832 (GRCm39) missense probably benign 0.01
R7729:Trav6-5 UTSW 14 53,728,964 (GRCm39) missense probably benign 0.01
Predicted Primers
Posted On 2017-04-14