Incidental Mutation 'R4051:Trav7-3'
ID475395
Institutional Source Beutler Lab
Gene Symbol Trav7-3
Ensembl Gene ENSMUSG00000096908
Gene NameT cell receptor alpha variable 7-3
SynonymsGm13946
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.079) question?
Stock #R4051 ()
Quality Score225
Status Not validated
Chromosome14
Chromosomal Location53443249-53443838 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 53443746 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 82 (T82A)
Ref Sequence ENSEMBL: ENSMUSP00000137590 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177622]
Predicted Effect probably benign
Transcript: ENSMUST00000177622
AA Change: T82A

PolyPhen 2 Score 0.325 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000137590
Gene: ENSMUSG00000096908
AA Change: T82A

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
IGv 40 111 1.41e-12 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 93.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 A C 7: 45,986,563 L1020R probably damaging Het
Ahnak A C 19: 9,014,327 D4325A probably damaging Het
Chtf18 A G 17: 25,719,194 V955A probably damaging Het
Dclk2 A G 3: 86,830,822 probably null Het
Disc1 A G 8: 125,148,425 T547A possibly damaging Het
Eif4b A G 15: 102,086,604 Y211C probably benign Het
Fli1 T G 9: 32,452,162 D176A probably benign Het
Hcn2 A C 10: 79,733,687 probably null Het
Ice1 A G 13: 70,603,527 V1480A probably damaging Het
Ier5l A C 2: 30,473,312 S234A probably benign Het
Ino80b G C 6: 83,122,333 P178R probably damaging Het
Itga11 C T 9: 62,755,651 Q550* probably null Het
Kdr T A 5: 75,968,408 M193L probably benign Het
Kif3b G A 2: 153,323,557 R628Q probably damaging Het
Ldlrad3 C T 2: 101,953,162 D240N probably damaging Het
Met T C 6: 17,548,729 V924A possibly damaging Het
Olfr554 T C 7: 102,641,026 V260A possibly damaging Het
Peg10 T C 6: 4,754,534 L105P probably benign Het
Phtf1 A G 3: 104,005,508 T717A possibly damaging Het
Ptafr T C 4: 132,579,994 W232R probably benign Het
Rnase4 A G 14: 51,105,005 K62R probably benign Het
Slamf7 T C 1: 171,637,383 K261E possibly damaging Het
Slc9c1 T A 16: 45,543,230 Y120N probably damaging Het
Sstr2 A C 11: 113,624,656 T134P probably damaging Het
Steap4 A G 5: 7,980,404 Y420C probably damaging Het
Tbc1d9b T C 11: 50,171,243 C1210R probably benign Het
Tnfsf10 T A 3: 27,335,354 I188N probably damaging Het
Usp46 T C 5: 74,002,755 N283S probably benign Het
Vmn2r84 T G 10: 130,390,898 N357T probably damaging Het
Zfp217 T C 2: 170,112,616 probably null Het
Other mutations in Trav7-3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4052:Trav7-3 UTSW 14 53443746 missense probably benign 0.32
R4207:Trav7-3 UTSW 14 53443746 missense probably benign 0.32
R4208:Trav7-3 UTSW 14 53443746 missense probably benign 0.32
R5261:Trav7-3 UTSW 14 53443750 missense probably benign 0.05
R7809:Trav7-3 UTSW 14 53443615 missense probably benign 0.00
Predicted Primers
Posted On2017-04-14