Mutagenetix > Incidental Mutations

Incidental Mutation 'R2872:Zzz3'

475587

Institutional Source

Beutler Lab

Gene Symbol

Zzz3

Ensembl Gene

ENSMUSG00000039068

Gene Name

zinc finger, ZZ domain containing 3

Synonyms

3110065C23Rik, 6430567E01Rik

MMRRC Submission

040460-MU

Accession Numbers

Is this an essential gene?

Essential (E-score: 1.000) question?

Stock #

R2872 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

152395473-152462826 bp(+) (GRCm38)

Type of Mutation

synonymous

DNA Base Change (assembly)

T to A at 152446844 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000143693 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089982] [ENSMUST00000106100] [ENSMUST00000106101] [ENSMUST00000106103] [ENSMUST00000200570]

AlphaFold

Q6KAQ7

Predicted Effect

silent
Transcript: ENSMUST00000089982

SMART Domains

Protein: ENSMUSP00000087428
Gene: ENSMUSG00000039068

Domain	Start	End	E-Value	Type
SANT	657	711	1.42e-9	SMART
low complexity region	776	787	N/A	INTRINSIC
low complexity region	799	814	N/A	INTRINSIC
ZnF_ZZ	823	871	6.46e-3	SMART

Predicted Effect

silent
Transcript: ENSMUST00000106100

SMART Domains

Protein: ENSMUSP00000101706
Gene: ENSMUSG00000039068

Domain	Start	End	E-Value	Type
SANT	658	712	1.42e-9	SMART
low complexity region	777	788	N/A	INTRINSIC
low complexity region	800	815	N/A	INTRINSIC
ZnF_ZZ	824	872	6.46e-3	SMART

Predicted Effect

silent
Transcript: ENSMUST00000106101

SMART Domains

Protein: ENSMUSP00000101707
Gene: ENSMUSG00000039068

Domain	Start	End	E-Value	Type
SANT	658	712	1.42e-9	SMART
low complexity region	777	788	N/A	INTRINSIC
low complexity region	800	815	N/A	INTRINSIC
ZnF_ZZ	824	872	6.46e-3	SMART

Predicted Effect

silent
Transcript: ENSMUST00000106103

SMART Domains

Protein: ENSMUSP00000101709
Gene: ENSMUSG00000039068

Domain	Start	End	E-Value	Type
SANT	157	211	1.42e-9	SMART
low complexity region	276	287	N/A	INTRINSIC
low complexity region	299	314	N/A	INTRINSIC
ZnF_ZZ	323	371	6.46e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150802

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000197987

Predicted Effect

silent
Transcript: ENSMUST00000200570

SMART Domains

Protein: ENSMUSP00000143693
Gene: ENSMUSG00000039068

Domain	Start	End	E-Value	Type
SANT	161	215	1.42e-9	SMART
low complexity region	280	291	N/A	INTRINSIC
low complexity region	303	318	N/A	INTRINSIC
ZnF_ZZ	327	375	6.46e-3	SMART

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.5%

Validation Efficiency

99% (72/73)

Allele List at MGI

Other mutations in this stock

Total: 83 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	T	C	12: 71,154,756		probably benign	Het
Abca8b	A	G	11: 109,955,176	C811R	possibly damaging	Het
AI481877	A	C	4: 59,093,850	L226R	probably damaging	Het
Ak8	T	C	2: 28,742,720	I317T	possibly damaging	Het
Akr1e1	G	A	13: 4,602,684		silent	Het
Als2	A	G	1: 59,211,137	S483P	probably damaging	Het
Arhgef10	A	G	8: 14,975,666	I459V	probably benign	Het
Arhgef10	T	C	8: 14,975,093		probably null	Het
Armc2	C	T	10: 41,966,700		probably null	Het
Atp12a	A	G	14: 56,386,950	R952G	possibly damaging	Het
Atp6v1g1	A	G	4: 63,550,021	Y87C	probably benign	Het
Carmil1	G	A	13: 24,045,068		silent	Het
Col12a1	A	T	9: 79,699,549	F531I	probably damaging	Het
Csmd2	T	C	4: 128,557,718	F113S	unknown	Het
Ctnnd1	C	T	2: 84,620,888	V123I	possibly damaging	Het
Cyp4a14	C	A	4: 115,487,301	G456W	probably damaging	Het
Cyp4a30b	A	G	4: 115,458,362	H260R	possibly damaging	Het
Elmsan1	C	T	12: 84,156,471	G886S	probably benign	Het
Frmpd4	A	T	X: 167,477,247	D1166E	probably benign	Homo
Gm21759	T	A	5: 8,180,863		probably benign	Het
Gm37340	G	A	2: 6,950,928		probably benign	Het
Gpr156	T	A	16: 37,992,223	V307D	probably damaging	Het
Gpr35	G	A	1: 92,983,126	V187I	probably benign	Het
Gria2	G	A	3: 80,702,492	T670I	probably damaging	Het
Hdac10	G	T	15: 89,125,856	Q300K	possibly damaging	Het
Hdhd2	T	C	18: 76,955,006	F44L	probably damaging	Het
Hmcn1	A	T	1: 150,738,716	V1313D	possibly damaging	Het
Ick	A	T	9: 78,140,100		probably null	Het
Ift172	C	T	5: 31,257,861	V1335I	probably benign	Het
Igsf9b	A	G	9: 27,322,223	I340V	probably benign	Het
Kif1c	A	G	11: 70,724,081	E567G	probably damaging	Het
Klf8	A	T	X: 153,382,682	E82D	probably damaging	Homo
Knop1	T	C	7: 118,855,963		probably null	Het
Mapk7	C	A	11: 61,490,212		probably benign	Het
Matr3	T	A	18: 35,572,296	S91R	probably benign	Het
Mtor	T	A	4: 148,540,030	M2089K	probably benign	Het
Myo9b	T	C	8: 71,290,966	Y224H	probably benign	Het
Nav1	A	G	1: 135,460,757		silent	Het
Ndufs1	A	G	1: 63,164,723		probably benign	Het
Nlrc3	T	C	16: 3,957,326	D774G	possibly damaging	Het
Notum	A	G	11: 120,660,196	V48A	probably benign	Het
Nox3	T	C	17: 3,682,916	H240R	probably damaging	Het
Nsun2	A	G	13: 69,629,682	T425A	probably damaging	Het
Olfr1510	T	G	14: 52,410,861	T4P	probably benign	Het
Olfr419	T	C	1: 174,250,526	S134G	probably benign	Het
Olfr654	T	C	7: 104,588,493	S230P	possibly damaging	Het
Olfr99	A	G	17: 37,279,976	V148A	possibly damaging	Het
Ostc	T	C	3: 130,703,508	N80S	probably damaging	Het
Otud4	T	A	8: 79,661,073	N300K	possibly damaging	Het
Palmd	T	C	3: 116,923,751	R366G	possibly damaging	Het
Paqr5	A	T	9: 61,968,779		probably null	Het
Parp1	A	G	1: 180,573,665	D45G	probably damaging	Het
Pcdhga9	T	A	18: 37,737,471	Y118N	possibly damaging	Het
Pkd1l2	C	T	8: 117,038,164	V1332I	probably benign	Het
Plcl1	A	T	1: 55,697,150	D550V	probably benign	Het
Plekhg1	T	G	10: 3,963,982	S1235A	probably benign	Het
Plekhg5	T	A	4: 152,107,503	C433S	probably benign	Het
Plin2	A	G	4: 86,668,678	M1T	probably null	Het
Plxna3	T	A	X: 74,339,396		probably benign	Homo
Polg2	A	G	11: 106,775,425		probably null	Het
Ppp1r7	T	A	1: 93,357,863		probably null	Het
Prdx4	A	G	X: 155,340,464	V15A	probably benign	Homo
Prps1	C	T	X: 140,471,994		probably benign	Homo
Rapgef6	T	A	11: 54,661,175	F956L	probably damaging	Het
Rasl12	A	G	9: 65,408,323	N83S	probably benign	Het
Rel	T	C	11: 23,761,129	I13V	probably benign	Het
Reln	C	T	5: 22,049,791	V527I	possibly damaging	Het
Sel1l3	C	T	5: 53,137,883	W792*	probably null	Het
Slc39a8	T	A	3: 135,886,793		probably null	Het
Slc6a9	T	A	4: 117,849,381	M1K	probably null	Het
Smpdl3a	T	A	10: 57,802,530	F143Y	possibly damaging	Het
Son	A	G	16: 91,664,317		probably null	Het
Spsb4	G	T	9: 96,996,018	T84K	probably damaging	Het
Tbc1d8	A	G	1: 39,405,317	F187S	probably damaging	Het
Tdpoz3	T	A	3: 93,826,428	F137I	probably benign	Het
Tgm7	G	A	2: 121,109,693		probably benign	Het
Tmem161a	C	T	8: 70,178,915		probably benign	Het
Tnni3k	C	T	3: 154,938,750		probably null	Het
Tpd52	A	T	3: 9,003,406	Y16*	probably null	Het
Trpa1	A	G	1: 14,887,620	C705R	probably damaging	Het
Ttn	A	G	2: 76,750,851	S23233P	probably damaging	Het
Uevld	T	C	7: 46,947,945	D154G	probably null	Het
Zfp292	G	A	4: 34,808,595	T1483M	probably damaging	Het

Other mutations in Zzz3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00691:Zzz3	APN	3	152428514	missense	probably benign	0.16
IGL00707:Zzz3	APN	3	152449043	nonsense	probably null
IGL00983:Zzz3	APN	3	152455810	splice site	probably benign
IGL01586:Zzz3	APN	3	152455839	missense	possibly damaging	0.80
IGL01973:Zzz3	APN	3	152428370	missense	probably benign	0.00
IGL02002:Zzz3	APN	3	152451369	missense	probably damaging	0.98
IGL02009:Zzz3	APN	3	152428115	missense	possibly damaging	0.80
IGL02260:Zzz3	APN	3	152452083	missense	probably benign	0.04
IGL02336:Zzz3	APN	3	152428059	missense	possibly damaging	0.74
IGL02454:Zzz3	APN	3	152428574	missense	probably benign	0.03
IGL02519:Zzz3	APN	3	152427390	missense	probably damaging	1.00
R0067:Zzz3	UTSW	3	152428403	missense	possibly damaging	0.88
R0067:Zzz3	UTSW	3	152428403	missense	possibly damaging	0.88
R0314:Zzz3	UTSW	3	152427448	missense	probably benign	0.00
R0536:Zzz3	UTSW	3	152448828	missense	probably damaging	1.00
R1706:Zzz3	UTSW	3	152449098	missense	probably damaging	1.00
R2869:Zzz3	UTSW	3	152446844	synonymous	silent
R2870:Zzz3	UTSW	3	152446844	synonymous	silent
R2871:Zzz3	UTSW	3	152446844	synonymous	silent
R3927:Zzz3	UTSW	3	152455862	missense	probably damaging	1.00
R4195:Zzz3	UTSW	3	152428465	missense	probably benign	0.02
R4768:Zzz3	UTSW	3	152448783	missense	probably damaging	1.00
R5248:Zzz3	UTSW	3	152427545	missense	probably damaging	0.99
R5566:Zzz3	UTSW	3	152455824	missense	probably damaging	1.00
R5752:Zzz3	UTSW	3	152452122	missense	possibly damaging	0.48
R5782:Zzz3	UTSW	3	152428100	missense	possibly damaging	0.69
R5884:Zzz3	UTSW	3	152450658	missense	probably damaging	1.00
R6008:Zzz3	UTSW	3	152428151	missense	probably benign	0.01
R6155:Zzz3	UTSW	3	152427682	missense	possibly damaging	0.57
R6557:Zzz3	UTSW	3	152428460	missense	probably damaging	1.00
R6865:Zzz3	UTSW	3	152428053	missense	probably benign	0.01
R7344:Zzz3	UTSW	3	152452099	missense	probably damaging	0.98
R7588:Zzz3	UTSW	3	152422768	missense	possibly damaging	0.85
R7636:Zzz3	UTSW	3	152427652	missense	probably benign
R7732:Zzz3	UTSW	3	152448842	missense	probably damaging	1.00
R8157:Zzz3	UTSW	3	152449648	missense	probably null	0.71
R8490:Zzz3	UTSW	3	152428653	nonsense	probably null
R8926:Zzz3	UTSW	3	152427892	missense	possibly damaging	0.76
R9143:Zzz3	UTSW	3	152458271	missense	probably benign	0.04
R9243:Zzz3	UTSW	3	152428283	missense	probably damaging	1.00
X0018:Zzz3	UTSW	3	152428733	missense	possibly damaging	0.88
Z1176:Zzz3	UTSW	3	152449097	missense	possibly damaging	0.94

Predicted Primers

Posted On

2017-05-11