Incidental Mutation 'R3439:Naip1'
ID 475690
Institutional Source Beutler Lab
Gene Symbol Naip1
Ensembl Gene ENSMUSG00000021640
Gene Name NLR family, apoptosis inhibitory protein 1
Synonyms Naip, Birc1a, D13Lsd1
MMRRC Submission 040657-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3439 (G1)
Quality Score 100
Status Not validated
Chromosome 13
Chromosomal Location 100544272-100589372 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 100559727 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 1092 (D1092E)
Ref Sequence ENSEMBL: ENSMUSP00000152583 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022142] [ENSMUST00000221727] [ENSMUST00000221943] [ENSMUST00000222155]
AlphaFold Q9QWK5
Predicted Effect probably benign
Transcript: ENSMUST00000022142
AA Change: D1092E

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000022142
Gene: ENSMUSG00000021640
AA Change: D1092E

DomainStartEndE-ValueType
low complexity region 36 51 N/A INTRINSIC
BIR 58 129 1.18e-20 SMART
BIR 157 229 1.06e-36 SMART
BIR 276 347 7.82e-26 SMART
AAA 462 603 1.14e-2 SMART
low complexity region 908 919 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000221727
Predicted Effect probably benign
Transcript: ENSMUST00000221943
Predicted Effect probably benign
Transcript: ENSMUST00000222155
AA Change: D1092E

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency 100% (30/30)
MGI Phenotype PHENOTYPE: Mice homozygous for disruptions in this gene display a normal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agxt2 C A 15: 10,381,511 (GRCm39) P255Q probably benign Het
Cdcp3 T C 7: 130,790,508 (GRCm39) probably null Het
Dnah10 T C 5: 124,873,322 (GRCm39) Y2458H possibly damaging Het
Dnhd1 A G 7: 105,343,992 (GRCm39) T1779A probably damaging Het
Glb1l A T 1: 75,179,264 (GRCm39) C222S probably damaging Het
Gnb1l A G 16: 18,371,117 (GRCm39) T203A probably benign Het
Helq T C 5: 100,946,170 (GRCm39) E57G probably damaging Het
Kng2 T C 16: 22,830,821 (GRCm39) I163V probably benign Het
Larp7-ps A C 4: 92,079,919 (GRCm39) V23G possibly damaging Het
Lingo1 T C 9: 56,528,017 (GRCm39) T191A probably benign Het
Lrrc37a G A 11: 103,388,690 (GRCm39) T2245I unknown Het
Med13 T C 11: 86,176,123 (GRCm39) D1624G probably damaging Het
Mthfsd A G 8: 121,825,860 (GRCm39) V218A possibly damaging Het
Nom1 T C 5: 29,640,615 (GRCm39) S314P probably benign Het
Nwd2 G A 5: 63,961,895 (GRCm39) R493H probably benign Het
Or4f58 T C 2: 111,851,792 (GRCm39) M136V possibly damaging Het
Or5an11 A T 19: 12,245,759 (GRCm39) H55L possibly damaging Het
Palm C T 10: 79,652,618 (GRCm39) probably benign Het
Pitpnm1 A G 19: 4,162,752 (GRCm39) E1115G probably benign Het
Plod3 G C 5: 137,017,000 (GRCm39) A50P probably benign Het
Prrc2b T C 2: 32,096,359 (GRCm39) F577L probably benign Het
Rnpepl1 A T 1: 92,844,662 (GRCm39) T385S possibly damaging Het
Serpinb7 A T 1: 107,356,081 (GRCm39) I35F probably damaging Het
Srbd1 C T 17: 86,365,187 (GRCm39) S623N probably benign Het
Tchh A G 3: 93,354,700 (GRCm39) E1380G unknown Het
Tet2 G T 3: 133,172,592 (GRCm39) A1890D possibly damaging Het
Tfr2 G T 5: 137,572,913 (GRCm39) V215F probably benign Het
Vpreb3 C T 10: 75,779,056 (GRCm39) probably benign Het
Vwde T A 6: 13,208,374 (GRCm39) L169F probably damaging Het
Other mutations in Naip1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01115:Naip1 APN 13 100,580,228 (GRCm39) critical splice acceptor site probably null
IGL01145:Naip1 APN 13 100,545,629 (GRCm39) missense probably benign 0.00
IGL01356:Naip1 APN 13 100,559,722 (GRCm39) missense probably damaging 0.99
IGL01414:Naip1 APN 13 100,545,681 (GRCm39) critical splice acceptor site probably null
IGL01505:Naip1 APN 13 100,562,441 (GRCm39) missense probably damaging 1.00
IGL01573:Naip1 APN 13 100,563,890 (GRCm39) missense probably benign 0.03
IGL01931:Naip1 APN 13 100,545,540 (GRCm39) nonsense probably null
IGL02043:Naip1 APN 13 100,563,304 (GRCm39) missense probably benign 0.03
IGL02097:Naip1 APN 13 100,562,096 (GRCm39) missense probably benign 0.03
IGL02331:Naip1 APN 13 100,563,304 (GRCm39) missense probably benign 0.03
IGL02627:Naip1 APN 13 100,562,156 (GRCm39) missense possibly damaging 0.68
IGL02675:Naip1 APN 13 100,545,626 (GRCm39) missense probably benign
IGL02801:Naip1 APN 13 100,580,876 (GRCm39) missense probably damaging 1.00
IGL02851:Naip1 APN 13 100,569,770 (GRCm39) missense probably damaging 1.00
IGL03038:Naip1 APN 13 100,573,841 (GRCm39) nonsense probably null
IGL03399:Naip1 APN 13 100,545,426 (GRCm39) missense probably damaging 1.00
FR4340:Naip1 UTSW 13 100,559,584 (GRCm39) missense probably benign
FR4342:Naip1 UTSW 13 100,561,979 (GRCm39) missense probably benign 0.00
R0051:Naip1 UTSW 13 100,547,509 (GRCm39) missense probably damaging 0.96
R0095:Naip1 UTSW 13 100,559,591 (GRCm39) missense probably benign 0.24
R0147:Naip1 UTSW 13 100,563,418 (GRCm39) missense possibly damaging 0.67
R0375:Naip1 UTSW 13 100,545,656 (GRCm39) missense probably benign 0.21
R0442:Naip1 UTSW 13 100,581,024 (GRCm39) missense probably benign 0.00
R0455:Naip1 UTSW 13 100,559,727 (GRCm39) missense probably benign 0.00
R0491:Naip1 UTSW 13 100,559,727 (GRCm39) missense probably benign 0.00
R0614:Naip1 UTSW 13 100,580,708 (GRCm39) missense probably benign 0.00
R0785:Naip1 UTSW 13 100,559,593 (GRCm39) missense probably benign 0.00
R0785:Naip1 UTSW 13 100,559,584 (GRCm39) missense probably benign
R0787:Naip1 UTSW 13 100,562,604 (GRCm39) missense probably benign 0.22
R1081:Naip1 UTSW 13 100,559,578 (GRCm39) missense probably benign 0.21
R1177:Naip1 UTSW 13 100,563,572 (GRCm39) missense possibly damaging 0.91
R1476:Naip1 UTSW 13 100,563,378 (GRCm39) missense probably benign 0.35
R1672:Naip1 UTSW 13 100,559,657 (GRCm39) missense probably benign 0.00
R1809:Naip1 UTSW 13 100,562,747 (GRCm39) missense probably benign
R2057:Naip1 UTSW 13 100,562,081 (GRCm39) missense probably damaging 0.96
R2182:Naip1 UTSW 13 100,550,188 (GRCm39) missense probably benign 0.01
R2395:Naip1 UTSW 13 100,559,614 (GRCm39) missense possibly damaging 0.83
R2518:Naip1 UTSW 13 100,559,727 (GRCm39) missense probably benign 0.00
R3033:Naip1 UTSW 13 100,568,966 (GRCm39) missense probably benign 0.01
R3122:Naip1 UTSW 13 100,545,503 (GRCm39) missense probably damaging 1.00
R4167:Naip1 UTSW 13 100,580,794 (GRCm39) missense probably benign 0.04
R4179:Naip1 UTSW 13 100,562,684 (GRCm39) missense probably damaging 0.99
R4212:Naip1 UTSW 13 100,563,383 (GRCm39) splice site probably null
R4639:Naip1 UTSW 13 100,580,791 (GRCm39) missense probably benign 0.31
R4674:Naip1 UTSW 13 100,580,682 (GRCm39) missense probably damaging 1.00
R4736:Naip1 UTSW 13 100,581,034 (GRCm39) missense possibly damaging 0.47
R4740:Naip1 UTSW 13 100,581,034 (GRCm39) missense possibly damaging 0.47
R4778:Naip1 UTSW 13 100,563,156 (GRCm39) missense probably damaging 1.00
R4806:Naip1 UTSW 13 100,562,129 (GRCm39) missense probably benign 0.00
R4855:Naip1 UTSW 13 100,559,728 (GRCm39) splice site probably null
R5740:Naip1 UTSW 13 100,569,009 (GRCm39) critical splice acceptor site probably null
R5797:Naip1 UTSW 13 100,581,034 (GRCm39) missense possibly damaging 0.47
R5806:Naip1 UTSW 13 100,581,243 (GRCm39) start codon destroyed probably null 1.00
R5895:Naip1 UTSW 13 100,559,636 (GRCm39) missense probably benign 0.00
R5896:Naip1 UTSW 13 100,559,636 (GRCm39) missense probably benign 0.00
R6023:Naip1 UTSW 13 100,562,694 (GRCm39) missense probably benign 0.00
R6109:Naip1 UTSW 13 100,563,690 (GRCm39) missense probably damaging 1.00
R6117:Naip1 UTSW 13 100,581,245 (GRCm39) start codon destroyed probably damaging 0.99
R6133:Naip1 UTSW 13 100,581,151 (GRCm39) missense probably benign 0.10
R6241:Naip1 UTSW 13 100,562,169 (GRCm39) missense probably damaging 0.99
R6335:Naip1 UTSW 13 100,563,060 (GRCm39) missense probably damaging 1.00
R6404:Naip1 UTSW 13 100,559,727 (GRCm39) missense probably benign 0.00
R6475:Naip1 UTSW 13 100,545,596 (GRCm39) missense probably damaging 1.00
R6508:Naip1 UTSW 13 100,572,973 (GRCm39) missense probably damaging 1.00
R6580:Naip1 UTSW 13 100,581,157 (GRCm39) missense probably damaging 0.99
R6600:Naip1 UTSW 13 100,559,666 (GRCm39) missense probably benign 0.00
R6600:Naip1 UTSW 13 100,559,578 (GRCm39) missense probably benign 0.21
R6603:Naip1 UTSW 13 100,559,666 (GRCm39) missense probably benign 0.00
R6603:Naip1 UTSW 13 100,559,578 (GRCm39) missense probably benign 0.21
R6633:Naip1 UTSW 13 100,559,593 (GRCm39) missense probably benign 0.00
R6633:Naip1 UTSW 13 100,559,584 (GRCm39) missense probably benign
R6720:Naip1 UTSW 13 100,559,585 (GRCm39) missense probably benign 0.00
R6805:Naip1 UTSW 13 100,563,849 (GRCm39) missense probably benign 0.04
R7043:Naip1 UTSW 13 100,563,422 (GRCm39) missense probably damaging 1.00
R7615:Naip1 UTSW 13 100,562,284 (GRCm39) missense probably benign 0.00
R7797:Naip1 UTSW 13 100,580,986 (GRCm39) missense probably damaging 1.00
R7820:Naip1 UTSW 13 100,559,578 (GRCm39) missense probably benign 0.21
R7842:Naip1 UTSW 13 100,563,506 (GRCm39) missense probably damaging 1.00
R8117:Naip1 UTSW 13 100,563,509 (GRCm39) missense possibly damaging 0.67
R8132:Naip1 UTSW 13 100,573,883 (GRCm39) missense possibly damaging 0.84
R8177:Naip1 UTSW 13 100,563,911 (GRCm39) missense probably benign 0.00
R8203:Naip1 UTSW 13 100,562,328 (GRCm39) missense probably benign 0.02
R8283:Naip1 UTSW 13 100,563,695 (GRCm39) missense probably damaging 1.00
R8319:Naip1 UTSW 13 100,565,721 (GRCm39) missense probably benign 0.13
R8377:Naip1 UTSW 13 100,562,374 (GRCm39) missense possibly damaging 0.53
R8864:Naip1 UTSW 13 100,562,828 (GRCm39) missense possibly damaging 0.55
R8871:Naip1 UTSW 13 100,580,146 (GRCm39) missense probably damaging 1.00
R8987:Naip1 UTSW 13 100,563,434 (GRCm39) missense probably damaging 1.00
R9079:Naip1 UTSW 13 100,559,727 (GRCm39) missense probably benign 0.00
R9275:Naip1 UTSW 13 100,562,684 (GRCm39) missense probably damaging 0.99
R9354:Naip1 UTSW 13 100,563,994 (GRCm39) missense probably benign 0.31
R9524:Naip1 UTSW 13 100,563,101 (GRCm39) missense probably benign 0.06
R9617:Naip1 UTSW 13 100,569,821 (GRCm39) missense probably benign 0.01
R9776:Naip1 UTSW 13 100,559,584 (GRCm39) missense probably benign
R9802:Naip1 UTSW 13 100,562,713 (GRCm39) missense probably benign
RF007:Naip1 UTSW 13 100,562,642 (GRCm39) missense probably benign 0.03
X0066:Naip1 UTSW 13 100,573,830 (GRCm39) missense probably damaging 1.00
Y4335:Naip1 UTSW 13 100,562,030 (GRCm39) missense probably benign 0.00
Y4336:Naip1 UTSW 13 100,562,030 (GRCm39) missense probably benign 0.00
Predicted Primers
Posted On 2017-05-11