Incidental Mutation 'R3159:Trav4-4-dv10'
ID 475796
Institutional Source Beutler Lab
Gene Symbol Trav4-4-dv10
Ensembl Gene ENSMUSG00000096096
Gene Name T cell receptor alpha variable 4-4-DV10
Synonyms Gm13908
MMRRC Submission 040610-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.207) question?
Stock # R3159 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 53921134-53921634 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 53921559 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 86 (K86*)
Ref Sequence ENSEMBL: ENSMUSP00000100440 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103663]
AlphaFold A0A075B651
Predicted Effect probably null
Transcript: ENSMUST00000103663
AA Change: K86*
SMART Domains Protein: ENSMUSP00000100440
Gene: ENSMUSG00000096096
AA Change: K86*

DomainStartEndE-ValueType
Pfam:V-set 21 110 3.6e-14 PFAM
Pfam:I-set 22 110 4.3e-9 PFAM
Pfam:Ig_2 23 110 1.3e-6 PFAM
Pfam:ig 39 109 2.9e-7 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bltp1 T C 3: 37,013,564 (GRCm39) V1931A probably benign Het
Ccdc146 T C 5: 21,604,790 (GRCm39) E16G unknown Het
Ccr4 G T 9: 114,321,350 (GRCm39) N238K probably benign Het
Cdk15 T C 1: 59,340,440 (GRCm39) I313T probably damaging Het
Celsr3 T C 9: 108,704,909 (GRCm39) V464A possibly damaging Het
Cfap54 T C 10: 92,834,918 (GRCm39) I1096V probably benign Het
Dmpk A G 7: 18,826,944 (GRCm39) T579A probably benign Het
Dscam T C 16: 96,479,710 (GRCm39) T1146A probably benign Het
Galnt12 A G 4: 47,104,264 (GRCm39) D174G probably damaging Het
Gm5145 A G 17: 20,791,155 (GRCm39) I178V probably benign Het
Gxylt1 A G 15: 93,142,913 (GRCm39) I384T probably benign Het
Hmgcr C T 13: 96,802,355 (GRCm39) V110I probably damaging Het
Hsd17b2 A C 8: 118,485,491 (GRCm39) D318A probably damaging Het
Ighv8-6 A G 12: 115,129,508 (GRCm39) S83P probably damaging Het
Isg20 C A 7: 78,564,201 (GRCm39) A36E possibly damaging Het
Jade3 A G X: 20,345,783 (GRCm39) K54E probably damaging Het
Mark1 A T 1: 184,640,584 (GRCm39) Y505N probably damaging Het
Mmp11 C T 10: 75,762,948 (GRCm39) probably benign Het
Myo1g G T 11: 6,464,527 (GRCm39) T511K possibly damaging Het
Ociad1 A T 5: 73,467,688 (GRCm39) R155* probably null Het
Or5t7 A G 2: 86,506,855 (GRCm39) I274T probably benign Het
Pcdha2 C T 18: 37,074,250 (GRCm39) T627I probably damaging Het
Polg2 A C 11: 106,659,163 (GRCm39) V450G probably benign Het
Rbm48 A T 5: 3,646,105 (GRCm39) V33D possibly damaging Het
Rfx6 A T 10: 51,602,816 (GRCm39) R778W probably damaging Het
Sav1 A T 12: 70,031,326 (GRCm39) D65E probably benign Het
Sh3rf1 C T 8: 61,679,321 (GRCm39) P121L probably benign Het
Shank2 C A 7: 143,635,611 (GRCm39) N328K probably damaging Het
Slc8a3 C A 12: 81,361,766 (GRCm39) R351L probably damaging Het
Slc9b1 G A 3: 135,077,606 (GRCm39) G100E probably damaging Het
Slit1 A G 19: 41,592,812 (GRCm39) Y1214H probably benign Het
Smu1 T A 4: 40,754,529 (GRCm39) R123S possibly damaging Het
Tgfb3 A T 12: 86,105,760 (GRCm39) W332R probably damaging Het
Tmem132a C T 19: 10,836,901 (GRCm39) W680* probably null Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Zfp667 T C 7: 6,308,999 (GRCm39) C556R probably damaging Het
Zranb3 A G 1: 127,900,686 (GRCm39) I713T probably benign Het
Other mutations in Trav4-4-dv10
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4472:Trav4-4-dv10 UTSW 14 53,921,187 (GRCm39) critical splice donor site probably benign
R8984:Trav4-4-dv10 UTSW 14 53,921,574 (GRCm39) missense probably benign 0.17
Predicted Primers
Posted On 2017-05-11