Incidental Mutation 'R0506:Nalcn'
| ID |
47612 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nalcn
|
| Ensembl Gene |
ENSMUSG00000000197 |
| Gene Name |
sodium leak channel, non-selective |
| Synonyms |
Vgcnl1, A530023G15Rik |
| MMRRC Submission |
038701-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0506 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
14 |
| Chromosomal Location |
123514046-123864556 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 123834026 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 50
(V50I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000000201
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000000201]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000000201
AA Change: V50I
PolyPhen 2
Score 0.819 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000000201
Gene: ENSMUSG00000000197
AA Change: V50I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Ion_trans
|
35 |
333 |
2.8e-37 |
PFAM |
|
low complexity region
|
338 |
348 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
383 |
609 |
5.7e-34 |
PFAM |
|
coiled coil region
|
796 |
830 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
885 |
1166 |
2.4e-42 |
PFAM |
|
Pfam:Ion_trans
|
1209 |
1458 |
6.9e-30 |
PFAM |
|
low complexity region
|
1548 |
1560 |
N/A |
INTRINSIC |
|
low complexity region
|
1634 |
1649 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226617
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000227818
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228766
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228789
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228860
|
| Meta Mutation Damage Score |
0.0924 |
| Coding Region Coverage |
- 1x: 99.6%
- 3x: 98.8%
- 10x: 96.7%
- 20x: 93.3%
|
| Validation Efficiency |
100% (100/100) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007 [PubMed 17448995]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit abnormal breathing at birth and die within 24 hours. Mice homozygous for a gain of function ENU mutation exhibit reduced the total amount and episode duration of REMS. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsm5 |
T |
A |
7: 119,137,319 (GRCm39) |
C378* |
probably null |
Het |
| Ago3 |
T |
C |
4: 126,311,045 (GRCm39) |
D56G |
possibly damaging |
Het |
| Ahnak |
G |
T |
19: 8,986,492 (GRCm39) |
G2592V |
probably damaging |
Het |
| Aldh6a1 |
C |
T |
12: 84,480,300 (GRCm39) |
G470D |
probably damaging |
Het |
| Ankub1 |
T |
A |
3: 57,597,796 (GRCm39) |
N58I |
probably damaging |
Het |
| Apol7b |
G |
T |
15: 77,309,728 (GRCm39) |
T23K |
probably benign |
Het |
| Arap2 |
G |
A |
5: 62,763,474 (GRCm39) |
P1557S |
possibly damaging |
Het |
| Arhgap24 |
T |
C |
5: 103,023,643 (GRCm39) |
Y136H |
probably damaging |
Het |
| Atp1a1 |
A |
G |
3: 101,497,128 (GRCm39) |
F393L |
probably damaging |
Het |
| Bcdin3d |
A |
T |
15: 99,368,873 (GRCm39) |
C109S |
probably damaging |
Het |
| Catsperd |
A |
G |
17: 56,965,078 (GRCm39) |
K475R |
possibly damaging |
Het |
| Cblb |
A |
G |
16: 52,024,843 (GRCm39) |
T913A |
probably benign |
Het |
| Cbx6 |
A |
G |
15: 79,712,404 (GRCm39) |
L341P |
probably benign |
Het |
| Cd177 |
T |
C |
7: 24,457,781 (GRCm39) |
Y159C |
probably damaging |
Het |
| Cdh20 |
A |
G |
1: 110,027,844 (GRCm39) |
N530D |
probably damaging |
Het |
| Cdk8 |
T |
C |
5: 146,235,682 (GRCm39) |
F270L |
probably damaging |
Het |
| Ces2c |
A |
T |
8: 105,574,656 (GRCm39) |
T38S |
probably damaging |
Het |
| Chst14 |
T |
C |
2: 118,758,202 (GRCm39) |
L357P |
probably damaging |
Het |
| Clca3b |
T |
A |
3: 144,528,627 (GRCm39) |
|
probably benign |
Het |
| Cluh |
A |
G |
11: 74,555,720 (GRCm39) |
S839G |
probably benign |
Het |
| Cnga4 |
T |
A |
7: 105,056,947 (GRCm39) |
V350E |
probably damaging |
Het |
| Creb1 |
G |
A |
1: 64,609,426 (GRCm39) |
G180R |
probably damaging |
Het |
| Csmd3 |
T |
C |
15: 48,320,907 (GRCm39) |
E301G |
probably benign |
Het |
| Cyp4f18 |
A |
T |
8: 72,749,844 (GRCm39) |
D268E |
probably benign |
Het |
| Dock5 |
A |
G |
14: 68,022,241 (GRCm39) |
|
probably benign |
Het |
| Dpy19l4 |
T |
A |
4: 11,289,715 (GRCm39) |
H332L |
probably benign |
Het |
| Dync2h1 |
T |
A |
9: 7,113,153 (GRCm39) |
H224L |
probably benign |
Het |
| Dzip1l |
C |
A |
9: 99,545,134 (GRCm39) |
Q585K |
possibly damaging |
Het |
| Erf |
C |
T |
7: 24,943,801 (GRCm39) |
G510D |
probably damaging |
Het |
| Fanci |
T |
C |
7: 79,081,926 (GRCm39) |
L623P |
probably benign |
Het |
| Fat1 |
T |
C |
8: 45,475,988 (GRCm39) |
V1655A |
probably damaging |
Het |
| Fat4 |
T |
C |
3: 38,942,463 (GRCm39) |
V452A |
probably benign |
Het |
| Gal3st4 |
C |
T |
5: 138,264,151 (GRCm39) |
G283S |
probably benign |
Het |
| Gm5422 |
A |
G |
10: 31,126,318 (GRCm39) |
|
noncoding transcript |
Het |
| Gnal |
C |
T |
18: 67,221,744 (GRCm39) |
T49I |
unknown |
Het |
| Gng5 |
A |
G |
3: 146,209,103 (GRCm39) |
N57S |
probably damaging |
Het |
| Herc1 |
A |
G |
9: 66,355,441 (GRCm39) |
I2231V |
probably damaging |
Het |
| Hgfac |
G |
T |
5: 35,201,584 (GRCm39) |
G272W |
probably damaging |
Het |
| Hmcn1 |
T |
A |
1: 150,618,092 (GRCm39) |
D1265V |
possibly damaging |
Het |
| Ifi207 |
T |
A |
1: 173,563,878 (GRCm39) |
Q47L |
possibly damaging |
Het |
| Klhl40 |
G |
A |
9: 121,607,133 (GRCm39) |
E98K |
probably damaging |
Het |
| Lepr |
G |
T |
4: 101,630,207 (GRCm39) |
|
probably benign |
Het |
| Lyst |
A |
G |
13: 13,812,600 (GRCm39) |
H1004R |
probably benign |
Het |
| Map3k1 |
T |
A |
13: 111,892,298 (GRCm39) |
R986* |
probably null |
Het |
| Mmp1b |
C |
A |
9: 7,387,013 (GRCm39) |
Q66H |
possibly damaging |
Het |
| Mpo |
T |
C |
11: 87,694,330 (GRCm39) |
S107P |
probably benign |
Het |
| Mroh9 |
T |
C |
1: 162,888,205 (GRCm39) |
H290R |
possibly damaging |
Het |
| Myo7b |
A |
G |
18: 32,097,439 (GRCm39) |
|
probably null |
Het |
| Myom1 |
T |
C |
17: 71,399,215 (GRCm39) |
|
probably benign |
Het |
| Negr1 |
A |
G |
3: 156,866,385 (GRCm39) |
|
probably benign |
Het |
| Nlrc5 |
T |
G |
8: 95,219,753 (GRCm39) |
|
probably benign |
Het |
| Nyap2 |
G |
A |
1: 81,065,029 (GRCm39) |
D14N |
probably damaging |
Het |
| Or10w1 |
T |
A |
19: 13,632,261 (GRCm39) |
I151N |
possibly damaging |
Het |
| Or2h1 |
C |
A |
17: 37,404,203 (GRCm39) |
G188W |
probably damaging |
Het |
| Or5b105 |
G |
A |
19: 13,080,642 (GRCm39) |
R3C |
possibly damaging |
Het |
| Parp14 |
A |
T |
16: 35,661,779 (GRCm39) |
S1419T |
possibly damaging |
Het |
| Piezo2 |
A |
G |
18: 63,160,615 (GRCm39) |
F2347S |
probably damaging |
Het |
| Pigf |
A |
G |
17: 87,316,337 (GRCm39) |
V147A |
probably benign |
Het |
| Pkhd1 |
A |
T |
1: 20,629,693 (GRCm39) |
M637K |
probably benign |
Het |
| Plce1 |
T |
C |
19: 38,748,582 (GRCm39) |
I1771T |
probably benign |
Het |
| Ppp6c |
A |
T |
2: 39,096,660 (GRCm39) |
|
probably benign |
Het |
| Prag1 |
T |
C |
8: 36,570,854 (GRCm39) |
V479A |
possibly damaging |
Het |
| Prss33 |
A |
T |
17: 24,054,079 (GRCm39) |
D42E |
probably benign |
Het |
| Psmb10 |
A |
G |
8: 106,664,177 (GRCm39) |
V64A |
possibly damaging |
Het |
| Psmd14 |
A |
G |
2: 61,630,407 (GRCm39) |
T306A |
probably benign |
Het |
| Psmg1 |
C |
T |
16: 95,790,687 (GRCm39) |
|
probably benign |
Het |
| Rc3h2 |
A |
T |
2: 37,266,671 (GRCm39) |
|
probably null |
Het |
| Reln |
C |
T |
5: 22,125,494 (GRCm39) |
V2730I |
probably damaging |
Het |
| Sec24a |
A |
T |
11: 51,634,622 (GRCm39) |
H101Q |
probably benign |
Het |
| Selenoi |
A |
G |
5: 30,471,954 (GRCm39) |
N385S |
probably benign |
Het |
| Slc24a4 |
T |
C |
12: 102,097,882 (GRCm39) |
|
probably null |
Het |
| Slc4a10 |
G |
A |
2: 62,080,877 (GRCm39) |
S338N |
probably benign |
Het |
| Slfn3 |
A |
T |
11: 83,103,986 (GRCm39) |
T286S |
probably damaging |
Het |
| Snx29 |
A |
G |
16: 11,213,167 (GRCm39) |
D111G |
probably benign |
Het |
| Sp8 |
T |
C |
12: 118,812,300 (GRCm39) |
S52P |
possibly damaging |
Het |
| Srek1 |
G |
T |
13: 103,897,098 (GRCm39) |
T81K |
probably damaging |
Het |
| Sry |
C |
G |
Y: 2,662,864 (GRCm39) |
Q265H |
unknown |
Het |
| Taf3 |
A |
G |
2: 9,945,804 (GRCm39) |
V600A |
probably benign |
Het |
| Tatdn2 |
C |
A |
6: 113,679,550 (GRCm39) |
D298E |
probably benign |
Het |
| Tmem253 |
A |
T |
14: 52,254,663 (GRCm39) |
|
probably benign |
Het |
| Tmem63a |
T |
A |
1: 180,785,614 (GRCm39) |
|
probably null |
Het |
| Tmprss11b |
T |
C |
5: 86,809,499 (GRCm39) |
D331G |
probably damaging |
Het |
| Tor1aip1 |
T |
A |
1: 155,883,420 (GRCm39) |
K143* |
probably null |
Het |
| Trappc8 |
A |
T |
18: 20,977,245 (GRCm39) |
N841K |
possibly damaging |
Het |
| Trio |
T |
C |
15: 27,855,049 (GRCm39) |
Q711R |
probably benign |
Het |
| Trmt10b |
C |
A |
4: 45,304,306 (GRCm39) |
T114N |
probably damaging |
Het |
| Trpv2 |
C |
A |
11: 62,473,732 (GRCm39) |
A129D |
probably benign |
Het |
| Ttll4 |
T |
G |
1: 74,727,777 (GRCm39) |
D846E |
probably benign |
Het |
| Ugt2a3 |
A |
G |
5: 87,484,508 (GRCm39) |
L172P |
possibly damaging |
Het |
| Usp19 |
T |
A |
9: 108,371,686 (GRCm39) |
F355Y |
probably damaging |
Het |
| Vmn1r209 |
C |
T |
13: 22,990,114 (GRCm39) |
G192D |
probably damaging |
Het |
| Vmn2r107 |
T |
G |
17: 20,578,021 (GRCm39) |
D443E |
probably benign |
Het |
| Wee2 |
A |
T |
6: 40,440,187 (GRCm39) |
E445V |
probably benign |
Het |
| Zer1 |
A |
T |
2: 29,991,819 (GRCm39) |
I680N |
probably damaging |
Het |
| Zfhx4 |
T |
C |
3: 5,467,795 (GRCm39) |
L2651P |
probably damaging |
Het |
| Zfp692 |
C |
T |
11: 58,199,881 (GRCm39) |
Q157* |
probably null |
Het |
| Zfp964 |
T |
A |
8: 70,116,587 (GRCm39) |
C396S |
unknown |
Het |
|
| Other mutations in Nalcn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00952:Nalcn
|
APN |
14 |
123,586,201 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00964:Nalcn
|
APN |
14 |
123,532,796 (GRCm39) |
splice site |
probably benign |
|
|
IGL01310:Nalcn
|
APN |
14 |
123,554,661 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01578:Nalcn
|
APN |
14 |
123,809,503 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01925:Nalcn
|
APN |
14 |
123,529,260 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02072:Nalcn
|
APN |
14 |
123,560,770 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02096:Nalcn
|
APN |
14 |
123,831,915 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02212:Nalcn
|
APN |
14 |
123,752,742 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02306:Nalcn
|
APN |
14 |
123,560,750 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02471:Nalcn
|
APN |
14 |
123,560,726 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02478:Nalcn
|
APN |
14 |
123,558,717 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL02551:Nalcn
|
APN |
14 |
123,560,750 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02630:Nalcn
|
APN |
14 |
123,555,291 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL02632:Nalcn
|
APN |
14 |
123,555,265 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02661:Nalcn
|
APN |
14 |
123,830,321 (GRCm39) |
splice site |
probably benign |
|
|
IGL02830:Nalcn
|
APN |
14 |
123,530,881 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02939:Nalcn
|
APN |
14 |
123,536,284 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL03035:Nalcn
|
APN |
14 |
123,515,630 (GRCm39) |
nonsense |
probably null |
|
|
IGL03226:Nalcn
|
APN |
14 |
123,518,527 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03242:Nalcn
|
APN |
14 |
123,558,899 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Narnia
|
UTSW |
14 |
123,528,459 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0019:Nalcn
|
UTSW |
14 |
123,744,901 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0144:Nalcn
|
UTSW |
14 |
123,647,251 (GRCm39) |
splice site |
probably benign |
|
|
R0144:Nalcn
|
UTSW |
14 |
123,608,948 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0359:Nalcn
|
UTSW |
14 |
123,536,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0383:Nalcn
|
UTSW |
14 |
123,744,971 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0400:Nalcn
|
UTSW |
14 |
123,528,372 (GRCm39) |
splice site |
probably benign |
|
|
R0467:Nalcn
|
UTSW |
14 |
123,528,459 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0583:Nalcn
|
UTSW |
14 |
123,531,755 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0620:Nalcn
|
UTSW |
14 |
123,536,553 (GRCm39) |
splice site |
probably benign |
|
|
R0624:Nalcn
|
UTSW |
14 |
123,607,444 (GRCm39) |
missense |
probably benign |
|
|
R0883:Nalcn
|
UTSW |
14 |
123,702,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1381:Nalcn
|
UTSW |
14 |
123,551,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Nalcn
|
UTSW |
14 |
123,702,068 (GRCm39) |
splice site |
probably benign |
|
|
R1689:Nalcn
|
UTSW |
14 |
123,522,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1726:Nalcn
|
UTSW |
14 |
123,545,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Nalcn
|
UTSW |
14 |
123,515,678 (GRCm39) |
missense |
probably benign |
|
|
R1854:Nalcn
|
UTSW |
14 |
123,697,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1869:Nalcn
|
UTSW |
14 |
123,831,965 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1871:Nalcn
|
UTSW |
14 |
123,831,965 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1873:Nalcn
|
UTSW |
14 |
123,521,013 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1899:Nalcn
|
UTSW |
14 |
123,553,538 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1915:Nalcn
|
UTSW |
14 |
123,540,181 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2016:Nalcn
|
UTSW |
14 |
123,831,993 (GRCm39) |
splice site |
probably null |
|
|
R2034:Nalcn
|
UTSW |
14 |
123,521,015 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2087:Nalcn
|
UTSW |
14 |
123,518,557 (GRCm39) |
missense |
probably benign |
|
|
R2149:Nalcn
|
UTSW |
14 |
123,607,429 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2157:Nalcn
|
UTSW |
14 |
123,647,164 (GRCm39) |
missense |
probably benign |
0.32 |
|
R2166:Nalcn
|
UTSW |
14 |
123,607,363 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2932:Nalcn
|
UTSW |
14 |
123,830,430 (GRCm39) |
missense |
probably benign |
0.06 |
|
R3408:Nalcn
|
UTSW |
14 |
123,834,029 (GRCm39) |
missense |
probably null |
0.98 |
|
R3778:Nalcn
|
UTSW |
14 |
123,702,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3807:Nalcn
|
UTSW |
14 |
123,515,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3835:Nalcn
|
UTSW |
14 |
123,530,834 (GRCm39) |
splice site |
probably benign |
|
|
R3937:Nalcn
|
UTSW |
14 |
123,607,357 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4001:Nalcn
|
UTSW |
14 |
123,834,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4015:Nalcn
|
UTSW |
14 |
123,723,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4033:Nalcn
|
UTSW |
14 |
123,837,401 (GRCm39) |
splice site |
probably benign |
|
|
R4231:Nalcn
|
UTSW |
14 |
123,837,325 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4464:Nalcn
|
UTSW |
14 |
123,560,762 (GRCm39) |
missense |
probably benign |
|
|
R4512:Nalcn
|
UTSW |
14 |
123,532,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4542:Nalcn
|
UTSW |
14 |
123,558,889 (GRCm39) |
synonymous |
silent |
|
|
R4557:Nalcn
|
UTSW |
14 |
123,558,647 (GRCm39) |
intron |
probably benign |
|
|
R4869:Nalcn
|
UTSW |
14 |
123,837,296 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5083:Nalcn
|
UTSW |
14 |
123,560,706 (GRCm39) |
splice site |
probably null |
|
|
R5109:Nalcn
|
UTSW |
14 |
123,515,650 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5131:Nalcn
|
UTSW |
14 |
123,753,182 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5158:Nalcn
|
UTSW |
14 |
123,753,149 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5259:Nalcn
|
UTSW |
14 |
123,753,063 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5422:Nalcn
|
UTSW |
14 |
123,752,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5514:Nalcn
|
UTSW |
14 |
123,521,123 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5523:Nalcn
|
UTSW |
14 |
123,647,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5551:Nalcn
|
UTSW |
14 |
123,515,698 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R5667:Nalcn
|
UTSW |
14 |
123,532,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5671:Nalcn
|
UTSW |
14 |
123,532,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5750:Nalcn
|
UTSW |
14 |
123,809,450 (GRCm39) |
missense |
probably benign |
|
|
R5765:Nalcn
|
UTSW |
14 |
123,702,138 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6324:Nalcn
|
UTSW |
14 |
123,647,161 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6523:Nalcn
|
UTSW |
14 |
123,555,255 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6558:Nalcn
|
UTSW |
14 |
123,723,919 (GRCm39) |
missense |
probably benign |
|
|
R6631:Nalcn
|
UTSW |
14 |
123,697,663 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6667:Nalcn
|
UTSW |
14 |
123,558,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6670:Nalcn
|
UTSW |
14 |
123,702,084 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6724:Nalcn
|
UTSW |
14 |
123,535,479 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6731:Nalcn
|
UTSW |
14 |
123,837,346 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6957:Nalcn
|
UTSW |
14 |
123,744,966 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6970:Nalcn
|
UTSW |
14 |
123,551,506 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7010:Nalcn
|
UTSW |
14 |
123,530,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7018:Nalcn
|
UTSW |
14 |
123,647,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7040:Nalcn
|
UTSW |
14 |
123,525,267 (GRCm39) |
missense |
probably benign |
|
|
R7089:Nalcn
|
UTSW |
14 |
123,515,761 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7128:Nalcn
|
UTSW |
14 |
123,831,914 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7149:Nalcn
|
UTSW |
14 |
123,837,277 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7361:Nalcn
|
UTSW |
14 |
123,529,251 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7378:Nalcn
|
UTSW |
14 |
123,540,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7408:Nalcn
|
UTSW |
14 |
123,529,272 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7470:Nalcn
|
UTSW |
14 |
123,809,456 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7483:Nalcn
|
UTSW |
14 |
123,551,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7521:Nalcn
|
UTSW |
14 |
123,530,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7558:Nalcn
|
UTSW |
14 |
123,723,797 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7585:Nalcn
|
UTSW |
14 |
123,753,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7591:Nalcn
|
UTSW |
14 |
123,561,297 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7761:Nalcn
|
UTSW |
14 |
123,531,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7761:Nalcn
|
UTSW |
14 |
123,531,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7811:Nalcn
|
UTSW |
14 |
123,536,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7983:Nalcn
|
UTSW |
14 |
123,830,409 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8089:Nalcn
|
UTSW |
14 |
123,537,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8110:Nalcn
|
UTSW |
14 |
123,702,113 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8190:Nalcn
|
UTSW |
14 |
123,837,351 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8273:Nalcn
|
UTSW |
14 |
123,554,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8407:Nalcn
|
UTSW |
14 |
123,554,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8497:Nalcn
|
UTSW |
14 |
123,752,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8544:Nalcn
|
UTSW |
14 |
123,608,935 (GRCm39) |
missense |
probably benign |
0.40 |
|
R8549:Nalcn
|
UTSW |
14 |
123,607,448 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8731:Nalcn
|
UTSW |
14 |
123,837,266 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8862:Nalcn
|
UTSW |
14 |
123,647,199 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8919:Nalcn
|
UTSW |
14 |
123,561,284 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9072:Nalcn
|
UTSW |
14 |
123,532,863 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9073:Nalcn
|
UTSW |
14 |
123,532,863 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9182:Nalcn
|
UTSW |
14 |
123,834,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9193:Nalcn
|
UTSW |
14 |
123,545,792 (GRCm39) |
nonsense |
probably null |
|
|
R9241:Nalcn
|
UTSW |
14 |
123,809,429 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9267:Nalcn
|
UTSW |
14 |
123,518,567 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9274:Nalcn
|
UTSW |
14 |
123,753,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9277:Nalcn
|
UTSW |
14 |
123,518,523 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9376:Nalcn
|
UTSW |
14 |
123,515,713 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
X0060:Nalcn
|
UTSW |
14 |
123,522,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Nalcn
|
UTSW |
14 |
123,831,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Nalcn
|
UTSW |
14 |
123,531,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCTCCTTTACAGGCATCAAGGGAT -3'
(R):5'- AGAACATGGCTGCTAGTTCTGGGT -3'
Sequencing Primer
(F):5'- CCTTTACAGGCATCAAGGGATATAAG -3'
(R):5'- CTTAAACTTCAGAACCCTGGTATG -3'
|
| Posted On |
2013-06-12 |
Incidental Mutation