Incidental Mutation 'R2449:Il10rb'
Institutional Source Beutler Lab
Gene Symbol Il10rb
Ensembl Gene ENSMUSG00000022969
Gene Nameinterleukin 10 receptor, beta
SynonymsCRF2-4, 6620401D04Rik, Crfb4, Il10r2, D16H21S58, D21S58h
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R2449 (G1)
Quality Score225
Status Not validated
Chromosomal Location91406164-91425834 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 91411903 bp
Amino Acid Change Histidine to Arginine at position 67 (H67R)
Ref Sequence ENSEMBL: ENSMUSP00000023691 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023691] [ENSMUST00000156133]
Predicted Effect probably benign
Transcript: ENSMUST00000023691
AA Change: H67R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000023691
Gene: ENSMUSG00000022969
AA Change: H67R

signal peptide 1 21 N/A INTRINSIC
FN3 23 100 4.6e-2 SMART
FN3 114 204 7.1e-3 SMART
transmembrane domain 228 250 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137612
Predicted Effect probably benign
Transcript: ENSMUST00000144215
SMART Domains Protein: ENSMUSP00000120485
Gene: ENSMUSG00000022969

Pfam:Tissue_fac 7 65 1.7e-11 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152729
Predicted Effect probably benign
Transcript: ENSMUST00000156133
SMART Domains Protein: ENSMUSP00000120227
Gene: ENSMUSG00000022969

low complexity region 39 48 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000160764
AA Change: H153R
SMART Domains Protein: ENSMUSP00000123997
Gene: ENSMUSG00000093701
AA Change: H153R

FN3 2 92 5.1e1 SMART
FN3 110 187 9.09e0 SMART
FN3 201 291 1.39e0 SMART
Predicted Effect unknown
Transcript: ENSMUST00000161517
AA Change: T112A
SMART Domains Protein: ENSMUSP00000125579
Gene: ENSMUSG00000093701
AA Change: T112A

Pfam:Interfer-bind 1 100 7.5e-20 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
PHENOTYPE: Most mice homozygous for a knock-out allele develop moderate to severe colitis without small intestinal involvement and splenomegaly with a hyperproliferative splenic red pulp. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 16 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,164,546 E685* probably null Het
2700049A03Rik A T 12: 71,164,547 E685V possibly damaging Het
Cd83 A T 13: 43,797,656 T95S probably damaging Het
Cdc27 T C 11: 104,505,638 D819G probably benign Het
Hey2 A T 10: 30,840,446 I64K possibly damaging Het
Itgav T A 2: 83,768,750 probably null Het
Lhx1 G A 11: 84,521,738 R119C probably damaging Het
Ltbp3 G A 19: 5,754,022 R854Q probably benign Het
Obscn T C 11: 59,131,646 R758G possibly damaging Het
Olfr527 A T 7: 140,336,432 Q190L probably benign Het
Siglec1 T C 2: 131,078,725 T720A probably benign Het
Sycp1 T C 3: 102,925,206 I215V probably benign Het
Trim63 A G 4: 134,323,107 E234G probably damaging Het
Vmn2r56 C T 7: 12,694,155 S728N possibly damaging Het
Wdr64 A T 1: 175,698,913 I43L probably benign Het
Wsb1 T C 11: 79,240,352 K406R probably benign Het
Other mutations in Il10rb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Il10rb APN 16 91406339 missense probably benign 0.11
R0393:Il10rb UTSW 16 91412010 missense probably benign 0.13
R1013:Il10rb UTSW 16 91414693 missense probably benign 0.00
R1444:Il10rb UTSW 16 91421787 splice site probably null
R4425:Il10rb UTSW 16 91407715 missense possibly damaging 0.93
R4779:Il10rb UTSW 16 91414657 missense possibly damaging 0.54
R6051:Il10rb UTSW 16 91421864 missense probably benign 0.05
Predicted Primers
Posted On2017-05-11