Mutagenetix > Incidental Mutation

Incidental Mutation 'R2426:Olfr329-ps'

476335

Institutional Source

Beutler Lab

Gene Symbol

Olfr329-ps

Ensembl Gene

ENSMUSG00000064252

Gene Name

olfactory receptor 329, pseudogene

Synonyms

MOR275-6P, GA_x6K02T2NKPP-882068-883006

MMRRC Submission

040388-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

R2426 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

58539801-58546422 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 58543094 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 127 (Y127*)

Ref Sequence

ENSEMBL: ENSMUSP00000151648 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108822] [ENSMUST00000108823] [ENSMUST00000134055] [ENSMUST00000219448]

AlphaFold

M9MMK4

Predicted Effect

probably null
Transcript: ENSMUST00000108822
AA Change: Y140*

SMART Domains

Protein: ENSMUSP00000104450
Gene: ENSMUSG00000064252
AA Change: Y140*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	1.1e-47	PFAM
Pfam:7TM_GPCR_Srsx	33	299	5.1e-7	PFAM
Pfam:7tm_1	39	288	4.6e-28	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000108823
AA Change: Y127*

SMART Domains

Protein: ENSMUSP00000104451
Gene: ENSMUSG00000064252
AA Change: Y127*

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	33	299	5.1e-7	PFAM
Pfam:7tm_1	39	288	4.4e-35	PFAM
Pfam:7tm_4	137	281	5.8e-43	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000134055
AA Change: Y127*

SMART Domains

Protein: ENSMUSP00000145126
Gene: ENSMUSG00000050818
AA Change: Y127*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	312	1.6e-46	PFAM
Pfam:7TM_GPCR_Srsx	39	309	4.4e-6	PFAM
Pfam:7tm_1	45	294	2.3e-27	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000204252
AA Change: Y127*

SMART Domains

Protein: ENSMUSP00000145167
Gene: ENSMUSG00000064252
AA Change: Y127*

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	30	158	4.3e-6	PFAM
Pfam:7tm_4	35	157	5.9e-19	PFAM
Pfam:7tm_1	45	158	2.9e-22	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000219448
AA Change: Y127*

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 96.9%
20x: 93.8%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610010F05Rik	T	A	11: 23,576,801 (GRCm38)	R190W	probably damaging	Het
Abca14	G	T	7: 120,283,223 (GRCm38)	V1203L	probably benign	Het
Adamtsl1	G	A	4: 86,156,788 (GRCm38)	V131I	probably benign	Het
Adgra3	A	T	5: 50,009,449 (GRCm38)	M187K	possibly damaging	Het
Agbl1	T	C	7: 76,421,902 (GRCm38)	V324A	probably damaging	Het
Ahnak	A	T	19: 9,002,851 (GRCm38)	I500F	possibly damaging	Het
Aldh1l1	A	G	6: 90,598,284 (GRCm38)	D851G	probably damaging	Het
Amot	T	C	X: 145,476,291 (GRCm38)	K460E	probably damaging	Het
Arhgef3	G	T	14: 27,384,181 (GRCm38)	E161*	probably null	Het
Atg9b	A	T	5: 24,386,994 (GRCm38)	I669N	probably damaging	Het
AY761184	T	G	8: 21,702,637 (GRCm38)	K114N	possibly damaging	Het
Ccdc83	A	G	7: 90,228,431 (GRCm38)	Y268H	probably damaging	Het
Cep170	A	G	1: 176,774,635 (GRCm38)	S302P	probably benign	Het
Cyp4a31	T	A	4: 115,571,016 (GRCm38)	M303K	probably damaging	Het
Cyp4v3	T	A	8: 45,317,776 (GRCm38)	Y231F	probably benign	Het
Dock3	A	T	9: 106,914,541 (GRCm38)	L1411Q	possibly damaging	Het
Dsg1a	T	A	18: 20,336,804 (GRCm38)	I629N	probably damaging	Het
Dst	A	T	1: 34,192,812 (GRCm38)	H2837L	probably benign	Het
Fam114a2	G	A	11: 57,493,080 (GRCm38)	P343L	probably benign	Het
Fbrs	A	G	7: 127,487,339 (GRCm38)		probably null	Het
Fbxl13	A	C	5: 21,522,137 (GRCm38)	D620E	probably damaging	Het
Frmd4a	T	A	2: 4,529,862 (GRCm38)	S164T	probably damaging	Het
Gdi2	T	G	13: 3,562,034 (GRCm38)	S330A	probably benign	Het
Gm5878	A	T	6: 85,118,631 (GRCm38)	M70K	probably benign	Het
H2-Q6	G	T	17: 35,424,937 (GRCm38)	A21S	probably benign	Het
Hfm1	A	T	5: 106,847,653 (GRCm38)		probably null	Het
Hnmt	C	T	2: 24,019,155 (GRCm38)	C82Y	probably benign	Het
Il1rl1	C	A	1: 40,446,619 (GRCm38)	A310D	probably damaging	Het
Ints1	A	T	5: 139,771,814 (GRCm38)		probably null	Het
Kcne4	C	A	1: 78,817,971 (GRCm38)	A112E	possibly damaging	Het
Krt32	T	C	11: 100,086,366 (GRCm38)	K236R	possibly damaging	Het
Maml2	T	C	9: 13,706,498 (GRCm38)	L380P	probably damaging	Het
Meis1	A	T	11: 18,988,356 (GRCm38)	D218E	possibly damaging	Het
Mon1b	G	A	8: 113,639,120 (GRCm38)	G360D	probably damaging	Het
Mpp4	A	G	1: 59,130,057 (GRCm38)	S383P	probably damaging	Het
Neb	A	G	2: 52,169,053 (GRCm38)		probably null	Het
Nlgn2	A	T	11: 69,827,086 (GRCm38)	I431N	probably damaging	Het
Nr2e1	A	G	10: 42,563,485 (GRCm38)	L134P	probably damaging	Het
Olfr371	T	C	8: 85,231,064 (GRCm38)	S190P	probably damaging	Het
Olfr777	T	C	10: 129,269,266 (GRCm38)	Q19R	probably benign	Het
Opcml	G	A	9: 28,903,367 (GRCm38)		probably null	Het
Pate2	A	T	9: 35,670,480 (GRCm38)		probably null	Het
Pgr	G	A	9: 8,900,717 (GRCm38)	V84M	probably damaging	Het
Pigu	A	T	2: 155,299,082 (GRCm38)	V296D	probably damaging	Het
Plcb2	G	A	2: 118,715,649 (GRCm38)	T555M	probably damaging	Het
Pld5	T	G	1: 175,963,976 (GRCm38)	D426A	probably benign	Het
Prdm2	G	T	4: 143,111,750 (GRCm38)	C1679*	probably null	Het
Psme2b	A	T	11: 48,946,063 (GRCm38)	V19D	probably benign	Het
Ptpn9	A	T	9: 57,027,428 (GRCm38)	N159Y	possibly damaging	Het
Sdc3	A	T	4: 130,818,803 (GRCm38)	T64S	unknown	Het
Serping1	T	G	2: 84,770,219 (GRCm38)	S260R	probably damaging	Het
Slc20a1	T	C	2: 129,208,230 (GRCm38)	F436S	probably benign	Het
Sntb1	A	T	15: 55,906,179 (GRCm38)	I138N	probably damaging	Het
Sorcs3	A	T	19: 48,722,925 (GRCm38)	Y643F	probably damaging	Het
Spink1	G	T	18: 43,735,222 (GRCm38)	S23*	probably null	Het
Stag1	T	C	9: 100,845,116 (GRCm38)		probably null	Het
Tnfaip8l1	G	A	17: 56,172,030 (GRCm38)	V107I	probably benign	Het
Tnik	A	G	3: 28,646,681 (GRCm38)	S907G	probably damaging	Het
Ttf1	T	A	2: 29,067,185 (GRCm38)	M489K	probably damaging	Het
Ugcg	C	T	4: 59,207,798 (GRCm38)	P46S	probably benign	Het
Usp54	G	A	14: 20,564,940 (GRCm38)	A811V	probably benign	Het
Xirp2	A	G	2: 67,514,471 (GRCm38)	N2352S	probably benign	Het
Zan	T	C	5: 137,388,992 (GRCm38)	Y4933C	unknown	Het
Zbtb8a	A	G	4: 129,360,219 (GRCm38)	S161P	probably benign	Het
Zkscan5	A	T	5: 145,220,940 (GRCm38)	I751L	probably benign	Het
Zscan4d	A	G	7: 11,165,095 (GRCm38)	F85S	probably damaging	Het
Zzef1	A	G	11: 72,915,265 (GRCm38)	M2647V	probably benign	Het

Other mutations in Olfr329-ps

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0744:Olfr329-ps	UTSW	11	58,543,162 (GRCm38)	missense	possibly damaging	0.76
R4805:Olfr329-ps	UTSW	11	58,542,570 (GRCm38)	missense	probably benign	0.03
R6498:Olfr329-ps	UTSW	11	58,542,582 (GRCm38)	missense	probably damaging	1.00
R7341:Olfr329-ps	UTSW	11	58,542,707 (GRCm38)	nonsense	probably null
R7768:Olfr329-ps	UTSW	11	58,542,867 (GRCm38)	missense	possibly damaging	0.94
R7768:Olfr329-ps	UTSW	11	58,542,640 (GRCm38)	missense	probably damaging	0.99
R7957:Olfr329-ps	UTSW	11	58,542,798 (GRCm38)	missense	probably damaging	1.00
R8416:Olfr329-ps	UTSW	11	58,542,952 (GRCm38)	missense	possibly damaging	0.75
R9076:Olfr329-ps	UTSW	11	58,542,956 (GRCm38)	nonsense	probably null
R9606:Olfr329-ps	UTSW	11	58,542,927 (GRCm38)	missense	probably damaging	1.00
Z1186:Olfr329-ps	UTSW	11	58,543,446 (GRCm38)	missense	probably benign
Z1187:Olfr329-ps	UTSW	11	58,543,446 (GRCm38)	missense	probably benign
Z1188:Olfr329-ps	UTSW	11	58,543,446 (GRCm38)	missense	probably benign
Z1189:Olfr329-ps	UTSW	11	58,543,446 (GRCm38)	missense	probably benign
Z1190:Olfr329-ps	UTSW	11	58,543,446 (GRCm38)	missense	probably benign
Z1191:Olfr329-ps	UTSW	11	58,543,446 (GRCm38)	missense	probably benign
Z1192:Olfr329-ps	UTSW	11	58,543,446 (GRCm38)	missense	probably benign

Predicted Primers

Posted On

2017-05-11