Incidental Mutation 'R2426:Olfr329-ps'
ID 476335
Institutional Source Beutler Lab
Gene Symbol Olfr329-ps
Ensembl Gene ENSMUSG00000064252
Gene Name olfactory receptor 329, pseudogene
Synonyms MOR275-6P, GA_x6K02T2NKPP-882068-883006
MMRRC Submission 040388-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R2426 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 58539801-58546422 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 58543094 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 127 (Y127*)
Ref Sequence ENSEMBL: ENSMUSP00000151648 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108822] [ENSMUST00000108823] [ENSMUST00000134055] [ENSMUST00000219448]
AlphaFold M9MMK4
Predicted Effect probably null
Transcript: ENSMUST00000108822
AA Change: Y140*
SMART Domains Protein: ENSMUSP00000104450
Gene: ENSMUSG00000064252
AA Change: Y140*

Pfam:7tm_4 29 306 1.1e-47 PFAM
Pfam:7TM_GPCR_Srsx 33 299 5.1e-7 PFAM
Pfam:7tm_1 39 288 4.6e-28 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000108823
AA Change: Y127*
SMART Domains Protein: ENSMUSP00000104451
Gene: ENSMUSG00000064252
AA Change: Y127*

Pfam:7TM_GPCR_Srsx 33 299 5.1e-7 PFAM
Pfam:7tm_1 39 288 4.4e-35 PFAM
Pfam:7tm_4 137 281 5.8e-43 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000134055
AA Change: Y127*
SMART Domains Protein: ENSMUSP00000145126
Gene: ENSMUSG00000050818
AA Change: Y127*

Pfam:7tm_4 35 312 1.6e-46 PFAM
Pfam:7TM_GPCR_Srsx 39 309 4.4e-6 PFAM
Pfam:7tm_1 45 294 2.3e-27 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204252
AA Change: Y127*
SMART Domains Protein: ENSMUSP00000145167
Gene: ENSMUSG00000064252
AA Change: Y127*

Pfam:7TM_GPCR_Srsx 30 158 4.3e-6 PFAM
Pfam:7tm_4 35 157 5.9e-19 PFAM
Pfam:7tm_1 45 158 2.9e-22 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000219448
AA Change: Y127*
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610010F05Rik T A 11: 23,576,801 (GRCm38) R190W probably damaging Het
Abca14 G T 7: 120,283,223 (GRCm38) V1203L probably benign Het
Adamtsl1 G A 4: 86,156,788 (GRCm38) V131I probably benign Het
Adgra3 A T 5: 50,009,449 (GRCm38) M187K possibly damaging Het
Agbl1 T C 7: 76,421,902 (GRCm38) V324A probably damaging Het
Ahnak A T 19: 9,002,851 (GRCm38) I500F possibly damaging Het
Aldh1l1 A G 6: 90,598,284 (GRCm38) D851G probably damaging Het
Amot T C X: 145,476,291 (GRCm38) K460E probably damaging Het
Arhgef3 G T 14: 27,384,181 (GRCm38) E161* probably null Het
Atg9b A T 5: 24,386,994 (GRCm38) I669N probably damaging Het
AY761184 T G 8: 21,702,637 (GRCm38) K114N possibly damaging Het
Ccdc83 A G 7: 90,228,431 (GRCm38) Y268H probably damaging Het
Cep170 A G 1: 176,774,635 (GRCm38) S302P probably benign Het
Cyp4a31 T A 4: 115,571,016 (GRCm38) M303K probably damaging Het
Cyp4v3 T A 8: 45,317,776 (GRCm38) Y231F probably benign Het
Dock3 A T 9: 106,914,541 (GRCm38) L1411Q possibly damaging Het
Dsg1a T A 18: 20,336,804 (GRCm38) I629N probably damaging Het
Dst A T 1: 34,192,812 (GRCm38) H2837L probably benign Het
Fam114a2 G A 11: 57,493,080 (GRCm38) P343L probably benign Het
Fbrs A G 7: 127,487,339 (GRCm38) probably null Het
Fbxl13 A C 5: 21,522,137 (GRCm38) D620E probably damaging Het
Frmd4a T A 2: 4,529,862 (GRCm38) S164T probably damaging Het
Gdi2 T G 13: 3,562,034 (GRCm38) S330A probably benign Het
Gm5878 A T 6: 85,118,631 (GRCm38) M70K probably benign Het
H2-Q6 G T 17: 35,424,937 (GRCm38) A21S probably benign Het
Hfm1 A T 5: 106,847,653 (GRCm38) probably null Het
Hnmt C T 2: 24,019,155 (GRCm38) C82Y probably benign Het
Il1rl1 C A 1: 40,446,619 (GRCm38) A310D probably damaging Het
Ints1 A T 5: 139,771,814 (GRCm38) probably null Het
Kcne4 C A 1: 78,817,971 (GRCm38) A112E possibly damaging Het
Krt32 T C 11: 100,086,366 (GRCm38) K236R possibly damaging Het
Maml2 T C 9: 13,706,498 (GRCm38) L380P probably damaging Het
Meis1 A T 11: 18,988,356 (GRCm38) D218E possibly damaging Het
Mon1b G A 8: 113,639,120 (GRCm38) G360D probably damaging Het
Mpp4 A G 1: 59,130,057 (GRCm38) S383P probably damaging Het
Neb A G 2: 52,169,053 (GRCm38) probably null Het
Nlgn2 A T 11: 69,827,086 (GRCm38) I431N probably damaging Het
Nr2e1 A G 10: 42,563,485 (GRCm38) L134P probably damaging Het
Olfr371 T C 8: 85,231,064 (GRCm38) S190P probably damaging Het
Olfr777 T C 10: 129,269,266 (GRCm38) Q19R probably benign Het
Opcml G A 9: 28,903,367 (GRCm38) probably null Het
Pate2 A T 9: 35,670,480 (GRCm38) probably null Het
Pgr G A 9: 8,900,717 (GRCm38) V84M probably damaging Het
Pigu A T 2: 155,299,082 (GRCm38) V296D probably damaging Het
Plcb2 G A 2: 118,715,649 (GRCm38) T555M probably damaging Het
Pld5 T G 1: 175,963,976 (GRCm38) D426A probably benign Het
Prdm2 G T 4: 143,111,750 (GRCm38) C1679* probably null Het
Psme2b A T 11: 48,946,063 (GRCm38) V19D probably benign Het
Ptpn9 A T 9: 57,027,428 (GRCm38) N159Y possibly damaging Het
Sdc3 A T 4: 130,818,803 (GRCm38) T64S unknown Het
Serping1 T G 2: 84,770,219 (GRCm38) S260R probably damaging Het
Slc20a1 T C 2: 129,208,230 (GRCm38) F436S probably benign Het
Sntb1 A T 15: 55,906,179 (GRCm38) I138N probably damaging Het
Sorcs3 A T 19: 48,722,925 (GRCm38) Y643F probably damaging Het
Spink1 G T 18: 43,735,222 (GRCm38) S23* probably null Het
Stag1 T C 9: 100,845,116 (GRCm38) probably null Het
Tnfaip8l1 G A 17: 56,172,030 (GRCm38) V107I probably benign Het
Tnik A G 3: 28,646,681 (GRCm38) S907G probably damaging Het
Ttf1 T A 2: 29,067,185 (GRCm38) M489K probably damaging Het
Ugcg C T 4: 59,207,798 (GRCm38) P46S probably benign Het
Usp54 G A 14: 20,564,940 (GRCm38) A811V probably benign Het
Xirp2 A G 2: 67,514,471 (GRCm38) N2352S probably benign Het
Zan T C 5: 137,388,992 (GRCm38) Y4933C unknown Het
Zbtb8a A G 4: 129,360,219 (GRCm38) S161P probably benign Het
Zkscan5 A T 5: 145,220,940 (GRCm38) I751L probably benign Het
Zscan4d A G 7: 11,165,095 (GRCm38) F85S probably damaging Het
Zzef1 A G 11: 72,915,265 (GRCm38) M2647V probably benign Het
Other mutations in Olfr329-ps
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0744:Olfr329-ps UTSW 11 58,543,162 (GRCm38) missense possibly damaging 0.76
R4805:Olfr329-ps UTSW 11 58,542,570 (GRCm38) missense probably benign 0.03
R6498:Olfr329-ps UTSW 11 58,542,582 (GRCm38) missense probably damaging 1.00
R7341:Olfr329-ps UTSW 11 58,542,707 (GRCm38) nonsense probably null
R7768:Olfr329-ps UTSW 11 58,542,867 (GRCm38) missense possibly damaging 0.94
R7768:Olfr329-ps UTSW 11 58,542,640 (GRCm38) missense probably damaging 0.99
R7957:Olfr329-ps UTSW 11 58,542,798 (GRCm38) missense probably damaging 1.00
R8416:Olfr329-ps UTSW 11 58,542,952 (GRCm38) missense possibly damaging 0.75
R9076:Olfr329-ps UTSW 11 58,542,956 (GRCm38) nonsense probably null
R9606:Olfr329-ps UTSW 11 58,542,927 (GRCm38) missense probably damaging 1.00
Z1186:Olfr329-ps UTSW 11 58,543,446 (GRCm38) missense probably benign
Z1187:Olfr329-ps UTSW 11 58,543,446 (GRCm38) missense probably benign
Z1188:Olfr329-ps UTSW 11 58,543,446 (GRCm38) missense probably benign
Z1189:Olfr329-ps UTSW 11 58,543,446 (GRCm38) missense probably benign
Z1190:Olfr329-ps UTSW 11 58,543,446 (GRCm38) missense probably benign
Z1191:Olfr329-ps UTSW 11 58,543,446 (GRCm38) missense probably benign
Z1192:Olfr329-ps UTSW 11 58,543,446 (GRCm38) missense probably benign
Predicted Primers
Posted On 2017-05-11