Incidental Mutation 'R2655:Prb1'
ID476526
Institutional Source Beutler Lab
Gene Symbol Prb1
Ensembl Gene ENSMUSG00000067543
Gene Nameproline-rich protein BstNI subfamily 1
Synonymsproline-rich proteoglycan 2
MMRRC Submission 040430-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.070) question?
Stock #R2655 (G1)
Quality Score139
Status Not validated
Chromosome6
Chromosomal Location132206795-132210521 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to C at 132210462 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Glutamic Acid at position 19 (Q19E)
Ref Sequence ENSEMBL: ENSMUSP00000085159 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087853]
Predicted Effect unknown
Transcript: ENSMUST00000087853
AA Change: Q19E
SMART Domains Protein: ENSMUSP00000085159
Gene: ENSMUSG00000067543
AA Change: Q19E

DomainStartEndE-ValueType
Pfam:Pro-rich 1 118 6.7e-33 PFAM
Pfam:Pro-rich 115 195 4e-13 PFAM
Pfam:Pro-rich 191 269 2.6e-13 PFAM
Pfam:Pro-rich 229 305 1.2e-10 PFAM
Pfam:Pro-rich 264 342 3.3e-11 PFAM
Pfam:Pro-rich 302 366 7.6e-12 PFAM
Pfam:Pro-rich 338 403 7.5e-11 PFAM
Pfam:Pro-rich 357 434 1.3e-10 PFAM
Pfam:Pro-rich 394 454 1.9e-11 PFAM
Pfam:Pro-rich 430 498 8.8e-12 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 100% (39/39)
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot5 T A 12: 84,075,876 S411R probably benign Het
Adamts12 A T 15: 11,065,088 N20Y possibly damaging Het
Bbs9 G A 9: 22,504,052 E91K probably damaging Het
Casp4 C A 9: 5,322,894 L57I possibly damaging Het
Cat T C 2: 103,471,846 K169E probably damaging Het
Cav1 A G 6: 17,339,360 Y148C probably damaging Het
Cep112 T C 11: 108,437,201 probably benign Het
Chaf1b T C 16: 93,891,511 S165P probably damaging Het
Crat A G 2: 30,402,691 S115P probably damaging Het
Eif2b1 A G 5: 124,576,854 S120P probably damaging Het
Epor A G 9: 21,960,720 S236P probably damaging Het
Ggt1 T A 10: 75,581,385 Y5* probably null Het
Igfbpl1 T C 4: 45,816,289 T179A probably damaging Het
Ighv14-4 T G 12: 114,176,448 Y114S probably damaging Het
Ipcef1 T C 10: 6,979,657 I29V probably benign Het
Junb A G 8: 84,977,508 S308P probably damaging Het
Kcnh5 T C 12: 75,114,540 E198G probably damaging Het
Ltbp1 G A 17: 75,005,983 R33H possibly damaging Het
Map3k20 C A 2: 72,433,420 T471K probably damaging Het
Nr2c2 C T 6: 92,163,138 R464W probably damaging Het
Olfr642 T C 7: 104,049,431 M308V probably benign Het
Olfr955 A T 9: 39,470,628 S33T probably benign Het
Patj T C 4: 98,437,450 V508A possibly damaging Het
Pkd1 T C 17: 24,576,490 V2319A probably damaging Het
Pnpla7 A G 2: 25,052,318 Y83C probably damaging Het
Rasa3 T C 8: 13,595,373 T189A possibly damaging Het
Reck T A 4: 43,938,966 D777E probably benign Het
Rfx6 A G 10: 51,693,777 probably benign Het
Serpinb13 A G 1: 107,000,427 D259G probably damaging Het
Slit2 G A 5: 48,189,575 R253Q possibly damaging Het
Slu7 A G 11: 43,440,648 E203G probably benign Het
Syt4 A T 18: 31,443,544 D252E probably benign Het
Tpte A G 8: 22,311,278 probably null Het
Ttc25 T A 11: 100,553,579 W237R probably damaging Het
Ttll7 A G 3: 146,947,621 Y729C probably damaging Het
Usp35 T A 7: 97,312,147 T691S probably benign Het
Vmn1r211 A G 13: 22,852,416 V27A probably benign Het
Vmn2r72 T C 7: 85,751,269 T191A possibly damaging Het
Vwa5b1 C T 4: 138,594,303 G393D probably damaging Het
Other mutations in Prb1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00670:Prb1 APN 6 132207146 utr 3 prime probably benign
IGL01017:Prb1 APN 6 132207231 missense unknown
R0369:Prb1 UTSW 6 132207657 nonsense probably null
R1500:Prb1 UTSW 6 132207476 missense unknown
R1544:Prb1 UTSW 6 132209460 critical splice acceptor site probably null
R1544:Prb1 UTSW 6 132209461 critical splice acceptor site probably null
R1559:Prb1 UTSW 6 132208544 missense unknown
R2142:Prb1 UTSW 6 132207203 missense unknown
R4065:Prb1 UTSW 6 132207695 missense unknown
R4505:Prb1 UTSW 6 132207570 nonsense probably null
R5925:Prb1 UTSW 6 132210512 missense unknown
R6391:Prb1 UTSW 6 132207176 missense unknown
R6525:Prb1 UTSW 6 132207504 missense unknown
R6745:Prb1 UTSW 6 132209420 splice site probably null
R7192:Prb1 UTSW 6 132207372 missense unknown
R7536:Prb1 UTSW 6 132207221 missense unknown
Predicted Primers
Posted On2017-05-11