Incidental Mutation 'R2566:Rapgef6'
| ID |
476639 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rapgef6
|
| Ensembl Gene |
ENSMUSG00000037533 |
| Gene Name |
Rap guanine nucleotide exchange factor (GEF) 6 |
| Synonyms |
PDZ-GEF2, Pdzgef2, C030018K18Rik, RA-GEF-2 |
| MMRRC Submission |
040425-MU
|
| Accession Numbers |
Genbank: NM_175258; MGI: 2384761 |
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2566 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
54522847-54699285 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 54687711 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 1028
(T1028A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104522
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094536]
[ENSMUST00000101206]
[ENSMUST00000102743]
[ENSMUST00000108894]
[ENSMUST00000207429]
|
| AlphaFold |
Q5NCJ1 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000094536
AA Change: T1020A
PolyPhen 2
Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000092114
Gene: ENSMUSG00000037533
AA Change: T1020A
| Domain | Start | End | E-Value | Type |
|---|
|
cNMP
|
1 |
113 |
6.64e-7 |
SMART |
|
RasGEFN
|
127 |
240 |
4.35e-33 |
SMART |
|
PDZ
|
255 |
327 |
8.86e-16 |
SMART |
|
low complexity region
|
409 |
420 |
N/A |
INTRINSIC |
|
RA
|
464 |
550 |
1.47e-20 |
SMART |
|
RasGEF
|
571 |
853 |
3.88e-84 |
SMART |
|
low complexity region
|
944 |
957 |
N/A |
INTRINSIC |
|
low complexity region
|
972 |
989 |
N/A |
INTRINSIC |
|
low complexity region
|
1016 |
1061 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000101206
|
| SMART Domains |
Protein: ENSMUSP00000098766
Gene: ENSMUSG00000037533
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
10 |
82 |
1.45e-5 |
PROSPERO |
|
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
|
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
|
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
|
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
|
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
|
RA
|
749 |
835 |
1.47e-20 |
SMART |
|
RasGEF
|
856 |
1095 |
5.35e-87 |
SMART |
|
low complexity region
|
1237 |
1250 |
N/A |
INTRINSIC |
|
low complexity region
|
1270 |
1293 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1364 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1380 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1452 |
N/A |
INTRINSIC |
|
low complexity region
|
1555 |
1568 |
N/A |
INTRINSIC |
|
low complexity region
|
1591 |
1604 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000102743
|
| SMART Domains |
Protein: ENSMUSP00000099804
Gene: ENSMUSG00000037533
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
10 |
82 |
1.42e-5 |
PROSPERO |
|
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
|
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
|
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
|
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
|
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
|
RA
|
749 |
835 |
1.47e-20 |
SMART |
|
RasGEF
|
856 |
1138 |
3.88e-84 |
SMART |
|
low complexity region
|
1229 |
1242 |
N/A |
INTRINSIC |
|
low complexity region
|
1262 |
1285 |
N/A |
INTRINSIC |
|
low complexity region
|
1337 |
1356 |
N/A |
INTRINSIC |
|
low complexity region
|
1360 |
1372 |
N/A |
INTRINSIC |
|
low complexity region
|
1436 |
1444 |
N/A |
INTRINSIC |
|
low complexity region
|
1547 |
1560 |
N/A |
INTRINSIC |
|
low complexity region
|
1583 |
1596 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000108894
AA Change: T1028A
PolyPhen 2
Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000104522
Gene: ENSMUSG00000037533
AA Change: T1028A
| Domain | Start | End | E-Value | Type |
|---|
|
cNMP
|
1 |
113 |
6.64e-7 |
SMART |
|
RasGEFN
|
127 |
240 |
4.35e-33 |
SMART |
|
PDZ
|
255 |
327 |
8.86e-16 |
SMART |
|
low complexity region
|
409 |
420 |
N/A |
INTRINSIC |
|
RA
|
464 |
550 |
1.47e-20 |
SMART |
|
RasGEF
|
571 |
810 |
5.35e-87 |
SMART |
|
low complexity region
|
952 |
965 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
997 |
N/A |
INTRINSIC |
|
low complexity region
|
1024 |
1069 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000136494
|
| SMART Domains |
Protein: ENSMUSP00000114574
Gene: ENSMUSG00000037533
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
47 |
55 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000207429
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele exhibit an inlarged spleen, increased IgE and IgG levels and altered cytokine production. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(16) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(13) |
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2010315B03Rik |
T |
A |
9: 124,293,153 (GRCm38) |
K380N |
probably damaging |
Het |
| 2010315B03Rik |
T |
C |
9: 124,293,071 (GRCm38) |
K408E |
probably damaging |
Het |
| 9230104M06Rik |
C |
T |
12: 113,000,739 (GRCm38) |
|
probably benign |
Het |
| Ahi1 |
T |
A |
10: 20,970,911 (GRCm38) |
C413* |
probably null |
Het |
| Alms1 |
T |
A |
6: 85,622,482 (GRCm38) |
M1430K |
possibly damaging |
Het |
| Ankrd52 |
G |
T |
10: 128,389,351 (GRCm38) |
A894S |
probably benign |
Het |
| Arhgap33 |
C |
A |
7: 30,527,229 (GRCm38) |
V494L |
probably damaging |
Het |
| Atic |
G |
T |
1: 71,568,971 (GRCm38) |
V275F |
probably damaging |
Het |
| Atoh1 |
T |
A |
6: 64,729,684 (GRCm38) |
V121E |
probably damaging |
Het |
| Atp5h |
T |
A |
11: 115,416,038 (GRCm38) |
|
probably null |
Het |
| Baiap2l2 |
A |
T |
15: 79,261,974 (GRCm38) |
|
probably null |
Het |
| Brca2 |
A |
T |
5: 150,541,762 (GRCm38) |
T1664S |
probably benign |
Het |
| Cdh15 |
G |
A |
8: 122,862,024 (GRCm38) |
R279Q |
probably damaging |
Het |
| Celf3 |
ACAGCAGCAGCAGCAGCAGCAGCA |
ACAGCAGCAGCAGCAGCAGCA |
3: 94,488,230 (GRCm38) |
|
probably benign |
Het |
| Cep350 |
A |
T |
1: 155,959,718 (GRCm38) |
|
probably null |
Het |
| Ces2g |
T |
C |
8: 104,965,989 (GRCm38) |
|
probably null |
Het |
| Csmd3 |
CCTTTGCGCTT |
CCTT |
15: 47,741,236 (GRCm38) |
|
probably null |
Het |
| Cyp2d34 |
A |
G |
15: 82,616,167 (GRCm38) |
F457S |
probably damaging |
Het |
| Disp3 |
T |
A |
4: 148,241,423 (GRCm38) |
T1293S |
probably damaging |
Het |
| Dock10 |
T |
A |
1: 80,540,253 (GRCm38) |
I1348F |
possibly damaging |
Het |
| Dsp |
A |
T |
13: 38,196,404 (GRCm38) |
H1776L |
probably damaging |
Het |
| Efhd1 |
A |
T |
1: 87,309,755 (GRCm38) |
Q228L |
possibly damaging |
Het |
| Entpd2 |
T |
A |
2: 25,399,283 (GRCm38) |
I259N |
probably benign |
Het |
| Fam149b |
A |
T |
14: 20,375,510 (GRCm38) |
M138L |
probably damaging |
Het |
| Fastkd5 |
T |
C |
2: 130,616,365 (GRCm38) |
K102E |
probably benign |
Het |
| Fzd7 |
C |
A |
1: 59,484,536 (GRCm38) |
T526K |
possibly damaging |
Het |
| G6pd2 |
T |
A |
5: 61,808,987 (GRCm38) |
I35N |
probably damaging |
Het |
| Gars |
T |
A |
6: 55,065,563 (GRCm38) |
M427K |
probably damaging |
Het |
| Gimap4 |
C |
T |
6: 48,690,865 (GRCm38) |
R57C |
probably damaging |
Het |
| Gm11232 |
C |
A |
4: 71,757,785 (GRCm38) |
W41L |
probably benign |
Het |
| Gm15737 |
T |
A |
6: 92,879,720 (GRCm38) |
C43* |
probably null |
Het |
| Gm853 |
A |
T |
4: 130,209,888 (GRCm38) |
L420Q |
probably benign |
Het |
| Gpr180 |
T |
C |
14: 118,139,773 (GRCm38) |
V62A |
probably benign |
Het |
| H2-M11 |
C |
T |
17: 36,548,150 (GRCm38) |
T194I |
possibly damaging |
Het |
| Jakmip3 |
A |
T |
7: 138,989,468 (GRCm38) |
E27V |
possibly damaging |
Het |
| Kcnq3 |
T |
C |
15: 66,031,427 (GRCm38) |
T145A |
probably damaging |
Het |
| Krt8 |
A |
G |
15: 101,998,024 (GRCm38) |
M350T |
probably benign |
Het |
| Krtap4-9 |
T |
A |
11: 99,785,666 (GRCm38) |
|
probably benign |
Het |
| Lbr |
G |
T |
1: 181,836,127 (GRCm38) |
D109E |
probably damaging |
Het |
| Med23 |
A |
G |
10: 24,888,575 (GRCm38) |
H42R |
probably damaging |
Het |
| Mgat5 |
A |
T |
1: 127,307,004 (GRCm38) |
M77L |
probably benign |
Het |
| Mlf1 |
A |
T |
3: 67,384,586 (GRCm38) |
N28I |
possibly damaging |
Het |
| Mroh3 |
A |
C |
1: 136,198,126 (GRCm38) |
L343R |
probably damaging |
Het |
| Mrpl37 |
T |
A |
4: 107,064,493 (GRCm38) |
I180F |
possibly damaging |
Het |
| Mrps27 |
T |
A |
13: 99,400,328 (GRCm38) |
C116* |
probably null |
Het |
| Muc6 |
A |
G |
7: 141,640,384 (GRCm38) |
S1354P |
possibly damaging |
Het |
| Myh7 |
A |
T |
14: 54,983,242 (GRCm38) |
D1033E |
probably damaging |
Het |
| Myo16 |
A |
T |
8: 10,594,820 (GRCm38) |
E1717D |
probably benign |
Het |
| Myo1g |
T |
A |
11: 6,512,539 (GRCm38) |
|
probably null |
Het |
| Olfr610 |
A |
G |
7: 103,506,160 (GRCm38) |
M262T |
probably benign |
Het |
| Olfr815 |
A |
C |
10: 129,902,095 (GRCm38) |
L205R |
probably damaging |
Het |
| Pan2 |
T |
C |
10: 128,313,897 (GRCm38) |
L576P |
probably damaging |
Het |
| Parp8 |
A |
G |
13: 116,895,687 (GRCm38) |
S278P |
possibly damaging |
Het |
| Pdk2 |
A |
G |
11: 95,027,202 (GRCm38) |
|
probably null |
Het |
| Phf1 |
T |
C |
17: 26,937,088 (GRCm38) |
S450P |
probably damaging |
Het |
| Pkd1l2 |
T |
C |
8: 117,019,494 (GRCm38) |
Y1919C |
probably damaging |
Het |
| Postn |
T |
A |
3: 54,376,953 (GRCm38) |
S614T |
probably damaging |
Het |
| Psmg1 |
A |
T |
16: 95,982,195 (GRCm38) |
Y213* |
probably null |
Het |
| Rab11b |
T |
A |
17: 33,747,718 (GRCm38) |
T203S |
probably benign |
Het |
| Rad54l2 |
T |
A |
9: 106,703,626 (GRCm38) |
T899S |
possibly damaging |
Het |
| Ramp2 |
TTGCTGCTGCTGCTGCTGCTGCTG |
TTGCTGCTGCTGCTGCTGCTG |
11: 101,246,545 (GRCm38) |
|
probably benign |
Het |
| Rbm6 |
A |
G |
9: 107,791,998 (GRCm38) |
S58P |
possibly damaging |
Het |
| Rreb1 |
G |
T |
13: 37,929,792 (GRCm38) |
A376S |
possibly damaging |
Het |
| Rsbn1l |
T |
A |
5: 20,919,769 (GRCm38) |
N345I |
probably benign |
Het |
| Sf3b2 |
A |
T |
19: 5,275,090 (GRCm38) |
S785T |
possibly damaging |
Het |
| Sh2b1 |
C |
T |
7: 126,468,926 (GRCm38) |
D519N |
probably damaging |
Het |
| Slitrk6 |
T |
C |
14: 110,750,272 (GRCm38) |
T668A |
probably benign |
Het |
| Stkld1 |
T |
A |
2: 26,950,638 (GRCm38) |
I444N |
probably damaging |
Het |
| Sucla2 |
A |
T |
14: 73,552,804 (GRCm38) |
|
probably benign |
Het |
| Tmem67 |
T |
A |
4: 12,079,918 (GRCm38) |
L190F |
probably damaging |
Het |
| Tns2 |
C |
T |
15: 102,108,934 (GRCm38) |
R281C |
probably damaging |
Het |
| Trem2 |
G |
A |
17: 48,351,835 (GRCm38) |
W191* |
probably null |
Het |
| Ube2d4 |
A |
T |
15: 58,846,679 (GRCm38) |
|
noncoding transcript |
Het |
| Uimc1 |
G |
T |
13: 55,075,804 (GRCm38) |
D218E |
probably damaging |
Het |
| Wdr62 |
A |
T |
7: 30,273,999 (GRCm38) |
V95E |
probably damaging |
Het |
| Zfhx4 |
T |
C |
3: 5,245,143 (GRCm38) |
V862A |
probably damaging |
Het |
| Zfp462 |
T |
A |
4: 55,008,522 (GRCm38) |
S163T |
probably benign |
Het |
| Zfp704 |
T |
C |
3: 9,609,493 (GRCm38) |
D76G |
unknown |
Het |
|
| Other mutations in Rapgef6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00436:Rapgef6
|
APN |
11 |
54,679,265 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL00507:Rapgef6
|
APN |
11 |
54,664,109 (GRCm38) |
nonsense |
probably null |
|
|
IGL00809:Rapgef6
|
APN |
11 |
54,649,300 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00843:Rapgef6
|
APN |
11 |
54,691,273 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL00899:Rapgef6
|
APN |
11 |
54,620,018 (GRCm38) |
nonsense |
probably null |
|
|
IGL01372:Rapgef6
|
APN |
11 |
54,668,611 (GRCm38) |
splice site |
probably benign |
|
|
IGL01604:Rapgef6
|
APN |
11 |
54,694,563 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01935:Rapgef6
|
APN |
11 |
54,610,842 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
IGL01991:Rapgef6
|
APN |
11 |
54,552,869 (GRCm38) |
missense |
probably benign |
0.37 |
|
IGL02243:Rapgef6
|
APN |
11 |
54,676,400 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02407:Rapgef6
|
APN |
11 |
54,676,355 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
IGL02676:Rapgef6
|
APN |
11 |
54,649,346 (GRCm38) |
unclassified |
probably benign |
|
|
IGL02934:Rapgef6
|
APN |
11 |
54,625,864 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03076:Rapgef6
|
APN |
11 |
54,625,967 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03110:Rapgef6
|
APN |
11 |
54,696,089 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL03256:Rapgef6
|
APN |
11 |
54,657,429 (GRCm38) |
missense |
probably damaging |
1.00 |
|
shocker
|
UTSW |
11 |
54,620,016 (GRCm38) |
missense |
probably damaging |
1.00 |
|
D4216:Rapgef6
|
UTSW |
11 |
54,668,746 (GRCm38) |
splice site |
probably benign |
|
|
PIT4305001:Rapgef6
|
UTSW |
11 |
54,679,377 (GRCm38) |
missense |
probably damaging |
1.00 |
|
PIT4366001:Rapgef6
|
UTSW |
11 |
54,691,620 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0047:Rapgef6
|
UTSW |
11 |
54,546,378 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R0047:Rapgef6
|
UTSW |
11 |
54,546,378 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R0125:Rapgef6
|
UTSW |
11 |
54,625,875 (GRCm38) |
nonsense |
probably null |
|
|
R0189:Rapgef6
|
UTSW |
11 |
54,691,249 (GRCm38) |
missense |
probably benign |
|
|
R0201:Rapgef6
|
UTSW |
11 |
54,619,941 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0505:Rapgef6
|
UTSW |
11 |
54,625,963 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0524:Rapgef6
|
UTSW |
11 |
54,690,284 (GRCm38) |
missense |
probably benign |
0.32 |
|
R0853:Rapgef6
|
UTSW |
11 |
54,668,677 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1203:Rapgef6
|
UTSW |
11 |
54,691,699 (GRCm38) |
missense |
probably benign |
0.09 |
|
R1440:Rapgef6
|
UTSW |
11 |
54,626,708 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1453:Rapgef6
|
UTSW |
11 |
54,639,727 (GRCm38) |
splice site |
probably null |
|
|
R1530:Rapgef6
|
UTSW |
11 |
54,661,183 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1593:Rapgef6
|
UTSW |
11 |
54,546,397 (GRCm38) |
frame shift |
probably null |
|
|
R1620:Rapgef6
|
UTSW |
11 |
54,626,594 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R1628:Rapgef6
|
UTSW |
11 |
54,546,397 (GRCm38) |
frame shift |
probably null |
|
|
R1629:Rapgef6
|
UTSW |
11 |
54,546,397 (GRCm38) |
frame shift |
probably null |
|
|
R1630:Rapgef6
|
UTSW |
11 |
54,546,397 (GRCm38) |
frame shift |
probably null |
|
|
R1634:Rapgef6
|
UTSW |
11 |
54,546,397 (GRCm38) |
frame shift |
probably null |
|
|
R1640:Rapgef6
|
UTSW |
11 |
54,657,405 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1686:Rapgef6
|
UTSW |
11 |
54,691,632 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R1722:Rapgef6
|
UTSW |
11 |
54,546,397 (GRCm38) |
frame shift |
probably null |
|
|
R1743:Rapgef6
|
UTSW |
11 |
54,676,284 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1816:Rapgef6
|
UTSW |
11 |
54,694,488 (GRCm38) |
missense |
probably benign |
|
|
R1851:Rapgef6
|
UTSW |
11 |
54,642,811 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1852:Rapgef6
|
UTSW |
11 |
54,642,811 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1868:Rapgef6
|
UTSW |
11 |
54,546,397 (GRCm38) |
frame shift |
probably null |
|
|
R1888:Rapgef6
|
UTSW |
11 |
54,660,828 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1888:Rapgef6
|
UTSW |
11 |
54,660,828 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1942:Rapgef6
|
UTSW |
11 |
54,657,263 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1943:Rapgef6
|
UTSW |
11 |
54,657,263 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R2031:Rapgef6
|
UTSW |
11 |
54,552,858 (GRCm38) |
missense |
probably benign |
0.30 |
|
R2087:Rapgef6
|
UTSW |
11 |
54,631,249 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2106:Rapgef6
|
UTSW |
11 |
54,668,686 (GRCm38) |
missense |
probably benign |
0.17 |
|
R2362:Rapgef6
|
UTSW |
11 |
54,694,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2484:Rapgef6
|
UTSW |
11 |
54,642,756 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R2872:Rapgef6
|
UTSW |
11 |
54,661,175 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2872:Rapgef6
|
UTSW |
11 |
54,661,175 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3744:Rapgef6
|
UTSW |
11 |
54,625,934 (GRCm38) |
missense |
probably benign |
0.40 |
|
R3848:Rapgef6
|
UTSW |
11 |
54,691,308 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4823:Rapgef6
|
UTSW |
11 |
54,694,500 (GRCm38) |
missense |
probably benign |
0.08 |
|
R4859:Rapgef6
|
UTSW |
11 |
54,636,163 (GRCm38) |
missense |
probably benign |
|
|
R4906:Rapgef6
|
UTSW |
11 |
54,552,836 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4911:Rapgef6
|
UTSW |
11 |
54,622,317 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4937:Rapgef6
|
UTSW |
11 |
54,657,317 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5033:Rapgef6
|
UTSW |
11 |
54,691,381 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R5249:Rapgef6
|
UTSW |
11 |
54,523,117 (GRCm38) |
missense |
probably benign |
0.19 |
|
R5304:Rapgef6
|
UTSW |
11 |
54,657,374 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5656:Rapgef6
|
UTSW |
11 |
54,636,136 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R5701:Rapgef6
|
UTSW |
11 |
54,676,394 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
R5758:Rapgef6
|
UTSW |
11 |
54,668,644 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5973:Rapgef6
|
UTSW |
11 |
54,639,783 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6177:Rapgef6
|
UTSW |
11 |
54,620,016 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6268:Rapgef6
|
UTSW |
11 |
54,649,247 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6287:Rapgef6
|
UTSW |
11 |
54,626,338 (GRCm38) |
splice site |
probably null |
|
|
R6293:Rapgef6
|
UTSW |
11 |
54,634,781 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6471:Rapgef6
|
UTSW |
11 |
54,691,737 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6863:Rapgef6
|
UTSW |
11 |
54,546,380 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6950:Rapgef6
|
UTSW |
11 |
54,676,380 (GRCm38) |
missense |
probably benign |
0.09 |
|
R7144:Rapgef6
|
UTSW |
11 |
54,657,365 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R7171:Rapgef6
|
UTSW |
11 |
54,676,363 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7199:Rapgef6
|
UTSW |
11 |
54,546,426 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7291:Rapgef6
|
UTSW |
11 |
54,691,239 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7436:Rapgef6
|
UTSW |
11 |
54,610,921 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7498:Rapgef6
|
UTSW |
11 |
54,620,004 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7506:Rapgef6
|
UTSW |
11 |
54,636,171 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7527:Rapgef6
|
UTSW |
11 |
54,634,961 (GRCm38) |
missense |
unknown |
|
|
R7646:Rapgef6
|
UTSW |
11 |
54,625,954 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7655:Rapgef6
|
UTSW |
11 |
54,694,453 (GRCm38) |
missense |
probably benign |
0.10 |
|
R7656:Rapgef6
|
UTSW |
11 |
54,694,453 (GRCm38) |
missense |
probably benign |
0.10 |
|
R7687:Rapgef6
|
UTSW |
11 |
54,661,075 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R7768:Rapgef6
|
UTSW |
11 |
54,626,588 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7788:Rapgef6
|
UTSW |
11 |
54,694,399 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7890:Rapgef6
|
UTSW |
11 |
54,626,723 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8113:Rapgef6
|
UTSW |
11 |
54,625,958 (GRCm38) |
missense |
probably benign |
0.03 |
|
R8337:Rapgef6
|
UTSW |
11 |
54,631,301 (GRCm38) |
nonsense |
probably null |
|
|
R8393:Rapgef6
|
UTSW |
11 |
54,687,661 (GRCm38) |
missense |
probably benign |
|
|
R8465:Rapgef6
|
UTSW |
11 |
54,691,482 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8492:Rapgef6
|
UTSW |
11 |
54,690,237 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8791:Rapgef6
|
UTSW |
11 |
54,568,469 (GRCm38) |
missense |
probably benign |
0.15 |
|
R8866:Rapgef6
|
UTSW |
11 |
54,552,874 (GRCm38) |
critical splice donor site |
probably null |
|
|
R8917:Rapgef6
|
UTSW |
11 |
54,691,566 (GRCm38) |
nonsense |
probably null |
|
|
R8921:Rapgef6
|
UTSW |
11 |
54,679,239 (GRCm38) |
missense |
probably benign |
0.09 |
|
R9031:Rapgef6
|
UTSW |
11 |
54,687,841 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9093:Rapgef6
|
UTSW |
11 |
54,597,086 (GRCm38) |
nonsense |
probably null |
|
|
R9354:Rapgef6
|
UTSW |
11 |
54,619,923 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R9514:Rapgef6
|
UTSW |
11 |
54,552,858 (GRCm38) |
missense |
probably benign |
0.14 |
|
R9516:Rapgef6
|
UTSW |
11 |
54,691,343 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9739:Rapgef6
|
UTSW |
11 |
54,622,363 (GRCm38) |
missense |
probably benign |
0.03 |
|
R9789:Rapgef6
|
UTSW |
11 |
54,649,271 (GRCm38) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
|
| Posted On |
2017-05-11 |
Incidental Mutation