Incidental Mutation 'R2860:Wiz'
ID 476865
Institutional Source Beutler Lab
Gene Symbol Wiz
Ensembl Gene ENSMUSG00000024050
Gene Name widely-interspaced zinc finger motifs
Synonyms
MMRRC Submission 040450-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R2860 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 32573029-32608413 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 32580680 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 257 (T257K)
Ref Sequence ENSEMBL: ENSMUSP00000069443 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064694] [ENSMUST00000087703] [ENSMUST00000163107] [ENSMUST00000165912] [ENSMUST00000169488] [ENSMUST00000170617]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000064694
AA Change: T257K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000069443
Gene: ENSMUSG00000024050
AA Change: T257K

DomainStartEndE-ValueType
low complexity region 27 35 N/A INTRINSIC
ZnF_C2H2 74 96 8.67e-1 SMART
ZnF_C2H2 175 197 4.72e-2 SMART
ZnF_C2H2 348 370 1.67e-2 SMART
low complexity region 401 412 N/A INTRINSIC
low complexity region 439 458 N/A INTRINSIC
ZnF_C2H2 532 554 1.67e-2 SMART
low complexity region 576 588 N/A INTRINSIC
low complexity region 607 623 N/A INTRINSIC
ZnF_C2H2 702 724 1.41e0 SMART
low complexity region 784 793 N/A INTRINSIC
low complexity region 869 887 N/A INTRINSIC
ZnF_C2H2 901 927 1.06e2 SMART
low complexity region 936 956 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000087703
AA Change: T257K

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000084993
Gene: ENSMUSG00000024050
AA Change: T257K

DomainStartEndE-ValueType
low complexity region 27 35 N/A INTRINSIC
ZnF_C2H2 74 96 8.67e-1 SMART
ZnF_C2H2 175 197 4.72e-2 SMART
ZnF_C2H2 348 370 1.67e-2 SMART
low complexity region 401 412 N/A INTRINSIC
low complexity region 439 458 N/A INTRINSIC
ZnF_C2H2 531 553 1.67e-2 SMART
low complexity region 575 587 N/A INTRINSIC
low complexity region 606 622 N/A INTRINSIC
ZnF_C2H2 701 723 1.41e0 SMART
low complexity region 783 792 N/A INTRINSIC
low complexity region 868 886 N/A INTRINSIC
ZnF_C2H2 900 926 1.06e2 SMART
low complexity region 935 955 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000163107
SMART Domains Protein: ENSMUSP00000127943
Gene: ENSMUSG00000024050

DomainStartEndE-ValueType
low complexity region 27 35 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000165912
SMART Domains Protein: ENSMUSP00000127651
Gene: ENSMUSG00000024050

DomainStartEndE-ValueType
low complexity region 27 35 N/A INTRINSIC
ZnF_C2H2 74 96 8.67e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168943
Predicted Effect probably benign
Transcript: ENSMUST00000169488
AA Change: T136K

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000126253
Gene: ENSMUSG00000024050
AA Change: T136K

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
ZnF_C2H2 54 76 4.72e-2 SMART
ZnF_C2H2 227 249 3.52e-1 SMART
low complexity region 294 318 N/A INTRINSIC
ZnF_C2H2 357 379 1.67e-2 SMART
low complexity region 410 421 N/A INTRINSIC
low complexity region 448 467 N/A INTRINSIC
ZnF_C2H2 541 563 1.67e-2 SMART
low complexity region 585 597 N/A INTRINSIC
low complexity region 616 632 N/A INTRINSIC
ZnF_C2H2 711 733 1.41e0 SMART
low complexity region 793 802 N/A INTRINSIC
low complexity region 878 896 N/A INTRINSIC
ZnF_C2H2 910 936 1.06e2 SMART
low complexity region 945 965 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000169741
Predicted Effect probably benign
Transcript: ENSMUST00000170617
SMART Domains Protein: ENSMUSP00000130517
Gene: ENSMUSG00000024050

DomainStartEndE-ValueType
low complexity region 27 35 N/A INTRINSIC
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 94.9%
Validation Efficiency 100% (44/44)
MGI Phenotype PHENOTYPE: Homozygous mutant mice die prenatally. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,259,057 (GRCm39) S2928G probably damaging Het
Abcc9 C T 6: 142,571,736 (GRCm39) V1131M probably benign Het
Abcd1 T A X: 72,781,064 (GRCm39) L713H probably damaging Het
Actg1 T C 11: 120,237,627 (GRCm39) I52V probably benign Het
Ang G T 14: 51,339,275 (GRCm39) D139Y probably damaging Het
Ano1 C T 7: 144,143,749 (GRCm39) G1011E probably damaging Het
Apoe T C 7: 19,431,479 (GRCm39) Y46C probably damaging Het
Ash1l T C 3: 88,961,785 (GRCm39) W2386R probably damaging Het
Asph T C 4: 9,598,277 (GRCm39) D250G probably damaging Het
Atr A G 9: 95,756,296 (GRCm39) N836S probably benign Het
Bltp1 G A 3: 37,019,998 (GRCm39) S2079N probably damaging Het
Btg3 A G 16: 78,161,868 (GRCm39) V114A probably damaging Het
C2 T C 17: 35,082,854 (GRCm39) T471A possibly damaging Het
C4b T A 17: 34,953,732 (GRCm39) S959C probably damaging Het
Cap1 A T 4: 122,758,518 (GRCm39) S221T probably benign Het
Capn2 A T 1: 182,300,485 (GRCm39) probably benign Het
Cd38 A G 5: 44,058,775 (GRCm39) S130G probably damaging Het
Cd8b1 A G 6: 71,311,085 (GRCm39) R202G probably damaging Het
Col22a1 A G 15: 71,687,792 (GRCm39) probably null Het
Cps1 A T 1: 67,205,534 (GRCm39) E519V probably benign Het
Cyp2c38 G A 19: 39,449,138 (GRCm39) R72W probably benign Het
Cyp3a16 A T 5: 145,392,309 (GRCm39) Y215* probably null Het
Dennd10 T C 19: 60,803,232 (GRCm39) S80P probably benign Het
F5 A T 1: 164,012,533 (GRCm39) K482N probably damaging Het
Gab1 T C 8: 81,511,382 (GRCm39) M488V probably benign Het
Gabpb1 A G 2: 126,495,494 (GRCm39) I86T probably damaging Het
Gbx2 C T 1: 89,856,853 (GRCm39) R179Q probably damaging Het
Gm11938 C A 11: 99,493,972 (GRCm39) R41L probably damaging Het
Gpn1 A G 5: 31,654,664 (GRCm39) D72G probably damaging Het
Greb1 A G 12: 16,761,746 (GRCm39) S545P probably benign Het
Hsd3b7 T G 7: 127,401,442 (GRCm39) L189R probably damaging Het
Iglc1 T C 16: 18,880,660 (GRCm39) probably benign Het
Il18r1 T C 1: 40,537,717 (GRCm39) V494A possibly damaging Het
Inka1 T C 9: 107,861,603 (GRCm39) T238A probably benign Het
Itsn2 C A 12: 4,750,315 (GRCm39) probably benign Het
Kcnn1 T C 8: 71,299,179 (GRCm39) K487R probably benign Het
Kdf1 G A 4: 133,255,852 (GRCm39) E190K probably damaging Het
Lama3 G T 18: 12,586,807 (GRCm39) L723F probably damaging Het
Lama5 T C 2: 179,829,040 (GRCm39) T2034A probably benign Het
Maged1 G A X: 93,582,530 (GRCm39) P366S probably damaging Het
Med14 A G X: 12,585,936 (GRCm39) I521T probably benign Het
Mia2 A G 12: 59,201,196 (GRCm39) K841E probably damaging Het
Mrgbp G A 2: 180,225,203 (GRCm39) R53Q possibly damaging Het
Nmnat2 G A 1: 152,988,171 (GRCm39) V267I probably benign Het
Opn4 A G 14: 34,315,785 (GRCm39) probably null Het
Or2d2b T A 7: 106,705,675 (GRCm39) H131L probably benign Het
Or4f56 G T 2: 111,703,818 (GRCm39) C127* probably null Het
Or5p66 A G 7: 107,886,169 (GRCm39) S55P probably damaging Het
Or6k6 A G 1: 173,945,298 (GRCm39) Y95H probably damaging Het
Ovgp1 T C 3: 105,893,883 (GRCm39) probably benign Het
Parp16 G T 9: 65,141,086 (GRCm39) D219Y probably damaging Het
Pitpnm2 G C 5: 124,259,500 (GRCm39) H1224Q probably damaging Het
Pkd1 C T 17: 24,784,420 (GRCm39) T322I probably benign Het
Pkhd1l1 A C 15: 44,404,267 (GRCm39) T2299P probably damaging Het
Plin4 T C 17: 56,413,668 (GRCm39) D319G probably damaging Het
Ppp6r3 A C 19: 3,571,782 (GRCm39) S122R possibly damaging Het
Pum3 A T 19: 27,397,525 (GRCm39) probably benign Het
Pwwp3b G A X: 138,137,429 (GRCm39) G656S possibly damaging Het
Rims1 A T 1: 22,503,227 (GRCm39) F653I probably benign Het
Rnf113a1 A G X: 36,455,736 (GRCm39) E231G probably damaging Het
Rnf41 T C 10: 128,274,023 (GRCm39) L225P possibly damaging Het
Ryr2 T C 13: 11,607,979 (GRCm39) E876G probably damaging Het
Slc25a10 G A 11: 120,386,003 (GRCm39) V115M probably damaging Het
Snx13 T A 12: 35,188,116 (GRCm39) I798N probably benign Het
Sri A T 5: 8,117,540 (GRCm39) Q178L probably benign Het
Tex14 T G 11: 87,365,243 (GRCm39) D62E probably damaging Het
Tshz1 G T 18: 84,033,105 (GRCm39) H434Q probably damaging Het
Vegfd A G X: 163,168,879 (GRCm39) E57G probably damaging Het
Vmn2r112 T A 17: 22,822,096 (GRCm39) V258E probably damaging Het
Vmn2r59 A G 7: 41,696,427 (GRCm39) I105T possibly damaging Het
Vmn2r6 G T 3: 64,454,760 (GRCm39) T513N probably benign Het
Vmn2r72 A T 7: 85,400,044 (GRCm39) I335N probably damaging Het
Xirp1 A G 9: 119,847,444 (GRCm39) S41P probably benign Het
Xirp1 T C 9: 119,848,881 (GRCm39) M1V probably null Het
Other mutations in Wiz
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02145:Wiz APN 17 32,575,893 (GRCm39) missense probably benign 0.43
IGL02176:Wiz APN 17 32,575,876 (GRCm39) missense probably damaging 0.96
IGL02212:Wiz APN 17 32,587,109 (GRCm39) missense probably damaging 1.00
IGL02213:Wiz APN 17 32,586,834 (GRCm39) missense probably benign 0.03
IGL02616:Wiz APN 17 32,578,443 (GRCm39) missense probably damaging 1.00
IGL02654:Wiz APN 17 32,578,324 (GRCm39) missense probably damaging 1.00
IGL02833:Wiz APN 17 32,576,853 (GRCm39) missense probably damaging 1.00
IGL03032:Wiz APN 17 32,575,532 (GRCm39) missense probably benign
E0370:Wiz UTSW 17 32,574,092 (GRCm39) missense probably damaging 1.00
IGL03138:Wiz UTSW 17 32,578,093 (GRCm39) missense probably damaging 1.00
PIT4494001:Wiz UTSW 17 32,580,905 (GRCm39) missense probably damaging 1.00
R0197:Wiz UTSW 17 32,575,415 (GRCm39) missense probably damaging 1.00
R0207:Wiz UTSW 17 32,576,007 (GRCm39) missense probably damaging 1.00
R0701:Wiz UTSW 17 32,575,415 (GRCm39) missense probably damaging 1.00
R0883:Wiz UTSW 17 32,575,415 (GRCm39) missense probably damaging 1.00
R1055:Wiz UTSW 17 32,606,616 (GRCm39) missense probably damaging 0.99
R1968:Wiz UTSW 17 32,578,346 (GRCm39) missense probably damaging 1.00
R2225:Wiz UTSW 17 32,575,899 (GRCm39) missense probably damaging 1.00
R2423:Wiz UTSW 17 32,580,859 (GRCm39) missense probably damaging 1.00
R2861:Wiz UTSW 17 32,580,680 (GRCm39) missense probably damaging 1.00
R3056:Wiz UTSW 17 32,576,671 (GRCm39) missense probably benign 0.01
R3755:Wiz UTSW 17 32,578,106 (GRCm39) missense probably damaging 1.00
R3885:Wiz UTSW 17 32,576,012 (GRCm39) missense possibly damaging 0.48
R3933:Wiz UTSW 17 32,576,872 (GRCm39) missense probably damaging 1.00
R4038:Wiz UTSW 17 32,578,198 (GRCm39) missense probably damaging 1.00
R4118:Wiz UTSW 17 32,588,331 (GRCm39) utr 3 prime probably benign
R4181:Wiz UTSW 17 32,586,959 (GRCm39) missense probably damaging 1.00
R4651:Wiz UTSW 17 32,576,655 (GRCm39) missense probably damaging 1.00
R4822:Wiz UTSW 17 32,575,411 (GRCm39) nonsense probably null
R4891:Wiz UTSW 17 32,576,602 (GRCm39) missense possibly damaging 0.85
R4923:Wiz UTSW 17 32,580,570 (GRCm39) missense probably benign 0.01
R5014:Wiz UTSW 17 32,578,340 (GRCm39) missense probably damaging 1.00
R5194:Wiz UTSW 17 32,596,822 (GRCm39) utr 3 prime probably benign
R5254:Wiz UTSW 17 32,597,470 (GRCm39) splice site probably benign
R5944:Wiz UTSW 17 32,576,671 (GRCm39) missense probably benign 0.01
R6015:Wiz UTSW 17 32,606,574 (GRCm39) missense probably damaging 0.99
R6263:Wiz UTSW 17 32,579,417 (GRCm39) splice site probably null
R6571:Wiz UTSW 17 32,578,298 (GRCm39) missense probably damaging 1.00
R6823:Wiz UTSW 17 32,579,395 (GRCm39) missense probably damaging 0.99
R7014:Wiz UTSW 17 32,580,840 (GRCm39) missense probably damaging 0.98
R7051:Wiz UTSW 17 32,580,507 (GRCm39) missense probably damaging 1.00
R7144:Wiz UTSW 17 32,576,602 (GRCm39) missense possibly damaging 0.85
R7221:Wiz UTSW 17 32,578,139 (GRCm39) missense probably benign 0.03
R7260:Wiz UTSW 17 32,578,085 (GRCm39) missense probably damaging 0.99
R7453:Wiz UTSW 17 32,598,049 (GRCm39) missense probably benign 0.00
R7849:Wiz UTSW 17 32,576,760 (GRCm39) missense probably benign 0.26
R8686:Wiz UTSW 17 32,586,821 (GRCm39) missense probably damaging 1.00
R9150:Wiz UTSW 17 32,586,809 (GRCm39) missense probably benign 0.31
R9298:Wiz UTSW 17 32,580,714 (GRCm39) missense probably benign
R9564:Wiz UTSW 17 32,575,939 (GRCm39) missense probably benign 0.00
R9565:Wiz UTSW 17 32,575,939 (GRCm39) missense probably benign 0.00
U24488:Wiz UTSW 17 32,606,649 (GRCm39) missense probably damaging 1.00
X0026:Wiz UTSW 17 32,606,732 (GRCm39) start codon destroyed probably null 0.94
Z1176:Wiz UTSW 17 32,580,469 (GRCm39) missense probably damaging 1.00
Z1177:Wiz UTSW 17 32,576,752 (GRCm39) missense possibly damaging 0.88
Predicted Primers
Posted On 2017-05-15