Incidental Mutation 'R2863:Ifna6'
ID 476884
Institutional Source Beutler Lab
Gene Symbol Ifna6
Ensembl Gene ENSMUSG00000101252
Gene Name interferon alpha 6
Synonyms Ifa6, Ifna8
MMRRC Submission 040453-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R2863 (G1)
Quality Score 199
Status Not validated
Chromosome 4
Chromosomal Location 88745653-88746222 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 88746086 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 145 (T145K)
Ref Sequence ENSEMBL: ENSMUSP00000100777 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105146]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000105146
AA Change: T145K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000100777
Gene: ENSMUSG00000101252
AA Change: T145K

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IFabd 58 175 5.8e-71 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice heterozygous for reporter allele are viable and fertile, and show normal production of interferon-alpha in response to viral infection. [provided by MGI curators]
Allele List at MGI

All alleles(1) : Targeted(1)

Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Armh3 A T 19: 45,874,396 (GRCm39) N592K probably damaging Het
Bag5 T C 12: 111,677,029 (GRCm39) T265A probably benign Het
Bmper A G 9: 23,395,237 (GRCm39) N656S probably benign Het
Boc A G 16: 44,313,323 (GRCm39) S514P probably benign Het
Ddx6 G T 9: 44,525,553 (GRCm39) L103F probably damaging Het
Epb41l3 C T 17: 69,517,316 (GRCm39) P115S probably benign Het
Exoc6 T C 19: 37,641,861 (GRCm39) F709S probably benign Het
Fnip1 T C 11: 54,393,250 (GRCm39) I562T probably damaging Het
Fxr2 T A 11: 69,530,253 (GRCm39) I40N probably damaging Het
Ldb2 T C 5: 44,637,666 (GRCm39) Q214R probably damaging Het
Mus81 T G 19: 5,536,528 (GRCm39) Y146S probably damaging Het
Myh11 T C 16: 14,057,290 (GRCm39) I335V probably benign Het
Nid2 G A 14: 19,818,471 (GRCm39) E322K possibly damaging Het
Odad1 T C 7: 45,597,736 (GRCm39) S549P probably benign Het
Ofcc1 A T 13: 40,226,236 (GRCm39) S765R probably damaging Het
Ofcc1 T A 13: 40,241,414 (GRCm39) H698L possibly damaging Het
Or8b56 T A 9: 38,739,835 (GRCm39) F283I possibly damaging Het
Otog T G 7: 45,918,730 (GRCm39) C935W probably damaging Het
Pcdhga3 T C 18: 37,807,643 (GRCm39) V32A probably damaging Het
Phc3 C T 3: 30,968,277 (GRCm39) D920N probably damaging Het
Pou6f1 A G 15: 100,478,689 (GRCm39) probably null Het
Ppp4c A T 7: 126,391,272 (GRCm39) I20N probably damaging Het
Prkag2 T A 5: 25,226,790 (GRCm39) T156S probably benign Het
Psd T C 19: 46,303,201 (GRCm39) D95G probably damaging Het
Riox2 A G 16: 59,309,756 (GRCm39) D370G probably damaging Het
Spink14 T A 18: 44,163,948 (GRCm39) C39S probably damaging Het
Tdrd9 T C 12: 111,997,695 (GRCm39) V728A probably benign Het
Tgm2 T C 2: 157,985,019 (GRCm39) E29G probably benign Het
Wdr35 T A 12: 9,078,060 (GRCm39) Y1139* probably null Het
Wdr95 T A 5: 149,505,321 (GRCm39) C367* probably null Het
Zfp35 T A 18: 24,137,352 (GRCm39) D565E probably damaging Het
Other mutations in Ifna6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03403:Ifna6 APN 4 88,745,695 (GRCm39) missense possibly damaging 0.69
R0336:Ifna6 UTSW 4 88,746,178 (GRCm39) missense probably damaging 0.97
R0521:Ifna6 UTSW 4 88,745,887 (GRCm39) missense probably benign 0.30
R2863:Ifna6 UTSW 4 88,746,099 (GRCm39) missense probably benign 0.36
R2865:Ifna6 UTSW 4 88,746,086 (GRCm39) missense probably benign
R2865:Ifna6 UTSW 4 88,746,099 (GRCm39) missense probably benign 0.36
R4171:Ifna6 UTSW 4 88,746,038 (GRCm39) missense probably benign 0.06
R4534:Ifna6 UTSW 4 88,746,099 (GRCm39) missense probably benign 0.36
R4534:Ifna6 UTSW 4 88,746,086 (GRCm39) missense probably benign
R4992:Ifna6 UTSW 4 88,745,777 (GRCm39) missense probably benign 0.00
R5667:Ifna6 UTSW 4 88,745,906 (GRCm39) missense probably damaging 1.00
R5671:Ifna6 UTSW 4 88,745,906 (GRCm39) missense probably damaging 1.00
R5677:Ifna6 UTSW 4 88,745,956 (GRCm39) missense probably benign 0.00
R6487:Ifna6 UTSW 4 88,745,743 (GRCm39) missense probably damaging 1.00
R6751:Ifna6 UTSW 4 88,745,987 (GRCm39) missense probably damaging 1.00
R7424:Ifna6 UTSW 4 88,746,044 (GRCm39) missense possibly damaging 0.53
R7711:Ifna6 UTSW 4 88,745,971 (GRCm39) missense probably benign 0.06
R8850:Ifna6 UTSW 4 88,746,222 (GRCm39) makesense probably null
Predicted Primers
Posted On 2017-05-15