Incidental Mutation 'R2865:Ifna6'
ID476893
Institutional Source Beutler Lab
Gene Symbol Ifna6
Ensembl Gene ENSMUSG00000101252
Gene Nameinterferon alpha 6
SynonymsIfna8, Ifa6
MMRRC Submission 040454-MU
Accession Numbers

VEGA: OTTMUST00000026427; MGI: 107662; Ncbi RefSeq: NM_206871

Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock #R2865 (G1)
Quality Score218
Status Not validated
Chromosome4
Chromosomal Location88827416-88827985 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 88827849 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Lysine at position 145 (T145K)
Ref Sequence ENSEMBL: ENSMUSP00000100777 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105146]
Predicted Effect probably benign
Transcript: ENSMUST00000105146
AA Change: T145K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000100777
Gene: ENSMUSG00000101252
AA Change: T145K

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IFabd 58 175 5.8e-71 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 100% (30/30)
MGI Phenotype PHENOTYPE: Mice heterozygous for reporter allele are viable and fertile, and show normal production of interferon-alpha in response to viral infection. [provided by MGI curators]
Allele List at MGI

All alleles(1) : Targeted(1)

Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A230072I06Rik A G 8: 12,279,635 Q30R unknown Het
Bmper A G 9: 23,483,941 N656S probably benign Het
Cic T A 7: 25,273,221 D792E probably damaging Het
Dab1 G A 4: 104,680,146 C192Y probably benign Het
Ddx6 G T 9: 44,614,256 L103F probably damaging Het
Fhod1 T C 8: 105,332,911 K714R probably null Het
Flt1 T C 5: 147,594,621 Q844R possibly damaging Het
Fnip1 T C 11: 54,502,424 I562T probably damaging Het
Fxr2 T A 11: 69,639,427 I40N probably damaging Het
Gm5065 G T 7: 5,359,669 D100Y probably benign Het
Gm7168 A G 17: 13,949,855 K495E probably benign Het
Gria2 C T 3: 80,732,085 V207I probably benign Het
Igf2r T C 17: 12,686,724 H2240R probably damaging Het
Ighv8-9 G A 12: 115,468,446 P82S probably benign Het
Itpr3 T C 17: 27,091,551 V436A probably benign Het
Ldb3 T G 14: 34,529,503 D609A probably damaging Het
Luc7l C A 17: 26,266,361 Q112K probably damaging Het
March4 C T 1: 72,452,575 R179H probably damaging Het
Myt1l A G 12: 29,910,789 T75A probably benign Het
Olfr1094 A T 2: 86,828,854 D34V probably benign Het
Olfr1100 A T 2: 86,978,461 C112S possibly damaging Het
Parp4 C T 14: 56,613,724 T728M probably damaging Het
Ppp1r10 A G 17: 35,928,492 T398A possibly damaging Het
Ppp4c A T 7: 126,792,100 I20N probably damaging Het
Rph3a C T 5: 120,947,927 G482D probably damaging Het
Rtel1 T A 2: 181,349,972 F388I probably benign Het
Slc12a6 G A 2: 112,347,317 V594I probably benign Het
Slc2a4 G A 11: 69,946,116 S134F probably damaging Het
Tead4 A T 6: 128,248,099 probably null Het
Usp40 G A 1: 87,949,979 Q1152* probably null Het
Other mutations in Ifna6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03403:Ifna6 APN 4 88827458 missense possibly damaging 0.69
R0336:Ifna6 UTSW 4 88827941 missense probably damaging 0.97
R0521:Ifna6 UTSW 4 88827650 missense probably benign 0.30
R2863:Ifna6 UTSW 4 88827862 missense probably benign 0.36
R2863:Ifna6 UTSW 4 88827849 missense probably benign
R2865:Ifna6 UTSW 4 88827862 missense probably benign 0.36
R4171:Ifna6 UTSW 4 88827801 missense probably benign 0.06
R4534:Ifna6 UTSW 4 88827849 missense probably benign
R4534:Ifna6 UTSW 4 88827862 missense probably benign 0.36
R4992:Ifna6 UTSW 4 88827540 missense probably benign 0.00
R5667:Ifna6 UTSW 4 88827669 missense probably damaging 1.00
R5671:Ifna6 UTSW 4 88827669 missense probably damaging 1.00
R5677:Ifna6 UTSW 4 88827719 missense probably benign 0.00
R6487:Ifna6 UTSW 4 88827506 missense probably damaging 1.00
R6751:Ifna6 UTSW 4 88827750 missense probably damaging 1.00
R7424:Ifna6 UTSW 4 88827807 missense possibly damaging 0.53
R7711:Ifna6 UTSW 4 88827734 missense probably benign 0.06
Predicted Primers
Posted On2017-05-15