Incidental Mutation 'R2869:Prdx4'
ID 476934
Institutional Source Beutler Lab
Gene Symbol Prdx4
Ensembl Gene ENSMUSG00000025289
Gene Name peroxiredoxin 4
Synonyms Prx4, Prx IV, AOE372, Prx-iv
MMRRC Submission 040457-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R2869 (G1)
Quality Score 222
Status Not validated
Chromosome X
Chromosomal Location 154106914-154123750 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 154123460 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 15 (V15A)
Ref Sequence ENSEMBL: ENSMUSP00000122997 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026328] [ENSMUST00000130349]
AlphaFold O08807
Predicted Effect probably benign
Transcript: ENSMUST00000026328
SMART Domains Protein: ENSMUSP00000026328
Gene: ENSMUSG00000025289

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
Pfam:AhpC-TSA 84 217 4.3e-36 PFAM
Pfam:Redoxin 84 232 4.4e-15 PFAM
Pfam:1-cysPrx_C 237 272 9.6e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123915
Predicted Effect probably benign
Transcript: ENSMUST00000130349
AA Change: V15A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000122997
Gene: ENSMUSG00000025289
AA Change: V15A

DomainStartEndE-ValueType
low complexity region 32 47 N/A INTRINSIC
Pfam:AhpC-TSA 67 200 2.9e-37 PFAM
Pfam:Redoxin 68 217 9.6e-16 PFAM
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.4%
  • 10x: 93.9%
  • 20x: 77.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased testicular weight, testis atrophy, and oligozoospermia due to increased apoptosis associated with oxidative damage. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Als2 A G 1: 59,250,296 (GRCm39) S483P probably damaging Het
Ccl27a C T 4: 41,769,640 (GRCm39) R73Q probably benign Het
Cd6 A G 19: 10,771,990 (GRCm39) I307T possibly damaging Het
Ch25h T A 19: 34,452,210 (GRCm39) H106L probably benign Het
Dennd2b A T 7: 109,156,637 (GRCm39) Y38N probably benign Het
Dhx57 A T 17: 80,558,805 (GRCm39) D1051E probably benign Het
Eef2 GCCC GCCCC 10: 81,014,601 (GRCm39) probably null Het
Eif4enif1 C T 11: 3,192,586 (GRCm39) P805S probably damaging Het
Fan1 A G 7: 64,012,938 (GRCm39) I668T probably benign Het
Frmpd4 A T X: 166,260,243 (GRCm39) D1166E probably benign Het
Gbp11 C T 5: 105,478,866 (GRCm39) D191N probably benign Het
Ggt6 A T 11: 72,328,187 (GRCm39) N229I probably benign Het
Gria2 G A 3: 80,609,799 (GRCm39) T670I probably damaging Het
Gsdme A T 6: 50,185,157 (GRCm39) C432* probably null Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Hmcn1 A T 1: 150,614,467 (GRCm39) V1313D possibly damaging Het
Kcnb1 A G 2: 166,947,855 (GRCm39) L331P probably damaging Het
Klf8 A T X: 152,165,678 (GRCm39) E82D probably damaging Het
Krt13 A G 11: 100,008,475 (GRCm39) S421P unknown Het
Lactbl1 G A 4: 136,354,097 (GRCm39) C37Y probably damaging Het
Lzts2 C A 19: 45,012,534 (GRCm39) S321* probably null Het
Meikin T C 11: 54,264,333 (GRCm39) V103A possibly damaging Het
Mki67 G A 7: 135,309,878 (GRCm39) P191L probably benign Het
Mlxip A G 5: 123,590,730 (GRCm39) M878V probably benign Het
Mpp7 G A 18: 7,461,678 (GRCm39) P65L possibly damaging Het
Mroh2a GCCC GC 1: 88,159,979 (GRCm39) probably null Het
Myo9b G A 8: 71,786,981 (GRCm39) R721Q probably benign Het
Nbn T A 4: 15,963,810 (GRCm39) D70E probably damaging Het
Nomo1 C A 7: 45,696,361 (GRCm39) T293N probably damaging Het
Notum A G 11: 120,551,022 (GRCm39) V48A probably benign Het
Nwd2 A T 5: 63,957,671 (GRCm39) I334L probably benign Het
Or10z1 T C 1: 174,078,092 (GRCm39) S134G probably benign Het
Or4k2 T C 14: 50,423,811 (GRCm39) T288A probably benign Het
Or6c211 A T 10: 129,505,628 (GRCm39) C253* probably null Het
Ostc T C 3: 130,497,157 (GRCm39) N80S probably damaging Het
Otud4 T A 8: 80,387,702 (GRCm39) N300K possibly damaging Het
Palmd T C 3: 116,717,400 (GRCm39) R366G possibly damaging Het
Parp1 A G 1: 180,401,230 (GRCm39) D45G probably damaging Het
Pes1 C A 11: 3,926,834 (GRCm39) T372K probably benign Het
Plcl1 A T 1: 55,736,309 (GRCm39) D550V probably benign Het
Ppp1r7 T A 1: 93,285,585 (GRCm39) probably null Het
Psmb8 T C 17: 34,419,144 (GRCm39) I146T probably damaging Het
Psmd13 A T 7: 140,466,968 (GRCm39) T116S probably damaging Het
Pzp A T 6: 128,462,519 (GRCm39) probably null Het
Serinc2 A G 4: 130,159,005 (GRCm39) S29P probably damaging Het
Slc39a8 T A 3: 135,592,554 (GRCm39) probably null Het
Sppl2c C T 11: 104,078,141 (GRCm39) P314S probably benign Het
St7 C T 6: 17,819,276 (GRCm39) P60L probably damaging Het
Stx3 A T 19: 11,766,938 (GRCm39) V91D probably damaging Het
Tafa2 A T 10: 123,540,270 (GRCm39) H42L possibly damaging Het
Tnni3k C T 3: 154,644,387 (GRCm39) probably null Het
Tprg1 T C 16: 25,231,590 (GRCm39) W189R probably damaging Het
Trim32 A G 4: 65,532,694 (GRCm39) D417G probably damaging Het
Vmn2r68 A C 7: 84,882,834 (GRCm39) M306R probably benign Het
Vwa7 G A 17: 35,240,218 (GRCm39) M395I probably damaging Het
Ybx3 G A 6: 131,347,376 (GRCm39) A253V probably damaging Het
Zfp53 A T 17: 21,728,340 (GRCm39) E124D probably benign Het
Other mutations in Prdx4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02536:Prdx4 APN X 154,115,443 (GRCm39) missense probably damaging 1.00
R2869:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R2871:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R2871:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R2872:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R2872:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R2874:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R3115:Prdx4 UTSW X 154,113,407 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2017-05-15