Incidental Mutation 'R2842:Tox2'
ID 477016
Institutional Source Beutler Lab
Gene Symbol Tox2
Ensembl Gene ENSMUSG00000074607
Gene Name TOX high mobility group box family member 2
Synonyms LOC269389, RxHMG1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2842 (G1)
Quality Score 89
Status Not validated
Chromosome 2
Chromosomal Location 163045047-163166092 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) G to A at 163046550 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000105055 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109428] [ENSMUST00000128999]
AlphaFold A2A472
Predicted Effect probably benign
Transcript: ENSMUST00000109428
SMART Domains Protein: ENSMUSP00000105055
Gene: ENSMUSG00000074607

DomainStartEndE-ValueType
low complexity region 68 80 N/A INTRINSIC
low complexity region 190 206 N/A INTRINSIC
HMG 245 315 1.44e-18 SMART
low complexity region 382 409 N/A INTRINSIC
low complexity region 415 429 N/A INTRINSIC
low complexity region 457 482 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000128999
AA Change: R9Q
SMART Domains Protein: ENSMUSP00000122344
Gene: ENSMUSG00000074607
AA Change: R9Q

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
low complexity region 46 57 N/A INTRINSIC
low complexity region 94 106 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aplp2 C T 9: 31,069,122 (GRCm39) R569Q probably benign Het
Arl8a T C 1: 135,082,989 (GRCm39) S181P probably damaging Het
Armc8 A G 9: 99,387,734 (GRCm39) S396P probably benign Het
Baz2b A G 2: 59,743,348 (GRCm39) V1541A probably benign Het
Crebbp G A 16: 3,927,062 (GRCm39) R628C probably damaging Het
Ep400 T A 5: 110,846,681 (GRCm39) K295* probably null Het
Frem3 T A 8: 81,395,978 (GRCm39) probably null Het
Gon4l T C 3: 88,802,794 (GRCm39) V1135A probably damaging Het
Gprc5b G A 7: 118,583,302 (GRCm39) T189M possibly damaging Het
Gucy2g C T 19: 55,229,379 (GRCm39) C97Y probably damaging Het
Heatr5a T A 12: 52,002,261 (GRCm39) K225M probably null Het
Heatr5a C T 12: 52,002,260 (GRCm39) probably null Het
Insr A G 8: 3,252,986 (GRCm39) I391T probably damaging Het
Lce1e T A 3: 92,615,056 (GRCm39) H97L unknown Het
Macf1 A G 4: 123,270,210 (GRCm39) V6647A probably damaging Het
Mast1 T C 8: 85,650,537 (GRCm39) R399G probably damaging Het
Mast4 C A 13: 102,872,939 (GRCm39) S1951I probably benign Het
Mdc1 C T 17: 36,159,686 (GRCm39) P648S probably benign Het
Mgam T C 6: 40,638,279 (GRCm39) F410L probably benign Het
Nr2e1 T C 10: 42,444,441 (GRCm39) R223G probably damaging Het
Otud7b G A 3: 96,043,905 (GRCm39) E19K probably damaging Het
Plce1 T C 19: 38,512,727 (GRCm39) S9P probably damaging Het
Plxna2 C T 1: 194,431,625 (GRCm39) S538F probably damaging Het
Plxna4 A G 6: 32,192,566 (GRCm39) probably null Het
Prkag3 T C 1: 74,780,334 (GRCm39) I444V probably benign Het
Rsph10b T G 5: 143,916,710 (GRCm39) V310G possibly damaging Het
Tmem225 T C 9: 40,061,097 (GRCm39) Y135H probably damaging Het
Ttc3 C T 16: 94,232,857 (GRCm39) P1003L probably damaging Het
Wfikkn2 G A 11: 94,129,085 (GRCm39) T352I probably benign Het
Other mutations in Tox2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01444:Tox2 APN 2 163,067,386 (GRCm39) utr 5 prime probably benign
IGL01891:Tox2 APN 2 163,164,903 (GRCm39) missense possibly damaging 0.48
IGL02190:Tox2 APN 2 163,164,926 (GRCm39) missense possibly damaging 0.91
IGL02576:Tox2 APN 2 163,118,100 (GRCm39) missense probably damaging 0.99
R0881:Tox2 UTSW 2 163,163,365 (GRCm39) missense probably benign 0.18
R1739:Tox2 UTSW 2 163,089,705 (GRCm39) missense probably damaging 0.99
R1742:Tox2 UTSW 2 163,067,446 (GRCm39) missense probably benign 0.04
R1900:Tox2 UTSW 2 163,118,087 (GRCm39) missense probably damaging 1.00
R1937:Tox2 UTSW 2 163,067,476 (GRCm39) missense probably benign
R2345:Tox2 UTSW 2 163,161,518 (GRCm39) missense probably damaging 1.00
R3753:Tox2 UTSW 2 163,156,243 (GRCm39) missense probably damaging 1.00
R4614:Tox2 UTSW 2 163,162,567 (GRCm39) missense probably damaging 1.00
R4615:Tox2 UTSW 2 163,162,567 (GRCm39) missense probably damaging 1.00
R4616:Tox2 UTSW 2 163,162,567 (GRCm39) missense probably damaging 1.00
R4618:Tox2 UTSW 2 163,162,567 (GRCm39) missense probably damaging 1.00
R4625:Tox2 UTSW 2 163,156,336 (GRCm39) missense possibly damaging 0.71
R5410:Tox2 UTSW 2 163,162,293 (GRCm39) missense probably benign 0.04
R5493:Tox2 UTSW 2 163,046,649 (GRCm39) nonsense probably null
R6731:Tox2 UTSW 2 163,162,297 (GRCm39) missense probably damaging 1.00
R6965:Tox2 UTSW 2 163,164,930 (GRCm39) makesense probably null
R7038:Tox2 UTSW 2 163,156,264 (GRCm39) missense probably damaging 0.99
R7078:Tox2 UTSW 2 163,162,501 (GRCm39) missense
R7422:Tox2 UTSW 2 163,163,435 (GRCm39) missense
R7577:Tox2 UTSW 2 163,157,822 (GRCm39) nonsense probably null
R7829:Tox2 UTSW 2 163,162,296 (GRCm39) missense probably damaging 1.00
R8356:Tox2 UTSW 2 163,046,550 (GRCm39) missense unknown
R8456:Tox2 UTSW 2 163,046,550 (GRCm39) missense unknown
R8754:Tox2 UTSW 2 163,163,360 (GRCm39) missense
R9085:Tox2 UTSW 2 163,067,481 (GRCm39) missense probably benign 0.19
R9153:Tox2 UTSW 2 163,045,091 (GRCm39) missense
R9526:Tox2 UTSW 2 163,164,930 (GRCm39) makesense probably null
RF011:Tox2 UTSW 2 163,067,484 (GRCm39) missense probably benign 0.02
Predicted Primers
Posted On 2017-05-15