Incidental Mutation 'R2874:Prdx4'
ID477086
Institutional Source Beutler Lab
Gene Symbol Prdx4
Ensembl Gene ENSMUSG00000025289
Gene Nameperoxiredoxin 4
SynonymsPrx4, AOE372, Prx-iv, Prx IV
MMRRC Submission 040462-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.086) question?
Stock #R2874 (G1)
Quality Score222
Status Not validated
ChromosomeX
Chromosomal Location155323918-155340754 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 155340464 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 15 (V15A)
Ref Sequence ENSEMBL: ENSMUSP00000122997 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026328] [ENSMUST00000130349]
Predicted Effect probably benign
Transcript: ENSMUST00000026328
SMART Domains Protein: ENSMUSP00000026328
Gene: ENSMUSG00000025289

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
Pfam:AhpC-TSA 84 217 4.3e-36 PFAM
Pfam:Redoxin 84 232 4.4e-15 PFAM
Pfam:1-cysPrx_C 237 272 9.6e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123915
Predicted Effect probably benign
Transcript: ENSMUST00000130349
AA Change: V15A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000122997
Gene: ENSMUSG00000025289
AA Change: V15A

DomainStartEndE-ValueType
low complexity region 32 47 N/A INTRINSIC
Pfam:AhpC-TSA 67 200 2.9e-37 PFAM
Pfam:Redoxin 68 217 9.6e-16 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased testicular weight, testis atrophy, and oligozoospermia due to increased apoptosis associated with oxidative damage. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210016F16Rik T A 13: 58,382,570 I209F probably damaging Het
4931428F04Rik A G 8: 105,282,032 M451T possibly damaging Het
A930029G22Rik T A 17: 69,418,111 noncoding transcript Het
Ankrd42 T C 7: 92,605,358 K348E possibly damaging Het
Arhgef10 T C 8: 14,975,093 probably null Het
Arhgef10 A G 8: 14,975,666 I459V probably benign Het
Cd6 A G 19: 10,794,626 I307T possibly damaging Het
Cebpz A T 17: 78,932,103 probably benign Het
Clcn4 A G 7: 7,290,521 I412T probably benign Het
Clstn3 T A 6: 124,438,335 D690V probably damaging Het
Col12a1 A T 9: 79,699,549 F531I probably damaging Het
Dhx57 A T 17: 80,251,376 D1051E probably benign Het
Ext2 A G 2: 93,739,686 V460A possibly damaging Het
Frmpd4 A T X: 167,477,247 D1166E probably benign Het
Fscb T C 12: 64,473,436 K419E probably benign Het
Ggct G T 6: 54,992,774 A21D probably damaging Het
Gm10717 A G 9: 3,025,532 Y39C probably benign Het
Gm813 A T 16: 58,613,979 I125K probably benign Het
Grid2ip C A 5: 143,357,929 Q127K probably benign Het
Ighv2-2 G A 12: 113,588,498 T40I possibly damaging Het
Itpr2 T C 6: 146,426,498 K79R possibly damaging Het
Klf8 A T X: 153,382,682 E82D probably damaging Het
Kpna7 T C 5: 144,993,935 T367A probably benign Het
Lactbl1 G A 4: 136,626,786 C37Y probably damaging Het
Lrp1b A G 2: 40,851,693 L3188P probably damaging Het
Myo9b G A 8: 71,334,337 R721Q probably benign Het
Noc4l A G 5: 110,649,103 V465A probably benign Het
Notch1 A G 2: 26,460,235 C2298R possibly damaging Het
Olfr419 T C 1: 174,250,526 S134G probably benign Het
Parp1 A G 1: 180,573,665 D45G probably damaging Het
Plxna3 T A X: 74,339,396 probably benign Het
Prps1 C T X: 140,471,994 probably benign Het
Psmb8 T C 17: 34,200,170 I146T probably damaging Het
Ralgds A G 2: 28,548,769 probably null Het
Rasl12 A G 9: 65,408,323 N83S probably benign Het
Rnf6 T C 5: 146,210,405 Y601C probably benign Het
Rreb1 T C 13: 37,916,508 I205T probably benign Het
Sgk2 A G 2: 162,994,529 probably benign Het
Spsb4 G T 9: 96,996,018 T84K probably damaging Het
St5 A T 7: 109,557,430 Y38N probably benign Het
St7 C T 6: 17,819,277 P60L probably damaging Het
Stx3 A T 19: 11,789,574 V91D probably damaging Het
Tbc1d8 A G 1: 39,405,317 F187S probably damaging Het
Tep1 A G 14: 50,850,650 I85T possibly damaging Het
Trpa1 A G 1: 14,887,620 C705R probably damaging Het
Vmn2r68 A C 7: 85,233,626 M306R probably benign Het
Vwa7 G A 17: 35,021,242 M395I probably damaging Het
Zfp53 A T 17: 21,508,078 E124D probably benign Het
Other mutations in Prdx4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02536:Prdx4 APN X 155332447 missense probably damaging 1.00
R2869:Prdx4 UTSW X 155340464 missense probably benign 0.00
R2869:Prdx4 UTSW X 155340464 missense probably benign 0.00
R2871:Prdx4 UTSW X 155340464 missense probably benign 0.00
R2871:Prdx4 UTSW X 155340464 missense probably benign 0.00
R2872:Prdx4 UTSW X 155340464 missense probably benign 0.00
R2872:Prdx4 UTSW X 155340464 missense probably benign 0.00
R3115:Prdx4 UTSW X 155330411 missense probably damaging 1.00
Predicted Primers
Posted On2017-05-15