Incidental Mutation 'R3004:Art2a-ps'
ID477368
Institutional Source Beutler Lab
Gene Symbol Art2a-ps
Ensembl Gene ENSMUSG00000092517
Gene NameADP-ribosyltransferase 2a, pseudogene
SynonymsRt6-1, Rt6, Rt-6
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.054) question?
Stock #R3004 (G1)
Quality Score225
Status Not validated
Chromosome7
Chromosomal Location101552453-101560865 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 101554765 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 189 (I189V)
Ref Sequence ENSEMBL: ENSMUSP00000134404 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000173420]
Predicted Effect probably benign
Transcript: ENSMUST00000173420
AA Change: I189V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000134404
Gene: ENSMUSG00000092517
AA Change: I189V

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ART 27 241 1.2e-89 PFAM
low complexity region 266 286 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk3 G A 7: 81,103,355 W1553* probably null Het
BC049715 A G 6: 136,839,792 E10G possibly damaging Het
BC067074 T C 13: 113,366,154 F131S probably damaging Het
Ccdc158 A G 5: 92,649,070 L469P probably damaging Het
Ctsm T C 13: 61,539,868 I59V possibly damaging Het
Daam2 A G 17: 49,460,654 F970L probably damaging Het
Gm21903 A T 17: 39,042,656 probably benign Het
Gpr158 T A 2: 21,826,999 M970K probably damaging Het
Hist1h2bf G A 13: 23,574,181 probably benign Het
Hoxd10 T A 2: 74,692,362 V128D probably benign Het
Ighv5-9 T C 12: 113,661,947 T59A probably benign Het
Nlrp4c G A 7: 6,065,525 V142M probably benign Het
Npc1 A G 18: 12,197,254 F947L probably benign Het
Olfr356 T A 2: 36,937,209 I30N possibly damaging Het
Olfr504 G T 7: 108,564,944 H284N probably benign Het
Piezo2 G T 18: 63,024,435 Y223* probably null Het
Rhog A T 7: 102,240,138 V36E probably damaging Het
Sbno1 G A 5: 124,381,708 T1168I probably damaging Het
Sin3a T A 9: 57,096,834 L290* probably null Het
Slco1c1 G T 6: 141,532,654 A48S probably damaging Het
Slfn9 A T 11: 82,981,764 S715R possibly damaging Het
Sox17 T C 1: 4,492,617 E120G probably damaging Het
Other mutations in Art2a-ps
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01014:Art2a-ps APN 7 101554908 missense probably damaging 1.00
IGL01754:Art2a-ps APN 7 101554852 missense probably damaging 1.00
R4585:Art2a-ps UTSW 7 101554749 nonsense probably null
R4586:Art2a-ps UTSW 7 101554749 nonsense probably null
R6063:Art2a-ps UTSW 7 101555206 missense probably damaging 1.00
R6143:Art2a-ps UTSW 7 101555223 missense possibly damaging 0.81
R6241:Art2a-ps UTSW 7 101555245 missense probably benign 0.01
R6757:Art2a-ps UTSW 7 101555014 missense probably benign 0.02
R7693:Art2a-ps UTSW 7 101554849 makesense probably null
R7889:Art2a-ps UTSW 7 101555211 missense not run
Predicted Primers
Posted On2017-05-15