Incidental Mutation 'R2929:Cnnm3'
ID 477475
Institutional Source Beutler Lab
Gene Symbol Cnnm3
Ensembl Gene ENSMUSG00000001138
Gene Name cyclin M3
Synonyms Acdp3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R2929 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 36550948-36567318 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 36563140 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 701 (F701L)
Ref Sequence ENSEMBL: ENSMUSP00000095383 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001166] [ENSMUST00000097776]
AlphaFold Q32NY4
Predicted Effect probably benign
Transcript: ENSMUST00000001166
SMART Domains Protein: ENSMUSP00000001166
Gene: ENSMUSG00000001138

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
low complexity region 25 35 N/A INTRINSIC
low complexity region 87 104 N/A INTRINSIC
low complexity region 128 140 N/A INTRINSIC
Pfam:DUF21 142 295 3.2e-10 PFAM
Blast:CBS 329 379 9e-12 BLAST
Pfam:CBS 388 452 6.4e-6 PFAM
Blast:cNMP 527 668 2e-38 BLAST
Predicted Effect possibly damaging
Transcript: ENSMUST00000097776
AA Change: F701L

PolyPhen 2 Score 0.548 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000095383
Gene: ENSMUSG00000001138
AA Change: F701L

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
low complexity region 25 35 N/A INTRINSIC
low complexity region 87 104 N/A INTRINSIC
low complexity region 128 140 N/A INTRINSIC
Pfam:DUF21 142 300 1e-19 PFAM
Blast:CBS 329 379 9e-12 BLAST
Pfam:CBS 388 452 5.1e-6 PFAM
Blast:cNMP 527 668 1e-37 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135100
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154225
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192037
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195264
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI

All alleles(3) : Gene trapped(3)

Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cd177 G A 7: 24,453,704 (GRCm39) Q396* probably null Het
Cdadc1 A T 14: 59,835,284 (GRCm39) M1K probably null Het
Cdc23 ACC AC 18: 34,770,371 (GRCm39) probably null Het
Cul7 C G 17: 46,962,526 (GRCm39) D52E probably benign Het
Dennd4a T C 9: 64,759,699 (GRCm39) V268A possibly damaging Het
Deup1 C T 9: 15,486,484 (GRCm39) V399I probably benign Het
Dscam T A 16: 96,486,612 (GRCm39) Q1021L possibly damaging Het
Dst A T 1: 34,206,143 (GRCm39) K932* probably null Het
Neurl2 T C 2: 164,675,264 (GRCm39) N33D possibly damaging Het
Pnma8b T C 7: 16,680,617 (GRCm39) S534P possibly damaging Het
Pole2 G A 12: 69,256,712 (GRCm39) T271M probably benign Het
Ppfibp2 A G 7: 107,296,858 (GRCm39) M191V probably damaging Het
Rad51ap2 A G 12: 11,507,185 (GRCm39) Q369R probably benign Het
Rbm45 A G 2: 76,208,763 (GRCm39) I300V probably benign Het
Ro60 G A 1: 143,633,616 (GRCm39) A494V possibly damaging Het
Sco1 T A 11: 66,954,748 (GRCm39) I251K probably damaging Het
Spmip4 G A 6: 50,551,285 (GRCm39) T388I probably benign Het
Zfp202 T C 9: 40,122,984 (GRCm39) V582A possibly damaging Het
Zfp219 T A 14: 52,246,436 (GRCm39) E230D probably benign Het
Other mutations in Cnnm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01310:Cnnm3 APN 1 36,551,956 (GRCm39) missense probably benign 0.12
IGL02679:Cnnm3 APN 1 36,559,239 (GRCm39) missense probably benign 0.01
IGL02700:Cnnm3 APN 1 36,552,189 (GRCm39) missense probably damaging 1.00
IGL03165:Cnnm3 APN 1 36,564,313 (GRCm39) unclassified probably benign
R0003:Cnnm3 UTSW 1 36,563,124 (GRCm39) missense probably benign 0.02
R0358:Cnnm3 UTSW 1 36,560,303 (GRCm39) missense probably damaging 0.98
R1129:Cnnm3 UTSW 1 36,552,097 (GRCm39) missense probably damaging 1.00
R1772:Cnnm3 UTSW 1 36,558,038 (GRCm39) missense probably damaging 1.00
R3153:Cnnm3 UTSW 1 36,560,303 (GRCm39) missense probably damaging 0.98
R3154:Cnnm3 UTSW 1 36,560,303 (GRCm39) missense probably damaging 0.98
R5376:Cnnm3 UTSW 1 36,559,759 (GRCm39) missense probably damaging 1.00
R5810:Cnnm3 UTSW 1 36,564,280 (GRCm39) missense probably benign 0.02
R6389:Cnnm3 UTSW 1 36,559,603 (GRCm39) missense probably damaging 0.99
R8288:Cnnm3 UTSW 1 36,551,074 (GRCm39) missense possibly damaging 0.93
R8951:Cnnm3 UTSW 1 36,558,019 (GRCm39) splice site probably benign
R8959:Cnnm3 UTSW 1 36,558,096 (GRCm39) missense probably damaging 1.00
R9068:Cnnm3 UTSW 1 36,551,962 (GRCm39) missense probably damaging 1.00
R9121:Cnnm3 UTSW 1 36,563,158 (GRCm39) nonsense probably null
X0064:Cnnm3 UTSW 1 36,552,061 (GRCm39) missense probably damaging 1.00
Z1177:Cnnm3 UTSW 1 36,552,114 (GRCm39) missense possibly damaging 0.96
Predicted Primers
Posted On 2017-05-15