Incidental Mutation 'R2971:Pou6f2'
ID477687
Institutional Source Beutler Lab
Gene Symbol Pou6f2
Ensembl Gene ENSMUSG00000009734
Gene NamePOU domain, class 6, transcription factor 2
SynonymsRPF-1, D130006K24Rik
MMRRC Submission 040525-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R2971 (G1)
Quality Score225
Status Not validated
Chromosome13
Chromosomal Location18121098-18397686 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 18381967 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 25 (T25A)
Gene Model predicted gene model for transcript(s):
Predicted Effect unknown
Transcript: ENSMUST00000139064
AA Change: T25A
SMART Domains Protein: ENSMUSP00000114173
Gene: ENSMUSG00000009734
AA Change: T25A

DomainStartEndE-ValueType
low complexity region 67 79 N/A INTRINSIC
coiled coil region 107 143 N/A INTRINSIC
low complexity region 248 266 N/A INTRINSIC
POU 422 532 9.61e-26 SMART
HOX 553 615 3.01e-21 SMART
Predicted Effect unknown
Transcript: ENSMUST00000175703
AA Change: T25A
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175768
Predicted Effect noncoding transcript
Transcript: ENSMUST00000222900
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223058
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.6%
Validation Efficiency 100% (35/35)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and of normal size with no apparent phenotypic abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan A G 7: 79,099,699 D1406G possibly damaging Het
Aebp2 T C 6: 140,633,898 probably null Het
Ap5m1 T A 14: 49,083,882 Y49* probably null Het
Atp8b5 T C 4: 43,361,953 probably benign Het
Baz1a A G 12: 54,923,439 S518P probably damaging Het
Ces1c T A 8: 93,104,193 D445V probably benign Het
Ctnnbl1 C T 2: 157,871,186 H464Y probably benign Het
Cyp2j6 T C 4: 96,531,781 K238E probably benign Het
Gdf10 G A 14: 33,924,191 R99H probably damaging Het
Gm4779 G A X: 101,792,962 P116L possibly damaging Het
Gucy2g A G 19: 55,210,276 S812P probably damaging Het
Ifit3b C T 19: 34,612,017 Q198* probably null Het
Irgm1 A T 11: 48,866,590 Y131* probably null Het
Man1c1 G C 4: 134,703,438 P11R probably damaging Het
Myh7b A G 2: 155,632,255 N1630S probably benign Het
Myo5a T C 9: 75,116,202 I15T probably damaging Het
Naip6 C T 13: 100,300,600 A472T probably benign Het
Nme6 A G 9: 109,842,091 probably benign Het
Olfr1040 T C 2: 86,146,564 T57A probably damaging Het
Olfr741 T A 14: 50,485,608 I50N probably damaging Het
Plch2 T G 4: 154,990,767 M797L probably benign Het
Plscr2 G T 9: 92,290,671 E128* probably null Het
Plxna2 T A 1: 194,797,731 D1403E probably damaging Het
Psmb11 T C 14: 54,625,343 V6A possibly damaging Het
Ptch1 T G 13: 63,524,959 E944A probably benign Het
Ptprd T G 4: 76,107,324 S546R probably benign Het
Rbp3 A G 14: 33,954,454 N120D probably benign Het
Skint1 C A 4: 112,021,330 P153H possibly damaging Het
Slc15a4 A G 5: 127,604,536 probably null Het
Tmem201 A G 4: 149,722,445 probably benign Het
Ube2v1 T C 2: 167,610,336 N89D probably damaging Het
Zfp282 A T 6: 47,897,932 probably null Het
Zfp560 C A 9: 20,348,944 M207I probably benign Het
Zfp697 T C 3: 98,428,301 Y461H probably damaging Het
Other mutations in Pou6f2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00486:Pou6f2 APN 13 18139585 missense probably damaging 1.00
IGL03046:Pou6f2 UTSW 13 18129027 utr 3 prime probably benign
PIT4402001:Pou6f2 UTSW 13 18125346 missense
PIT4519001:Pou6f2 UTSW 13 18239564 missense unknown
R0349:Pou6f2 UTSW 13 18152004 missense probably damaging 1.00
R0510:Pou6f2 UTSW 13 18139723 splice site probably benign
R1449:Pou6f2 UTSW 13 18172415 missense probably damaging 1.00
R1911:Pou6f2 UTSW 13 18151963 missense probably damaging 0.98
R5193:Pou6f2 UTSW 13 18125544 utr 3 prime probably benign
R5218:Pou6f2 UTSW 13 18152001 missense probably damaging 1.00
R6226:Pou6f2 UTSW 13 18129154 missense possibly damaging 0.83
R6747:Pou6f2 UTSW 13 18129187 missense probably benign 0.26
R6805:Pou6f2 UTSW 13 18239489 missense
R6978:Pou6f2 UTSW 13 18172478 missense probably damaging 1.00
R7072:Pou6f2 UTSW 13 18125169 missense
R7158:Pou6f2 UTSW 13 18152038 missense
R7187:Pou6f2 UTSW 13 18239713 missense
R7198:Pou6f2 UTSW 13 18129163 missense probably damaging 0.97
R7203:Pou6f2 UTSW 13 18239794 missense unknown
R7241:Pou6f2 UTSW 13 18125289 missense
R7307:Pou6f2 UTSW 13 18239713 missense
R7827:Pou6f2 UTSW 13 18378507 missense
Predicted Primers
Posted On2017-05-15