Incidental Mutation 'R3106:Or4g17'
ID 477735
Institutional Source Beutler Lab
Gene Symbol Or4g17
Ensembl Gene ENSMUSG00000108931
Gene Name olfactory receptor family 4 subfamily G member 17
Synonyms GA_x6K02T2Q125-72430580-72431515, MOR245-13, Olfr1284
MMRRC Submission 040580-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.186) question?
Stock # R3106 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 111209347-111210282 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 111209840 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 165 (N165S)
Ref Sequence ENSEMBL: ENSMUSP00000147014 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062407] [ENSMUST00000209096]
AlphaFold Q8VF29
Predicted Effect probably benign
Transcript: ENSMUST00000062407
AA Change: N165S

PolyPhen 2 Score 0.233 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000052153
Gene: ENSMUSG00000108931
AA Change: N165S

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 7.2e-45 PFAM
Pfam:7TM_GPCR_Srsx 34 302 2.4e-5 PFAM
Pfam:7tm_1 41 287 2e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209096
AA Change: N165S

PolyPhen 2 Score 0.233 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca15 A T 7: 119,995,856 (GRCm39) E1331V possibly damaging Het
Adam22 A G 5: 8,167,583 (GRCm39) probably null Het
Adamts17 T A 7: 66,774,820 (GRCm39) S980T probably damaging Het
Adarb1 C A 10: 77,157,591 (GRCm39) K285N probably damaging Het
Atp5f1c A G 2: 10,068,276 (GRCm39) S160P probably benign Het
Baz2a AGCGGCGGTACTTGCGGG AG 10: 127,960,946 (GRCm39) probably null Het
Btf3 T G 13: 98,447,496 (GRCm39) E145D probably benign Het
Ccdc184 G T 15: 98,066,482 (GRCm39) A96S probably damaging Het
Ccdc191 T C 16: 43,751,573 (GRCm39) F301S probably damaging Het
Ceacam5 T C 7: 17,481,248 (GRCm39) Y332H probably benign Het
Clip2 T C 5: 134,551,918 (GRCm39) K68R probably benign Het
Cntln C T 4: 84,875,406 (GRCm39) T280M possibly damaging Het
Col6a3 T C 1: 90,744,024 (GRCm39) R515G probably damaging Het
Ctnnal1 G A 4: 56,813,246 (GRCm39) L662F probably benign Het
Dennd3 C A 15: 73,436,973 (GRCm39) S118* probably null Het
Dgkg T A 16: 22,394,091 (GRCm39) T321S probably damaging Het
Dzip1l A T 9: 99,524,625 (GRCm39) K249* probably null Het
Dzip1l A G 9: 99,529,174 (GRCm39) E301G probably benign Het
Emc10 G A 7: 44,142,616 (GRCm39) R109W probably damaging Het
Ezh1 A C 11: 101,086,468 (GRCm39) C575W probably damaging Het
Fam187b A G 7: 30,676,665 (GRCm39) D58G probably benign Het
Galnt4 T C 10: 98,945,243 (GRCm39) Y323H probably benign Het
Grm1 A G 10: 10,955,601 (GRCm39) S228P probably benign Het
H1f2 G T 13: 23,922,883 (GRCm39) A18S unknown Het
Hnf4g T G 3: 3,717,916 (GRCm39) S388R probably benign Het
Il1rap A G 16: 26,541,502 (GRCm39) E581G probably benign Het
Lemd2 C A 17: 27,420,644 (GRCm39) L256F probably damaging Het
Mnd1 C A 3: 84,041,416 (GRCm39) C62F probably benign Het
Nphs1 C A 7: 30,166,965 (GRCm39) S724* probably null Het
Or5w13 T C 2: 87,523,849 (GRCm39) I126V probably damaging Het
Osgep T C 14: 51,154,286 (GRCm39) T225A probably benign Het
Pan3 T C 5: 147,476,189 (GRCm39) probably benign Het
Pld3 A G 7: 27,235,212 (GRCm39) probably null Het
Plekha7 C T 7: 115,763,639 (GRCm39) R321K probably benign Het
Plekhg5 C T 4: 152,196,635 (GRCm39) T694M probably damaging Het
Pramel31 T C 4: 144,088,246 (GRCm39) V14A probably benign Het
Ptpn20 A G 14: 33,334,253 (GRCm39) I44V probably benign Het
Ptprj T A 2: 90,270,975 (GRCm39) H1251L probably damaging Het
Sbspon T C 1: 15,962,806 (GRCm39) E24G probably benign Het
Sfmbt1 G A 14: 30,539,753 (GRCm39) C847Y probably damaging Het
Sparcl1 T C 5: 104,241,203 (GRCm39) T74A probably benign Het
Sppl2b A G 10: 80,703,325 (GRCm39) E529G probably benign Het
Stradb C A 1: 59,031,450 (GRCm39) H212Q possibly damaging Het
Tkfc G T 19: 10,574,357 (GRCm39) C198* probably null Het
Tm4sf4 C T 3: 57,345,043 (GRCm39) R150C possibly damaging Het
Tmem212 T C 3: 27,939,019 (GRCm39) S156G probably damaging Het
Tmem51 T C 4: 141,765,035 (GRCm39) N8D probably damaging Het
Tmigd1 A G 11: 76,801,124 (GRCm39) T204A possibly damaging Het
Trp53bp1 A G 2: 121,067,133 (GRCm39) L531S probably damaging Het
Tsga10 G A 1: 37,840,872 (GRCm39) L445F probably damaging Het
Urb1 C T 16: 90,592,331 (GRCm39) V310I probably damaging Het
Vmn2r129 T A 4: 156,685,730 (GRCm39) noncoding transcript Het
Wdr19 T C 5: 65,359,966 (GRCm39) S24P probably benign Het
Other mutations in Or4g17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03024:Or4g17 APN 2 111,209,935 (GRCm39) missense possibly damaging 0.94
R0526:Or4g17 UTSW 2 111,209,837 (GRCm39) missense possibly damaging 0.95
R0731:Or4g17 UTSW 2 111,209,638 (GRCm39) missense probably damaging 0.99
R1762:Or4g17 UTSW 2 111,209,918 (GRCm39) missense probably damaging 0.99
R1765:Or4g17 UTSW 2 111,209,491 (GRCm39) missense probably benign 0.39
R3803:Or4g17 UTSW 2 111,209,638 (GRCm39) missense possibly damaging 0.95
R3894:Or4g17 UTSW 2 111,209,982 (GRCm39) missense probably benign 0.09
R4005:Or4g17 UTSW 2 111,210,088 (GRCm39) missense probably benign 0.05
R4227:Or4g17 UTSW 2 111,209,410 (GRCm39) missense probably benign
R4637:Or4g17 UTSW 2 111,209,927 (GRCm39) missense probably benign 0.03
R4707:Or4g17 UTSW 2 111,209,990 (GRCm39) missense probably damaging 1.00
R4762:Or4g17 UTSW 2 111,210,082 (GRCm39) missense probably damaging 1.00
R5150:Or4g17 UTSW 2 111,209,598 (GRCm39) missense probably damaging 1.00
R5309:Or4g17 UTSW 2 111,210,179 (GRCm39) missense possibly damaging 0.52
R5312:Or4g17 UTSW 2 111,210,179 (GRCm39) missense possibly damaging 0.52
R6554:Or4g17 UTSW 2 111,209,504 (GRCm39) missense possibly damaging 0.95
R6913:Or4g17 UTSW 2 111,209,347 (GRCm39) start codon destroyed probably null 0.03
R6980:Or4g17 UTSW 2 111,209,620 (GRCm39) missense possibly damaging 0.77
R6995:Or4g17 UTSW 2 111,209,708 (GRCm39) missense probably damaging 1.00
R7168:Or4g17 UTSW 2 111,210,224 (GRCm39) missense probably damaging 1.00
R7332:Or4g17 UTSW 2 111,209,738 (GRCm39) missense not run
R7464:Or4g17 UTSW 2 111,209,543 (GRCm39) missense probably damaging 1.00
R8125:Or4g17 UTSW 2 111,210,086 (GRCm39) missense probably damaging 0.99
R8963:Or4g17 UTSW 2 111,209,645 (GRCm39) missense probably damaging 1.00
R9660:Or4g17 UTSW 2 111,210,239 (GRCm39) missense probably damaging 0.97
Predicted Primers
Posted On 2017-05-15