Incidental Mutation 'R3109:Igkv11-125'
ID477840
Institutional Source Beutler Lab
Gene Symbol Igkv11-125
Ensembl Gene ENSMUSG00000095737
Gene Nameimmunoglobulin kappa variable 11-125
SynonymsENSMUSG00000050218
MMRRC Submission 040583-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.276) question?
Stock #R3109 (G1)
Quality Score225
Status Not validated
Chromosome6
Chromosomal Location67913573-67914052 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 67913871 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 58 (F58L)
Ref Sequence ENSEMBL: ENSMUSP00000142805 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103311] [ENSMUST00000197406]
Predicted Effect probably benign
Transcript: ENSMUST00000103311
AA Change: F57L

PolyPhen 2 Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000100112
Gene: ENSMUSG00000095737
AA Change: F57L

DomainStartEndE-ValueType
IGv 39 111 2.26e-20 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000197406
AA Change: F58L

PolyPhen 2 Score 0.556 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000142805
Gene: ENSMUSG00000095737
AA Change: F58L

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
IGv 40 112 9.2e-23 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 100% (33/33)
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik A G 2: 152,442,456 E323G probably damaging Het
Adamts20 T C 15: 94,345,904 probably benign Het
Alkbh3 T C 2: 94,004,763 E80G probably damaging Het
Amfr T C 8: 94,000,306 Y93C probably damaging Het
Arid2 T C 15: 96,356,746 Y158H probably damaging Het
Camk1g T C 1: 193,354,993 Y133C probably damaging Het
Cnnm1 T C 19: 43,441,561 C373R probably damaging Het
Cnot1 A G 8: 95,735,749 V1691A probably damaging Het
Cubn T C 2: 13,362,347 S1571G possibly damaging Het
Dclk2 G A 3: 86,920,035 P46S probably damaging Het
Dennd1b G A 1: 139,041,916 probably benign Het
Dmrt2 C A 19: 25,677,691 T218N probably benign Het
Drd4 T A 7: 141,292,282 V82E possibly damaging Het
Fat1 G A 8: 45,045,173 probably null Het
Fyn G C 10: 39,551,455 D445H probably damaging Het
Igfn1 T C 1: 135,997,848 D56G probably benign Het
Klhdc4 A C 8: 121,821,334 H72Q probably damaging Het
Kmt2c A G 5: 25,275,735 Y1459H probably damaging Het
Lama2 C T 10: 27,001,235 E2652K probably benign Het
Muc5b C T 7: 141,858,759 T1814M unknown Het
Ntrk3 C T 7: 78,460,515 V324M probably benign Het
Olfr591 T A 7: 103,173,086 M184L probably damaging Het
Per2 A T 1: 91,445,575 C164S probably benign Het
Ptprn2 A G 12: 116,876,180 D441G probably benign Het
Rbl2 T A 8: 91,102,235 I588N probably benign Het
Rslcan18 C T 13: 67,098,607 E314K possibly damaging Het
Ubr3 A T 2: 69,988,840 T1325S probably damaging Het
Unc45a A G 7: 80,331,546 probably benign Het
Vmn1r175 A G 7: 23,808,968 V78A probably benign Het
Other mutations in Igkv11-125
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02542:Igkv11-125 APN 6 67914007 missense probably damaging 0.99
R0532:Igkv11-125 UTSW 6 67913619 nonsense probably null
R3108:Igkv11-125 UTSW 6 67913871 missense possibly damaging 0.56
R8065:Igkv11-125 UTSW 6 67913830 missense probably benign 0.26
R8067:Igkv11-125 UTSW 6 67913830 missense probably benign 0.26
Predicted Primers
Posted On2017-05-15