Incidental Mutation 'R3112:Psg23'
ID 477859
Institutional Source Beutler Lab
Gene Symbol Psg23
Ensembl Gene ENSMUSG00000074359
Gene Name pregnancy-specific glycoprotein 23
Synonyms 1620401C02Rik
MMRRC Submission 040585-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # R3112 (G1)
Quality Score 181
Status Not validated
Chromosome 7
Chromosomal Location 18606343-18616501 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 18610444 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 362 (D362G)
Ref Sequence ENSEMBL: ENSMUSP00000056586 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057810]
AlphaFold Q9D2U0
Predicted Effect possibly damaging
Transcript: ENSMUST00000057810
AA Change: D362G

PolyPhen 2 Score 0.724 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000056586
Gene: ENSMUSG00000074359
AA Change: D362G

DomainStartEndE-ValueType
IG 39 138 2.03e-4 SMART
IG 159 260 4.16e-1 SMART
IG 276 375 1.25e-4 SMART
IGc2 393 457 4.7e-9 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 100% (38/38)
MGI Phenotype PHENOTYPE: Mice homozygous for this spontaneous mutation display no phenotypic abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930430A15Rik T G 2: 111,228,054 L131F probably damaging Het
Abca6 T A 11: 110,178,829 K1554* probably null Het
Acads T C 5: 115,117,698 H26R probably benign Het
Acer1 G A 17: 56,958,406 T141I probably damaging Het
Adam15 C G 3: 89,347,457 V99L probably benign Het
Ankrd13b A G 11: 77,477,505 V97A possibly damaging Het
Anpep T C 7: 79,841,972 T94A probably benign Het
Atp1a3 T C 7: 24,994,694 N345S probably damaging Het
Btn1a1 T A 13: 23,461,551 N216I possibly damaging Het
Cacna1s G A 1: 136,075,093 W62* probably null Het
Ccdc141 C T 2: 77,039,486 V892I probably benign Het
Ccdc180 T A 4: 45,900,470 I278K possibly damaging Het
Cdc7 T G 5: 106,974,698 probably null Het
Cpb1 C T 3: 20,265,357 V188M probably damaging Het
Dock5 A G 14: 67,857,922 I101T possibly damaging Het
Dqx1 T C 6: 83,058,972 V95A probably damaging Het
Dvl1 T A 4: 155,853,666 D90E probably damaging Het
Fam135b T C 15: 71,464,030 I438M probably benign Het
Fam57a A G 11: 76,202,231 D33G probably benign Het
Fpr1 A T 17: 17,876,635 M364K probably benign Het
Gm14139 C G 2: 150,192,221 P185R probably damaging Het
Gm7030 T C 17: 36,129,146 Y32C probably damaging Het
Gpat4 G A 8: 23,180,155 P286L probably damaging Het
Gpx7 C A 4: 108,403,273 V109F probably damaging Het
Grhl2 T C 15: 37,336,347 probably null Het
Grn A G 11: 102,433,243 T53A probably benign Het
Hist1h1e T C 13: 23,621,846 probably benign Het
Hmgxb3 T C 18: 61,147,382 N683S probably damaging Het
Iigp1 T C 18: 60,390,911 I367T probably benign Het
Itfg2 T C 6: 128,411,669 E285G probably damaging Het
Itgav T A 2: 83,792,571 C662* probably null Het
Jarid2 T A 13: 44,906,276 N661K probably damaging Het
Lipe T C 7: 25,398,423 T32A probably benign Het
Lrrk2 A G 15: 91,814,695 Y2475C probably benign Het
Mcc T C 18: 44,449,263 D607G probably damaging Het
Mip T A 10: 128,226,006 L42* probably null Het
Mlc1 A T 15: 88,965,996 D192E probably benign Het
Muc2 T C 7: 141,745,488 probably benign Het
Mybl1 T C 1: 9,681,870 D260G probably damaging Het
Ncln C T 10: 81,487,685 V51I probably benign Het
Nlrp9a T C 7: 26,557,872 V305A probably benign Het
Nodal G A 10: 61,424,497 R309Q possibly damaging Het
Olfr1338 A T 4: 118,754,224 F105I probably damaging Het
Olfr294 T C 7: 86,615,676 Y323C probably benign Het
Olfr536 A G 7: 140,503,919 I180T probably damaging Het
Olr1 T C 6: 129,499,918 N128S possibly damaging Het
Orc1 T A 4: 108,604,560 C585S probably benign Het
Pcmtd2 A T 2: 181,855,129 I300F probably damaging Het
Pfkfb4 C T 9: 109,025,042 probably benign Het
Phactr3 T A 2: 178,279,017 L180Q possibly damaging Het
Pigo T C 4: 43,021,083 T612A probably benign Het
Plch1 T A 3: 63,709,531 D766V probably damaging Het
Plekhh3 T C 11: 101,164,147 probably benign Het
Ppp1r12b T A 1: 134,872,832 T547S probably damaging Het
Prkcb T A 7: 122,516,856 M186K probably damaging Het
Prpf3 A T 3: 95,849,800 probably benign Het
Reg3a T C 6: 78,381,131 L15P probably damaging Het
Scrib A T 15: 76,069,374 I5N probably damaging Het
Speg C T 1: 75,422,682 Q2005* probably null Het
Sppl3 A T 5: 115,074,864 S51C possibly damaging Het
Sspo A G 6: 48,457,600 T1009A probably damaging Het
Syce1l A G 8: 113,654,947 Q164R probably benign Het
Sympk T C 7: 19,034,484 V126A possibly damaging Het
Tas2r110 T A 6: 132,868,024 I6K unknown Het
Tas2r120 A T 6: 132,657,768 H271L probably damaging Het
Tnn T A 1: 160,116,286 T986S possibly damaging Het
Trim5 T C 7: 104,279,638 H32R probably damaging Het
Ttc13 A G 8: 124,683,834 I360T possibly damaging Het
Uaca A G 9: 60,871,499 E1054G probably damaging Het
Usp16 T A 16: 87,471,848 probably null Het
Wee1 T A 7: 110,130,836 S382R probably damaging Het
Wnt11 T C 7: 98,846,564 S92P probably damaging Het
Zfp786 A G 6: 47,820,226 C593R probably damaging Het
Zfp879 T G 11: 50,833,162 I283L possibly damaging Het
Other mutations in Psg23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00814:Psg23 APN 7 18614683 nonsense probably null
IGL01309:Psg23 APN 7 18614540 missense probably damaging 1.00
IGL01736:Psg23 APN 7 18612197 missense possibly damaging 0.76
IGL02142:Psg23 APN 7 18610420 missense probably benign 0.01
IGL02728:Psg23 APN 7 18606928 missense probably benign 0.02
IGL03080:Psg23 APN 7 18606985 missense probably damaging 1.00
IGL03130:Psg23 APN 7 18610416 missense probably benign 0.25
R0113:Psg23 UTSW 7 18612002 missense probably benign 0.31
R0137:Psg23 UTSW 7 18614633 missense probably benign 0.00
R0544:Psg23 UTSW 7 18614682 missense probably damaging 1.00
R1368:Psg23 UTSW 7 18614720 missense probably benign 0.13
R1840:Psg23 UTSW 7 18610438 missense possibly damaging 0.67
R1869:Psg23 UTSW 7 18614618 missense probably benign 0.09
R1875:Psg23 UTSW 7 18610450 missense probably benign 0.10
R2041:Psg23 UTSW 7 18614778 missense possibly damaging 0.78
R2096:Psg23 UTSW 7 18614743 missense probably damaging 1.00
R3110:Psg23 UTSW 7 18610444 missense possibly damaging 0.72
R3790:Psg23 UTSW 7 18612201 missense probably benign 0.00
R3892:Psg23 UTSW 7 18612041 missense probably damaging 1.00
R4074:Psg23 UTSW 7 18607118 missense possibly damaging 0.66
R4200:Psg23 UTSW 7 18612065 missense probably damaging 1.00
R4865:Psg23 UTSW 7 18612114 missense probably benign 0.14
R5337:Psg23 UTSW 7 18612072 missense probably benign 0.00
R6016:Psg23 UTSW 7 18612187 missense probably benign 0.00
R6951:Psg23 UTSW 7 18614711 missense probably damaging 1.00
R7033:Psg23 UTSW 7 18614744 missense possibly damaging 0.82
R7212:Psg23 UTSW 7 18607139 missense probably benign 0.00
R7427:Psg23 UTSW 7 18611983 splice site probably null
R7527:Psg23 UTSW 7 18614774 missense probably damaging 1.00
R7814:Psg23 UTSW 7 18606914 makesense probably null
R7864:Psg23 UTSW 7 18610510 missense possibly damaging 0.87
R7897:Psg23 UTSW 7 18607183 missense possibly damaging 0.83
R8155:Psg23 UTSW 7 18612254 missense probably damaging 1.00
R8358:Psg23 UTSW 7 18614597 missense probably benign 0.00
R9032:Psg23 UTSW 7 18614735 missense possibly damaging 0.83
R9085:Psg23 UTSW 7 18614735 missense possibly damaging 0.83
R9365:Psg23 UTSW 7 18610468 missense probably damaging 1.00
Predicted Primers
Posted On 2017-05-15