Incidental Mutation 'LCD18:Cd22'
| ID |
478038 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cd22
|
| Ensembl Gene |
ENSMUSG00000030577 |
| Gene Name |
CD22 antigen |
| Synonyms |
Lyb8, Lyb-8 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
LCD18 (G1)
|
| Quality Score |
999 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
30564829-30579767 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 30577507 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Histidine
at position 2
(R2H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140528
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000019248]
[ENSMUST00000108125]
[ENSMUST00000186154]
[ENSMUST00000190753]
[ENSMUST00000187989]
[ENSMUST00000190646]
[ENSMUST00000190617]
[ENSMUST00000188157]
[ENSMUST00000189718]
[ENSMUST00000214289]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000019248
AA Change: R2H
PolyPhen 2
Score 0.857 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000019248
Gene: ENSMUSG00000030577
AA Change: R2H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IG
|
31 |
147 |
2.75e-1 |
SMART |
|
IG_like
|
156 |
254 |
4.07e1 |
SMART |
|
IGc2
|
269 |
337 |
2.68e-4 |
SMART |
|
IGc2
|
365 |
424 |
4.52e-11 |
SMART |
|
IG
|
448 |
523 |
1.21e-2 |
SMART |
|
IGc2
|
541 |
599 |
6.75e-10 |
SMART |
|
IGc2
|
628 |
687 |
2.68e-4 |
SMART |
|
transmembrane domain
|
709 |
726 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000108125
AA Change: R2H
PolyPhen 2
Score 0.857 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000103760
Gene: ENSMUSG00000030577
AA Change: R2H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IG
|
31 |
147 |
2.75e-1 |
SMART |
|
IG_like
|
156 |
254 |
4.07e1 |
SMART |
|
IGc2
|
269 |
337 |
2.68e-4 |
SMART |
|
IGc2
|
365 |
424 |
4.52e-11 |
SMART |
|
IG
|
448 |
523 |
1.21e-2 |
SMART |
|
IGc2
|
541 |
599 |
6.75e-10 |
SMART |
|
IGc2
|
628 |
687 |
2.68e-4 |
SMART |
|
transmembrane domain
|
709 |
726 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000186154
AA Change: R2H
PolyPhen 2
Score 0.857 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000139685
Gene: ENSMUSG00000030577
AA Change: R2H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IG
|
31 |
147 |
2.75e-1 |
SMART |
|
IG_like
|
156 |
254 |
4.07e1 |
SMART |
|
IGc2
|
269 |
337 |
2.68e-4 |
SMART |
|
IGc2
|
365 |
424 |
4.52e-11 |
SMART |
|
IG
|
448 |
523 |
1.21e-2 |
SMART |
|
IGc2
|
541 |
599 |
6.75e-10 |
SMART |
|
IGc2
|
628 |
687 |
2.68e-4 |
SMART |
|
transmembrane domain
|
709 |
726 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000186333
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000186354
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000187436
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000187585
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000190753
AA Change: R2H
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000187989
AA Change: R2H
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000190646
AA Change: R2H
PolyPhen 2
Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000140528
Gene: ENSMUSG00000030577
AA Change: R2H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IG
|
31 |
147 |
1.1e-3 |
SMART |
|
IG_like
|
166 |
245 |
1.6e-2 |
SMART |
|
IGc2
|
269 |
337 |
1.1e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000190617
AA Change: R2H
PolyPhen 2
Score 0.857 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000139871
Gene: ENSMUSG00000030577
AA Change: R2H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IG
|
31 |
147 |
2.75e-1 |
SMART |
|
IG_like
|
156 |
254 |
4.07e1 |
SMART |
|
IGc2
|
269 |
337 |
2.68e-4 |
SMART |
|
IGc2
|
365 |
424 |
4.52e-11 |
SMART |
|
IG
|
448 |
523 |
1.21e-2 |
SMART |
|
IGc2
|
541 |
599 |
6.75e-10 |
SMART |
|
IGc2
|
628 |
687 |
2.68e-4 |
SMART |
|
transmembrane domain
|
709 |
726 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000188157
AA Change: R2H
PolyPhen 2
Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000140450
Gene: ENSMUSG00000030577
AA Change: R2H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IG
|
31 |
147 |
1.1e-3 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000189718
AA Change: R2H
PolyPhen 2
Score 0.857 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000140521
Gene: ENSMUSG00000030577
AA Change: R2H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IG
|
31 |
147 |
2.75e-1 |
SMART |
|
IG_like
|
156 |
254 |
4.07e1 |
SMART |
|
IGc2
|
269 |
337 |
2.68e-4 |
SMART |
|
IGc2
|
365 |
424 |
4.52e-11 |
SMART |
|
IG
|
448 |
523 |
1.21e-2 |
SMART |
|
IGc2
|
541 |
599 |
6.75e-10 |
SMART |
|
IGc2
|
628 |
687 |
2.68e-4 |
SMART |
|
transmembrane domain
|
709 |
726 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000189996
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000190170
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000214289
AA Change: R2H
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190455
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 0.0%
- 3x: 0.0%
- 10x: 0.0%
- 20x: 0.0%
|
| Validation Efficiency |
88% (169/191) |
| MGI Phenotype |
PHENOTYPE: Homozygous null mice have reduced mature B cell numbers with altered proliferation kinetics and reduced antibody production to T cell independent antigens. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A330008L17Rik |
A |
G |
8: 100,450,057 (GRCm39) |
|
noncoding transcript |
Het |
| Aff2 |
C |
A |
X: 68,791,141 (GRCm39) |
|
probably benign |
Het |
| Aldh1a1 |
C |
A |
19: 20,604,010 (GRCm39) |
|
probably benign |
Het |
| Anxa7 |
C |
T |
14: 20,519,479 (GRCm39) |
G113E |
probably damaging |
Het |
| Apba2 |
A |
T |
7: 64,271,908 (GRCm39) |
|
probably benign |
Het |
| Apc2 |
G |
C |
10: 80,135,808 (GRCm39) |
|
probably benign |
Het |
| App |
C |
G |
16: 84,822,300 (GRCm39) |
|
probably benign |
Het |
| Asic2 |
C |
A |
11: 80,876,570 (GRCm39) |
|
probably benign |
Het |
| Btk |
T |
C |
X: 133,479,574 (GRCm39) |
|
probably benign |
Het |
| Car12 |
C |
A |
9: 66,668,958 (GRCm39) |
|
probably benign |
Het |
| Ccdc121 |
GAGAAG |
GAG |
5: 31,644,717 (GRCm39) |
|
probably benign |
Het |
| Ccdc191 |
G |
A |
16: 43,742,164 (GRCm39) |
|
probably benign |
Het |
| Ccdc34 |
N |
|
2: 110,016,318 (GRCm38) |
|
probably benign |
Het |
| Cd164 |
G |
T |
10: 41,397,922 (GRCm39) |
A59S |
probably benign |
Het |
| Cdv3 |
C |
A |
9: 103,242,553 (GRCm39) |
|
probably benign |
Het |
| Cdv3 |
A |
T |
9: 103,242,542 (GRCm39) |
|
probably benign |
Het |
| Celf2 |
N |
|
2: 6,779,076 (GRCm38) |
|
probably benign |
Het |
| Cfap299 |
G |
A |
5: 98,855,367 (GRCm39) |
|
probably benign |
Het |
| Clec18a |
C |
A |
8: 111,802,768 (GRCm39) |
|
probably benign |
Het |
| Cnpy3 |
GGATGGAT |
GGATAGATAGATAGATAGATGGAT |
17: 47,048,462 (GRCm39) |
|
probably benign |
Het |
| Cntn4 |
A |
G |
6: 106,530,901 (GRCm39) |
|
probably benign |
Het |
| Cntnap5c |
G |
C |
17: 58,469,155 (GRCm39) |
|
probably benign |
Het |
| Col2a1 |
C |
A |
15: 97,886,862 (GRCm39) |
|
probably null |
Het |
| Cpne3 |
G |
T |
4: 19,563,382 (GRCm39) |
|
probably benign |
Het |
| Cracd |
GGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG |
GGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG |
5: 76,806,589 (GRCm39) |
|
probably benign |
Het |
| Dab1 |
T |
G |
4: 103,903,769 (GRCm39) |
|
probably benign |
Het |
| Dapp1 |
G |
A |
3: 137,645,161 (GRCm39) |
|
probably benign |
Het |
| Dcc |
G |
A |
18: 72,430,518 (GRCm39) |
|
probably benign |
Het |
| Dcun1d1 |
GAAAAAAAAA |
GAAAAAAAAAA |
3: 35,992,154 (GRCm39) |
|
probably benign |
Het |
| Dennd1b |
G |
A |
1: 139,042,502 (GRCm39) |
|
probably benign |
Het |
| Dhdds |
TAA |
TA |
4: 133,697,674 (GRCm39) |
|
probably benign |
Het |
| Dnah12 |
G |
T |
14: 26,571,342 (GRCm39) |
G2817V |
probably damaging |
Het |
| Dnm3 |
CATATATATATATATATATATATA |
CATATATATATATATATATATA |
1: 162,234,130 (GRCm39) |
|
probably benign |
Het |
| Dock10 |
N |
|
1: 80,716,623 (GRCm38) |
|
probably benign |
Het |
| Dusp10 |
G |
T |
1: 183,769,253 (GRCm39) |
C73F |
probably damaging |
Het |
| Fgf20 |
A |
C |
8: 40,745,359 (GRCm39) |
|
probably benign |
Het |
| Ftsj3 |
G |
T |
11: 106,140,885 (GRCm39) |
|
probably benign |
Het |
| Gls |
T |
G |
1: 52,222,526 (GRCm39) |
|
probably benign |
Het |
| Gm12130 |
T |
C |
11: 38,397,750 (GRCm39) |
|
noncoding transcript |
Het |
| Gm14936 |
G |
A |
X: 111,908,447 (GRCm39) |
|
noncoding transcript |
Het |
| Gm16630 |
C |
T |
6: 48,118,203 (GRCm39) |
|
noncoding transcript |
Het |
| Gm22194 |
AGTGTGTGTGTGTGTGTGTGTGTGTGTGTG |
AGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG |
10: 11,816,707 (GRCm39) |
|
noncoding transcript |
Het |
| Gm26917 |
C |
G |
17: 40,154,862 (GRCm39) |
|
noncoding transcript |
Het |
| Gm35048 |
GACACACACACACACACACACACACACACACACACACAC |
GACACACACACACACACACACACACACACACACACAC |
1: 90,449,248 (GRCm39) |
|
noncoding transcript |
Het |
| Gm37311 |
G |
A |
16: 77,415,169 (GRCm39) |
|
noncoding transcript |
Het |
| Gm37928 |
AACACACACACACACACACACACACACACACACA |
AACACACACACACACACACACACACACACACACACA |
3: 118,328,206 (GRCm39) |
|
noncoding transcript |
Het |
| Gm4302 |
T |
C |
10: 100,177,306 (GRCm39) |
W197R |
probably benign |
Het |
| H2-Q4 |
G |
A |
17: 35,599,381 (GRCm39) |
D155N |
probably damaging |
Het |
| H2-T23 |
T |
C |
17: 36,342,108 (GRCm39) |
|
probably benign |
Het |
| Hgs |
CTTTTTTT |
CTTTTTT |
11: 120,360,404 (GRCm39) |
|
probably benign |
Het |
| Ighv5-9 |
C |
T |
12: 113,625,497 (GRCm39) |
S82N |
probably benign |
Het |
| Il1rap |
C |
A |
16: 26,450,343 (GRCm39) |
|
probably benign |
Het |
| Inhbc |
N |
|
10: 127,367,140 (GRCm38) |
|
probably benign |
Het |
| Inpp4b |
C |
T |
8: 82,419,639 (GRCm39) |
|
probably benign |
Het |
| Kars1 |
N |
|
8: 111,993,708 (GRCm38) |
|
probably benign |
Het |
| Kcng4 |
G |
T |
8: 120,360,258 (GRCm39) |
Y39* |
probably null |
Het |
| Kcnh7 |
A |
G |
2: 62,880,143 (GRCm39) |
|
probably benign |
Het |
| Klhl1 |
G |
C |
14: 96,555,166 (GRCm39) |
|
probably benign |
Het |
| Lrch1 |
C |
T |
14: 75,142,461 (GRCm39) |
|
probably benign |
Het |
| Lrp1b |
G |
C |
2: 42,127,574 (GRCm39) |
|
probably benign |
Het |
| Lsm8 |
G |
A |
6: 18,844,315 (GRCm39) |
|
probably benign |
Het |
| Lsm8 |
G |
A |
6: 18,854,320 (GRCm39) |
|
probably benign |
Het |
| Magi2 |
T |
C |
5: 20,159,509 (GRCm39) |
|
probably benign |
Het |
| Matcap2 |
N |
|
9: 22,442,083 (GRCm38) |
|
probably benign |
Het |
| Mef2c |
G |
A |
13: 83,753,942 (GRCm39) |
|
probably benign |
Het |
| Mei4 |
A |
G |
9: 82,069,012 (GRCm39) |
|
probably benign |
Het |
| Mid1 |
T |
A |
X: 168,788,560 (GRCm39) |
|
probably benign |
Het |
| Mndal |
G |
C |
1: 173,707,784 (GRCm39) |
|
probably benign |
Het |
| Mpped2 |
C |
A |
2: 106,551,773 (GRCm39) |
|
probably benign |
Het |
| Mtarc2 |
TAGGCAGCCAATCAGAGCACTGCCTCTCAGCGCCAGGCAGCCAATCAGAGCACTGCCTCTCAGCGCCAGGCA |
TAGGCAGCCAATCAGAGCACTGCCTCTCAGCGCCAGGCA |
1: 184,554,985 (GRCm39) |
|
probably benign |
Het |
| Mtf1 |
A |
G |
4: 124,723,109 (GRCm39) |
|
probably benign |
Het |
| Mxd1 |
T |
C |
6: 86,644,388 (GRCm39) |
|
probably benign |
Het |
| Nbea |
G |
T |
3: 55,608,948 (GRCm39) |
|
probably benign |
Het |
| Ncor1 |
N |
|
11: 62,419,782 (GRCm38) |
|
probably benign |
Het |
| Nox4 |
A |
G |
7: 86,892,275 (GRCm39) |
|
probably benign |
Het |
| Ocln |
C |
T |
13: 100,657,075 (GRCm39) |
|
probably benign |
Het |
| Ofcc1 |
G |
A |
13: 40,246,443 (GRCm39) |
|
probably benign |
Het |
| Or5af2 |
T |
A |
11: 58,708,266 (GRCm39) |
V144D |
possibly damaging |
Het |
| Paics |
N |
|
5: 76,956,744 (GRCm38) |
|
probably null |
Het |
| Paqr8 |
G |
T |
1: 20,984,882 (GRCm39) |
|
probably benign |
Het |
| Pate9 |
T |
C |
9: 36,444,849 (GRCm39) |
|
probably benign |
Het |
| Pdss1 |
C |
T |
2: 22,790,980 (GRCm39) |
|
probably benign |
Het |
| Piezo1 |
G |
A |
8: 123,222,308 (GRCm39) |
R503W |
probably damaging |
Het |
| Pkhd1 |
G |
A |
1: 20,681,638 (GRCm39) |
|
probably benign |
Het |
| Ppp1r3f |
C |
A |
X: 7,426,575 (GRCm39) |
G562V |
probably damaging |
Het |
| Prr16 |
C |
T |
18: 51,333,396 (GRCm39) |
|
probably benign |
Het |
| Prss38 |
T |
G |
11: 59,266,467 (GRCm39) |
|
probably benign |
Het |
| Prxl2c |
G |
A |
13: 64,435,099 (GRCm39) |
|
probably benign |
Het |
| Ptprk |
T |
C |
10: 28,450,983 (GRCm39) |
|
probably benign |
Het |
| Pum1 |
N |
|
4: 130,730,549 (GRCm38) |
|
probably benign |
Het |
| Rabgef1 |
N |
|
5: 130,187,586 (GRCm38) |
|
probably null |
Het |
| Rgs16 |
G |
A |
1: 153,619,976 (GRCm39) |
|
probably benign |
Het |
| Riok3 |
G |
T |
18: 12,263,039 (GRCm39) |
|
probably benign |
Het |
| Rn18s-rs5 |
T |
C |
17: 40,159,446 (GRCm39) |
|
noncoding transcript |
Het |
| Robo2 |
N |
|
16: 74,055,954 (GRCm38) |
|
probably benign |
Het |
| Rps6ka3 |
A |
G |
X: 158,062,211 (GRCm39) |
|
probably benign |
Het |
| Rptn |
T |
A |
3: 93,304,848 (GRCm39) |
L727Q |
probably benign |
Het |
| Slc25a46 |
C |
A |
18: 31,730,366 (GRCm39) |
|
probably benign |
Het |
| Spata31f1e |
T |
C |
4: 42,792,885 (GRCm39) |
T416A |
probably benign |
Het |
| Spsb1 |
C |
T |
4: 150,036,943 (GRCm39) |
|
probably benign |
Het |
| Tbc1d19 |
A |
C |
5: 53,974,051 (GRCm39) |
|
probably benign |
Het |
| Trav7-4 |
C |
T |
14: 53,698,975 (GRCm39) |
L41F |
probably benign |
Het |
| Trip12 |
N |
|
1: 84,754,482 (GRCm38) |
|
probably benign |
Het |
| Ttc13 |
G |
A |
8: 125,402,605 (GRCm39) |
|
probably benign |
Het |
| Ttll6 |
C |
T |
11: 96,046,084 (GRCm39) |
|
probably benign |
Het |
| Unc5b |
C |
G |
10: 60,621,950 (GRCm39) |
|
probably benign |
Het |
| Vmn2r87 |
C |
T |
10: 130,314,583 (GRCm39) |
M334I |
probably benign |
Het |
| Vps13b |
G |
T |
15: 35,847,103 (GRCm39) |
A2629S |
probably damaging |
Het |
| Wars2 |
N |
|
3: 99,214,774 (GRCm38) |
|
probably null |
Het |
| Zdhhc3 |
AACACACACACACACACACACACACACACACAC |
AACACACACACACACACACACACACACACACACAC |
9: 122,912,087 (GRCm39) |
|
probably benign |
Het |
| Zfp26 |
C |
A |
9: 20,349,842 (GRCm39) |
A241S |
probably benign |
Het |
| Zfp442 |
C |
T |
2: 150,261,768 (GRCm39) |
|
probably benign |
Het |
| Zfp808 |
C |
T |
13: 62,314,465 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Cd22 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00714:Cd22
|
APN |
7 |
30,575,572 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02236:Cd22
|
APN |
7 |
30,566,893 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL02321:Cd22
|
APN |
7 |
30,569,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02335:Cd22
|
APN |
7 |
30,575,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02397:Cd22
|
APN |
7 |
30,577,050 (GRCm39) |
missense |
probably benign |
|
|
IGL02402:Cd22
|
APN |
7 |
30,576,955 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02538:Cd22
|
APN |
7 |
30,576,985 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL02736:Cd22
|
APN |
7 |
30,577,470 (GRCm39) |
splice site |
probably null |
|
|
blitz
|
UTSW |
7 |
30,569,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
crullers
|
UTSW |
7 |
30,569,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
gansu
|
UTSW |
7 |
30,569,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
lacrima
|
UTSW |
7 |
30,575,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Lluvia
|
UTSW |
7 |
30,569,912 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
Mist
|
UTSW |
7 |
30,566,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
rain
|
UTSW |
7 |
30,576,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
well
|
UTSW |
7 |
30,577,212 (GRCm39) |
nonsense |
probably null |
|
|
Yosemite
|
UTSW |
7 |
30,568,934 (GRCm39) |
critical splice donor site |
probably null |
|
|
FR4304:Cd22
|
UTSW |
7 |
30,577,507 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
FR4340:Cd22
|
UTSW |
7 |
30,577,507 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
FR4342:Cd22
|
UTSW |
7 |
30,577,507 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
FR4589:Cd22
|
UTSW |
7 |
30,577,507 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
PIT4142001:Cd22
|
UTSW |
7 |
30,577,224 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0123:Cd22
|
UTSW |
7 |
30,566,533 (GRCm39) |
splice site |
probably benign |
|
|
R0130:Cd22
|
UTSW |
7 |
30,569,389 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0926:Cd22
|
UTSW |
7 |
30,568,934 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1245:Cd22
|
UTSW |
7 |
30,569,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1332:Cd22
|
UTSW |
7 |
30,569,912 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1457:Cd22
|
UTSW |
7 |
30,572,595 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1716:Cd22
|
UTSW |
7 |
30,577,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1980:Cd22
|
UTSW |
7 |
30,572,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Cd22
|
UTSW |
7 |
30,572,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2061:Cd22
|
UTSW |
7 |
30,575,581 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2061:Cd22
|
UTSW |
7 |
30,569,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2075:Cd22
|
UTSW |
7 |
30,569,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2216:Cd22
|
UTSW |
7 |
30,566,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3886:Cd22
|
UTSW |
7 |
30,569,532 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R4599:Cd22
|
UTSW |
7 |
30,575,325 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4701:Cd22
|
UTSW |
7 |
30,575,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4796:Cd22
|
UTSW |
7 |
30,572,381 (GRCm39) |
splice site |
probably null |
|
|
R5179:Cd22
|
UTSW |
7 |
30,575,299 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5233:Cd22
|
UTSW |
7 |
30,576,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5456:Cd22
|
UTSW |
7 |
30,575,464 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5511:Cd22
|
UTSW |
7 |
30,569,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5513:Cd22
|
UTSW |
7 |
30,566,450 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5611:Cd22
|
UTSW |
7 |
30,577,575 (GRCm39) |
unclassified |
probably benign |
|
|
R5656:Cd22
|
UTSW |
7 |
30,569,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5966:Cd22
|
UTSW |
7 |
30,566,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6329:Cd22
|
UTSW |
7 |
30,577,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6356:Cd22
|
UTSW |
7 |
30,577,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6455:Cd22
|
UTSW |
7 |
30,575,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6550:Cd22
|
UTSW |
7 |
30,576,977 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6656:Cd22
|
UTSW |
7 |
30,577,182 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6688:Cd22
|
UTSW |
7 |
30,572,389 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6844:Cd22
|
UTSW |
7 |
30,572,856 (GRCm39) |
splice site |
probably null |
|
|
R6957:Cd22
|
UTSW |
7 |
30,566,999 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7068:Cd22
|
UTSW |
7 |
30,577,504 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7083:Cd22
|
UTSW |
7 |
30,567,473 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7225:Cd22
|
UTSW |
7 |
30,577,059 (GRCm39) |
missense |
not run |
|
|
R7732:Cd22
|
UTSW |
7 |
30,569,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8686:Cd22
|
UTSW |
7 |
30,569,494 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8851:Cd22
|
UTSW |
7 |
30,577,084 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8987:Cd22
|
UTSW |
7 |
30,577,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9051:Cd22
|
UTSW |
7 |
30,575,449 (GRCm39) |
missense |
probably benign |
|
|
R9098:Cd22
|
UTSW |
7 |
30,567,391 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9124:Cd22
|
UTSW |
7 |
30,572,662 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9167:Cd22
|
UTSW |
7 |
30,575,430 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9319:Cd22
|
UTSW |
7 |
30,569,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9369:Cd22
|
UTSW |
7 |
30,576,999 (GRCm39) |
missense |
probably benign |
0.09 |
|
X0025:Cd22
|
UTSW |
7 |
30,572,844 (GRCm39) |
splice site |
probably null |
|
|
Z1176:Cd22
|
UTSW |
7 |
30,568,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Cd22
|
UTSW |
7 |
30,567,388 (GRCm39) |
missense |
probably benign |
0.03 |
|
Z1186:Cd22
|
UTSW |
7 |
30,566,891 (GRCm39) |
missense |
probably benign |
|
|
Z1186:Cd22
|
UTSW |
7 |
30,566,478 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1186:Cd22
|
UTSW |
7 |
30,575,292 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGGGTGAGAACTTCCACTG -3'
(R):5'- CAACAAGATGGCTCAAAGGC -3'
Sequencing Primer
(F):5'- TTCCACTGGAAGTAGGAGAGG -3'
(R):5'- AAGGCAAATTCCTTTTGTTGTTCTTG -3'
|
| Posted On |
2017-05-17 |
Incidental Mutation