Incidental Mutation 'R5341:Cpxm2'
ID 478258
Institutional Source Beutler Lab
Gene Symbol Cpxm2
Ensembl Gene ENSMUSG00000030862
Gene Name carboxypeptidase X, M14 family member 2
Synonyms 4632435C11Rik
MMRRC Submission 042920-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R5341 (G1)
Quality Score 50
Status Validated
Chromosome 7
Chromosomal Location 131634416-131756468 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to A at 131756342 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000130971 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033149] [ENSMUST00000124096]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000033149
AA Change: M1L
SMART Domains Protein: ENSMUSP00000033149
Gene: ENSMUSG00000030862
AA Change: M1L

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
low complexity region 52 59 N/A INTRINSIC
low complexity region 72 82 N/A INTRINSIC
low complexity region 87 98 N/A INTRINSIC
FA58C 143 301 2.18e-46 SMART
Zn_pept 448 736 9.21e-58 SMART
low complexity region 751 764 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000124096
SMART Domains Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849

DomainStartEndE-ValueType
Pfam:Pkinase 1 118 4.8e-19 PFAM
Pfam:Pkinase_Tyr 1 118 1.7e-50 PFAM
low complexity region 146 160 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127039
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152302
Meta Mutation Damage Score 0.2589 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.7%
  • 20x: 96.2%
Validation Efficiency 97% (64/66)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb3 A G 10: 85,223,236 (GRCm39) D15G unknown Het
Actr5 C A 2: 158,467,144 (GRCm39) S28* probably null Het
Adcy1 A C 11: 7,080,375 (GRCm39) M373L probably damaging Het
Adcyap1r1 C G 6: 55,455,054 (GRCm39) F111L probably benign Het
Arid5b A T 10: 68,113,957 (GRCm39) F27I possibly damaging Het
Art5 C A 7: 101,747,306 (GRCm39) V158L probably benign Het
Bora T A 14: 99,305,530 (GRCm39) Y300N probably damaging Het
Cd300a A G 11: 114,784,288 (GRCm39) T99A probably damaging Het
Cdon A G 9: 35,381,431 (GRCm39) Y607C probably damaging Het
Cenatac A G 9: 44,328,406 (GRCm39) probably null Het
Cstdc7 A G 18: 42,306,496 (GRCm39) D21G possibly damaging Het
Dhx8 AGACCGGGACCGGGACCGGGACCGGGAC AGACCGGGACCGGGACCGGGAC 11: 101,629,016 (GRCm39) probably benign Het
Dync2i1 T C 12: 116,219,534 (GRCm39) E136G possibly damaging Het
Enox1 A C 14: 77,815,096 (GRCm39) T85P possibly damaging Het
Fanci T C 7: 79,055,926 (GRCm39) L158P probably damaging Het
Gbgt1 C A 2: 28,395,019 (GRCm39) T219N probably damaging Het
Gulo T C 14: 66,225,707 (GRCm39) D373G probably benign Het
Hivep2 C A 10: 14,008,336 (GRCm39) Q1645K possibly damaging Het
Iqce A C 5: 140,675,814 (GRCm39) M114R possibly damaging Het
Lmbrd1 A T 1: 24,785,892 (GRCm39) K396* probably null Het
Lrrk2 A T 15: 91,657,061 (GRCm39) D1785V probably damaging Het
Matcap1 A T 8: 106,011,687 (GRCm39) M226K probably damaging Het
Mcmdc2 ATAAAAAAAAAGGAAAAATTACCTT AT 1: 10,011,142 (GRCm39) probably null Het
Mepce A G 5: 137,781,522 (GRCm39) V564A probably damaging Het
Mmp17 A T 5: 129,679,193 (GRCm39) D364V possibly damaging Het
Mrgpre T C 7: 143,335,246 (GRCm39) N86D probably benign Het
Ms4a20 T C 19: 11,087,745 (GRCm39) probably benign Het
Or2r11 A T 6: 42,437,098 (GRCm39) L285Q probably damaging Het
Or4f53 T A 2: 111,087,982 (GRCm39) I174K probably damaging Het
Pate11 A T 9: 36,388,357 (GRCm39) K61* probably null Het
Pax5 T C 4: 44,697,630 (GRCm39) D35G probably damaging Het
Pip5k1b T A 19: 24,281,440 (GRCm39) T473S probably benign Het
Pkd2l2 A G 18: 34,542,987 (GRCm39) probably null Het
Pygo2 C A 3: 89,340,067 (GRCm39) P155Q probably damaging Het
Rb1cc1 G T 1: 6,285,266 (GRCm39) probably benign Het
Rbpj A G 5: 53,799,425 (GRCm39) E80G possibly damaging Het
Sbno1 A C 5: 124,546,538 (GRCm39) probably null Het
Slc1a1 T A 19: 28,874,968 (GRCm39) V182E probably benign Het
Slc34a3 A T 2: 25,120,671 (GRCm39) F419I probably benign Het
Snx8 A G 5: 140,343,886 (GRCm39) V62A probably damaging Het
Sp9 T C 2: 73,104,858 (GRCm39) S471P possibly damaging Het
Sspo A T 6: 48,436,549 (GRCm39) S1270C probably damaging Het
Stk11 A T 10: 79,962,094 (GRCm39) T83S probably benign Het
Syt13 A G 2: 92,783,897 (GRCm39) E389G probably benign Het
Taf10 T C 7: 105,390,139 (GRCm39) probably benign Het
Tgm1 A T 14: 55,937,705 (GRCm39) S801R possibly damaging Het
Thoc2l A T 5: 104,665,942 (GRCm39) T155S probably damaging Het
Timeless T C 10: 128,083,047 (GRCm39) F628L possibly damaging Het
Tmem171 G T 13: 98,824,956 (GRCm39) P225T probably damaging Het
Tspan12 A T 6: 21,835,458 (GRCm39) C72S possibly damaging Het
Txk T C 5: 72,853,964 (GRCm39) T458A probably benign Het
Txndc9 A G 1: 38,026,704 (GRCm39) probably benign Het
Uap1 C A 1: 169,971,000 (GRCm39) C464F probably damaging Het
Ugt2b36 A T 5: 87,240,087 (GRCm39) Y99* probably null Het
Usp35 T C 7: 96,975,134 (GRCm39) Y13C probably damaging Het
Vmn1r6 T G 6: 56,979,789 (GRCm39) N128K probably damaging Het
Vmn2r106 T A 17: 20,497,788 (GRCm39) I484L probably benign Het
Zdbf2 T A 1: 63,347,092 (GRCm39) S1824T probably benign Het
Zdhhc4 A G 5: 143,311,915 (GRCm39) V19A probably benign Het
Zfp955b C T 17: 33,524,095 (GRCm39) probably benign Het
Zfp97 T A 17: 17,365,472 (GRCm39) C324S probably damaging Het
Zswim8 G A 14: 20,766,122 (GRCm39) D803N probably damaging Het
Other mutations in Cpxm2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01862:Cpxm2 APN 7 131,661,540 (GRCm39) missense probably benign 0.01
IGL02039:Cpxm2 APN 7 131,649,482 (GRCm39) missense probably damaging 1.00
IGL03011:Cpxm2 APN 7 131,650,807 (GRCm39) missense possibly damaging 0.46
R0033:Cpxm2 UTSW 7 131,663,886 (GRCm39) missense possibly damaging 0.55
R0100:Cpxm2 UTSW 7 131,656,600 (GRCm39) missense possibly damaging 0.90
R0100:Cpxm2 UTSW 7 131,656,600 (GRCm39) missense possibly damaging 0.90
R0453:Cpxm2 UTSW 7 131,730,134 (GRCm39) missense probably damaging 1.00
R0555:Cpxm2 UTSW 7 131,645,772 (GRCm39) nonsense probably null
R0655:Cpxm2 UTSW 7 131,656,549 (GRCm39) missense possibly damaging 0.87
R0834:Cpxm2 UTSW 7 131,756,342 (GRCm39) intron probably benign
R1145:Cpxm2 UTSW 7 131,659,377 (GRCm39) missense probably damaging 0.99
R1145:Cpxm2 UTSW 7 131,659,377 (GRCm39) missense probably damaging 0.99
R1249:Cpxm2 UTSW 7 131,730,079 (GRCm39) critical splice donor site probably null
R1563:Cpxm2 UTSW 7 131,745,411 (GRCm39) missense probably benign 0.00
R1565:Cpxm2 UTSW 7 131,663,874 (GRCm39) missense probably damaging 1.00
R1709:Cpxm2 UTSW 7 131,661,563 (GRCm39) missense probably damaging 1.00
R1863:Cpxm2 UTSW 7 131,745,392 (GRCm39) splice site probably null
R1874:Cpxm2 UTSW 7 131,661,563 (GRCm39) missense probably damaging 1.00
R1958:Cpxm2 UTSW 7 131,663,876 (GRCm39) missense probably damaging 1.00
R2273:Cpxm2 UTSW 7 131,661,581 (GRCm39) intron probably benign
R3806:Cpxm2 UTSW 7 131,681,820 (GRCm39) missense probably benign 0.12
R3861:Cpxm2 UTSW 7 131,656,648 (GRCm39) missense probably benign 0.00
R4570:Cpxm2 UTSW 7 131,745,435 (GRCm39) missense probably benign 0.11
R4642:Cpxm2 UTSW 7 131,672,610 (GRCm39) missense probably benign 0.11
R4684:Cpxm2 UTSW 7 131,650,767 (GRCm39) missense possibly damaging 0.92
R4717:Cpxm2 UTSW 7 131,656,574 (GRCm39) missense possibly damaging 0.61
R4863:Cpxm2 UTSW 7 131,661,476 (GRCm39) missense probably benign 0.13
R5079:Cpxm2 UTSW 7 131,756,014 (GRCm39) critical splice donor site probably null
R5626:Cpxm2 UTSW 7 131,661,581 (GRCm39) intron probably benign
R5666:Cpxm2 UTSW 7 131,656,625 (GRCm39) missense probably benign 0.44
R5815:Cpxm2 UTSW 7 131,645,839 (GRCm39) missense probably damaging 1.00
R6114:Cpxm2 UTSW 7 131,756,035 (GRCm39) missense probably benign
R6133:Cpxm2 UTSW 7 131,730,182 (GRCm39) missense probably damaging 1.00
R6224:Cpxm2 UTSW 7 131,745,460 (GRCm39) missense probably benign
R6468:Cpxm2 UTSW 7 131,672,589 (GRCm39) missense probably damaging 1.00
R6657:Cpxm2 UTSW 7 131,650,806 (GRCm39) missense probably damaging 1.00
R7058:Cpxm2 UTSW 7 131,745,408 (GRCm39) missense probably benign 0.32
R7100:Cpxm2 UTSW 7 131,656,544 (GRCm39) missense probably benign 0.06
R7198:Cpxm2 UTSW 7 131,681,813 (GRCm39) missense probably damaging 1.00
R7712:Cpxm2 UTSW 7 131,756,107 (GRCm39) missense possibly damaging 0.69
R7855:Cpxm2 UTSW 7 131,659,424 (GRCm39) missense possibly damaging 0.56
R7867:Cpxm2 UTSW 7 131,650,800 (GRCm39) missense probably damaging 1.00
R8513:Cpxm2 UTSW 7 131,745,431 (GRCm39) missense probably benign 0.01
R8694:Cpxm2 UTSW 7 131,681,783 (GRCm39) missense probably benign 0.03
R8874:Cpxm2 UTSW 7 131,708,010 (GRCm39) critical splice donor site probably null
R8967:Cpxm2 UTSW 7 131,661,564 (GRCm39) missense probably damaging 1.00
R9680:Cpxm2 UTSW 7 131,661,651 (GRCm39) missense probably damaging 1.00
R9759:Cpxm2 UTSW 7 131,756,242 (GRCm39) missense probably benign 0.03
RF014:Cpxm2 UTSW 7 131,672,592 (GRCm39) missense possibly damaging 0.85
Z1177:Cpxm2 UTSW 7 131,656,730 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TTCATGCATTGAAGGCGAGAAG -3'
(R):5'- TTCAACACCTGCTGGAGAGG -3'

Sequencing Primer
(F):5'- CATTGAAGGCGAGAAGAGCTCC -3'
(R):5'- TGCTGGAGAGGCCCTGG -3'
Posted On 2017-06-01